>1??9@,9A'B9&A#$?

!"#$%"$&'()&*+,-./0&1"$%.2,3/4"$%&.$&5$6,3+3,4$7&8.9,3&:;$-4"$&<,%6%)&=>&

)

:/>&?#@%.-./$)&ABBB&=+3&ACDCBEFGHIIIJKIIJL

!"#$#%&"'(&)*+&,*+-'.&,&'/0&"1&2*$'
3&""'4567'
!8'(99:'8;&+<.:'=!8>:'=!88'

6'

4'

(9%,1+9'C1,"#$9''

O*P'1@9F1"'#@'&',9@,Q'

31$A&<9$,&"'%*$%9D,@'

>9$@#20#,-'
(#R9"#;**A'*F'&'D*@#209'+9@1",'#$'D9+@*$'P#,;',;9'A#@9&@9'
'''S'''''''''''''''',+19'D*@#209@TTTTTTT''''''U'655V'
'''''''''G+19'D*@#209@'W'F&"@9'$9?&209@'
>D9%#X%#,-'
(#R9"#;**A'*F'&'$9?&209'+9@1",'#$'&'D9+@*$'P#,;*1,',;9'A#@9&@9'
'''''''S''''''''''',+19'$9?&209@TTTTTTU'655V'
''''G+19'$9?&209@'W'F&"@9'D*@#209@'
G;9'#A9&"'#@'F*+')*,;'@9$@#20#,-'&$A'@D9%#X%#,-',*')9'&,'"9&@,'YZV'

E@9F1"$9@@'
G-D9@'*F',9@,'

H$,9+D+9,&2*$'*F'%*<<*$'"&)*+&,*+-'A&,&'
/"9%,+*"-,9@'IJ&''K'LM''
(#09+'F1$%2*$',9@,@'
!=!'
G;-+*#A'F1$%2*$',9@,''
N'

7'

G-D9'*F'G9@,'

[1&$2,&209',9@,'

[1&$2,&209',9@,'
B9D*+,',;9'&<*1$,'*F'@1)@,&$%9'D+9@9$,'
/U\'/"9%,+*"-,9@'

[1&"#,&209',9@,'
.9,9%,',;9'D+9@9$%9'*+'&)@9$%9'*F'@1)@,&$%9'
/U\'8+9?$&$%-',9@,'

>9<#]^1&$2,&209',9@,'
B9D*+,'+9@1",'#$'0&+-#$?'A9?+99'*F'D*@#20#,-'
/U\'1+#$&"-@#@'

Z'

[1&"#,&209',9@,'

_'

J*+<&"'IB9F9+9$%9M'a&"19'
G;9'+&$?9'*F'0&"19@'P;9+9'YZV'*F'$*+<&"'D9*D"9'F&""'
b9&$'Wc]'4'@,&$A&+A'A90#&2*$'
J*,9',;&,'@*<9'D&+&<9,9+@'A*'JCG'F*""*P'&'$*+<&"'
A#@,+#)12*$d''
J*+<&"'+&$?9'<&-'0&+-'F+*<'"&)',*'"&)'A19',*'0&+#&2*$'#$'
,9%;$#^19'&$A'+9&?9$,'1@9A'
H$,9+D+9,'"&)'0&"19')&@9A'*$'+&$?9'F+*<'"&)'+9D*+,'&$A'$*,'
F+*<',9U,)**R'

`'

e'

J*+<&"'IB9F9+9$%9M'a&"19'
J*+<&""-'A#@,+#)1,9A''''''''J*,]$*+<&""-'A#@,+#)1,9A''
!"#$%$!&#

=06#";7#&/9,3/7,&9/0;,%&M"3&=8<&
/$2&=*<&/3,&%.>.0/3&.$&2.N,3,$6&
+"+;0/4"$%O&6#,&2.%63.P;4"$%&
/3,&>"3,&%Q,R,2&.$&>/0,%&/$2&
.$&$"$R#.6,&,6#$.-&73";+%)&

H$,9+D+9,&2*$'*F'!"#$#%&"'(&)'.&,&'
B9$&"'31$%2*$'G9@,@'I,*')9'%*09+9AM''
/"9%,+*"-,9@'IA9,&#"',*')9'%*09+9AM''
j%#A')&@9'A#@*+A9+@'I,*')9'%*09+9AM''
!*<D"9,9')"**A'%*1$,'I!=!M'
(#09+'F1$%2*$',9@,@'
G;-+*#A'F1$%2*$',9@,'
'
G*')9'%*09+9A'#$'#$A#0#A1&"'A#@9&@9'
<*A1"9@\''
!&+A#&%:'1+#$&"-@#@:'9,%f'''

.9,9%2*$'*F'%;+*$#%'"#09+'A#@9&@9\'%*@,@'&$A')9$9X,@f'
Y'
g&@,+*9$,9+*"*?#@,'6YY`hZ\Zei``f

.+1?'"&)'#$,9+&%2*$'

l;&,'&m9%,9Ac'%;&$?9A',;9''
'
8+*A1%2*$'
H$,&R9'
/"#<#$&2*$'
'
'
65'

!&@9'6 ''

.+1?@'+9&%,'P#,;'+9&?9$,@'
!9F*U#2$'K'%9F&n*"#$'%&1@9'F&"@9'9"90&2*$'*F'
%+9&2$#$9'"909"'P;9$'!+'#@'&$&"-n9A')-'&'%*"*+#<9,+#%'
&@@&-'Io9m9]+9&%2*$'&@@&-M''

.+1?@'&",9+'DO''
j%9,&n*"&<#A9'D+*A1%9@'&"R&"#$9'1+#$9'"9&A#$?',*'F&"@9'
W09'D+*,9#$1+#&'+9@1",@'#$'A#D@2U'

