The Ultimate Synergy Against Cancer: Fucoidan and AHCC

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The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter 1
Learn about two nutrients that can precisely target and kill
cancer cells by modulating the immune system
THE ULTIMATE SYNERGY

AGAINST CANCER:
FUCOIDAN AND AHCC
Dr. Susana trujillo

THE ULTIMATE SYNERGY
AGAINST CANCER:
Fucoidan and AHCC

Learn about two nutrients that can precisely
target and kill cancer cells by modulating the
immune system
The purpose of this book is to educate. It is not intended to serve as a replacement for professional medical advice. Any use of the information in this
book is at the readers discretion. This book is sold with the understanding
that neither the publisher nor the author has any liability or responsibility for
any injury caused or alleged to be caused directly or indirectly by the information contained in this book. While every effort has been made to ensure
its accuracy, the books content should not be constructed as medical advice.
To obtain medical advice on your individual health needs, please consult a
qualified health care practitioner.
Copyright 2015 Martha Susana Trujillo Frias
All rights reserved. No part of this book may be reproduced, scanned, or
distributed in any printed or electronic form without permission. Please do
not participate in or encourage piracy of copyrighted materials in violation of
the authors rights. Purchase only authorized editions.
All rights reserved. Except as permitted under the United States Copyright
Act of 1976, no part of this publication in any format, electronic or physical, may
be reproduced or distributed in any form or by any means, or stored in a database or retrieval system without the prior written permission of the publisher.
ISBN: 978-1-4951-4033-4
Editor: Sherry L. Granader
Cover and editorial design: Carol Rodriguez
Neither the publisher nor the author is engaged in rendering professional advice or services to the individual reader. The ideas, procedures, and suggestions contained in this book are not intended as a substitute for consulting
with your physician. All matters regarding your health require medical supervision. Neither the author nor the publisher shall be liable or responsible
for any loss or damage allegedly arising from any information or suggestion
in this book.
While the author has made every effort to provide accurate telephone
numbers and Internet addresses at the time of publication, neither the publisher nor the author assumes any responsibility for errors, or for changes
that occur after publication. Further, the publisher does not have any control
over and does not assume any responsibility for author or third-party websites or their content.
contents
INTRODUCTION
Fucoidan
CHAPTER 1: What is Fucoidan?
CHAPTER 2: Fucoidan and its anti-cancer effects
CHAPTER 3: Alleviating the chemotherapy side

effects with Fucoidan
CHAPTER 4: Fucoidans effectiveness on other

diseases
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AHCC
CHAPTER 5: What is AHCC?
CHAPTER 6: AHCC and liver function
CHAPTER 7: Enhancing the immunce system

with AHCC
CHAPTER 8: Alleviating the chemotherapy side

effects with AHCC
CHAPTER 9: Clinical Trials on AHCC
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Fucoidan and AHCC

CHAPTER 10: Fucoidan and AHCC anti-cancer

synergy
54
references
67
about the author
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introduction
Chapter 1 The Ultimate Synergy Against Cancer: Fucoidan and AHCC
INTRODUCTION
mproving your quality of life and supporting good health can

be achieved with the powerful benefits and unique properties of Fucoidan and AHCC (Active Hexose Correlated Compound). They are a powerful team that must be taken together
to keep your immune system in good condition. Fucoidan contains water-soluble fiber and polysaccharides, which have
a high molecular weight that comes from large amounts of
brown seaweed. It supports the bodys natural defense system
by priming the immune system for the best defense against
mutation of cells and infections.
Seaweed is the most nutrient-dense sea vegetable in the
marine environment serving up invaluable health benefits. It
is abundant in vitamins, minerals, iodine, calcium, manganese, zinc, iron and potassium. Seaweed absorbs the minerals
that are dissolved in the seawater as it grows, giving you all
the beneficial goodness in the sea. Plants, such as seaweed,
grow by photosynthesis, using light and chlorophyll and
when ingested, can replenish the body with necessary vitamins and minerals.
Still, the natural goodness of sea vegetables is not the only
secret to longevity and good health. For thousands of years,
Eastern cultures have received great health benefits from
mushrooms as well. The use of medicinal mushrooms dates
back to the ancient Egyptians and ancient Chinese cultures
that used them to promote general health and longevity. Maitake, Shiitake and Reishi mushrooms have many overlapping
properties: all boost up immune function, support cardiovascular health, and show promise in lowering the risk of and
treating cancer.
They are a good source of B-vitamins, including riboflavin,
niacin and pantothenic acid, which help provide energy by
breaking down proteins, fats and carbohydrates. Mushrooms
are also a good source of important minerals, like selenium,
copper and potassium. Beta-glucans, which are also found in
The Ultimate Synergy Against Cancer: Fucoidan and AHCC INTRODUCCIN

Chapter 1
mushrooms, have shown to be great immune stimulators and

contribute to resistance against allergies and metabolism.
More importantly, with Shiitake, AHCC can be obtained, which
appears to be more effective than other mushroom extracts.
AHCC is detected faster in the body due to its low molecular weight and provides a strong immune-modulating activity
and liver support.
THE SECRET TO LONGEVITY AND VITALITY COULD BE AS

SIMPLE AS HAVING A SYNERGISTIC COMBINATION OF TWO
AMAZING INGREDIENTS FUCOIDAN AND AHCC. THE FUSION
BETWEEN THESE TWO INGREDIENTS MAKES PERFECT
SENSE, AS THEY BOTH ARE CREATION OF A HEALThY, LONG
LIFE IN DIFFERENT CULTURES.
Fucoidan
The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

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what is fucoidan?
ucoidan is the key ingredient found in brown seaweeds

such as Mozuku, Wakame, and Kombu and has been studied extensively for its bioactive functions and incredible
health benefits. The sliminess found in brown seaweeds is
where fucoidan is found. It contains water-soluble dietary fiber
and polysaccharides, a complex carbohydrate that is the key
ingredient in brown seaweed. Fucoidan has a unique molecular structure that makes it an effective and unique ingredient
for natural health.
Okinawa is touted as having the highest longevity in Japan

with the lowest mortality rate from cancer. The unique dietary habits of the people in Okinawa are one of the reasons for
their longevity that include a wide variety of sea vegetables
including Mozuku, Wakame and Kombu. For example, Mozuku
is used in making miso soup and zosui, a Japanese porridge of
vegetables and rice.
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1 1 The Ultimate Synergy Against Cancer: Fucoidan and AHCC
Sea vegetables absorb all the goodness from the sea as they
grow including calcium, iodine, manganese, zinc, iron, potassium and other minerals. However, the wholesome goodness
of sea vegetables is not the whole story behind the longevity
of Okinawans. The secret is found in Fucoidan that allows the
immune system to operate at optimum levels. Brown seaweed
Fucoidan is made up of molecular polysaccharides and fiber
that support your bodys natural defense system, providing the
best protection against cell mutation and infection.
The medical community has taken notice because Fucoidan offers an anti-cancer effect by inducing apoptosis (death
of cancer cells). Recent studies show that polysaccharides,
found in brown algae, offer amazing health benefits. The slippery and glue-like substance is Fucoidan that is bonded by a
sugar known as fucose. However, the main difference between Fucoidan and other polysaccharides is that Fucoidan
contains quite a few sulfate groups that cause cancer cells to
weaken and shrink naturally.

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chapter 2
FUCOIDAN AND ITS

ANTI-CANCER EFFECT
ancer is a devastating, often debilitating disease that

affects people from all walks of life, all over the world.
Resistance to chemotherapy treatments is more noticeable with tumors not responding or growing back at a faster
rate. More anti-cancer drugs are often given that brings considerable side effects to the human body including hair loss,
bleeding, diarrhea and suppression of the immune system.
People often use complementary therapies to help them feel
better and cope with having cancer and treatment.
There is also increasing evidence that certain natural ingredients can help control some of the symptoms and side effects
of cancer and treatments. For example, several species of
brown seaweeds have shown to have anti-tumor, anti-Angiogenic, antiviral and immunomodulatory effects (immune system modification during treatment). These effects are brought
about by stimulating the natural killer cells. Specially, Fucoidan, a sulfated polysaccharide found in the cell walls of many
species of brown seaweeds have shown to be very effective in
treating cancer because it offers three important anticancer
effects including:
Activating Apoptosis or the programmed death of cancer
cells
Suppressing the formation of blood vessels that feed
tumors (Angiogenesis)
Modulating the immune system
FUCOIDANS THREE FUNCTIONS CAUSE CANCER CELLS

TO NATURALLY SHRINK, WEAKEN AND EVENTUALLY die.
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CELLS DIE IN MORE THAN ONE WAY: NECROSIS VS. Apoptosis

There are two ways that cells die. One is when a cell is damaged and dies known as necrosis, which may result in the
damage to the plasma. The cell membrane collapses causing
inflammation and heat in the surrounding tissues. Necrosis is
caused by external factors, such as infection, toxins or trauma.
This is in contrast to apoptosis, which is a naturally occurring
cause of cellular death. This process is referred to as a programmed cell death because the cells undergoing apoptosis
show characteristic features like the shrinkage of cells becoming smaller and eventually breaking into smaller pieces. The
broken pieces are swallowed up and processed by cells that
remove unwanted substances. As a result, inflammation or
other damage does not occur to the surrounding tissues.
All cells are programmed to die, however this process is an
important part of nature and is in our DNA. For example, when
a fetus is formed in the womb, the hands and feet are web-like.
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Apoptosis
(programmed cell death)
normal cell
cell shrinkage
chromatin condens ation
apoptotic body
formation
membrane
blebbing
nuclear collapse
continued
blebbing
lysis of apoptotic
bodies
As the fetus grows, the webs are separated and form individual
toes and fingers. These changes occur in the body every single
day involving a process where the body discharges old cells
that are no longer needed.
On the other hand, cancer cells are mutated forms of normal cells. If the apoptosis process is working normally, these
cells die naturally, like normal cells. Cancer cells do not die by
themselves because the apoptosis system no longer functions
properly. In other words, normal cells have a specific lifespan
while cancer cells continue to split and grow, traveling throughout the body where they can take root and create new lesions.
ACTIVATION OF APOPTOSIS (PROGRAMMED CELL DEATH)
Apoptosis is of great importance because a failure to undergo
apoptosis is a common feature of many cancers. The ability of
cancer cells to evade engagement of apoptosis plays a significant role in their resistance to conventional treatments. One
of the major modes of action of chemotherapeutic drugs is to
damage the DNA of cancer cells. However, the major obstacle
with chemotherapy drugs is that despite the progress made in
their development, they continue to cause toxicity and damage
to normal tissues and adverse side effects in multiple organs.
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For this reason, many natural extracts have been researched due to their ability to serve as a promising anti-cancer
treatment. One of the main reasons why Fucoidan is so amazing is that it can lead the cancer cells to apoptosis without
damaging the normal cells. While side effects from drugs and
other supplements that are unsuccessful, Fucoidan is safely
absorbed, very effective and is all-natural. Fucoidan causes
cancer cells to self-destruct by activating the Apoptosis mechanism.
Traditional cancer therapy involves surgery to remove cancerous lesions and drugs to weaken and destroy cancer cells;
however they also damage normal cells to a certain degree.
The side effects are nausea, hair loss, fatigue, loss of appetite
and reduced quality of life. The apoptosis process of Fucoidan
causes cancer cells to kill themselves without any of the side
effects of traditional cancer treatments. Fucoidan issues a cue
that triggers a self-destruction switch on the surface of the
cancer cells that leads them to self-destruct. In particular, the
Fucoidan extracted from Mozuku (Cladosiphon okamuranus),
which is most commonly sourced from Okinawa, has shown to
have a greater Apoptosis activation effect on cancer cells.
SUPPRESSION OF NEW BLOOD VESSELS (ANGIOGENESIS)
Cancer has the ability to spread to nearby or distant organs,
which makes it life threatening. Tumor cells can penetrate
blood or the lymphatic system, circulate and then proliferate,
which is referred to as metastasis. In order for a metastasis to
occur, the growth of a network of new blood vessels is important. This process is known as Angiogenesis.
For some malignant tumors, surgery offers the potential to
remove it, but radiation and chemotherapy are also used to
enhance its effectiveness. Despite these advances, in patients
with advanced cancers, the results of the treatment are disappointing and continue to affect their overall health and quality of life. Therefore, a new approach is needed to control the
spread of the malignancy and damage caused to other organs
in the body.
Cancer cells require access to blood vessels for growth and
metastasis. One class of Angiogenic inhibitor that is natura-
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lly found in brown seaweeds is Fucoidan. Studies have shown

