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Community-Acquired Pneumonia
by Sanjay Sethi, MD
NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer
Version
Pneumonia
Overview of Pneumonia
Community-Acquired Pneumonia
Hospital-Acquired Pneumonia
Etiology
Many organisms cause community-acquired pneumonia, including bacteria, viruses, and
fungi. Pathogens vary by patient age and other factors (see Table: Community-Acquired
Pneumonia in Adults), but the relative importance of each as a cause of community-acquired
pneumonia is uncertain, because most patients do not undergo thorough testing, and because
even with testing, specific agents are identified in < 50% of cases (see Overview of
Pneumonia).
S. pneumoniae, H. influenzae, C. pneumoniae, and M. pneumoniaeare the most common
bacterial causes. Pneumonias caused by chlamydia and mycoplasma are often clinically
indistinguishable from other pneumonias. Common viral agents include respiratory syncytial
virus (RSV), adenovirus, influenza viruses, metapneumovirus, and parainfluenza viruses.
Bacterial superinfection can make distinguishing viral from bacterial infection difficult.
C. pneumoniae accounts for 2 to 5% of community-acquired pneumonia and is the 2nd most
common cause of lung infections in healthy people aged 5 to 35 yr. C. pneumoniae is
commonly responsible for outbreaks of respiratory infection within families, in college
dormitories, and in military training camps. It causes a relatively benign form of pneumonia
that infrequently requires hospitalization. Chlamydia psittacipneumonia (psittacosis) is rare
and occurs in patients who own or are often exposed to birds.
Since the year 2000, the incidence of community-acquired methicillin-resistant
Staphylococcus aureus (CA-MRSA) skin infections has increased markedly. This pathogen
can rarely cause severe, cavitating pneumonia and tends to affect young adults.
P. aeruginosa is an especially common cause of pneumonia in patients with cystic fibrosis,
neutropenia, advanced AIDS, and/or bronchiectasis.
A host of other organisms causes lung infection in immunocompetent patients. In patients
with pneumonia, a thorough history of exposures, travel, pets, hobbies, and other exposures is
essential to raise suspicion of less common organisms.
Q fever, tularemia, anthrax, and plague are uncommon bacterial syndromes in which
pneumonia may be a prominent feature. Tularemia (see Tularemia), anthrax (see Anthrax),
and plague (see Plague and Other Yersinia Infections) should raise the suspicion of
bioterrorism (see Biological Agents as Weapons).
Adenovirus, Epstein-Barr virus, and coxsackievirus are common viruses that rarely cause
pneumonia. Seasonal influenza can rarely cause a direct viral pneumonia but often
predisposes to the development of a serious secondary bacterial pneumonia. Varicella virus
and hantavirus cause lung infection as part of adult chickenpox and hantavirus pulmonary
syndrome. A coronavirus causes severe acute respiratory syndrome (SARS) and the Middle
East Respiratory syndrome (MERSsee Coronaviruses and Acute Respiratory Syndromes
(MERS and SARS)).
< 5 yr: Most often viruses; among bacteria, S. pneumoniae, S. aureus, and S.
pyogenes, are common
Diagnosis
Chest x-ray
Diagnosis is suspected on the basis of clinical presentation and infiltrate seen on chest x-ray.
When there is high clinical suspicion of pneumonia and the chest x-ray does not reveal an
infiltrate, doing CT or repeating the chest x-ray in 24 to 48 h is recommended.
Differential diagnosis in patients presenting with pneumonia-like symptoms includes heart
failure (see Heart Failure (HF)) and COPD exacerbation (see Chronic Obstructive Pulmonary
Disease (COPD)). Other disorders should be considered, particularly when findings are
inconsistent or not typical. The most serious common misdiagnosis is pulmonary embolism,
which may be more likely in patients with minimal sputum production, no accompanying
URI or systemic symptoms, and risk factors for thromboembolism (see Table: Risk Factors
for Deep Venous Thrombosis and Pulmonary Embolism); thus, testing for pulmonary
embolism should be considered. Quantitative cultures of bronchoscopic or suctioned
specimens, if they are obtained before antibiotic administration, can help distinguish between
bacterial colonization (ie, presence of microorganisms at levels that provoke neither
symptoms nor an immune response) and infection. However, bronchoscopy is usually done
only in patients receiving mechanical ventilation or for those with other risk factors for
unusual microorganisms or complicated pneumonia (eg, immunocompromise, failure of
empiric therapy).