.+1?@'+9&%,'P#,;'#<<1$*&@@&-k@'j)',;&,'#@'
#$,9$A9A',*')9'@D9%#X%'F*+',;9'&$&"-,9'
>D#+*$*"&%,*$9'&$A'#,@'<9,&)*"#,9'%+*@@]+9&%,'P#,;'
A#?*U#$'#<<1$*&@@&-@'
b&+-'(99f'455Yf'=&@#%'@R#""@'#$'#$,9+D+92$?'(&)*+&,*+-'A&,&h'j>O8f'
;pD\cc"9&+$9+@f$%1f9A1c@-""&)1@cA*P$"*&ATX"9f&@DQ@-""&)1@T++T#AS656YZY'

(**R'&,'9&%;'*$9')-'#,k@''
'
>*1+%9'
/"#<#$&2*$'
(*%&2*$'
31$%2*$'
'
'

66'

j'D&29$,'@1@D9%,9A'*F'9$A*%+#$9'A#@*+A9+'#@'
&@R9A',*'1$A9+?*',;9'A9U&<9,;&@*$9'
@1DD+9@@#*$',9@,',*'9U%"1A9'!1@;#$?k@'@-$A+*<9f''
G9@,'+9@1",'#$A#%&,9@',;9'@9+1<'%*+2@*"'"909"'P&@'
$*,'&A9^1&,9"-'@1DD+9@@9A:'@1??9@209'*F'
!1@;#$?k@'@-$A+*<9f'O*P909+:'D,k@'%"#$#%&"'@#?$@'
K'@-<D,*<@'&+9'#$%*$@#@,9$,f''
l;#%;'*F',;9'F*""*P#$?'<9A#%&2*$@',&R9$'D+#*+'
)-',;9'D&29$,'<&-';&09'#$,9+F9+9A'P#,;',;9',9@,'
+9@1",@Q''
64'

!&@9''6'
jf /@,+*?9$'
=f b9,*D+*"*"'
!f !9F&n*"#$'''
.f 8;9$-,*#$''
/f !"&+#,;+*<-%#$'''

/"9%,+*"-,9@'

6N'

J&W''j)$*+<&"#29@\'>c>U'

/"9%,+*"-,9@'
01)*+,-../.+*$

>*A#1<'IJ&WM'
!;"*+#A9'I!"]M'
!&"%#1<'I!&4WM'
=#%&+)*$&,9''

67'

'()*+,-../.+*$

'''''8*,&@@#1<'ILWM'
'
b&?$9@#1<'Ib?4WM'
8;*@D;&,9'I8C7M'

'

J&W'&)$*+<&"#29@'D+#<&+#"-'D+9@9$,'P#,;'!J>'
%;&$?9@'I#f9'A#nn#$9@@:'*,;9+\'Jca:'9,%M'''
>-<D,*<@'*F';-D*$&,+9<#&'*%%1+'1@1&""-'
P;9$'J&W'F&""@'q645<<*"c('
>-<D,*<@'*F';-D9+$&,+9<#&'*%%1+'P;9$'J&W'
&DD+*&%;9@'6_5]6`5'<<*"c('
>-<D,*<@'&+9'<*+9'&DD&+9$,'P;9$''
a9+-'"*P'*+'09+-';#?;'"909"@'*+''
P;9$'%;&$?9@'*%%1+'+&D#A"-'

6Z'

6_'

>*A#1<'IJ&WM'
J&W'j)$*+<&"#29@\'O-D*$&,+9<#&'

!&@9'4''
j'`5]-9&+]*"A'P*<&$'#@'&A<#p9A',*'',;9';*@D#,&"'A19',*'!O3'
9U&%9+)&2*$f''>;9'%*<D"&#$@'*F'@;*+,$9@@'*F')+9&,;'&$A'
*+,;*D$9&f''>;9';&@')99$'$*$]%*<D"#&$,'P#,;';9+'<9A#%&2*$'
F*+',;9'D&@,'4'P99R@f''8;-@#%&"'9U&<'+909&"@'7W'D9A&"'9A9<&'
&$A',;9'D&29$,'#@'#$'@909+9'+9@D#+&,*+-'A#@,+9@@f'''

>*A#1<'"909"\'234*+56($7)+)/7$*F'D&29$,'
.9%+9&@9A'>*A#1<'IO-D*$&,+9<#&M'
b&-')9'&@@*%#&,9A'P#,;'$*+<&":'#$%+9&@9A'*+'
A9%+9&@9A'%#+%1"&2$?'0*"1<9'Ir)"**AsM'

B9F9+9$%9'B&$?9
J&
L
E+9&
!+9&2$#$9

64N(

6N7]67Z<<*"c(

Nfe

NfZ]Zf6'<<*"c(

`fZ

Nf7]efY'<<*"c(

65eO

_4]65_1<*"c(

6`'

6e'

!&@9'4''

!&@9'4''

O*P'#@',;9'"*P'J&',*')9'9UD"&#$9AQ'
&M 8&29$,k@'@;*+,$9@@'*F')+9&,;'%*$,+#)1,9A',*'+9@D#+&,*+-'
&"R&"*@#@'"9&A#$?',*'&'%*<D9$@&,*+-'"*@@'*F'J&W'

l;&,'P*1"A'-*1+'+9%*<<9$A9A',+9&,<9$,'
)9Q'

'

&f
)f
%f
Af

)M' '(*P'J&W'#@'&$'9&+"-'@#?$'*F'+9$&"'A-@F1$%2*$'&@'@;*P$')-'
',;9'D&29$,k@''A9%+9&@9A'!+!"'
'
%M' 'G;9'D&29$,k@'"*P'J&W'#@'D+*)&)"-'A19',*'&';-D9+0*"9<#%'
';-D*,*$#%';-D*$&,+9<#&'IA#"12*$&"';-D*$&,+9<#&M'
'
AM' 'G;9'D&29$,k@'"*P'J&W'#@'D+*)&)"-'A19',*'&';-D*0*"9<#%'
';-D*,*$#%';-D*$&,+9<#&'
6Y'