that sulfated Fucoidan has the ability to limit new blood vessel formation by reducing the blood flow; therefore, it limits
the growth of the tumors and ability to metastasize. Fucoidan
stops the growth of tumor tissue with its Angiogenic potency.
In particular, Fucoidan extracted from Wakame (Undaria pinnatifida) has shown to have a greater Angiogenesis suppression
effect compared to other Fucoidan seaweed extracts. The mechanism for these effects appears to be the interaction with
vascular endothelial growth factor via surface receptors called
neuropilins. It is for this reason that considerable research on
Fucoidan is being undertaken in this area.
MODULATION OF THE IMMUNE SYSTEM
Macrophages play an important role in regulating innate immunity as well as adaptive immune responses by production
of cytokines such as IL-1, Il-6, TNF- and IFN- and various
types of chemokines. Splenocytes, mainly composed of many
types of immune-related cells such as T-cells, B-cells, dendritic cells and macrophages, regulate humoral and cellular
immune responses against foreign antigens like bacteria and
viruses, and tumors. The immunomodulating activity of splenocytes is partly associated with the production of cytokines
and chemokines. Therefore, it is likely that active substances
to enhance the ability of these immune cells to produce cytokines and chemokines can act as potent immunomodulators.
Fucoidan from various brown seaweeds, including Mozuku
(Cladosiphon okamuranus) and Wakame (Undaria pinnatifida); have shown to have a strong immunomodulatory activity.
In addition to preventing the growth of tumor cells, Fucoidan can restore the functions of the immune system. Many
sulfated polysaccharides like Fucoidan, obtained from natural sources, enhance immune system responses. Fucoidan
affects the immune cell activity and cytokine production and
it has also shown in research to enhance the killer activities
of T-cell mediated NK cells. NK cell activation was associated with an increased production of interferon (IFN)- and interleukin (IL)-12.
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Fucoidan has shown to modulate the immune responses

against different cancer cell types and help the body with cellular communication. This enables the body to function better and will enable the immune system to be more efficient. It
has also been found to help with cell regeneration by helping
to increase stem cells, which enables the body to be stronger
and resistant to diseases. In addition, Fucoidan has an immune-modulatory effect on cancer patients, which allows them to
restore their health and quality of life.
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chapter 3
ALLEVIATING THE
CHEMOTHERAPY SIDE
EFFECTS WITH FUCOIDAN
o prolong the survival rate of cancer patients, it is essential to effectively continue with the treatments for as long
as possible. Unfortunately, a great number of patients
discontinue these chemotherapy treatments due to toxicity.
Thus, the prognosis of patients with advanced cancers remains
low despite the advances in chemotherapeutic agents. Cancer
cells are so dangerous because they replicate quickly and can
resist being destroyed.
Chemotherapy and radiation are often used to destroy cancer cells but can have adverse effects on the body. Most of
them are temporary and can be managed including nausea,
vomiting, diarrhea, general fatigue and bone marrow suppression. They tend to gradually disappear once the treatment
has stopped and the normal healthy cells have recovered.
Therefore, many patients look for natural alternatives that
can offer a possibility to reduce the toxicity and to restore
their immune system.
There are over 200 known forms of cancer that can affect
people; however they all share the same characteristics. Cancer causes cells to replicate uncontrollably by dividing and
growing much faster than healthy cells. The result is often
a tumor that is treated with surgery, radiation, chemotherapy
and immunotherapy. Unfortunately, attacking cancer cells in
this way also brings with it the risk of attacking the entire body.
Because most conventional treatments damage healthy cells
and tissues while they destroy cancerous cells, they can cause
a series of unpleasant side effects.
The side effects can be more severe including damage to the
organs causing infertility, fibrosis and other issues later in life.
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High-dose chemotherapy directly destroys the bone marrows

ability to produce white blood cells, red blood cells and platelets. Patients experience side effects caused by low numbers
of white blood cells (neutropenia), red blood cells (anemia) and
platelets (thrombocytopenia). Patients usually need blood and
platelet transfusions to treat anemia and thrombocytopenia
until the new graft beings producing blood cells. The duration
of bone marrow suppression can be shortened by promoting
stem cell proliferation.
Brown seaweeds contain Fucoidan, which is a beneficial ingredient that can reduce the damage caused by chemotherapy and radiation by healing and protecting bone marrow cells
such as white blood cells and stem cells. Fucoidan can decrease the number of cell deaths in bone marrow cells while
increasing the number of cell signals responsible for the immune system response. In other words, Fucoidan can modulate the immune system and has been shown to increase the
number of adult stem cells in circulation, helping them migrate
and adhere to where they are needed.
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The effects of chemotherapy and radiation can be quite debilitating but Fucoidan can also help treat the cancer itself
by alleviating the damage from cancer and protect the body.
Studies continue to show that Fucoidan consistently increases
the number of viable bone marrow cells while decreasing the
death of bone marrow cells. Medical radiation decreases the
potential of the mitochondria in the cells however Fucoidan
can help them successfully recover. The results are reduced
toxicity levels.
Many patients discontinue chemotherapy due to high toxicity

levels that cause vomiting, nausea, diarrhea, fatigue, anemia
and liver dysfunction. Fucoidan can reduce the toxicity of chemotherapy drugs, allowing a patient to stay on them longer, if
needed. Fucoidan can also relieve and help prevent the side
effects from getting worse caused by chemotherapy including:
Fatigue
Hair loss
Impaired liver and spleen function
Loss of appetite
Fatigue reduces a patients reserve in their body that also
affects their nutritional health and well-being, increasing the
occurrence of a disease and presents a negative impact on the
cancer therapy dosage. Patients who take Fucoidan are able
to endure prolonged chemotherapy without fatigue and less
side effects.
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FUCOIDANS EFFECTIVENESS ON OTHER DISEASES
ucoidan exists in brown seaweed, algae and very few

forms of sea animal life such as sea snails and sea cucumbers. The purified chemical properties of Fucoidan
are sulfated polysaccharides composed of fucose and other
essential sugars. Fucoidan is not fully digested in the gastrointestinal tract, however this benefits the body by triggering the immune system in such a way that it retains its
chemical structure without being broken down and absorbed.
In addition to Fucoidans anti-tumor, anti-cancer and neuroprotective actions, it has also shown to offer other health
benefits. Fucoidan also seems to provide anti-coagulant and
anti-thrombotic effects that improve blood circulation. The
substance offers actions that modulate the immune system
and antioxidant actions as well. As a result, Fucoidan offers
different defense mechanisms including:
Inhibitory effects on Helicobacter pylori infections
Inhibitory effects on the symptoms of osteoarthritis
Protection to brain function
Inhibitory effects on viruses like influenza, herpes and
dengue
Anticoagulant and antithrombotic activity that improve
blood circulation
Antioxidant activity
Antiviral and antibacterial activity
Reduction of blood cholesterol levels
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INHIBITS H. PYLORI INFECTIONS

Helicobacter pylori are the only bacteria that can survive
the stomachs acidic environment. Its infection is associated
with gastrointestinal defects such as peptic and duodenal
(first section of small intestine) ulcers and gastritis (inflammation of the stomach lining). Fucoidan has shown to inhibit
the effects on Helicobacter pylori infections, largely by inhibiting (preventing) adhesion to mucosal surfaces. Fucoidan extracted from Mozuku (Cladosiphon okamuranus) has shown
to have an inhibitory effect on the adhesion of Helicobacter
pylori to human gastric cells.
REDUCES THE SYMPTOMS OF OSTEOARTHRITIS
Joint health, and in particular osteoarthritis, is the most common form of arthritis experienced by an increasing number
of people as the population ages. The main ingredient used
in most products is glucosamine sulfate with a few other nominal competitors. There has been a modest decline in joint
care supplements due to a lack of new candidates. The use of
Fucoidan in a dietary supplement may ignite interest from the
consumer either as a stand-alone product or within a matrix
of ingredients. Several studies have indicated that Fucoidan
can successfully inhibit pain.
PROTECTS THE BRAIN FUNCTION
Alzheimers is a brain disease that causes significant and
highly distressing loss of function. It is characterized by the
accumulation of beta amyloid plaques in the brain tissue.
Fucoidan shows promise in protecting brain function in a
number of ways. Fucoidan has the ability to protect several
enzyme functions and glutathione levels. It has also shown to
inhibit the amyloid-induced microglical clustering effect that
gives rise to the plaques.
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INHIBITS THE EFFECTS OF THE INFLUENZA, HERPES AND

