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Human blood PH is m
antained at 7.35-7.45 by many mechanisms, the most importan t are the regulation
of CO2, bicarbonate and H atoms by lungs and kidney. . PH < 7.35 = acidosis whi
le PH > 7.45 = alkalosis. . PaCO2 & HCO3 can differentiate between respiratory a
nd metabolic acid base dis turbance. . Sometimes mixed acid-base disorders prese
nt with PH within normal range. . Normal HCO3 = 24 mEq/L and normal PaCO2 = 40 m
mHg. . Metabolic acid-base disturbance is due to primary change in HCO3 concentr
ation . . Respiratory acid-base disturbance is due to primary change in PaCO2. .
Primary rise in PaCO2 (respiratory acidosis) and drop of plasma HCO3 (metaboli
c acidosis). . Primary drop in PaCO3 (respiratory alkalosis) and rise in plasma
HCO3 (metabol ic alkalosis). .. HCO3 primary change (metabolic) while PaCO2 prim
ary change (Respiratory). .. Primary = the main change is in Paco2 or HCO3. .. C
ompensatory = slight change in the other item. .. i.e: PaCO2 = 45 & HCO3 = 35 -> metabolic .... PaCO2 = 26 & HCO3 = 28 --> res piratory .. if great change in b
oth PaCO2 & HCO3 --> think of mixed acid-base imbalance ( fix the formula & calc
ulate PaCO2 and compaire it with that of the case). . METABOLIC ACIDOSIS: ______
________________ . Decreased blood PH < 7.35. . Decreased blood HCO3 < 24 mEq/L
(1ry). . Decreased PaCO2 (Compensatory respiratory alkalosis), . PaCO2s in metab
olic acidosis is calculated by winter's formua: PaCO2 = 1.5 (H CO3) + 8 . Causes
: See below N.B: . Hyperventilation (tachypnea) is the mode of repiratory compen
sation for metab olic acidosis (to wash CO2). . Calculating the plasma anion gap
is the best next step in diagnosis of patien t's acid-base status, . due to it
narrow the diffrential diagnosis in case of metabolic acidosis e.g. A) Some of t
he most common cause of anion gap metabolic acidosis: - Lactic acidosis: Hypoxia
, poor tissue perfusion, mitochondrial dysfunction. - Ketoacidosis: Type 1 D.M,
starvation & alcoholism. - Methanol ingestion: Formic acid accumulation. - Ethyl
ene glycol ingestion: glycolic and oxalic acid accumulation. - Salicylates poiso
ning: causes mixed metabolic acidosis and respiratory alkal osis. - Uremia: Fail
ure to excrete (H) as NH4. B) Most common causes of normal anion gap metabolic a
cidosis: - RTA (renal tubular acidosis) --> has +ve urine anion gap (UAG). - Dia
rrhea --> has -ve urine anion gap (UAG). . METABOLIC ALKALOSIS: ________________
____
Increased blood PH > 7.45. Increased blood HCO3 > 24 mEq/L (1ry). Increased PaCO
2 (compensatory respiratory acidosis). PaCO2 in metabolic alkalosis is calculate
d by the formula: PaCO2 = (0.9 HCO3) 16 +,- 2. Causes; - Vomiting, diuretic --> V
olume depletion --> + Renin-aldosterone system. - Exogenous alkali intake. - min
eralocorticoids excess --> bicarbonate retention, H & K loss --> metabol ic alka
losis. . Metabolic alkalosis is divided into: 1- Saline responsive condition (wi
th urine chloride < 20 mEq/L) and volum dep letion, - due to GIT proton (H) loss
(vomiting), volume contraction or diuretics, - treated by normale saline. 2- Sa
line resistant condition (with urine chloride > 20 mEq/L) and volum expa nsion,
- Hyperaldosteronism, Barrter syndrome, Gitelman syndrome and excessive, b lack
liqurice ingestion. - Not treated by normal saline. . Hyperemesis gravidarum cau
ses volume depletion --> metabolic alkalosis with re spiratory compensation. . R
ESPIRATORY ACIDOSIS: ________________________ . Increased blood paCO2 > 40 mmHg
(1ry). . Increased blood HCO3 (Compensatory). . Decreased minute ventilation. (M
inute ventilation = Respiratory rate Tidal vo lume. . Caused by alveolar hypovent
ilation as: - Chest disese: COPD, Obstructive sleep apnea, silicosis, obesity. Neuromuscular disease: Myasthenia gravis, lambert-eaton, polymeilitis, G. b arr
e. - CNS disease: Stroke, infection, brain stem lesion. - Druge induced: anesthe
sia, Narcotics and sedatives. . RESPIRATORY ALKALOSIS: ________________________
. Decreased blood PaCO2 < 40 mm Hg. . Decreased blood HCO3 (compensatory). . Inc
reased minute ventilation (washing co2). . Caused by alveolar hyperventilation d
ue to: pneumonia, high altitude, anaemia , anxiety, pain, fever, pulm. embolism,
pleural effusion, atelectasis & Salicylate intoxication. . MIXED ACID-BASE DISO
RDERS (Metabolic acidosis and respiratory alkalosis) ___________________________
______________________________________________ . It may cause inappropriately no
rmale laboratory values. . Calculate the expected change in PaCO2 & HCO3 and com
paire it with the patien t measured values in the case, . To determine if a mixe
d disorder exists or a normale physiologic compensation has occured, . PaCO2s in
metabolic acidosis is calculated by winter's formua: PaCO2 = 1.5 (H CO3) + 8. .
Salicylates intoxications --> + Respiratory center --> Tachypnea and respirat o
ry alkalosis,
. . . . + .