3"1#A'+9@,+#%,',;9'D&29$,'&$A'?#09'"**D'A#1+92%@''
g#09'NV'J&!"'W'"**D'A#1+92%@''
g#09'"**D'A#1+92%@''W'Z55<('J>')*"1@'
g#09'6('J>'#$F1@#*$'*09+'6';*1+'

45'

O-D*$&,+9<#&'
?"6,$4/0&-/;%,%&

!&@9'4'

l;&,'#F',;9'D&29$,k@'@!+'#@'4Z51<*"c(Q'
G*"0&D,&$'I>&<@%&tMQ''

@9"9%209'0&@*D+9@@#$'+9%9D,*+'&$,&?*$#@,''
#$A#%&,9A'F*+',;9',+9&,<9$,'*F'%"#$#%&""-'@#?$#X%&$,'
;-D9+0*"9<#%'&$A'910*"9<#%';-D*$&,+9<#&'I9?f'O3'K'
>Hj.OM'

46'

.#@*+A9+@'j@@*%#&,9A'
l#,;'>Hj.O

44'

.#@*+A9+@'j@@*%#&,9A'l#,;'>-$A+*<9'*F'H$&DD+*D+#&,9'j.O'
>9%+92*$'
.#@*+A9+''
/U&<D"9@''
!&$%9+'
!J>'
.1*A9$1<'
&/(8$
(-<D;*<&'
8&$%+9&@'
!J>'A#@*+A9+@'
j%1,9'#$,9+<#p9$,'D*+D;-+#&'
j%1,9'D@-%;*@#@'
=+&#$'&)@%9@@'
/$%9D;&"#2@'
g1#""&#$]=&++u'@-$A+*<9'
O9&A',+&1<&'
b9$#$?#2@'
>,+*R9'
>1)A1+&"'*+'@1)&+&%;$*#A';9<*++;&?9'
/$A*%+#$9'A#@*+A9+@'
jAA#@*$'A#@9&@9'
O-D*D#,1#,&+#@<'
O-D*,;-+*#A#@<'
81"<*$&+-'A#@*+A9+@'&$A' j@D9+?#""*@#@'
,+9&,<9$,@'
(1$?'&)@%9@@'
8$91<*$#&'
8*@#209]D+9@@1+9')+9&,;#$?'
#9$
b#@%9""&$9*1@'
8+*,9#$]9$9+?-'1$A9+$1,+#2*$'
>1+?9+-'

;pD\ccPPPf<9+%R<&$1&"@f%*<cD+*F9@@#*$&"c9$A*%+#$9T&$AT<9,&)*"#%TA#@*+A9+@c
9"9%,+*"-,9TA#@*+A9+@c;-D*$&,+9<#&f;,<"

4N'

o*$9@'/f'.+1?]#$A1%9A'@-$A+*<9'*F'#$&DD+*D+#&,9'
&$2A#1+92%';*+<*$9f'!8ocB8!:'455`h'675I_M'NY`]YY

47'

O-D*$&,+9<#&\'G+9&,<9$,'

!&@9'N'

G+9&,<9$,'jDD+*&%;9@'
:3;6(+)*-<=+$>:3;6)6(=,?$
O-D*0*"9<#%' J>'H$F1@#*$'
H@*0*"9<#%'' 3"1#A'+9@,+#%2*$'I<#"A',*'<*AM'
O-D9+0*"9<#%'' .#9,&+-'>*A#1<'+9@,+#%2*$'W'
.#1+92%',;9+&D-'
H<D*+,&$,'D*#$,@d''
!*++9%2$?',**'F&@,'<&-'"9&A',*'*@<*2%'A9<-9"#$&2*$'
B9%*<<9$A9A'%*++9%2*$'+&,9\''
65',*'64'<<*"c(cA&-'*+'6e'<<*"c('#$'7e';*1+@'
5fZ',*'6'<<*"c(c;+'#F'D&29$,';&@'@909+9'@-<D,*<@'

Z5'-c*'3:'Jca'v'6'PR:'F909+'v'4]N'A&-@'
8bO\'8a.:'OGJ:'g/B.'
8/\'&"9+,'K'*+#9$,9A'
=8\'YZcZ_:'8\'eY:'jF9):'%"9&+'"1$?@'
b*,*+\'@-<<9,+#%&":'+9w9U9@'#$,&%,'
!"#$#%&""-'A+-''''

4Z'

!&@9'<*A#X9A'F+*<'.+'Lx'G@&$?:'B9$&"'1$#,:''jOJO'

!&@9'N'

26

!&@9'N''

(&)@'

G+9&,<9$,'?#09$'
>,&+,9A'*$'j1?<9$2$'Ha'6f4?'[e;'
J>'Z55<"'[_;'W'L!"'45<<*"c'D#$,''
64];+'J&\'66e'<<*"c('
8/'#$'&<\'=8\'655c_Z:'8eZh'<#"A'%+&%R"9@'#$'
"1$?')&@9'

8"&@<&\'J&'65Y:'L'4f_:'!"'_5:'@!+'6N5:'=EJ'6Z'
Ej\'R9,*$9@:'745<C@<cR?:'J&'_`'
l=!\'6_''
j")'NfZ:'!&'efN:'Gg'66_:'g"1'`fe'

b8Gj'
b9,*D+*"*"'Z5<?'=.'