DENGUE VIRUS
The inhibitory effects of fucoidan on viruses like influenza,
herpes and dengue have been researched. Fucoidan has no
direct pathogen killing activity, but rather, it inhibits infection
via receptor entry blocking and interference with replicative
processes. Pathogens targetable from the lumen of the gut,
such as viruses harbored in the gut immune structures, have
been well targeted by fucoidan. Particularly, Wakame (Undaria pinnatifida) has shown to have an inhibitory effect on the
H1N1 influenza A virus. In addition, Fucoidan from Wakame
also showed to be highly effective in inhibiting the Herpes virus. Moreover, Fucoidan from Mozuku (Cladosiphon okamuranus) has been shown to inhibit type 2 dengue in vitro.
IMPROVES BLOOD CIRCULATION
Fucoidans anti-coagulant activity is by far the most researched
action. Every Fucoidan species has shown remarkable anticoagulant and antithrombotic activity, but Mozuku (Cladosiphon
okamuranus) exhibited the highest anticoagulant activity. Many
studies showed that the anticoagulant activity of Fucoidan may
have some relation with sulfate content and position, molecular weight and sugar composition. The higher content of sulfate
groups, the higher the anticoagulant activity of fucoidan.
DESTROYS HARMFUL FREE RADICALS
Free radicals are toxins, chemicals and pollutants that can
compromise the integrity and function of cells. Too many
free radicals in the body can lead to disease and other health
disorders including cancer, heart disease and dementia. There are many sources of antioxidants including organic berries,
green tea and nuts; however Fucoidan brings an enormous
amount of antioxidants to the body. Prevention is the key
when it comes to keeping healthy and taking in plenty of antioxidants is a great way to reduce the risk of developing severe
diseases or illness.
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ANTIVIRAL EFFECTS
Reducing the chances of getting a cold or flu is another added
benefit of Fucoidan. Plus, it can help repress the effects of
oral and genital herpes simplex virus strains, HIV and Hepatitis C and D. These viruses can actually hide inside healthy
cells, helping the immune system pursue and hinder the viral
cells. With the help of Fucoidan, these viruses are extremely
limited in their ability to replicate and infect other cells. Studies continue to show that Fucoidan can reduce the number
of outbreaks and lessen the length of time that it takes to
heal after an outbreak.
HELPS LOWER CHOLESTEROL
Lowering cholesterol can be a challenge for many people
and cholesterol-lowering drugs can produce side effects and
block the bodys ability to produce CoEnzymeQ10 needed for
energy in the cells. Your body creates enough cholesterol to
survive in a healthy way, however many foods we consume
are loaded with cholesterol that can lead to clogged veins
and decreased blood flow. Heart disease and stroke are often
the result.
Since the body cannot fully digest Fucoidan, cholesterol
binds to it and is carried out of the body instead of begin digested and reabsorbed through the small intestine. Fucoidan
can help lower cholesterol naturally without any side effects.
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ahcc
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what is AHCC?
HCC stands for Active Hexose Correlated Compound derived from a species of mushrooms that strengthen the
immune system. It has been developed as a functional
food for supportive therapy of those dealing with a suppressed
immune system, liver problems, diabetes, and cancer. AHCC is
considered a functional food that has achieved pharmacological
reliability for modulating the immune system while boosting the
functioning of the entire body. In fact, it is a health food that has
equivalent quality controls as pharmaceutical drugs. Though
classified as a health food, medical experts use it for their patients to improve and enhance their overall health.
AHCC is derived from Japanese edible mushrooms that have
long been recognized for their healing properties. AHCC is different from all the rest of the numerous mushroom products
available on the market today. This potent, versatile gift from
nature modulates the immune system, acts as an anti-inflammatory with other healing properties.
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A strong immune system is the key

to fighting off bacterial, parasitic and
viral infections to keep our bodies healthy. The immune system also plays a
role in restricting tumors and cancerous growths inside the body. Its important to keep your immune system
strong and healthy. AHCC can make
your immune system stronger and it
can help protect the body against serious chronic diseases such as:
Arthritis
Autoimmune diseases
Heart disease
Liver diseases
Cancer
All of the above share one common
thread they may be controlled by or
strongly associated with the immune
system. Although inflammation is the
bodys natural response to attack, reducing inflammation is a key element
in many serious disorders. An effective and safe functional food supplement like AHCC helps treat, manage
and reduce inflammation.
AHCC continues to be studied extensively with scientists learning more
about it every day. What has been discovered thus far is life changing in so
many ways, big and small. AHCC can
make a difference in your life. When
your immune system is healthy, it uncovers the presence of cancer cells
and tumors throughout the body. This
is a critical function because cancer
cells can hide, avoiding detection by
the immune system. AHCC is helpful
in this effort to modulate the immune
system so that it can attack any foreign cells.
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CHEMOTHERAPY AND YOUR IMMUNE SYSTEM

More than half of patients that are diagnosed with cancer
undergo chemotherapy that involve drugs designed to kill
cancer cells, however these drugs also kill healthy cells, causing unpleasant side effects and often complications resulting from the medication. Fatigue, loss of appetite, hair loss,
and impaired liver function, low levels of white blood cells,
red blood cells and platelets are common. White blood cells
are needed to fight infections, however if levels drop too low,
patients must stop chemotherapy for a while.
At one point, while undergoing chemotherapy, the blood
work will show that the white blood cell count hits a low
point, or nadir, between treatments. The cell count improves
as the marrow in the bones rebuilds the immune system by
producing new white blood cells, also known as leukocytes.
The immune system includes several types of white blood
cells, including granulocytes and lymphocytes, whose job is
to seek and destroy dangerous germs or cells that are damaged or abnormal because of an infection or mutation.
Lymphocyte
Monocyte
Neutrophil
Leukocyte
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Neutrophils, a type of granulocyte, are the most common

white cells in the blood; they help ward off the infection that
is common to cancer patients. White cells also include B-lymphocytes, or B cells, which produce antibodies and fight infection. T-lymphocytes or T-cells help regulate immune response
and attack bacteria and other harmful invaders in the blood.
If the levels are not rebounded before the next round of treatment, the doctor will stop the treatment or prescribe drugs to
help the body make more white blood cells. When the white
cells are low, a small infection can quickly escalate into a serious health threat.
Patients dealing with various types of cancer have shown to
benefit from AHCC, prolonging survival rate, improving quality
of life, mental stability, general health and the ability to perform normal activity. AHCC is a health food that has equivalent
quality controls as pharmaceutical drugs. Medical experts and
patients use it as a functional food, aimed at influencing the
bodys physical functions, to alleviate the side effects of chemotherapy. The focus in producing AHCC is on extracting the
main part of the fungus where the source of active ingredients
is located in the mushrooms for maximum benefit.
WHOLE MUSHROOMS ARE BENEFICIAL, BUT AHCC IS
EVEN MORE VALUABLE
Mushrooms have a spongy consistency and are composed
of large molecules that are not fully digested or absorbed by
the body. By breaking them down through a culturing process,
the nutrients are more absorbable and readily available to the
body. The consistent quality of AHCC is one of the factors that
set it apart from other health foods to help alleviate the side
effects of treatments.
The acetylated alpha-glucans are the active elements in
AHCC that play an important role in regulating various body
functions. They modulate the immune system and offer a beneficial effect on a wide range of diseases including alleviating
side effects from chemotherapy. Polysaccharides are complex
carbohydrates that are digested and absorbed more gradually
than simple sugars that can sometimes cause adverse effects
due to their sudden impact on blood sugar regulation. There
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is no reason to be concerned about adverse effects from consuming AHCC.

THE ROLE OF AHCC AS A SUPPLEMENTAL ALTERNATIVE
MEDICINE
AHCC has been extensively researched and the number of
health care professionals and doctors with a deeper understanding of the benefits of AHCC continues to increase. On the
other hand, there are many doctors who use only conventional
pharmaceuticals and do not consider alternative remedies. It
is important to respect the desires of the patient to help alleviate side effects of chemotherapy. There are no side effects of
AHCC and demonstrates the ability to control the side effects
of chemotherapy while enhancing the efficiency of treatments.
AHCC is an excellent choice to restore and build immunity.
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chapter 6
AHCC AND
LIVER FUNCTION
illions of people are living with chronic hepatitis that includes several types of the virus A, B, C and D. Chronic dysfunction of the liver as well as Type C and B hepatitis can
lead to cirrhosis of the liver and degenerate to HCC (Hepato-Cellular Carcinoma), a disease that is difficult to treat with modern medicine. In addition, there is a direct correlation between the development of chronic hepatitis and a decrease in the number of blood
platelets that are important for the blood-clotting process. Liver
cancer is one of the complications from cirrhosis of the liver.
The effect of AHCC on the liver is very positive, especially for those dealing with hepatitis and liver cancer. The decrease in the number of platelets is controlled, the viral burden is decreased or eliminated altogether and deterioration of liver function is halted. It is
possible to prevent deterioration of the liver with AHCC in patients
with hepatitis. Here is a list of factors that will enhance your life:
Maintain a healthy lifestyle
Get a minimum of 7-9 hours of sleep
Commit to regular exercise
De-stress before, during or after working hours
Eat a healthy diet that includes breakfast
Enjoy mini-meals throughout the day that keep blood
sugar stabilized
Make use of antioxidants
Do not smoke if you do smoke, do all you can to quit
Keep alcohol consumption to a minimum
All of the above helps the body increase its NK (natural killer)
cell activity. Antioxidants also help offset damage to the immune
system caused by stress. Stress suppresses the immune systems
response causing secretion of epinephrine (adrenaline), which acti-
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vates the nervous system, raising blood sugar levels. In addition to

activating NK cell function, AHCC also acts against stress by preventing the production of adrenaline.
LESS TOXICITY IN THE LIVER
The liver is susceptible to toxic chemicals like chemotherapy
and research continues to show that AHCC can protect the liver
against injury from chemicals like pharmaceutical drugs. AHCC
can help prevent liver damage in those receiving chemotherapy.
It can also be helpful in treating serious liver diseases, such as
hepatitis and acute liver failure. Hepatitis translates to inflammation of the liver and also refers to a group of viruses that
affect the organ. AHCC can protect a patient against drug-induced liver failure.
Hepatitis C is a chronic viral infection that is characterized by
elevated liver enzymes, inflammation, scarring of the liver and
high virus-related burdens. If left untreated, it can result in cirrhosis of the liver and liver cancer. AHCC can reduce liver enzyme levels and other chronic disease issues.
AHCC AND QUALITY OF LIFE
Taking AHCC is a safe and natural way to improve quality of life
when facing the battle of cancer. It all comes down to the quality of
life (QoL) defined as individual perception of life, objectives, values,
standards and interests of which illness can affect the outcome.
When curative treatments no longer work, the shift goes from prolonging life to optimizing quality of life. AHCC can help prolong the
survival of patients dealing with advanced liver cancer.
OTHER POSITIVE EFFECTS OF AHCC
The effects of AHCC, especially on the immune system, have a
powerful effect on the NK cells. AHCC is the strongest known immune system fighter, capable of modulating the immune system
function to prevent liver damage and to reduce the chemotherapy
side effects. AHCC is effective in:
Increasing the production and activity of immune cells to stimu
late the suppressed immune function.
Protecting itself from the side effects of chemotherapy such as
nausea and hair loss.
Enhancing the liver function to increase survival rate and better
quality of life.
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chapter 7
ENHANCING THE IMMUNE

