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Fish
o The circulatory plan in the fish is fairly simple
Blood is pumped by the heart, goes to the gills and is
oxygenated, the oxygenated blood is carried to the
systemic tissues where it gives up its oxygen and the
blood returns to the heart
o The problem with this circ sys is that the heart has to pump
blood to the gills and the systemic circulation both of which are
sites of resistance
Heart must generate relatively high pressures
The gills as the first point of the system are going to see
relatively high points of pressure
They are able to withstand this because there is
water on the other side of the gill to counter balance
this pressure
Pressure of the system as a whole is limited to the
pressure that the gills can withstand
o Fish heart has 4 chambers in a series
Blood enters the sinus venoses the atrium
ventriclebulbous or conus arteriosis
The ventricle is where the main force generation
occurs
Bulbous and conus arteriosis are structurally
different but share the same purpose functionally
which is to maintain blood flow when the heart
relaxes
o Same function as the aorta in a mammal
o Sinus venosus is only found in fish; it disappears it land living
organisms
Mammals and birth
o Essential there are 2 two chambered hearts
They are physically together in the same organ however
when broken down you have 2, 2 chambered hearts
o The left side of the heart and a right side.
Left side Always on the right when looking at a diagram
and right side is the left in the diagram
o The left side of the hear takes blood returning from the lungs
and pumps it out to the systemic circulation
o The right side of the heart takes blood returning from systemic
circulation(deoxygenated) and it pumps it to the lungs to be
oxygenated
In the mammalian heart there are vales between the atria and the
ventricles to control blood flow
Heart is made of cardiac muscle
o It is similar to skeletal muscle
o These are considered to be striated because they contain
sarcomeres
o They are quite short and are connected end to end by
intercalated discs
In these discs one will find gap junctions
Which are communicating junctions that allow
electrical communication between the different cells
of the heart so they can contract as a unit
o The heart is innervated by the ANS
Within the ANS; there are 2 divisions
Sympathetic
o Responsible for fight/flight alarm type
situations
o Neurotransmitter of choice is noradrenaline
Interact with receptor in the tissues that
are adrenergic receptors
o B-1 receptors are more important for the heart
Parasympathetic
o Responsible for housekeeping or vegetative
functions
o the rest and digest system
o Responsible for functions outside of alarm
situations
o Neurotransmitter of choice is acetylcholine
Interacts with muscular genic receptors
in the effector organ
Main one for the heart is the m2
receptor
Both sympathetic and parasympathetic divisions are active
and in most tissues you can find innervation from both
Heart is innervated by both but they have opposite
affects
o Sympathetic will increase heart rate to allow
for response in emergency situation
o Parasympathetic will slow it down
They have antagonistic effects
ANS allows good control of internal functions without any
conscious control
Most of the heart is made of cardiac muscle cells and these come in
two types
the pacemaker cells in human sinoatrial node fire at rate of 100 time
per minute
o 100 depolarizations a minute
o This means the heart rate should be 100beats/min
o Heart beat is controlled by other mechanisms
There is input from the parasympathetic nervous system
that regulates heart rate
Sinoatrial node is in the atrium of the mammalian heart and it fires its
action potential first and this spreads across the atria real quick
o It slows down when it gets to the atrial ventricular node
o There is a layer of connective tissue between the two atria and
the two ventricle
o The cells of the atria re connected by gap junctions and the cells
of the ventricle are connected by gap junctions
But the atria and the ventricles do not communicate
This layer of connective tissue means there is no electrical
communication between the atria and ventricles except
through the atrial ventricular node
Conduction though this part of the system is quite slow
Once it gets through this system it speeds up
tremendously and shoots up through the ventricles at a
rate of 4or 5 m/s
ECG
o Measures the consequence of all the action potentials in the bod
fluid as a whole
It is the sum effect of all the action potentials happening
together
o Measured by placing electrodes upon the bodys surface not by
trying to impale a single heart cell to measure membrane
potential of that cell
o In the standard mammalian EKG there is a small wave called the
p wave
This shows the atria depolarizing
o There is a larger wave(QRS): this is the ventricles depolarizing
o Small t wave- this is the ventricular repolarization
o The repolarizing of the atrium is not seen because it occurs at
the same time that the ventricles depolarize and so it is masked
by this
o Value of the EKG tries to figure out what is going on in the heart
The heart as a pump
o Electrical activity in the conducting system has to be converted
into muscle contractions in 99% contractile part of the heart
To get these cells to contract the heart first has to be
depolarized
Slide 22
Action potential f contractile cells
o Stable resting potential and when it is triggered it undergoes
depolarization and a voltage gated Na+ channel opens allowing
Na+ to pour into the cell and this gives you a strong
depolarization
There is also a voltage gated Ca2+ channel that opens a
little bit later and this calcium channel stays open for a
while and that is how one gets the plateau region
This is an L-type gates calcium channel; in
pacemaker there is a t-type calcium channel
The flow of calcium into the cell triggers calcium
release from stores within the cell
o Not only have calcium moving into the cell
through the voltage gated channels you also
have calcium being released from stores inside
the cell
o The release of these stored calcium the
triggers the contraction of the cell
Calcium inflow + calcium
released=occurrence of muscle
contraction
o The cell then repolarizes and this represents a K+ channel that
is opened which allows K+ ions to flow out.
o Note in the diagram there is a prolonged plateau phase and a
refractory period
This is long refractory period is important because the
heart has to relax and refill with blood before it can
contract again
So the refractory period allows for the cells to rest
and reset as well as gives time for the heart to relax
and be refilled with blood
The long plateau in the action potential is necessary
because it allows all the muscle cells to contract at the
same time
This also makes sure that the heart cannot go into a
tetanic contraction-no muscle cramp in the heart
Refractory period: period where the cell is resting before
another AP can occur
Slide 23
Systolic
o When heart is contracting
Diastolic
o When the heart is relaxing
Stroke volume
o Volume of blood pumped b the heart
o When heart contracts it ejects a volume of blood called the SV
and this is the difference in volume of the heart when it is
full(end diastolic volume) and after it contracts(end systolic
volume)
Most of the filling of the ventricles is due to venous pressure
o The valves between the atria and ventricle sis open and so the
blood flow through the valves to the ventricle from the atria
o This is driven by venous pressure; the atrial contraction helps
but it is only responsible for 1/3 of the volume in the ventricle
Venous pressure does all the work
For the heart to function properly output from the heart must match
the need for oxygen delivery
o This can be achieved by increasing heart rate or stroke volume
o Regulation of stroke volume is referred to as inotropic control
and its caused by both a mechanical relationship and neural and
hormonal control
The mechanical relationship is the frank-starling
relationship
See in slide 23
It shows that as end diastolic volume increases(as
heart if filled) SV also increases
o The fuller the heart the more forceful the
contraction and this ejects more blood
It is ;mechanical b/c as you fill the heart fuller it
stretches out muscle and this result in a more
forceful contraction
Very important because you always want to empty
the heart to the same point so by filling the heart
fuller you need more blood out of it to get back to
the same empty point
As heart rate goes higher there is less time needed
to fill it with blood and so the SV gets smaller there
hormonal and neural; mechanisms to accompany the
mechanical relationship and these mechs work to
stoop stroke volume from falling
o Neural/hormonal control of the heart
The sympathetic nerves innervate the ventricles and
strongly contractile muscle cells they release