27

28

CD2*$@'
jf !*$2$19'J>'&$A'+9%;9%R'#$'N]7';*1+@''
=f !;&$?9',*';#?;'%*$%'J&!"'Z55<":'y'655<"c;'
!f .#@%*$2$19'&""';-A+&2*$'&$A'?#09'*+&"'J&'
,&)"9,@''
.f .#@%*$2$19'&""';-A+&2*$'&$A'?#09'*+&"'
+9;-A+&2$?'@*"12*$'D&%R9,@'
/f >P#,%;',*'.Zl'655<"c';+'
l;&,'@;*1"A')9'A*$9'&,',;#@'<*<9$,Q'''

30

29

H@'#,'+9&@*$&)"9'F*+',;9'J&',*'+#@9'@*'
^1#%R"-Q'

j$-'*,;9+'@*1+%9'*F'J&Q'

!&"%1"&,9',;9'9UD9%,9A'@J&'&z9+'J>'#$F1@#*$'

!;9%R',;9'<9A#%&2*$@',&R9$''

l,'S'`5R?:',*,&"'')*A-'P&,9+'S'74(''
J&!"'6555<"'P&@'?#09$'#$'64';*1+@'S'6Z7'<<*"''

/UD9%,9A'@J&'&z9+'64';+@''
65Y<<*"c('{'74('W'6Z7<<*"c'I74W6M''
665'<<*"c('0@'66e'#$'&%,1&"''
IB*1?;'9@2<&2*$:'&@@1<D2*$'*F'9^1&"'A#@,+#)12*$'
*F'J&'&<*$?'/!3'K')"**A:'&$A'$*'1+#$9'*1,D1,M'''
Augmentin 1.2g Q8h
N6'

Total Na added = 2.7 *2 = 5.4 mmol within 12 hours

32

CD2*$'6'

>1<<&+#n#$?',;9'D+*)"9<|f''

J&!"'Z55<"'[_;'P&@'%*$2$19A'
N';*1+@'"&,9+:'

@J&'P9$,'F+*<'65Y',*'64N<<*"c('P#,;#$'6Z'
;*1+@'
O-D*R&"9<#&'
J9U,'@,9D'A*$9\''
.Z'Z55<"'WN5<<*"'L!"c'D#$,'[_'
65<<*"'L!"'*09+'6';*1+'U4'
>-+1D'L!"'4?'[6;'v'4'''
34

33

l;&,';&DD9$9A',;9$Q''

!&@9'N'IP;9$'@;9'X+@,'%&<9'#$M'
(&)@'
Ej\'R9,*$9@:'745<C@<cR?:'J&'_`'
8"&@<&\'J&'65Y:'L'4f_:'!"'_5:'@!+'6N5:'=EJ'6Z'
l=!\'6_''
j")\'NfZ:'!&'efN:'Gg'66_:'g"1'`fe'

b9A@'
b9,*D+*"*"'Z5<?'=.'

.Zl'?#09$'

L'#<D+*09Ah'D"&@<&'*@<*\'4_e'
=1,'J&'#@'@2""'+#@#$?'F+*<'64N',*'64e'P#,;#$'64';+@d''
35

36

!&@9'N'

b9%;&$#@<'*F'l&,9+'A#1+9@#@'
l&,9+'A#1+9@#@\'"*@#$?'"&+?9'&<*1$,'*F'P&,9+'#$'
1+#$9'

!*$@#A9+'1+#$9'K'D"&@<&'*@<*"&"#,-')9F*+9'K'&z9+'
w1#A'+9D"&%9<9$,''
C$'&A<#@@#*$\''

l;9$'?#0#$?'3"1#A'B9D"&%9<9$,\'

8"&@<&'*@<*\'474:'J&'65Y:'L'4f_''
E+#$9'*@<*\'745:'J&'_`:'L'Jcj'

!'a*"1<9'9UD&$@#*$'
!'>1DD+9@@'j$2]A#1+92%';*+<*$9'Ij.OM'+9"9&@9'

jz9+'w1#A'+9D"&%9<9$,:'

!'P&,9+'A#1+9@#@'I"*@#$?'P&,9+:'$*,'&@'<1%;'@*A#1<M'

8"&@<&'*@<*\'4_e:'J&'64Z:'L'4f`''
E+#$9'*@<*\'6YN:'J&'45:'L'6_fN'

!'C%%&@#*$&""-'"9&A@',*'&'+&D#A'+#@9'#$'@J&'
''

!'.9%+9&@#$?'1+#$9'*@<*"&"#,-'K'1+#$9'J&'
(*@@'*F'P&,9+'#$'1+#$9'
37

38

!*$A#2*$@',;&,'$99A',*'P&,%;'*1,'F*+'+#@R'
*F'P&,9+'A#1+9@#@\'
l;9$'<&$&?#$?',;9'F*""*P#$?'@#,1&2*$@\''

..ja8''
j.O'&$&"*?19h'#$%+9&@9@'1+#$9'*@<*"&"#,-'''
b&-')9'1@9A'P;9$''

O-D*0*"9<#&'IF*+'P;#%;',+9&,<9$,')-'+9@,*+&2*$'*F'
$*+<*0*"9<#&'@1DD+9@@9@'j.O'+9"9&@9M''
b9A#%&2*$]'#$A1%9A';-D*$&,+9<#&'I.#@%*$2$1&2*$'*F'
>>BH:'%&+)&<&n9D#$9:'..ja8'!'D9+<#,@'9U%+92*$'*F'
<&U#<&""-'A#"1,9'1+#$9M'
O-D*D#,1#,&+#@<'*+'&A+9$&"'#$@1}%#9$%-'IF*+'P;#%;'%*+2@*"'
+9D"&%9<9$,'+9,&#$@'@*A#1<'&$A'%*++9%,'J&'"*@@Mi'&"@*'<&-'
"9&A',*'&'+&D#A'+#@9'*F'@J&'"909"'''

J&'#@'+#@#$?',**'^1#%R"-'&$A'
,;9+9'#@'90#A9$%9'*F'P&,9+'A#1+9@#@''
E+#$9'*@<*"'q655]6Z5'
E+#$9'*@<*"\'D"&@<&'*@<*"'q'5f`''