SYSTEM WITH AHCC
NK CELL ACTIVITY AND CHRONIC DISEASES
A decrease in immunity in aged populations causes an increase
in influenza morbidity and mortality as well as decreased vaccine efficacy. NK cell activity is an important part of mind-body
medicine and is a key factor in chronic disease. The breakdown
of the immune system and more specifically, the ability of the
NK cells to scavenge free radicals (toxins, chemicals and pollutants) from the food we eat, air we breathe and water we
drink, may be the cause of diseases such as cancer, diabetes,
chronic infections and autoimmune diseases. Active Hexose
Correlated Compound (AHCC) has reported to increase immunity; it has been previously shown that it increases the natural
killer (NK) cell activity in both humans and mice.
AHCC IS A POWERFUL NUTRIENT FOR BOTH NK CELLS
AND THE IMMUNE SYSTEM.
Health problems are diseases of the whole system, not just
one. The inability of the body to dispose of abnormal cells
plays a role in the development of life-threatening diseases.
NK cells play a major role in preventing congestion, growth of
tissue (neoplasm) and tissue destruction. The abnormality of
NK cell function is associated with a wide spectrum of health
problems including cancer, autoimmune disorders and infectious diseases.
The ability of NK cells to kill microbes is an important
deterrent to chronic disease including heart disease, arteriosclerosis, diabetes, lupus, rheumatoid arthritis, multiple
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sclerosis, IBS (inflammatory bowel disease) and psychiatric

disorders. Chronic fatigue syndrome, cancer, hepatitis, diabetes and other diseases are the result of the dysfunction of the
immune system.
The natural killer (NK) cell activity blood test is useful in predicting the prognosis of a cancer patient. One, in-office, nonrandomized open-label trial was done to determine whether
four different dietary supplements commonly sold in health
food stores and over the Internet, consistently and statistically
affected NK cell activity in cancer patients.
Thirty-four patients were assigned to one of four groups:
Group A was given 1-3g/day of modified arabinoxylane with
meals. Group B was given 6000mg/day of coriolus mushroom.
Group C was given 4g/day of antigen-infused dialyzable bovine
colostrum/whey extract and group D was given 3-6g/day of active hexose correlated compound - AHCC.
NK cell activities were assessed before treatment and after
an average of 16 weeks of therapy. AHCC was the only supplement that consistently and statistically increased NK cell activity. The average increase was 249%. Modified arabinoxylane
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statistically increased NK cell activity, but did not consistently

help every patient. No side effects were encountered during
the study period in any of the four groups.
THE EFFECTS OF AHCC ON THE IMMUNE SYSTEM
The effects of AHCC on the immune system have a powerful
effect on the NK cells. AHCC is the strongest known immune system fighter, capable of modulating the immune system
function to prevent liver damage and to reduce the chemotherapy side effects. AHCC is effective in:
Increasing the production and activity of immune cells to
stimulate the suppressed immune function.
Protecting itself from the side effects of chemotherapy
such as nausea and hair loss.
Enhancing the liver function to increase survival rate and
better quality of life.
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ALLEVIATING THE CHEMOTHERAPY SIDE EFFECTS

WITH AHCC
ore than half of the people who are diagnosed with cancer undergo chemotherapy at some point. This means
tens of millions of children and adults are treated each
year with drugs designed to kill cancer cells, but these drugs
also destroy healthy cells and as a result cause some significant side effects. Some cancer cells grow slowly while others
grow rapidly. Therefore different chemotherapy drugs are designed to target specific growth patterns of a persons cancer
cells. Whether the drugs taken are designed to attack cancer
cells that grow slowly or rapidly, medication-related complications are often a result.
The side effects of chemotherapy range from life threatening
to psychologically stressful. Some of the most common side
effects caused by the chemotherapy are:
Hair loss
Nausea and vomiting
Damage to liver and spleen
Myelosuppression
Loss of appetite
Poor Quality of Life
The effects of the damage caused to the immune system
from cytotoxic chemotherapy for cancer are well known. The
suppression of the immune system makes the patient extremely susceptible to infection. Low immunity can also create
condition for cancer cell to proliferate. One study, at Hokkaido
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University in Japan, showed that AHCC could reverse the suppression of immunity caused by chemotherapy by increasing
the macrophage activity and increase the IL-12 levels, although there may be additional mechanisms.
AHCC AN EFFECTIVE OPTION FOR CANCER PATIENTS
Surgery, radiation, chemotherapy, hormone therapy, and
immunotherapy are the main tools used at conventional cancer treatment centers. The standard conventional medical
treatments for cancer are aimed at eliminating cancer cells.
Progress is measured by how well the treatment kills off malignant cells without destroying too many healthy cells. Unfortunately, attacking the cancer cells in this way also brings
with it the risk of attacking the entire body.
Since most conventional treatments damage unhealthy
cells and tissues while they destroy cancerous cells, they
can cause numerous unpleasant side effects. The debilitating
side effects of chemotherapy warrant the need for something
to alleviate and perhaps eliminate these issues and enhance quality of life. For example, the immune-modulating and
liver-protective effects of AHCC can help chemotherapy patients improve their lives in the following ways:
HAIR LOSS PREVENTION

Losing ones hair because of chemotherapy is not a life-threatening side effect, but it can be very life altering
and emotionally devastating. Chemotherapy can also cause hair loss throughout the body including eyelashes, eyebrows and underarms. Both men and women report that
hair loss is one of the side effects they most fear after they
are diagnosed with cancer. Not everyone who undergoes
chemotherapy loses their hair, because it depends on the
type and dose of drug used. However, hair root cells grow
rapidly and if you have a rapidly growing cancer, chances
are you can expect to lose hair and not just from your scalp.
Chemotherapy can cause eyebrow, armpit, pubic, eyelash
and other body hair to fall out.
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The good news is that in most cases, hair loss from chemotherapy is temporary: hair tends to regrow three to 10
months after treatment ends. The other good news is that
AHCC may help reduce hair loss. For example, scientists
evaluated the effect of AHCC on hair loss caused by a single dose of the chemotherapy drug cytosine arabinoside
(Ara-C). Rats used in the study were administered 500
mg/kg per day of AHCC for seven consecutive days plus
a single dose of Ara-C or a single dose of Ara-C. Results
of the study, which were published in Cancer Epidemiology in 2009, showed that five of seven rats treated with
Ara-C alone had severe hair loss and two had moderate
hair loss. Four of the nine rats that received both Ara-C
and AHCC, however, experienced no hair loss, two had
moderate and one had severe hair loss. . Four of the nine
rats that received both Ara-C and AHCC, however, experienced no hair loss, four had moderate and one had severe hair loss.
LESS NAUSEA AND VOMITING

This can significantly disrupt everyday life making it difficult to work or take care of children. While there are anti-nausea drugs available, most people do not want to take
additional drugs that can often cause additional side effects.
AHCC can improve patients quality of life when it comes to
vomiting and nausea, improving quality of life.
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According to the American Cancer Society, nausea and vomiting are among the most feared side effects of chemotherapy. Even though these symptoms are not considered life
threatening, they can significantly disrupt the lives of those
who experience them, making it very difficult or impossible
for them to work, care for their children and perform normal,
everyday functions.
Although the prevalence and severity of nausea and vomiting associated with chemotherapy have been somewhat
alleviated by the introduction of new drugs to treat these
symptoms, such drugs are not for everyone. Some patients
do not want to take additional drugs along with their chemotherapy. In addition, anti-nausea drugs are not always effective and may also have side effects of their own, which can
add to the discomfort cancer patients experience.
Clinical studies and case reports show that AHCC can improve patients quality of life regarding nausea and vomiting.
In one small study, for example, Dr. G.H. Ahn of Ok-Cherm
Hospital in South Korea prescribed AHCC for eight months
to 12 patients who had stage IIIV cancer. Over the treatment period Dr. Ahn noted any changes in nausea, vomiting
and pain experienced by the patients and found an improvement in all three symptoms, which results in a better quality
of life for these patients.
CLINICAL STUDIES AND CASE REPORTS SHOW THAT AHCC
CAN IMPORVE PATIENTS QUALITY OF LIFE REGARDING NAUSEA
AND VOMITING.
HELP PREVENT DAMAGE TO LIVER AND SPLEEN

In the same study that explored the effect of AHCC on hair
loss in rats exposed to a chemotherapy drug, researchers
also evaluated the impact of AHCC on modulating liver damage. To accomplish this, they administered a single dose
of 6-mercaptopurine (6-MP) plus methotrexate (MTX), two
antimetabolite, cancer-fighting drugs, to two groups of rats:
one group received the drugs only and a second group received AHCC for 28 days plus a single dose of 6-MP plus MTX.
The researchers then measured the levels of two liver en-
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zymes that are used to determine the degree of liver function: SGOT (serum glutamic oxaloacetic transaminase, also
called aspartate transaminase) and SGPT (serum glutamic
pyruvate transaminase, also called alanine transaminase).
The higher level of these enzymes, the greater the damage
and destruction to liver tissues.
The scientists found that rats given AHCC had normal levels of SGOT and SGPT while the untreated rats had large
increases in these enzyme levels. In addition, the rats treated with AHCC along with 6-MP and MTX demonstrated significantly increased body weight and levels of leukocytes
and red blood cells. All these factors together indicated that
AHCC significantly reduced the side effects associated with
the chemotherapy drugs.
The spleen is an organ that people dont hear much about,
but it plays an important role in immune function. This fist-sized organ is part of the lymphatic system, contains white
blood cells that fight infections and destroys damaged and
old cells. Although it is true that people can live without a
spleen, the body loses some of its ability to fight infections if
the spleen is removed because of disease or damage. A team
of scientists investigated the impact of AHCC on the spleen
after it was subjected to chemotherapy.
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The researchers used the chemotherapy drug cyclophosphamide, which typically causes the spleen to shrink in size
by 50 percent. In mouse models, the researchers noted that
the spleens in mice given cyclophosphamide plus AHCC
did not shrink as much as they did in mice not treated with
AHCC. The AHCC-treated mice also had a lower rate of infection than mice not treated with AHCC.
THE SPLEENS IN MICE GIVEN CYCLOPHOSPHAMIDE

PLUS AHCC DID NOT SHRINK AS MUCH AS THEY DID IN MICE
NOT TREATED WITH AHCC. THE AHCC-TREATED MICE ALSO
HAD A LOWER RATE OF INFECTION THAN MICE NOT TREATED
WITH AHCC.
INCREASE IN WHITE BLOOD CELLS

Chemotherapy can both destroy white blood cells as well as
damage bone marrow function, a condition also known as
Myelosuppression. Bone marrow is the spongy tissue located inside some large bones that houses stem cells. These
stem cells transform themselves into white and red blood
cells and platelets. When chemotherapy damages bone marrow, the production and levels of these critical immune system substances decline. The result is that patients become
highly susceptible to infections and they may also develop
anemia, which exacerbates their lowered resistance.
Overall, Myelosuppression is a very serious and life-threatening state. Several studies have shown that AHCC can
have a positive effect on Myelosuppression and improve the
white blood cell levels in response to chemotherapy. In South Korea, Dr. G.H. Ahn of Ok-Cherm Hospital administered
six grams daily of AHCC to 12 patients who had stage II
IV cancer (two patients each had breast, ovarian, stomach,
lung, uterine and lung cancers) and who were undergoing
chemotherapy. Over a period of seven months, levels of white blood cells rose from below 6,000 to nearly 8,000.
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In animal studies, scientists observed a reduction in damage to bone marrow when AHCC was administered. In one
such study, published in Cancer Epidemiology, two chemotherapy drugs (cyclophosphamide and 5-fluorouracil) were
given to four groups of mice: one group each received one of
the drugs, one group received AHCC plus cyclophosphamide
and one group received AHCC plus 5-fluorouracil.
The red blood cell count remained close to normal in the
two groups of mice that were treated with AHCC, but it declined in the two groups that received the chemotherapy drugs
only. A study in rats given chemotherapy also demonstrated that oral intake of AHCC protected the animals against a
loss of red blood cell production.
Similar results were observed in another mouse study reported in AHCC: Research and Commentary that used four
groups of mice. Two groups were injected with chemotherapy drugs (5-fluorouracil and cyclophosphamide, methotrexate and 6-mercaptopurine) alone and the other two received the drugs plus AHCC. Mice that received AHCC had
a normal weight and normal levels of red blood cells, while
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the mice not treated with AHCC expressed a decline in both

of these factors. Although the AHCC-treated mice showed
some decline in white blood cell counts, it was not as significant as the decline observed in the drug-only groups.
In a study published in the Journal of Experimental Therapeutics & Oncology, scientists evaluated the impact of
AHCC in groups of mice that were treated with a variety of
chemotherapy regimens, including paclitaxel alone or some
combination of paclitaxel, 5-fluorouracil, cisplatin, irinotecan, doxorubicin and/or cyclophosphamide.
THE MYELOSUPPRESSIVE EFFECTS OF CHEMOTHERAPY