Distinguishing between bacterial and viral pneumonias is challenging. Many studies have
investigated the utility of clinical, imaging, and routine blood tests, but no test is reliable
enough to make this differentiation. The use of serum biomarkers, such as procalcitonin and
C-reactive protein (CRP), to help in differentiating bacterial from nonbacterial pneumonia is
currently under investigation.
In outpatients with mild or moderate pneumonia, no further diagnostic testing is needed (see
Table: Risk Stratification for Community-Acquired Pneumonia (the Pneumonia Severity
Index)). In patients with moderate or severe pneumonia, a WBC count and electrolytes, BUN,
and creatinine are useful to classify risk and hydration status. Pulse oximetry or ABG testing
should also be done to assess oxygenation. For patients with moderate or severe pneumonia
who require hospitalization, 2 sets of blood cultures are obtained to assess for bacteremia and
sepsis. The IDSA provides a guide to recommended testing based on patient demographic and
risk factors ( Infectious Diseases Society of America Clinical Guideline on CommunityAcquired Pneumonia ).
Pathogen identification
Identification of the pathogen can be useful to direct therapy and verify bacterial
susceptibilities to antibiotics. However, because of the limitations of current diagnostic tests
and the success of empiric antibiotic treatment, experts recommend limiting attempts at
microbiologic identification (eg, cultures, specific antigen testing) unless patients are at high
risk or have complications (eg, severe pneumonia, immunocompromise, asplenia, failure to
respond to empiric therapy). In general, the milder the pneumonia, the less such diagnostic
testing is required. Critically ill patients require the most intensive testing, as do patients in
whom a antibiotic-resistant or unusual organism is suspected (eg, TB, P. jirovecii) and
patients whose condition is deteriorating or who are not responding to treatment within 72 h.
Chest x-ray findings generally cannot distinguish one type of infection from another,
although the following findings are suggestive:
Blood cultures, which are often obtained in patients hospitalized for pneumonia, can identify
causative bacterial pathogens if bacteremia is present. About 12% of all patients hospitalized
with pneumonia have bacteremia; S. pneumoniae accounts for two thirds of these cases.
Sputum testing can include Gram stain and culture for identification of the pathogen, but the
value of these tests is uncertain because specimens often are contaminated with oral flora and
overall diagnostic yield is low. Regardless, identification of a bacterial pathogen in sputum
cultures allows for susceptibility testing. Obtaining sputum samples also allows for testing for
viral pathogens via direct fluorescence antibody testing or PCR, but caution needs to be
exercised in interpretation because 15% of healthy adults carry a respiratory virus or potential
bacterial pathogen. In patients whose condition is deteriorating and in those unresponsive to
broad-spectrum antibiotics, sputum should be tested with mycobacterial and fungal stains and
cultures.
Sputum samples can be obtained noninvasively by simple expectoration or after hypertonic
saline nebulization (induced sputum) for patients unable to produce sputum. Alternatively,
patients can undergo bronchoscopy or endotracheal suctioning, either of which can be easily
done through an endotracheal tube in mechanically ventilated patients. Otherwise,
bronchoscopic sampling is usually done only for patients with other risk factors (eg,
immunocompromise, failure of empiric therapy).
Urine testing for Legionella antigen and pneumococcal antigen is now widely available.
These tests are simple and rapid and have higher sensitivity and specificity than sputum Gram
stain and culture for these pathogens. Patients at risk of Legionella pneumonia (eg, severe
illness, failure of outpatient antibiotic treatment, presence of pleural effusion, active alcohol
abuse, recent travel) should undergo testing for urinary Legionella antigen, which remains
present long after treatment is initiated, but the test detects only L. pneumophila serogroup 1
(70% of cases).