.*@9\'6]4~?h'?#09'6]4'A*@9@''
G*,&"'w1#A'#$,&R9')-'D&29$,'@;*1"A')9'
%&+9F1""-'%*$,+*""9A''''

HF'A*'$*,'?#09'w1#A'
B#@R'*F'A9;-A+&2*$Q''
39

Clin J Am Soc Nephrol 3:331-6, 2008

40

J&W'j)$*+<&"#29@\'O-D9+$&,+9<#&'

C,;9+'#@@19@',*'%*$@#A9+'
B9$&"'F1$%2*$''
@*=(-$6/);/)$
O3'*+'*,;9+'%*$A#2*$@',;&,'#<D&#+9A'P&,9+'*+'
J&'9U%+92*$''
8*@@#)#"#,-'*F'9$A*%+#$9'A#@*+A9+@'
8/'X$A#$?@'

H$%+9&@9A'>*A#1<'IO-D9+$&,+9<#&M'
E@1&""-'&@@*%#&,9A'P#,;'
81+9'w1#A'"*@@'I"*@@'*F'F+99'P&,9+M'
O-D*,*$#%'w1#A'"*@@'IA9;-A+&2*$M'
H$%+9&@9'@&",'#$,&R9'

41

J&W'j)$*+<&"#29@\'O-D9+$&,+9<#&'

74'

O-D9+$&,+9<#&\'G+9&,<9$,'
G+9&,<9$,'jDD+*&%;9@'
:3;-*(+)*-<=+$
O-D*0*"9<#%'' J>'1$2"'?*&"'0*"1<9',;9$'
@P#,%;',*';-D*,*$#%'
H@*0*"9<#%' Ha';-D*,*$#%'w1#A@'
O-D9+0*"9<#%' .Zl'#$F1@#*$'W'(**D'A#1+92%@'
H<D*+,&$,'D*#$,@d''
!*++9%2$?',**'F&@,'<&-'%&1@9'%9+9)+&"'9A9<&'
B9%*<<9$A9A'%*++9%2*$'+&,9\''
65<<*"c(cA&-'
5fZ',*'6'<<*"c(c;+'#F'D&29$,'#@'@909+9'@-<D,*<@'

7N'

77'

!&1@9@'*F'LW'j)$*+<&"#29@'

8*,&@@#1<'ILWM'
>*1+%9'
.#9,&+-'@*1+%9@'

/"#<#$&2*$'
e5]Y5V'#@'9U%+9,9A')-'R#A$9-'

(*%&2*$'
b&*+'%&2*$'#$'#$,+&%9""1"&+'w1#A'
@L'$*,'&"P&-@'&$'&%%1+&,9'#$A#%&,*+'*F'LW'"909"@'IYeV'F*1$A'
#$@#A9'%9""@M'

j%#A])&@9')&"&$%9\'#$'&%#A#%'9$0#+*$<9$,:'@L''
OW'<*09@'#$,*'%9""@:'LW'?9,@'D1@;9A'*1,'#$'*+A9+',*'
<&#$,&#$'9"9%,+*]$91,+&"#,-'
3*+'909+-'5f6'1$#,'A9%+9&@9'#$'DO:'@L'')-'5f_]5fe'</^c('
'

7Z'

7_'

'

LW''j)$*+<&"#29@\'>c>U'
'
'
'
'
'
'
'
'
'

LW''j)$*+<&"#29@\'>c>U'
O-D*R&"9<#&'

O-D9+R&"9<#&'

b#"A'

N'i'NfZ'<<*"c('

ZfZ'i'_'<<*"c('

b*A9+&,9'

4fZ'i'N'<<*"c('

_f6'i'_fY'<<*"c('

>909+9'

q4fZ'<<*"c('

`'<<*"c('

ST&/P$"3>/0.4,%&/N,-6&-/32./-&>;%-0,O&
%Q,0,6/0&>;%-0,&/$2&$,;3">;%-;0/3&6"$,'
7`'

7e'

LW''j)$*+<&"#29@\'G+9&,<9$,'
jDD+*&%;9@'

O-D*R&"9<#&\''
!*$%9$,+&2*$'K'#$F1@#*$'+&,9@'
b&U#<1<'%*$%9$,+&2*$'*F'+9D"&%9<9$,'LW'#@'
_5',*'e5'<<*"c('
L'#$F1@#*$'+&,9@'65<<*"c;+'+9^1#+9@'/!g'
<*$#,*+#$?'
3*+'@909+9';-D*R&"9<#&'ILW'q4<<*"c('M'

G+9&,<9$,'
O-D9+R&"9<#&' !&!"'4'IF*+'%&+A#&%'@,&)#"#n&2*$'*$"-M:'
H$@1"#$'&$A'?"1%*@9:'4'&?*$#@,@:'
B9@*$#1<'!t:'J&O!CN':'.#&"-@#@'

H$F1@#*$'+&,9@'@;*1"A'JCG'9U%99A'<*+9',;&$'75'
<<*"c;+'9@D'P;9$'"&+?9'0*"1<9@'&+9'?#09$f'

O-D*R&"9<#&' L!"'"#^1#A@:'8C'A*@&?9'F*+<@:'Ha'
#$,9+<#p9$,'#$F1@#*$'
{HF';-D*<&?$9@9<#&'#@'&"@*'D+9@9$,:'
%*++9%,'<&?$9@#1<'"909"@'X+@,'

!;9%R'"&)'0&"19@'N5'<#$1,9@'&z9+'#$F1@#*$',*'
&""*P'F*+'+9A#@,+#)12*$'
7Y'