WERE GENERALLY ALLEVIATED IN MICE THAT ALSO RECEIVED
AHCC AND THAT BOTH LIVER AND KIDNEY TOXICITY RELATED TO
CHEMOTHERAPY WERE SIGNIFICANTLY IMPROVED BY AHCC.
The ability of AHCC to mitigate Myelosuppression and to

enhance immune cell activity and function are critically important benefits for individuals who experience a decline in
white blood cell levels as a result of chemotherapy, as well
as a potential way to reduce the risks associated with this
life-threatening complication.
SEVERAL STUDIES HAVE SHOWN THAT AHCC CAN HAVE A

POSITIVE EFFECT ON MYELOSUPPRESSION AND IMPROVE THE
WHITE BLOOD CELL LEVELS IN RESPONSE TO CHEMOTHERAPY.
RESTORED APPETITE
Chemotherapy can certainly cause a change in taste that
leads to a loss of appetite and lack of nutrients. Those dealing with cancer already have a compromised immune system that is exacerbated by a breakdown in muscle, weight
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loss, infections and poorer quality of life. AHCC helps improve appetite so patients can maintain or regain lost weight, improve their nutrient intake and support their immune
system in the process.
Along with nausea and vomiting, chemotherapy can cause
cancer patients to experience changes in taste. These factors often add up to a loss of appetite and poor nutritional
intake. Because cancer patients already have a compromised immune system, a poor or inadequate diet can result in
weight loss, a breakdown in muscle, increased susceptibility
to infection and an overall poorer quality of life.
MANY CANCER PATIENTS WHO TAKE AHCC HAVE REPORTED

TO HAVE AN IMPROVEMENT IN LOSS OF APPETITE WHEN TAKING
THE SUPPLEMENT WHILE UNDERGOING CHEMOTHERAPY.
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When appetite is restored, patients are better able to

maintain or regain lost weight, improve their nutritional
intake and support their immune system.
PROLONGING SURVIVAL RATE AND BETTER QUALITY OF
LIFE
Making the functional food AHCC a part of their treatment
plan can provide them with a safe, natural way to improve
the quality of their lives while facing the battle of cancer.
The term quality of life (QoL) is used to evaluate the general well-being of individuals and societies. According to
the World Health Organization (WHO), quality of life (QoL)
defined as individual perception of life, values, objectives,
standards, and interests in the framework of culture. A
number of illness-related factors exist that can affect QoL.
The amount of symptoms distressed experienced by an individual has been related to QoL in a number of people
with cancer.
QoL is increasingly being used as a primary outcome
measure in studies to evaluate the effectiveness of treatment. Patients generally instead of measuring lipoprotein
level, blood pressure, and the electrocardiogram, make
decisions about their health care by means of QoL that estimates the effects on outcomes important to themselves.
When curative treatments no longer work, or are not an
option any more, we have to shift the focus from prolonging life to optimizing the patients QOL (quality of life).
AHCC has proven to help optimize the quality of life of
cancer patients. A small group of patients with liver cancer reported improved general health after taking AHCC
for three months. The Asian Pacific Journal of Allergy and
Immunology (2006) noted that AHCC might prolong the
survival of patients with advanced liver cancer.
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chapter 9
CLINICAL TRIALS ON AHCC
undamental research and clinical studies into AHCCs safety and efficacy are being carried out vigorously in over
six hundred medical institutions and in more than thirty universities in several countries. All studies and tests are
carried out with special priority to the well-being, health and
safety of all patients. To further emphasize the safety issue,
the mushrooms used to manufacture AHCC are the same ones
used as food since ancient times.
AHCC itself has been used by hundreds of thousands of people for over fifteen years, and no severe side effects have been
reported at the appropriate level of intake.
The results of the clinical trials have been presented at many
domestic and foreign conferences, and have appeared in numerous scientific journals. The expectations of AHCC and trust
in its use are increasing day by day. Published results can be
found on the AHCC Research Association website (www.ahccresearch.org).
LIFE-EXTENDING EFFECT ON AHCC
Since 1994, Professor Yasuo Kamiyama, chief of surgery at
Kansai Medical University, has prescribed 36g of AHCC per
day to hundreds of cancer patients, dividing it into three doses,
and has observed the effects for over a decade. Most of these patients were liver cancer patients diagnosed with chronic
hepatitis or cirrhosis, or both. This study has helped attract
significant scientific and professional recognition to AHCC internationally including an article published in the prestigious
Journal of Hepatology (2002), a well-respected, peer- reviewed journal.
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The research was of exceptionally high quality, and has been

carried out over an extended period with significant follow-up
and monitoring of large numbers of cancer patients. This procedure was then carried out on other cancer patients and the
collective results were reported to the European Surgical Academy.
OBJECTIVE
To administer AHCC to people who requested it after undergoing liver resection surgery and being histologically diagnosed with hepatocellular carcinoma (HCC) between February
1992 and December 2000 in the Primary Surgery Department
of Kansai Medical School.
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METHODOLOGY AND OUTCOME

AHCC-administered group: 107 patients (3g/day) Group receiving no AHCC: 101 patients (control group). The results of
detailed statistical analysis carried out after the tests showed
that the survival rate of the AHCC-administered group was significantly higher that the survival rate of the group who received no AHCC.
A follow-up survey was conducted for five years after the surgery for ten parameters to study the changes in the serological
test data related to liver function. The results showed that there
was a significant improvement in three parameters (AST, GTP,
and cholinesterase) in the AHCC-administered group.
CONCLUSION
These results suggest the possibility that intake of AHCC after
HCC surgery may lead to improvement in hepatitis, prevention
of relapse, and improvement in the survival rate. The five-year
survival rate is the percentage of patients from the population
of a certain kind of cancer who survive for five years from the
first detection of cancer. Although it also depends on the type
of cancer, patients are usually considered cured if there is no
metastasis or relapse over a period of five years.
In an overall impression of this report, Professor Kamiyama
identified the possibility of a decrease in hepatitis virus and a
suppression of the liver cirrhosis caused by chronic hepatitis.
When 6g of AHCC per day were administered orally in patients
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with a large amount of fluid from ascites (fluid in abdomen)

and an increase in the level of tumor markers associated with
HCC, four cases were reported in which a decrease in the peritoneal fluid, a decrease in the bilirubin levels, and a decrease
in the tumor markers (PIVKA-H) were seen. It is believed that
AHCC can be used as a symptomatic treatment for ascites,
which does not respond well to most types of diuretic drugs,
albumin drugs, or drainage.
AHCC CLINICAL TRIALS IN USA
AHCC was tested with healthy volunteers in a recent study
conducted by a team of researchers from Harvard, Yale and MD
Anderson. A group of volunteers were given a higher-than-normal dose of the supplement in liquid form. A small number of
the subjects experienced temporary stomach discomfort and
headache, but these effects were mild and lasted only a short
time. There were no abnormalities found in any of the subjects,
according to blood tests.
AHCC enhances immune function in a way that can prevent
cancer in elderly people. The research showed that the immune-boosting and cancer-preventive cytokines IFN and TNF increased within four weeks of taking the recommended dose
of AHCC. This immune-enhancing effect also persisted for at
least a month after stopping the daily dose.
Another research study showed that AHCC is unlikely to cause increased toxicity when combined with chemotherapy or supportive therapies, such as antidepressants and anti-nausea
medications.
A team of researchers at the M.D. Anderson Cancer Center of
the University of Texas studied liver enzymes (the cytochrome
P-450 family of enzymes) in an important liver detoxification
pathway involved in drug metabolism. This is a pathway through which many chemotherapy drugs are metabolized.
The results showed that AHCC is unlikely to cause increased
toxicity when combined with chemotherapy or supportive therapies. Since AHCC does increase the activity of the cytochrome P-450 detoxification pathway, further investigation will be
needed to see if there is any interaction between AHCC and
any type of drug that uses this pathway.
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AHCC IMPROVES THE 5-YEAR SURVIVAL RATES

Dr. Yusai Kawaguchi of the Kansai Medical University Department of Surgery performed a clinical study that convincingly
showed that the use of AHCC could remarkably enhance the five-year survival rate. He treated 132 stomach cancer patients
with AHCC after surgery. Patients at stages IIV were given 3g a
day of AHCC and patients at stage IV were treated with 6g a day.
Patients at stage II and higher were also given low-dose chemotherapy. In addition, he treated 113 patients with colon cancer. Patients at the early stages were treated with 3g of AHCC
per day and patients at stages III and IV were given 6g a day in
divided doses. Patients at stage II and higher were also given
low-dose chemotherapy. An analysis of survival rates revealed
that the five-year survival rates were remarkably enhanced.
AHCC INCREASES SURVIVAL TIME IN LATE-STAGE CANCER PATIENTS
Any treatment that can help late-stage cancer patients is
worth its weight in gold. Researchers at the Faculty of Allied
Health Sciences, Thammasat University, Rangsit Campus, Patumthani, Thailand, studied the use of AHCC with liver cancer
patients at advanced stages. Forty-four patients were randomized and divided into an AHCC group, taking 6g a day, and a
control group taking a placebo.
In this study, AHCC clearly significantly increased survival
time. In the study, the median patient survival time was twice
as high in the AHCC group as in the control group. The results
not only suggested that AHCC increased the probability of longer-term survival, but other factors the researchers monitored
indicated that it also improved quality of life.
AHCC AND liver CANCER
One important Japanese study showed that the rate of survival after five years was 14 percent higher in liver cancer
patients following surgery in a group given AHCC compare
to the control group. When the study had ended, 79 percent
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of the group taking AHCC was alive compared to 51 percent

of the control group. The post-operative occurrence of hepatitis and cirrhosis was reduced as shown by laboratory test
evidence even five years later. And best of all, fewer patients
had recurrence of cancer: 49 percent in the AHCC group compared to 67 percent in the control group. The survival rate
among the participants who took AHCC was an average of
twenty-three months longer.
AHCC administered to cancer patients also prevents hair
loss and Myelosuppression from cytotoxic chemotherapy. The
bone marrow is an important part of the immune system and
the site for red blood cell production. The result of bone marrow damage is low white blood cell counts, which is a cardinal
sign of impaired immunity, leaving the patient hypersensitive

to infections. Another result is anemia, which contributes to
the patients fatigue and overall loss of resistance.
Research in Korea showed that oral treatment with AHCC
raised the white blood cell count remarkably in cancer patients
who had received chemotherapy. In seven months white blood
cell counts averaging below 6,000 were elevated almost to
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8,000. AHCC has also been helpful in improving appetite in

cancer patients undergoing chemotherapy and helping them
to gain weight. Clinical studies in Korea and Japan have indicated that AHCC remarkably improves quality of life of late stage
cancer patients, not only in terms of nausea and vomiting, but
also in general well-being.
OTHER CLINICAL APPLICATIONS OF AHCC