The pneumococcal antigen test is recommended for patients who are severely ill; have had
unsuccessful outpatient antibiotic treatment; or who have pleural effusion, active alcohol
abuse, severe liver disease, or asplenia. This test is especially useful if adequate sputum
samples or blood cultures were not obtained before initiation of antibiotic therapy. A positive
test can be used to tailor antibiotic therapy, though it does not provide antimicrobial
susceptibility.
Multilobar
Pneumonia
Interstit
ial Opacities
Prognosis
Short-term mortality is related to severity of illness. Mortality is < 1% in patients who are
candidates for outpatient treatment. Mortality in hospitalized patients is 8%. Death may be
caused by pneumonia itself, progression to sepsis syndrome (see Sepsis and Septic Shock), or
exacerbation of coexisting conditions. In patients hospitalized for pneumonia, risk of death is
increased during the year after hospital discharge.
Mortality varies to some extent by pathogen. Mortality rates are highest with gram-negative
bacteria and CA-MRSA. However, because these pathogens are relatively infrequent causes
of pneumonia, S. pneumoniae remains the most common cause of death in patients with
community-acquired pneumonia. Atypical pathogens such as Mycoplasma have a good
prognosis. Mortality is higher in patients who do not respond to initial empiric antibiotics and
in those whose treatment regimen does not conform with guidelines.
Treatment
Antibiotics
Supportive measures
Risk stratification
Risk stratification via risk prediction rules may be used to estimate mortality risk and can
help guide decisions regarding hospitalization. These rules have been used to identify patients
who can be safely treated as outpatients and those who require hospitalization because of
high risk of complications (see Table: Risk Stratification for Community-Acquired
Pneumonia (the Pneumonia Severity Index)). However, these rules should supplement, not
replace, clinical judgment because many unrepresented factors, such as likelihood of
adherence, ability to care for self, and wish to avoid hospitalization, should also influence
triage decisions. An. ICU admission is required for patients who
Multilobar pneumonia
Diastolic BP < 60 mm Hg
Confusion
The Pneumonia Severity Index (PSI) is the most studied and validated prediction rule.
However, because the PSI is complex and requires several laboratory assessments, simpler
rules such as CURB-65 are usually recommended for clinical use. Use of these prediction
rules has led to a reduction in unnecessary hospitalizations for patients who have milder
illness.
In CURB-65, 1 point is allotted for each of the following risk factors:
C onfusion
Age 65 yr
Points
Patient demographics
Men
Factor
Points
Women
Age(in yr) 10
10
Coexisting illness
Cancer
30
Liver disease
20
Heart failure
10
Cerebrovascular disease
10
Renal disease
10
Physical examination
20
20
Systolic BP < 90 mm Hg
20
Temperature 40 C or <35C
15
10
Test results
Factor
Points
30
20
20
10
10
Pa o 2 < 60 mm Hg or
10
O 2 saturation <90%*
Pleural effusion
10
Points
Mortality
Recommendation
70
<1%
Outpatient treatment
7190
<5%
Outpatient treatment
91130
515%
Admit
>130
>15%
Admit
Acute care admission, subacute care admission, observation period, home IV antibiotics, or
home nursing visits should be considered for patients who are frail, isolated, or living in
Factor
Points
unstable environments.
Adapted from Pneumonia: New prediction model proves promising (AHCPR Publication No.
97-R031).
Antimicrobials
Antibiotic therapy is the mainstay of treatment for community-acquired pneumonia.
Appropriate treatment involves starting empiric antibiotics as soon as possible, preferably 8
h after presentation. Because organisms are difficult to identify, the empiric antibiotic
regimen is selected based on likely pathogens and severity of illness. Consensus guidelines
have been developed by many professional organizations; one widely used set is detailed in
Community-Acquired Pneumonia in Adults (see also Infectious Diseases Society of America
Clinical Guideline on Community-Acquired Pneumonia ). Guidelines should be adapted to
local susceptibility patterns, drug formularies, and individual patient circumstances. If a
pathogen is subsequently identified, the results of antibiotic susceptibility testing can help
guide any changes in antibiotic therapy.