!&@9'7'
j'`7]-9&+]*"A'<&$'P#,;'&A0&$%9A'=8O'A909"*D@')#"&,9+&"'
1+9,9+&"'*)@,+1%2*$'&$A'&%1,9'+9$&"'F&#"1+9f'O#@'D*,&@@#1<'+#@9@'
,*'_fN'</^c('P#,;'&'F9P'9"90&,9A'G]P&09@'*$'/Lgf'''
'
8&@,'b9A#%&"'O#@,*+-\'
j++;-,;<#&'I@#$%9'455NM'
=9$#?$'8+*@,&,9'O-D9+,+*D;-'I@#$%9'4555M'
'
O#@'%1++9$,'<9A#%&2*$@'#$%"1A9\'
j<#*A&+*$9'N55<?'6',&)"9,'8C'=.'
.#?*U#$'5f64Z'<?'6',&)"9,'8C'[.'
3#$&@,9+#A9'Z<?''6',&)"9,'8C'[O>'
Z6'
'

Z5'

!&@9'7'
l;&,'#@',;9'<*@,'"#R9"-'%&1@9'*F';#@'9"90&,9A'@9+1<'
8*,&@@#1<Q'
'
&M .#?*U#$'
)M j<#*A&+*$9'
%M 8&29$,k@'&%1,9'+9$&"'F&#"1+9'
AM >&<D"9'$*,'F+9@;'
9M j""'*F',;9'&)*09'
'
'
Z4'

j@@9@@#$?'(#09+'31$%2*$'

!&@9'7'

8+#<&+#"-'&@@9@@'"#09+'#$1+-'+&,;9+',;&$'F1$%2*$'
b&-'&"@*'#$A#%&,9'9U,+&];9D&2%'D+*)"9<@'

l;&,'#@',;9'<*@,'&DD+*D+#&,9'#$#2&"',;9+&D-'F*+',;9'
D&29$,Q'
'
&M O9<*A#&"-@#@'
)M B9@*$#1<'!'
%M H$,+&09$*1@'?"1%*@9'&$A'+9?1"&+'#$@1"#$'
AM H$,+&09$*1@'%&"%#1<'?"1%*$&,9'
9M H$,+&09$*1@'w1#A@'W'"**D'A#1+92%@'
'

O9<*"-@#@'I)#"#+1)#$M:'=*$9'A#@9&@9'Ij8M'''''

J*+<&"'(3G@'''"#09+'F1$%2*$'#@'$*+<&"'
="99A#$?'9@*D;&?9&"'0&+#%9@:'%#++;*@#@'
A+*+<-)-*7$

B6(2-;+5,$76/*,-7$

'
j@D&+,&,9'j<#$*,+&$F9+&@9'Ij>GM'
'

Skeletal muscle, cardiac muscle, red blood

cells!

j"&$#$9'j<#$*,+&$@F9+&@9'Ij(GM'

Skeletal muscle, cardiac muscle, kidneys!

j"R&"#$9'8;*@D;&,&@9'Ij(8M'

Bone, first trimester placenta, kidneys,

intestines!

G*,&"'>9+1<'8+*,9#$'IG>8M'
j")1<#$'Ij")M'
G*,&"'=#"#+1)#$'IGf'=#"#M'

B9A')"**A'%9""@'I9f?f:';9<*"-@#@:'#$,+&]
&)A*<#$&"')"99A:';9<&,*<&M''

8+*,;+*<)#$'2<9'I8GM'
ZN'

G-D9'*F'"#09+'A#@9&@9'0@''
/$n-<9'&)$*+<&"#29@'

Z7'

/U&<D"9'
j'D&29$,'P#,;'&$'j>G'"909"'*F'6N5'HEc<('
I$*+<&"'75'HEc<(M'&$A'&$'&"R&"#$9'
D;*@D;&,&@9'*F'6N5'HEc<('I$*+<&"'645'HEc
<(Mf''
l;#%;',-D9'*F'"#09+'A#@9&@9'#@'<*@,'"#R9"-:'
;9D&22@'0@')#"9'A1%,'*)@,+1%2*$'0@'"#09+'!jQ''

s;#?;9+s'S'A9?+99'*F'9"90&2*$''
.#m9+9$2&2*$')9,P99$'%;*"9@,&2%'0@'
#$X",+&209'+9^1#+9@'"#09+'#<&?#$?'@,1A#9@'''
;pD\ccPPPf%"909"&$A%"#$#%<9A9Af%*<c<9A#%&"D1)@cA#@9&@9<&$&?9<9$,c
;9D&,*"*?-c?1#A9],*]%*<<*$]"#09+],9@,@c'

U5$&1#.02K?;7#&-0/%%.V-/4"$&&

ZZ'

Z_'

!&1@9@'F*+'
9"90&2*$@'*F''
j(G'K'j>G

j>G'K'j(G

/"90&,9A'#$''

E@1&""-'&@-<D,*<&2%'
\'

j%1,9';9D&22@''
G*U#%'*+'#@%;9<#%'#$1+-'+9@1",@'#$'9$n-<9'"9&R&?9'#$,*'
%#+%1"&2*$'

(*P'@9$@#20#,-'F*+'!;+*$#%'"#09+'A#@9&@9'I9?f'O9D'!'K'
$9%+*@#@M'
(#09+'%9""@'A-#$?')-'&D*D,*@#@:'<&R9'"9@@'j>G'K'j(G'

j(G'%*++9"&,9@'*$"-'<*A9+&,9"-'P9""'P#,;',;9'#$w&<<&2*$'

>909+9'<1@%"9'#$1+-'c'9U9+2*$\''@909+&"'2<9@'
b#"A'<1@%"9'#$1+-'I9?f'O-D*,;-+*#A#@<M\'<#"A''''
C)9@9'D&29$,@\'@"#?;,'''
B9$&"'A#&"-@#@\'"*P'j>G'K'j(G'

'

Z`'

j"R&"#$9'8;*@D;&,&@9'
Ij(8c'j8M'

