DRUG STUDY:

Generic
Name

Classificatio
n

Action

Indication

Contraindications

Adverse
Effects

Side
Effects

Etoricoxib

Nonsteroidal
AntiInflammator
y
Drugs
(NSAIDs)

Like any
other
COX-2
selective
inhibitor
Etoricoxi
b
selective
ly
inhibits
isoform
2
of
cyclooxigenas
e
enzyme
(COX-2).
This
reduces
prostagl
andins
(PGs)
generati
on from
arachido
nic
acid..

Acute
&
chronic
treatment
of the signs
&
symptoms
osteoarthri
tis & RA.
Treatment
of
ankylosing
spondylitis.

-History
of
hypersensitivity
to
etoricoxib or to any of the
excipients of Arcoxia.
-Active peptic ulceration
or active GI bleeding.
-Patients
who
have
experienced
bronchospasm,
acute
rhinitis,
nasal
polyps,
angioneurotic
edema,
urticaria or allergic-type
reactions
after
taking
acetylsalicylic
acid
or
NSAIDs
including
cyclooxygenase-2 (COX-2)
inhibitors.
-Pregnancy and lactation.
-Severe
hepatic
dysfunction
(serum
albumin <25 g/L or ChildPugh score 10).
-Estimated
renal
creatinine clearance <30
mL/min.
-Inflammatory
bowel
disease.
-Congestive heart failure
(NYHA II-IV).
-Patients
with
hypertension whose blood
pressure has not been
adequately controlled.
-Established
ischemic
heart disease, peripheral
arterial disease and/or
cerebrovascular disease.

Immune
system,
nervous
system,
cardiac,
resp,
thoracic
mediastina
l,
GI,
hepatobili
ary, skin &
SC tissue,
renal
&
urinary
disorders.
Psychiatric
disorder,
hypertensi
ve crisis.
Blood
&
lymphatic
system
disorders.
Vascular
disorders.

Asthenia/
fatigue,
dizziness
,
lower
extremit
y edema,
hyperten
sion,
dyspepsi
a,
heartbur
n,
nausea,
headach
e,
increase
d
ALT
and AST.

Brand Name
Arcoxia
Dosage
90 mg (OD)

Treatment
of
acute
gouty
arthritis &
primary
dysmenorr
hea.
Relief
acute
chronic
pain

of
&

Nursing
Responsibiliti
es
Special
precautions:
*Advanced
renal disease
*Pre existing
edema
*hypertensio
n or heart
failure
*liver
dysfunction

Drugs Name

Classification

Action

Indication

Contraindications/
Precautions

Adverse
Reaction

Nursing
Responsibilitie
s

Tramadol

Non-opioid-derived
synthetic opioid;
centrally acting
analgesic, but may
act at least partially
by binding to opioid
mu receptors,
causing inhibition
of ascending pain
pathways

Physiologic
Mechanism

Moderate to
moderately
severe pain

abrupt
discontinuation, ethan
ol intoxication, opiate
agonist
hypersensitivity,
breast-feeding,
children, driving or
operating machinery,
elderly, GI disease,
head trauma, hepatic
disease, increased
intracranial pressure,
labor, pregnancy, renal
impairment,
respiratory depression,
seizure disorder,
substance abuse

Dizziness or
vertigo,
Nausea and
Vomiting,
Constipation,
Headache,
Somnolence,
Pruritus, CNS
Stimulation,
Asthenia,
Diaphoresis,
Dyspepsia,
Dry mouth,
Diarrhea,
Malaise,
Vasodilatation,
Anorexia,
Flatulence,
Rash, Visual
disturbance,
Urinary
retention or
frequency,
Menopausal
symptoms

Decreased
pain.
Pharmacologic
Mechanism
Binds to muopioid
receptors.
Inhibits
reuptake of
serotonin and
norepinephrin
e in the CNS

May cause
dependence.
Avoid
alcohol and
over-thecounter
medications.
May cause
drowsiness,
dizziness,
and blurred
vision.
Avoid tasks
requiring
alertness
and motor
skills until
response to
drug is
established.
Inform
physician if
severe
constipation,
difficulty in
breathing,
excessive
sedation,
seizures,
muscle
weakness,
tremors,
chest pain,
and
palpitations
occur.