For children, treatment depends on age, previous vaccinations, and whether treatment is
outpatient or inpatient. For outpatient treatment, treatments are dictated by age:
For children treated as inpatients, antibiotic therapy tends to be more broad-spectrum and
depends on the child's previous vaccinations:
Full details are described in the Clinical Practice Guidelines by the Pediatric Infectious
Diseases Society and the Infectious Diseases Society of America .
With empiric treatment, 90% of patients with bacterial pneumonia improve. Improvement is
manifested by decreased cough and dyspnea, defervescence, relief of chest pain, and decline
in WBC count. Failure to improve should trigger suspicion of
An unusual organism
Empyema
Immunosuppression
Metastatic focus of infection with reseeding (in the case of pneumococcal infection)
If none of these conditions can be proved, treatment failure is likely due to inadequate host
defenses. When therapy has failed, consultation with a pulmonary and/or infectious disease
specialist is indicated.
Antiviral therapy may be indicated for select viral pneumonias. Ribavirin is not used
routinely for RSV pneumonia in children or adults, but may be used in occasional high-risk
children age < 24 mo.
Oseltamivir 75 mg po bid or zanamivir 10 mg inhaled bid started within 48 h of symptom
onset and given for 5 days reduces the duration and severity of symptoms in patients who
develop influenza infection. In patients hospitalized with confirmed influenza infection,
observational studies suggest benefit even 48 h after symptom onset.
Acyclovir 5 to 10 mg/kg IV q 8 h for adults or 250 to 500 mg/m 2 body surface area IV q 8 h
for children is recommended for varicella lung infections. Though pure viral pneumonia does
occur, superimposed bacterial infections are common and require antibiotics directed against
S. pneumoniae, H. influenzae, and S. aureus.
Follow-up x-rays should be obtained 6 wk after treatment in patients > 35; persistence of an
infiltrate at 6 wk raises suspicions of TB or an underlying, possibly malignant
endobronchial lesion.
Group
Likely Organisms
Empiric Treatment
Azithromycin 500 mg IV q 24 h
III. Inpatient
not in ICU
S. pneumoniae, H. influenzae; M.
pneumoniae; C. pneumoniae; mixed
infection (bacteria + atypical pathogen
or virus); respiratory viruses;
Legionella sp, miscellaneous organisms
(eg, M. tuberculosis, endemic fungi,
Pneumocystis jirovecii)
plus
-Lactam IV (cefotaxime 1 to 2 g
q 8 to 12 h; ceftriaxone 1 g q 24 h)
or
Antipneumococcal
fluoroquinolone po or IV (alone)
Group
Likely Organisms
Empiric Treatment
-Lactam IV (cefotaxime 1 to 2 g
IV q 8 to 12 h; ceftriaxone 1 g IV
q 24 h)
plus either
Antipneumococcal
fluoroquinolone IV
or
Azithromycin 500 mg IV q 24 h
Antipseudomonal -lactam or
aztreonam (if allergic to or
intolerant of -lactams) 1 to 2 g q
8h
plus either
Ciprofloxacin 400 mg IV q 12 h or
levofloxacin 750 mg po or IV q 24
h
Modifying factors:
Group
Likely Organisms
Empiric Treatment
Data from Mandell A, Wunderink R, Azueto A, et al: Infectious Disease Society of America
and American Thoracic Society Guidelines for the management of adults with communityacquired pneumonia. Clinical Infectious Diseases 44:S27S72, 2007.
Supportive care
Supportive care includes fluids, antipyretics, analgesics, and, for patients with hypoxemia, O
2 . Prophylaxis against thromboembolic disease and early mobilization improve outcomes for
patients hospitalized with pneumonia. Cessation counseling should also be done for smokers.