B&$?9'*F'j>G'K'j(G''
j>G'K'j(G'B&2*@'

j%1,9'&"%*;*"#%';9D&22@'
j>G'K'j(G'1@1&""-'qZ55cN55h''
;#?;'ggG''

j>G'+#@9''j(G'+#@9''
j>Gcj(G''4'
.19',*'a#,'=_'A9X%#9$%-'
=_'A9X%#9$%-'#$;#)#,'j(G'
@-$,;9@#@'

O#?;9+',;9'+&2*:'<*+9'
"#R9"-'#,k@'&"%*;*"'#$A1%9A'
b&-'&"@*'*)@9+09A'#$'
%#++;*@#@'

''

.#@9&@9@'&m9%,';9D&,*%-,9'@9%+92*$'
I9f?f:'*)@,+1%209'A#@9&@9@'#$')#"9]A1%,M'
P#""')9'&%%*<D&$#9A')-'"'j8'
b#"A'#$%+9&@9'Iq6fZv'$*+<&"M'
+9@*"09@')-'#,@9"F''
B9%9$,'F+&%,1+9:')*$9'D&#$:')*$9'
A#@9&@9'I8&?9,k@'A#@9&@9M:'N+A'
,+#<9@,9+'*F'D+9?$&$%-''
a9+-';#?;'j8'"909"@'I9?f'_v'$*+<&"M''
.#m1@9'#$X",+&209'"#09+'A#@9&@9@'9?f'
G1<*+@'K'F1$?&"'#$F9%2*$@'

G-D#%&"'0#+&"'*+',*U#%'"#09+'
#$1+-'
E@1&""-'j(G'+#@9''j>G'+#@9'
I)1,'$*,'&"P&-@M'

;pD\ccPPPf&&FDf*+?c&FDc6YYYc576ZcD444Nf;,<"QD+#$,&)"9S&FD

Ze'

ZY'

89+@#@,9$,"-':'&@-<D,*<&2%:'9@D'3'
8+#<&+-')#"#&+-'%#++;*@#@'

'''''ggG

''

(#09+'@D9%#X%:')1,',**'@9$@#209''
N'+*"9@\''
b*$#,*+'&"%*;*"'1@9'
/$n-<9'#$A1%2*$')-'
''
/?f''N'&"%*;*"#%'A+#$R@cA&-'I7Z?'
9,;&$*"M'

/"90&2*$'%*$X+<@',;&,'
&%%*<D&$-#$?''j8'9"90&2*$'
P&@'+9"&,9A',*'"#09+'
/"90&2*$'%*$X+<@',;&,'
&%%*<D&$-#$?'j>G\'j(G'+&2*''
4'P&@'"#R9"-'&"%*;*"#%'"#09+'
A#@9&@9''

!*1"A')9'A+1?'#$A1%9A\''
C"A'&$2%*$01"@&$,@:'9?f'
8;9$-,*#$'K'D;9$*)&+)\''
ggG''4vh'j(8'&"@*'<#"A"-''P#,;'
D;9$-,*#$''''''

_5'

!,/)-$9=.-$4/,)$6C7)*/,56($6*$
,26.-7)+7=7'

j")1<#$'

3*+<9A'#$',;9'"#09+h'b&#$,&#$@'%*""*#A&"'*@<*2%'
D+9@@1+9'
r#$A9Us'*F'"#09+'@-$,;92%'%&D&%#,-:')1,'

l#,;#$'F9P';*1+@'*F'&%1,9')#"9'A1%,'
*)@,+1%2*$\'
j>G'K'j(G'"909"'?*'1D',;9$'A9%"#$9'''

%;&$?9@'#$'A#@,+#)12*$'#$'0&+#*1@'%*<D&+,<9$,@'

(*P\''

jz9+'@909+&"'A&-@\'

8+*,9#$1+#&'
j%1,9'*+'%;+*$#%'#$w&<<&,*+-'@,&,9@'

ggG'K'j8'+#@9',*'@909+&"'2<9@'*F'$*+<&"'

=1+$@:',+&1<&:'@9D@#@'
j%209'+;91<&2%'A#@*+A9+@''

/$A'@,&?9'<&"$1,+#2*$''

'&")1<#$'<&-''9m9%,'*F'D+*,9#$])*1$A'A+1?@'I#f9'
D;9$-,*#$:'&@D#+#$:'0&"D+*&,9M'
j"@*'&$'&"9+,',*',;#$R'&)*1,'Q'(#09+'F1$%2*$'
_4'

_6'

G*,&"'=#"#+1)#$'IGf'=#"#M'

G*,&"'=#"#+1)#$'IGf'=#"#M

j')+9&RA*P$'D+*A1%,'*F';9<*?"*)#$''
G;9',*,&"')#"#+1)#$'"909"'<&-')9'$*+<&"'*+'9"90&,9A'#$'9&%;',-D9'*F'
"#09+'A#@*+A9+'I%9""1"&+:'*)@,+1%209'*+'#$X",+&209M''

E$%*$1?&,9Ah'%*$09+,9A'#$,*'%*$1?&,9A'
IA#+9%,M')#"#+1)#$'#$'"#09+'
!*$1?&,9A\'9U%+9,9A'#$,*')#"9'''

H$'"#09+'A#@9&@9:'@9%+92*$'*F'
%*$1?&,9A')#"#+1)#$'#$,*')#"9'#@'
#<D&#+9A'

H@*"&,9A'<#"A''1$%*$1?&,9A')#"#+1)#$''
g#")9+,'@-$A+*<9'ID&+2&"'A9F9%,@'#$',;9'9$n-<9',;&,'%*$1?&,9@'
)#"#+1)#$M'
b#"A';9<*"-@#@''

!*$1?&,9A'=#"#+1)#$'?9,@'#$,*'
%#+%1"&2*$''
!*$')#"#+1)#$'"909"'*$"-'+#@9'P;9$'"#09+'
;&@'"*@,''Z5V'*F'9U%+9,*+-'%&D&%#,-'
/?f'=#"#+1)#$'"909"'#@'$*+<&"'P;9$'
*)@,+1%2*$'*F'*$"-'6';9D&2%'A1%,''