AHCC protects the liver from the effects of cytotoxic chemotherapy in cancer, but it can also protect the liver from damage
resulting from alcohol intake. AHCC also prevents liver deterioration in chronic viral hepatitis and low blood platelet count,
which can deteriorate into cirrhosis of the liver and liver cancer. Fred Pescatore, M.D. has reported marked reductions in
liver enzymes in hepatitis patients, and has seen the viral loads
in hepatitis C patients drop from 200,000 down to 20,000 in as
little as two months at a daily dose of three grams.
Several clinicians and researchers have reported that AHCC
reduces the blood glucose levels in diabetics. Diabetes was
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induced in rats by injecting STZ (streptozotocin), which destroys the insulin-secreting B cells of the Islets of Langerhans
in the pancreas. In one group oral AHCC was administered. In
the STZ group without AHCC, the body weight decreased and
even by the second day after STZ administration their general
appearance deteriorated. In the group that received STZ plus
AHCC, the weight remained steady and the appearance was
not affected.
Insulin levels decreased in the STZ-only group, but increased
with the STZ-plus-AHCC group. Damage to the B cells of the
Islets of Langerhans in the pancreas was also minimized in the
AHCC group. In humans 13 diabetic patients were given AHCC
over a six-month period. Glyco-hemoglobin levels, which change much more gradually than blood glucose levels, as well as
blood glucose levels, decreased significantly in all 13 subjects.
This indicates a potential therapeutic use for AHCC in diabetes.
AHCC was originally developed for the treatment for hypertension before its powerful immune enhancing effects were
observed. Patients taking AHCC often experience normalization of their blood pressure. Dr. M. Iwamoto of the En-Zan-Kai
Medical Corporation reported a beneficial influence of AHCC
on ventricular arrhythmias, a type of heart disorder in which
the heart rhythm is disrupted.
The problem of resistance to antibiotics by disease-causing
microbes has been a great cause of concern by the medical
profession in recent years. AHCC can work synergistically with
conventional antibiotics and can be used alone at early stages
of infection. Since AHCC helps control infections by protecting
the immune systems resources rather than killing microbes,
there can be no acquired antibiotic resistance to AHCC.
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AHCC has been shown to be effective in protecting patients from opportunistic infections.
Opportunistic infections occur in patients with
suppressed immune systems. Cancer patients
are susceptible to pseudomonas infections.
Diabetic patients are susceptible to pseudomonas and staphylococcus infections. AIDS
patients are susceptible to infections with candida, herpes, pneumocystis and others. According to reports, AHCC gives protection to candida, aspergillus, pseudomonas and a type of
Staphylococcus aureus, that is especially difficult to control (methicillin-resistant Staphylococcus aureus, sometimes called MRSA).
If the root cause of chronic degenerative diseases like cancer, hepatitis C, and diabetes
is immune dysfunction, it is also possible that
poor immunity is the root cause of infectious
disease. Microbes have long been thought to be
causative agents, but if the cause of infections
is high susceptibility brought on by poor resistance, as it appears to be in the case of opportunistic infections, then AHCC can address the
original cause of infection by bolstering immunity.
There are numerous other applications for
AHCC according to research and clinical experience. AHCC has been tested for its efficacy for
inflammation at Teikyo University where they
found that rats with peritonitis were protected
by AHCC taken orally. AHCC may be useful as
an anti-inflammatory agent, but it also has the
potential to protect the immune system from
the effects of anti-inflammatory drugs, possibly to work with them synergistically and even
possibly to improve the underlying cause of the
disease by activating cellular immunity.
Clinical trials being carried out in Bangkok
will confirm or deny anecdotal reports of the
efficacy of AHCC for treating AIDS patients. In
almost all HIV cases reported, T cell counts can
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be maintained and even increased. An increase in T cell counts

has been observed in as little as one month along with a significant increase in the activity of NK cells, which are weakened
by the presence of HIV.
Improved stamina and remissions have been reported in patients with chronic fatigue syndrome. Decreases in intraocular
pressure have been reported in cases of glaucoma. Healing
of wounds has been accelerated in slow-healing wounds and
bedsores. Patients have recovered from stomach and duodenal ulcers. Women with a questionable PAP smear, indicating
cervical dysplasia or atypia, have taken AHCC with no other
form of treatment, and returned to normal, even with PAP readings indicating stage II and stage III dysplasia. The reports of
improvement of a wide variety of complaints continue to accumulate from clinicians using AHCC.
The therapeutic limitations of AHCC are not yet known and
may be limited only by what can be accomplished by optimizing
macrophage and NK cell activity. The range of application of
AHCC extends from treatment of post-traumatic stress disorder to chronic and degenerative disease. Future research trials
will help to define how this powerful therapeutic superfood
can enhance the effects of natural and conventional therapies.
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chapter 1 0
FUCOIDAN AND AHCC

ANTI-CANCER SYNERGY
n this chapter, we will explore how Fucoidan and AHCCs

effectiveness can be maximized to increase the chance of reducing or eliminating the cancer and the various side effects
caused by conventional cancer treatments.
Cancer is treated in several ways, depending on each persons
medical condition and type of cancer. There are three conventional methods of treatment for cancer: 1) surgery, 2) chemotherapy, which includes angiogenesis inhibitors and immunotherapy
and 3) radiation therapy. For many people with cancer, treatment is a process that is designed to meet their needs.
CONVENTIONAL CANCER TREATMENTS
1. Surgery: Surgery can be used to prevent, treat, stage

(determine how advanced the cancer is), and diagnose cancer. In relation to cancer treatment, surgery is done to remove tumors or as much of the cancerous tissue as possible.
It is often performed in conjunction with chemotherapy or
radiation therapy. For those whose cancer is not treatable,
palliative surgery may be an option to relieve pain that may
be caused by the cancer. Palliative surgery is not intended to
treat or cure the cancer, or even to prolong life, but more to
lessen discomfort.
2. Chemotherapy: Chemotherapy is a type of cancer treatment that uses drugs to eliminate cancer cells. Unlike surgery, chemotherapy affects the entire body, not just a specific
part. It works by targeting rapidly multiplying cancer cells.
Unfortunately, other types of cells in our bodies also multiply
at high rates, like hair follicle cells and the cells that line our
stomachs. This is why chemo can cause side effects like hair
loss and an upset stomach.
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Chemotherapy is most commonly given by pill or intravenously (IV), but can be given in other ways. A single
type of chemotherapy, or a combination of drugs, may be
prescribed for a specific length of time. Like surgery, chemotherapy can be prescribed alone, in conjunction with
radiation therapy or other methods like:
a) The use of Angiogenesis inhibitors. Some cancerous
tumors are very efficient at creating new blood vessels,
which increases blood supply to the tumor and allows it
to grow. As researchers gained a better understanding
of this process, they have developed several drugs that
inhibit angiogenesis and short-circuit cancer development. A number of angiogenesis inhibitors have been
approved by the Food and Drug Administration and are
currently being used to treat brain tumors, breast, colon, kidney, lung, rectum, and liver cancers.
b) Immunotherapy, also known as biotherapy or biological response modifiers, works on white blood cells
- the bodys first line of defense against disease. White
blood cells can be stimulated in various ways to boost
the bodys immune response to cancer, with little or no
effect on healthy tissue. Immunotherapy can also be
used to lessen the side effects of other cancer treatments.
3. Radiation Therapy: Radiation therapy uses certain
types of energy to shrink tumors or eliminate cancer
cells. It works by damaging a cancer cells DNA, making
it unable to multiply. Cancer cells are highly sensitive to
radiation and typically die when treated. However, nearby
healthy cells can be damaged as well. Radiation therapy
may be given alone, along with chemotherapy, and/or with
surgery. The decision to combine radiation therapy with
other types of treatment depends on the stage of cancer
and other factors.
For many people with cancer, treatment is a process
that is designed to meet their needs. In modern medicine,
there are a variety of cancer treatments being offered.
Unfortunately, several of these treatments provide only
minimal benefits; moreover, complications and long term
side effects of these treatments are very common.
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PHYSICAL LIMITATIONS AFTER CONVENTIONAL TREATMENTS

Cancer patients need to deal with a series of physical limitations
after their cancer treatment. These treatments often affect
strength, motion, dexterity (i.e. inability to kneel, to sit for long
periods of time, etc.). Conventional treatments also have alarming qualities to them: disfiguring surgery, arduous chemotherapy, and treatment with invisible radiation.
Chemotherapy and radiation therapy cannot distinguish between cancer cells and healthy cells; thus, damaging both types
of cells and causing serious and often debilitating side effects,
frequently forcing patients to abandon treatment. The problem
with Angiogenesis inhibitors is the fact that they can cause negative reactions in the body. Some of these symptoms include
high blood pressure, headaches, chest pain, wheezing, chills,
sweating, etc.
Even other less toxic treatments, like immunotherapy, still
cause a series of side effects, including fatigue, a rash or swelling at the injection site, and flu-like symptoms including nausea, diarrhea and fever. These side effects often happen because
some of these immunotherapies are developed in a laboratory
and then injected into the body. Some examples are interferons,
interleukins and monoclonal antibodies.
FUCOIDAN AND AHCC COMPLEMENT CONVENTIONAL
TREATMENTS
It is not surprising that many cancer patients now opt to complement conventional treatments with alternative therapies
that may not only temper the adverse side effects of conventional cancer therapy, but also improve its effectiveness via
independent anti-cancer effects. This is the reason why more
and more people are turning to complementary and alternative therapies, like Fucoidan and AHCC, to augment their conventional cancer treatments.
These two ingredients can be one of the best complementary alternatives the cancer patient can select from, to make
the conventional treatments less damaging. Moreover, several synergistic effects can also be expected when Fucoidan
and AHCC are used jointly.
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FUCOIDAN GUIDES THE CANCER CELLS TO DIE NATURALLY

Fucoidan is a unique ingredient that is highly researched because
of its immune-modulating properties that enhance an anticancer activity through immune cell activation, influx and stimulation of the production of anticancer cytokines, which limits tumor development. As explained before, Fucoidan is well-known
for its Apoptosis-inducing effect on cancer cells. The benefit of
Fucoidan is that it can be a much more effective approach that
can also support conventional treatments. Some articles have
shown that Fucoidan is a potential natural bioactive compound
and its function allows it to work against cancer.
The inhibition (prevention) of apoptosis, a universal and efficient cellular suicide pathway, is known as one of the hallmark
characteristics of cancer. The inhibition of apoptosis in cancer
contributes to tumor growth, promotes neoplastic progression,
and is characteristic of resistance to toxic anticancer agents.
FUCOIDANS ROLE AGAINST CANCER RELIES ON ITS ABILITY TO ENHANCE AND PROTECT THE IMMUNE SYSTEM
Fucoidan, a natural ingredient, has the ability to induce apoptosis
in cancer cells and it can be of great support to the conventional
treatments, especially chemotherapy. The effect of Fucoidan on
prostate, breast, lung, bladder, and liver cancer, as well as the
means by which different forms of cancer travel through and
metastasize in other parts of the body, have all been researched
in multiple studies. In all of the studies, Fucoidan contributed to
the cell death of cancerous cells by disrupting and destroying the
cancer cells mitochondria. The mitochondria are responsible for
the cells ability to make energy. In spite of Fucoidans cytotoxic
effects on cancer cells, Fucoidan does not cause any damage to
healthy cells and it does not cause any harmful side effects.
FUCOIDAN INHIBITS INVASION OF CANCER CELLS
The research on Fucoidan has been going on for years and recently the focus has been directed toward its ability to encourage
apoptosis and to inhibit Angiogenesis. It is important to note that
apart from cancer treatment by supplementing surgery, che-
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motherapy or radiation therapy, an important factor for the