Prevention
Some forms of community-acquired pneumonia are preventable with vaccination.
Pneumococcal conjugate vaccine (PCV13) is recommended for children age 2 mo to 2 yr and
for adults 19 yr with certain comorbid (including immunocompromising) conditions.
Pneumococcal polysaccharide vaccine (PPSV23) is given to all adults 65 yr and to any
patient 2 yr who has risk factors for pneumococcal infections, including but not limited to
those with underlying heart, lung, or immune system disorders and those who smoke (see
Table: Vaccine Administration Guidelines for Adults). The full list of indications for both
pneumococcal vaccines can be seen at the CDC website. H. influenzae type b (Hib) vaccine
(for patients < 2 yr), varicella vaccine (for patients < 18 mo and a later booster vaccine), and
influenza vaccine (for patients age 65 and those at high risksee Overview of
Immunization and see Table: Recommended Immunization Schedule for Ages 06 yr) are
also indicated.
In high-risk patients who are not vaccinated against influenza and household contacts of
patients with influenza, oseltamivir 75 mg po once/day or zanamivir 10 po mg once/day can
be given for 2 wk and started within 48 h of exposure may prevent influenza (although
resistance has recently been described for oseltamivir).
Smoking cessation can reduce the risk of developing pneumonia.
Key Points
Common symptoms and signs include cough, fever, chills, fatigue, dyspnea, rigors,
sputum production, and pleuritic chest pain.
Treat patients with mild or moderate risk pneumonia with empiric antibiotics without
testing designed to identify the underlying pathogen.
Hospitalize patients with multiple risk factors, as delineated by the risk assessment
tools.
More Information
Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the
Infectious Diseases Society of America
Fig 1
Left Lower Lobe Infiltrate
Fig 2
Multilobar Pneumonia
Fig 3
Interstitial Opacities
Table 1
Risk Stratification for Community-Acquired Pneumonia (the Pneumonia Severity
Index)
Table 2
Community-Acquired Pneumonia in Adults
Drug Name
Select Trade
Ribavirin
VIRAZOLE
Oseltamivir
TAMIFLU
moxifloxacin
AVELOX
Acyclovir
ZOVIRAX
Doxycycline
PERIOSTAT, VIBRAMYCIN
gemifloxacin
FACTIVE
cefepime
MAXIPIME
ceftriaxone
ROCEPHIN
cefpodoxime
No US brand name
azithromycin
ZITHROMAX
vancomycin
VANCOCIN
levofloxacin
IQUIX, LEVAQUIN, QUIXIN
meropenem
MERREM
zanamivir
RELENZA
Amoxicillin
AMOXIL
Ciprofloxacin
CILOXAN, CIPRO
cefotaxime
CLAFORAN
clindamycin
CLEOCIN
cefuroxime
CEFTIN, ZINACEF
clarithromycin
BIAXIN
aztreonam
AZACTAM
Hmmune System
Defect
Disorders Or Therapy
Associated With Defect*
Likely Pathogens
Defective PMNs
Neutropenia
Gram-negative bacteria,
Acute leukemia, aplastic
Staphylococcus aureus, Aspergillus
anemia, cancer chemotherapy
sp, Candida sp
S. aureus
Defective alternative
pathway
Streptococcus pneumoniae,
Haemophilus influenzae
C5 deficiency
Congenital disorder
Cell-mediated
immunity
T-cell deficiency or
dysfunction
AIDS
Hmmune System
Defect
Disorders Or Therapy
Associated With Defect*
Likely Pathogens
Humoral
immunodeficiency
B-cell deficiency or
dysfunction
*Examples. Many
disorders cause
multiple defects.
PMN =
polymorphonuclear
leukocytes.
Multiple myeloma,
agammaglobulinemia
S. pneumoniae, H. influenzae,
Neisseria meningitidis
S. pneumoniae, H. influenzae
Hypogammaglobulinemia
P. jirovecii, cytomegalovirus, S.
pneumoniae, H. influenzae