. Also causes anion gap metabolic acidosis due to increased production and decr
eased renal elemination of organic acids as lactic and ketoacids. . ADRENAL INSU
FFICIENCY (Addison's disease): ____________________________________________ . No
n specific msnifestations: Anorexia, fatigue, GIT complains, weight loss an d hy
potension. . The most common electrolyte abnormality is HYPONATREMIA. . Also HYP
ERKALEMIA is common; due to decreased activation of aldosterone recep tors (with
mild hyperchloremic acidosis). . DIURETIC ABUSE: _________________ . Causes inc
reased excretion of water and electrolytes by the kidney. . Dehydration, weight
loss, orthostatic hypotension. . Hypokalemia and hyponatremia due to increased u
rinary excretion of Na & K --> increased urine Na & K. . Eating disorders may ca
use the patient abuse diuretics. . CAUSES OF ORTHOSTATIC HYPOTENSION: ---------------------------------. Decreased intravascular volume: Decreased fluid intake
, polyuria and diarrhea . . Decreased vascular tone: autonomic neuropathy or med
ications as (antihyperten sive and antipsychotics). . DIABETES INSIPIDUS: ______
_________________ . Causes euvolemic hypernatremia. . present with severe polyur
ia and mild hypernatremia. . Based on urine osmolality DI is of 2 types: - Compl
ete D.I: urine osmolality < 300 mosml/kg (Normally < 100 mosm/kg). - Incomplete
D.I: urine osmolality 300-400 mosm/kg. . Based on etiology D.I is of 2 types: Centeral D.I: decreased ADH release due to: CNS; trauma, hge, infection or tumor
. - Nephrogenic D.I: due resistance to ADH: common causes; hypercalcemia, sever
e hypokalemia, tubulointerstial renal disease, - medications as: Lithium(ttt of
bipolar disorder), demeclocycline, foscarnet , amphotricine and cidofovir. . N.B
:- Divalporic acid is used in bipolar disorder but doesn't cause D.I. - Dehydrat
ion --> HYPOVOLEMIC hypernatremia + increased urine osmolality. . PSYCHOGENIC PO
LYDIPSIAL: __________________________ . Excessive free water intake --> hyponatr
emia. . Patient with psychatric illness. . Like D.I euvolemic polyuria but psych
ogenic polydipsia (hyponatremia), wherea s D.I (hyppernatremia). . HYPONATREMIA:
_______________ . Serum sodium < 130 mEq/L. . Causes According to: ============
====================================================================
intoxication). . Causes mixed Respiratory alkalosis and anion gap metabolic acid
osis. . Explanation: - Aspirin stimulates respiratory center causing tachpnnea -> respiratory alka losis (CO2 wash). - Aspirin causes anion gap metabolic acido
sis by: . Uncoupling ofOxidative phosphorylation --> increasing O2 consumption b
y t issues & also hyperpyrexia. . Inhibites enzymes involved in carbohydrate and
lipid metabolism --> accum ulation of organic acids (pyruvate, lactate...). . I
mpaire renal function --> accumulation of organic acids. .N.B: - Normal acid-bas
e status --> PH 7.39-7.41, PaCO2 35-40 and HCO3 24. - Respiratory acidosis witho
ut compensation --> PH < 7.39, primary decrease in PaCO2 and normale HCO3. - Res
piratory acidosis with compensation --> PH < 7.39, primary decrease in PaC O2 an
d compensatory increase in HCO3. - Respiratory alkalosis with compensation --> P
H > 7.41, primary decrease in Pa CO2 and compensatory decrease in HCO3. - Respir
atory alkalosis without compensation --> PH > 7.41, primary decrease in PaCO2 an
d near normal HCO3 - Metabolic acidosis without compensation --> PH < 7.39, prim
ary decrease in HC O3 and near normale PaCO2. - Metabolic acidosis with compensa
tion --> PH < 7.39, primary decrease in HCO3 and compensatory decrease in PaCO2.
- Metabolic alkalosis with compensation --> PH > 7.41, primary increase in HCO3
and compensatory increase in PaCO2. - Metabolic alkalosis without compensation
--> PH > 7.41, primary increase in H CO3 and near normal PaCO2. .. HCO3 primary
change (metabolic) while PaCO2 primary change (Respiratory). .. Primary = the ma
in change is in Paco2 or HCO3. .. Compensatory = slight change in the other item
. .. if great change in both PaCO2 & HCO3 --> think of mixed acid-base imbalance
( fix the formula & calculate PaCO2 and compaire it with that of the case). . P
REGNANCY causes --> normal physiological chronic compensated respiratory alka lo
sis due to high progestrone level --> stimulate respiratory center --> Tachypnea
--> cons equent chronic mild respiratory alkalosis with metabolic compensation.
. It is common in late pregnancy due to increase of progesterone with the incre
a se of gestational age. . FAMILIAL HPOCALCURIC HYPERCALCEMIA: -----------------------------------. Increased serum calcium and increased/inappropriately norma
l PTH level are su specious for either: . PRIMARY HYPERPARATHYROIDISM -->normal
or increased urinary calcium excretion. . FAMILAR HYPOCALCURIC HYPERCALCEMIA -->
decreased urinary calcium excretion. . Ethylene glycol, Ethanol and Methanol: --------------------------------------. All of them cause metabolic acidosis wit
h an anion gap and an osmolar gap. . But Ethylene glycol --> calcium oxalate (re
ctangular, envelope shaped crystal s) in urine. .N.B: how to calculate osmolar g
ap ?? - 1st calculate serum osmolarit = {2Na + Glu/18 + BUN/2.8}.