prevention of a relapse in cancer is the ability to block or to
stop the tumor from growing. This is known as Angiogenesis
inhibition. In recent studies done by Dithmer, et al. in 2014,
Fucoidan showed to reduce the secretion and the expression
of vascular endothelial growth factor in the retinal pigment
epithelium (thin protective layer of tissue) and reduced angiogenesis (formation of blood vessels) in vitro.
The use of Fucoidan as a possible new anti-Angiogenic and
anti-cancer therapy appears to be of great interest. Some of
the studies done at the University of Fukuoka showed that Fucoidan appeared to block the blood vessel formation, which
usually accompanies the growth of malignant tissue in cancerous tumors. These results indicate that the anti-tumor
action of Fucoidan is due, at least in part, to its anti-Angiogenic potency and that increasing the number of sulfate groups
in the Fucoidan molecule contributes to the effectiveness of
its anti-Angiogenic and anti-tumor activity, the Fukuoka University researchers concluded.
Cutting off a tumors blood supply is one of the ways to
attack cancer cells. Another way, as mentioned above, is to
get the cancer cells to undergo Apoptosis or programmed
cell death by enhancing the immune system. Fucoidan has
the ability to do that without causing adverse effects; consequently, cancer patients can have a better Quality of Life
(QoL). With these three mechanisms at work, the chances of
being cancer-free greatly increase.
FUCOIDANS ROLE IN THE PROTECTION OF THE IMMUNE
SYSTEM
Fucoidan and other polysaccharides, from natural sources, are
a class of macromolecules that can profoundly affect the immune system and have the potential as immune-modulators.
Each polysaccharide will have a different mechanism depending on their molecular weight and structure. For example, Fucoidans properties vary depending on the species and location
where the extract is obtained. Usually, it is characterized by
having a high molecular weight (HMW) and its high sulfated
groups.
Other polysaccharides that are obtained from mushrooms
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are known as -glucans and they are also characterized for

having a high molecular weight (HMW) and they are not acetylated. On the contrary, special extracts like AHCC (-glucan)
has a low molecular weight (LMW) and it is characterized by
having acetylated compounds. Therefore, each polysaccharide
will work differently in the body and the immune system will
be modulated in a different way depending on their properties.
FUCOIDAN ACTIVATES MACROPHAGE ACTIVITY TO ATTACK CANCER CELLS
Fucoidan has been subject to many scientific studies due to
its immune-modulatory activities, which are mainly determined by the amount of sulfate groups and high molecular weight (HMW). The anti-tumor activity of Fucoidan is associated
with its ability to enhance the immune system. Compared to
other ingredients, Fucoidan can enhance the cytolytic (destruction of cells) activity of NK cells by increased production
of macrophage-mediated immune responses, namely interleukin (IL-2), interferon (IFN-), and IL-12.
There are two proposed mechanisms responsible for the
activity and immune-modulatory effect of Fucoidan that gives
an anticancer action:
1) Macrophage activation by Fucoidan is mediated by specific membrane receptors. The major receptors reported for
polysaccharide recognition in macrophages are glycoproteins
including the Toll-like receptor-4 (TLR-4) and others.
2) Activation of macrophages leads to production of cytokines such as interleukin-12 (IL-12) which in turn stimulate
the development of T cells. T cells produce interleukin-2 (IL2) that in turn activates NK cell proliferation. The NK cells
themselves produce immunological important cytokines,
notably IFN-, which can further provoke the participation
of macrophages in the stimulation of T cells via induction of
IL-12.
Macrophages help NK cells to attack tumor cells. Natural
killer (NK) cells and their crosstalk with other immune cells
are important for innate immunity against tumor.
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FUCOIDAN IS AN EFFECTIVE INGREDIENT, BUT IT WORKS

BETTER IN COMBINATION WITH AHCC
Even though Fucoidan has the ability to induce Apoptosis, to
inhibit Angiogenesis and to modulate the immune system the
benefits of these approaches vary depending on the type and
stage of cancer and the specific mechanism used to activate the immune cells. Some advanced types of cancer are very
difficult to treat because the body is already invaded and the
natural immune defenses of the person are weakened.
In some cases, physicians decide to stop all of the treatments because of the inability of their bodys to respond to the
treatment and to reinforce their immune system. Fucoidan is a
great complementary way of treating cancer, but it also needs
to be strengthened by other ingredients to make its function
even more powerful and effective.
FUCOIDAN AND AHCC MODULATE THE IMMUNE SYSTEM
MORE EFFICIENTLY
AHCC supplementation clearly affects immune outcomes and
immune cell populationsespecially natural killer cell activity.
Polysaccharides purified from certain mushrooms, like AHCC,
also have anti-tumor activities via macrophage activation. Although the exact mechanism by which AHCC boosts NK activity
remains under investigation, it is speculated that -1,4-glucans
are recognized by C-type lectins, such as Dectin-1 on NK cells,
thus initiating innate immunity. C-type lectins are also expressed on other cell types, including macrophages, dendritic cells,
and -T cells, that may further influence NK cells and the innate immune response through the production of cytokines.
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AHCC may help modulate the immunity by significantly increasing the number of dendritic cells (a type of cell involved
in the immune response). In addition, research completed at
other institutions with AHCC has shown that it activates important immune white blood cells including macrophages, Natural Killer (NK) cells and Lymphokine-Activated Killer (LAK)
cells. AHCC also induces the production of cytokines that serve as chemical messengers between cells.
Further, regarding the specific role of AHCC as an agent to
prime NK cell responses, studies are needed to establish the
mechanism of action by which this compound interacts with
cells of the immune system (possibly at the site of the intestinal epithelium) and how such interactions may result in systemic effects affecting immune competency. The activities of
-glucans derived from mushrooms and yeast cell walls have
been investigated and appear to activate innate immunity by
binding to innate pattern recognition receptors, such as toll-like receptors (TLRs). It remains unknown whether -1,4-glucans (AHCC) may mediate immunity through a similar mechanism, although such studies have been proposed.
If macrophages can help activate NK cells to attack tumor
cells, then the synergy between Fucoidan and AHCC is more
meaningful to allow the immune system to work even better
against cancer. Fucoidan is capable of stimulating the macrophage activity, which is greatly needed by the NK cells being
produced by AHCC to attack the cancer cells.
AHCC IS THE KEY TO BETTER LIVER FUNCTION
When many cancer patients decide to take a natural supplement, especially those patients with advanced cancers, they
have already been treated with surgery, chemotherapy or radiation therapy for a few months. Therefore, their health condition is extremely weak and their internal organ functions are
unbalanced and damaged. Among all the organs, the most important one is the liver, which is usually affected after chemotherapy and radiation therapy.
The liver has many functions in the body including:
Filtering blood
Processing food, drugs and toxins
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Adding protein to the blood

Making bile to help digest food
If the cancer is located in or metastasized to the liver, it can
also damage the liver function because the tumors at this location can infiltrate surrounding tissue and vessels, making their
removal difficult. If the liver begins to fail, certain noticeable
changes occur in the body, for example, jaundice (yellowing of
the skin) and increased abdominal girth (fluid build-up in the
abdomen, called ascites), which causes nausea and vomiting.
Therefore, it is very important to keep a strong liver to allow
its detoxification function to keep taking place and to restore
the energy that it provides to the body. Fucoidan is known to
support liver detox. However, if a better option is sought, AHCC
will be one of the best alternatives. AHCC has been studied
and proven to be effective in stimulating better liver function.
AHCC ENHANCES THE EFFECTIVENESS OF THE CHEMOTHERAPY DRUGS
One of the advantages of AHCC is that it lowers the toxicity of chemotherapy and radiotherapy by protecting the sick and overworked liver. This helps reduce their side effects without bringing any
of its own, like nausea, vomiting, loss of appetite, hair loss and
suppression of the bone marrow (Myelosuppression).
Damage to liver function is responsible for many of the systemic effects of chemotherapy. A study in mice that used carbon
tetrachloride as a model for drug induced liver injury, showed
that co-treatment with AHCC:
Prevented decline in liver function
Enhanced metabolism
Prevented the buildup of carcinogenic compounds
Prohibited the development of hormone disorders that
often accompany liver failure
AHCC SHOWED AN ANTIOXIDANT-LIKE PROTECTION
AGAINST FREE RADICALS AS MEASURED IN LIVER ENZYME PROFILES, PROTECTING THE LIVER ITSELF AND THE
BODY AS A WHOLE.
The ability of AHCC to enhance the effectiveness of chemotherapy
was demonstrated in a study where rats were implanted with a cell
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line of spontaneous mammary adenocarcinoma. Three groups were

observed for 38 days, a control group, a group treated with UFT, an
oral form of the chemotherapy drug fluorouracil, and a UFT plus
AHCC treatment group. Tumor growth was greatest in the control
group. There was a slight, but significant enhancement of tumor suppression in the UFT plus AHCC group compared to the UFT only
group. From this result, we can see that AHCC is a promising agent
that improves the effectiveness of the chemotherapy drugs.
AHCC: BETTER IMMUNITY FOR EVERYONE
One of the most promising ingredients that have shown to be helpful
in stimulating the immune cells is AHCC. It is a great partner for Fucoidan since both have a very specific way of not only supporting the
immune system, but also blocking cancer growth.
Stimulating NK cell function and supporting the immune systems front-line defense has become one of the most promising
avenues of cancer treatment and prevention. Since 1986, there
have been 29 published scientific studies showing that the use of a
proprietary natural compound called AHCC (Active Hexose Correlated Compound), can increase NK cells cancer killing function by
several hundred times.
Furthermore, among the benefits of using AHCC, as experienced
by a majority of cancer patients in several human clinical trials, is
substantial improvement in the functioning of macrophages. This
is another type of cytotoxic white blood cell that clears debris from
cell damage by directly attacking disease-causing cells and displaying antigens that stimulate antibody production by B-cell white
blood cells. This function proves that AHCC can offer immune system enhancing benefits.
AHCC also helps increase the production of specific cytokines, immune system chemical messengers that include:
Interferon, which directly inhibits the replication of viruses

and other parasites and increases NK cell activity.
Tumor Necrosis Factor (TNF), a group of proteins that help
destroy cancer cells by triggering apoptosis (programmed
cell death).
Interleukins IL-2 and IL-12, which suppress production of

tumor growth factor (TGF), stimulate still higher NK cell
activity, and accelerate the differentiation and proliferation of
T-cells.
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AHCC can also prevent the cancer from starting in the first
place. By significantly improving the efficiency of immune
cells, AHCC helps destroy rogue cancer cells that lurk inside
the body before those cells can multiply and begin to develop a
chronic disease. AHCC is highly beneficial in the face of:
Cancers that resist angiogenesis inhibitors (drugs that block
the vital blood flow and oxygen that feeds cancerous tumors).
HPV (human papilloma virus) 16 and 18 infections. Killing
these viruses may help prevent cervical cancer.
Either way, it is vital to strengthen the immune system to
prevent and battle against cancer, especially if you are getting
medical treatments that weaken your immune system. Cancer
can develop due to various factors such as a worn out immune system which is unable to kill cancer cells at an average
rate. In addition, exposure to a mass of harmful components
like toxins, radiation and such can increase the developmental
rate of cancer cells to an abnormally high level unable of being
sustained by the immune system.
Especially, along with the activation of Fucoidans Apoptosis
and Angiogenesis inhibition, it is important for AHCC to support the immune system in order to regain equilibrium. Conventional therapy doctors are well aware that cancer patients
need immune boosting therapy to build up the body to fight off
cancer and prevent harsh radiation or medications from holding back ones own natural defenses. If the immune system is
not strong enough to protect the body, cancer will eventually
attack every cell in it.
BY INCLUDING AHCC IN ADDITION TO FUCOIDAN, PATIENTS
ARE ABLE TO ENHANCE THEIR IMMUNE SYSTEM TO THE EXTENT
THAT IT ATTACKS CANCER.
FUCOIDAN AND AHCC REDUCE THE ARDOUS SIDE

EFFECTS
Fucoidan and AHCC have been used by some cancer patients
undergoing chemotherapy; it is thought to enhance the therapeutic effects and reduce the side effects of select anti-carcinogenic agents.
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If surgery, chemotherapy and radiation therapy for cancer

are unlikely to result in a cure, then cancer patients should
be able to seek further treatments. Fucoidan and AHCC are
scientifically proven to support and protect the body against
the toxicity and damage caused by conventional treatments.
In other words, by providing cancer patients with these functional foods, they can develop a stronger immune system. As a
result, they will be more capable of tolerating the side effects
as well as maintain a better quality of life to continue with their
treatments.
FUCOIDAN AND AHCC: THE ULTIMATE SYNERGY AGAINST
CANCER
Nowadays more and more people are turning to trusted complementary and alternative therapies with high-quality, evidence-based information such as Fucoidan and AHCC. As the
research shows, a Fucoidan and AHCC blend is one of the best
synergistic combinations available. It is a well-balanced blend
that combines specially processed mushroom and seaweed
extracts to deliver unique health benefits.
Each ingredient has unique properties that work synergistically to promote excellent health and increase the Quality of
Life (QoL). Fucoidan promotes the induction of Apoptosis and
the suppression of Angiogenesis and AHCC supports its function by enhancing the immune system and by detoxifying and
enhancing the livers function. These two ingredients combined
together can be the great support for the conventional treatments that will help patients maintain a healthy Quality of Life
(QoL). The combination of Fucoidan & AHCC will significantly
increase the chance of overcoming cancer.
FUCOIDAN AND AHCC SUPPORT THE IMMUNE SYSTEM

IN OPTIMUM WAYS TO ATTACK CANCER AND
TO HAVE A BETTER QUALITY OF LIFE.
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about the
1 author
a b o u t the a u th o r
During my first years of college I felt I could not go on... The

limitations imposed on immigrants in the USA, the difficulty
of learning and adaptation were my biggest challenges. But
thank God now I can tell my story and I have the opportunity
to create products that will be of assistance to those most in
need. This is what this doctor and biochemical answers to
young people who ask her about the amount of work and economic welfare that could provide to pursue a scientific career,
and as she stands, this is a road that runs through sacrifice,
but it also finds its reward in the satisfaction of making contributions to the knowledge of life from an innate vocation.
Martha Susana Trujillo Frias was born in Guadalajara, Jalisco on 17th June 1984. When she was just 15 years old she
came to the USA in order to study and develop her professional career. Adapting to a new culture and language, she
pursued her education while working multiple jobs in order
to pay tuition. She managed to obtain three AA degrees
from Cerritos College in Biology and Natural Sciences before
transferring to California State University to achieve a double
major in Biochemistry (BS) and Chemistry (BA). The Director
of the Chemical Engineering Department invited her to join
their Masters Program and eventually was hired by a company that made Fucoidan-based products while she received
a Masters of Science in Chemical Engineering.
She has always been attracted to chemical composition of
the living and the mechanisms that led to life and keep it until today. Also, since she was very young she liked medicine
and dentistry, but then she focused mainly on the processes
involved in the creation of the universe and the formation of
atomic particles, which, according to her perception, should
follow the same logic (the logic of God or the creative force,
according to each ones conviction).
Similarly, she was interested in chemistry, she was particularly curious about how some of the many atoms (carbon,
nitrogen, sulfur, oxygen and hydrogen) originated biological
macromolecules that sustain life, i.e., proteins, lipids, sugars
about theChapter
author 1 The Ultimate Synergy Against Cancer: Fucoidan and AHCC
and nucleic acids, and also the magic of water and its known
properties as a universal life solvent. Then, when she had to
choose a college career she chose Biochemistry as a base as
this training combined these three elements (biology, physics
and chemistry), but finally she decided to study two careers,
Biochemistry as well as Chemistry.
Dr. Susana Trujillo is a person devoted to her work, with
seaweed and its unique biological mechanisms, being one of
the main passions of her research. Dr. Susan Trujillo has generated successful ideas and projects in developing natural
products, she has also focused on human health and therefore continued to conduct research and studying the amazing substance known as Fucoidan and decided to go back to
school to pursue an ND (Naturopathic Doctor) so she could
help cancer patients interested in taking Fucoidan. She obtained her degree in 2011 and her thesis was based on Fucoidans chemical structure and its benefits to health. Later,
she studied cancer extensively, learning how it affects people
physiologically, mentally and spiritually. Due to limitations
to study as an immigrant in the USA, she could not continue
with a program of postdoctoral studies, and therefore, she
read more than 60 books related to cancer, nutrition, immunology, oncology, angiogenesis and apoptosis, among others.
Nutrition knowledge helped her develop in her a sense of
priority to help people dealing with cancer so she pursued
more education with a master in herbalism and a certificate
as nutritionist and therapist.
After several years, Dr. Susan Trujillo began developing
new natural products designed to help more patients with
cancer. One of these products is a formula that contains
Fucoidan enhanced with AHCC (Active Hexose Correlated
Compound). This formulation is supported by solid research.
Fucoidans unique formulation powered with AHCC is now a
reality that helps people regain their health and quality of
life. The main interest of Dr. Susan Trujillo is focused on
developing products that help people to achieve an optimal
health and vitality.
As Dr. Susan Trujillo says; Although new generations are
developing in more prosperous countries without many limitations, it is important to understand that we must fight in
order to conquer our dreams. For those young people who
83
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The Ultimate Synergy Against Cancer: Fucoidan and AHCC sobre

Chapter
la autora
1
opt for a scientific career and who want to make the science
one of their major goal of life, I suggest keep cultivating their
passion, as passion for science is not something acquired, is
a concern you born with, a concern to find out how all around
us works, and that is what bring to us the interest in research,
and its unique goal is not only the economic welfare, but to be
happy in the world of scientific research and helping others.
For more information, please visit www.DrSusanaT.com or

writer to Dr. Susana Trujillo by E-mail: Susana@DrSusanaT.com
85
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88
THE
SECRET TO LONGEVITY AND VITALITY COULD BE AS
SIMPLE AS HAVING A SYNERGISTIC COMBINATION OF TWO
AMAZING INGREDIENTS FUCOIDAN AND AHCC. THE FUSION
BETWEEN THESE TWO INGREDIENTS MAKES PERFECT
SENSE, AS THEY BOTH ARE CREATION OF A HEALTHY, LONG
LIFE IN DIFFERENT CULTURES.
Cancer is a devastating, often debilitating disease that affects people from
all walks of life, all over the world. Resistance to conventional treatments is
more noticeable with tumors not responding or growing back at a faster rate.
More anti-cancer drugs are often given that brings considerable side effects to
the human body including hair loss, bleeding, diarrhea and suppression of the
immune system. Therefore, many patients seek natural alternatives that can
provide the possibility of reducing the toxicity and restore their immune system.
FUCOIDAN AND AHCC SUPPORT THE IMMUNE SYSTEM IN

OPTIMUM WAYS AND PROVIDE THE SUPPORT NEEDED TO
ENHANCE THE QUALITY OF LIFE OF CANCER PATIENTS.
Learn about two nutrients that can precisely target and kill cancer cells by
modulating the immune system. Two of these effective, natural and reliable
alternatives are Fucoidan and AHCC. It is a well-balanced mix that combines
extracts of mushrooms and algae especially processed to provide specific
health benefits. These two ingredients combined together can be a great support for conventional treatments.
Dr. Susana Trujillo has a special interest

in research and integrative medicine. She
received a Naturopathic Doctorate in 2013,
a Masters in Chemical Engineering in 2011
and twin Bachelors in Biochemistry and
Chemistry in 2009. Dr. Susana has been
part of the Formulation and R&D Department of two major Fucoidan companies.
She has more than 6 years of experience in
the Fucoidan research area. She is the formulator of an exclusive product containing
Fucoidan, which is enriched with AHCC
(Active Hexose Correlated Compound).
This product is now a reality to support
people to recover their health and to enhance their Quality of Life.

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88

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter 1

THE ULTIMATE SYNERGY

Dr. Susana trujillo

Fucoidan and AHCC

Fucoidan and AHCC

about the author

mproving your quality of life and supporting good health can

The Ultimate Synergy Against Cancer: Fucoidan and AHCC INTRODUCCIN

mushrooms, have shown to be great immune stimulators and

THE SECRET TO LONGEVITY AND VITALITY COULD BE AS

Chapter 1 The Ultimate Synergy Against Cancer: Fucoidan and AHCC

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter 1

Chapter 1 The Ultimate Synergy Against Cancer: Fucoidan and AHCC

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

ucoidan is the key ingredient found in brown seaweeds

Okinawa is touted as having the highest longevity in Japan

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

FUCOIDAN AND ITS

ancer is a devastating, often debilitating disease that

FUCOIDANS THREE FUNCTIONS CAUSE CANCER CELLS

CELLS DIE IN MORE THAN ONE WAY: NECROSIS VS. Apoptosis

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

(programmed cell death)

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

lly found in brown seaweeds is Fucoidan. Studies have shown

Fucoidan has shown to modulate the immune responses

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

High-dose chemotherapy directly destroys the bone marrows

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

Many patients discontinue chemotherapy due to high toxicity

FUCOIDANS EFFECTIVENESS ON OTHER DISEASES

ucoidan exists in brown seaweed, algae and very few

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

INHIBITS H. PYLORI INFECTIONS

INHIBITS THE EFFECTS OF THE INFLUENZA, HERPES AND

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

Chapter 1 The Ultimate Synergy Against Cancer: Fucoidan and AHCC

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter 1

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

A strong immune system is the key

CHEMOTHERAPY AND YOUR IMMUNE SYSTEM

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

Neutrophils, a type of granulocyte, are the most common

is no reason to be concerned about adverse effects from consuming AHCC.

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

vates the nervous system, raising blood sugar levels. In addition to

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

ENHANCING THE IMMUNE

sclerosis, IBS (inflammatory bowel disease) and psychiatric

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

statistically increased NK cell activity, but did not consistently

ALLEVIATING THE CHEMOTHERAPY SIDE EFFECTS

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

HAIR LOSS PREVENTION

LESS NAUSEA AND VOMITING

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

HELP PREVENT DAMAGE TO LIVER AND SPLEEN

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

THE SPLEENS IN MICE GIVEN CYCLOPHOSPHAMIDE

INCREASE IN WHITE BLOOD CELLS

The Ultimate Synergy Against Cancer: Fucoidan and AHCC Chapter

the mice not treated with AHCC expressed a decline in both

THE MYELOSUPPRESSIVE EFFECTS OF CHEMOTHERAPY