8+*"*$?9A'K'@909+9')#"#&+-'*)@,+1%2*$'F*""*P9A')-')#"9'
w*P'+9@,*+&2*$''
B&D#A'A9%"#$9'F*+'&'F9P'A&-@'&$A',;9$'@"*P'+9,1+$',*'$*+<&"'
*09+'P99R@''
.9",&])#"#+1)#$'&p&%;9A',*'&")1<#$'I,6c4'S'N'PR@M''

/U%9@@#09'%#+%1"&2$?'%*$1?&,9A'
)#"#+1)#$'?9,@'X",9+9A'#$,*'1+#$9'''
.#D@2U\')#"#+1)#$'#$'1+#$9h'#$A#%&,9@'
"#09+'A#@9&@9''

_N'

_7'

8+*,;+*<)#$'2<9

!&@9'Z'
j'_5]-9&+]*"A'<&"9'D+9@9$,9A'P#,;'&'%;#9F'%*<D"&#$,'I!!M'*F')"**A-'
&$A'"&,9+',&++-'@,**"'*$'>9D,'e,;:'4567f'G;9'D&29$,'+9D*+,9A',;&,'
,;9'&)$*+<&"'F&9%9@'P&@'$*,9A'4'A&-@'&?*'P;#%;';9'&p+#)1,9A',*'
,*<&,*'#$,*"9+&$%9f'O9';&A'&'D&+2&"'?&@,+9,*<-'F*+'?&@,+#%'!j'*$'
j1?1@,'4e,;f'8*@,*D'%*1+@9'#$];*@D#,&"'P&@'1$909$1"'
C,;9+'@-<D,*@<';9'%*<D"&#$9A'*F'&+9'F&2?19'&$A'P9&R$9@@'I@#$%9'
@1+?9+-M'
G;9'D&29$,'A9$#9A'"#?;,;9&A9A$9@@:'%;9@,'D&#$:'>C='&$A'0#@1&"'
A#@,1+)&$%9@f'
8bO'

(#09+'<&R9@'%"*$?'F&%,*+@'HH:'a:'aHH:'Hv'K'v'
8G'#@'$*+<&"'1$2"''e5V'*F'"#09+'@-$,;92%'
%&D&%#,-'#@'"*@,'
8+*"*$?9A'8G'
>#?$'*F'@9+#*1@'"#09+'A-@F1$%2*$'IF&%,*+'aHHM''
a9+-'1@9F1"'F*+'<*$#,*+#$?'*F'"#09+'F1$%2*$'#$'&%1,9'"#09+'
F&#"1+9'

a#,&<#$'L'A9X%#9$%-'I%;+*$#%'%;*"9@,&@#@'*+'F&,'
<&"&)@*+D2*$'F+*<'D&$%+9&2%'*+'@<&""')*P9"'
A#@9&@9M''

G+#&"'*F'0#,'L'#$9%2*$',*'+1"9'*1,'0#,'L'A9X%#9$%-''

_Z'

>,+*R9'I`'-9&+@'&?*M''
B#?;,';#D'+9D"&%9<9$,'@1+?9+-'INfZ'-9&+@'&?*M''
OGJ''
.-@"#D#A&9<#&'
.b'
g*1,'I$*'+9%9$,'9D#@*A9@M'''
'

__'

!&@9'Z'
'b9A'"#@,'

!&@9'Z'
l;&,'+9"90&$,'^19@2*$@'P#""'-*1'&@R'F*+'<*+9'
#$F*+<&2*$Q''

_`'

''

(*@&+,&$'
O!G'
8#*?"#,&n*$9''
b9*+<#$''
!"*D#A*?+9"''
>#<0&@,&2$''

_e'

O8H'

!&@9'Z'
'

!"*D#A*?+9"'P&@'+9#$#2&,9A'A&-'_'D*@,'*D''
.&-'`'K'e'D*@,'*D\'F&9%9@'P9+9'$*+<&"'
E+#$9'%*"*+\'<*+9'-9""*P',;&$'1@1&"''
=8\'655]'66Zc'_5]`5'<<O?'
=g\''

J&W'I<<*"c(M'
LW'I<<*"c(M'
E+9&'I<<*"c(M'
@!+'I~<*"c(M'
jA1@,9A'!&4W'I<<*"c(M'
8;*@D;&,9'I<<*"c(M'
G*,&"'8+*,9#$'I<<*"c(M'
@9+1<'39'I<<*"c(M'
a#,&<#$'=64'
3*"&,9'
!B8'I<?c(M'

F&@2$?'S'_fe'
4';+'88'S'`fZ''

B9F9+9$%9'B&$?9'
6N7]67Z'
NfZ]Zf6'
Nf7]efY'
_4]65_'
4f6Z]4fZZ'
5fe4]6f75'
__]e6'
66]4e'
6`Y]__5'
65f7]74f7'
qYfY'

675'
Nf_'
6Nf4'IOM'
_Z'
4f7e''
5fYN'
`e'
6N'
N__'
6Nf6'
qYfY'

_Y'

!&@9'Z'
'
B=!'
O?)'
O%,'
b!a'
b!O'
8",'
l=!'
J91'

B9F9+9$%9'B&$?9'
'7f4]Zf`'v65'64c('
6Nf4'i'6_f`'?cA('
5fNY]5fZ'(c('
e6]Y`'F('
4`]N4'D?'
675]Ne5'v65Yc('
7]65fe'v'65Yc'('
76]`NV'

`5'

!&@9'Z'
l;&,'#@'-*1+'#$,9+D+9,&2*$'*F',;9'&)$*+<&"'
"&)'0&"19@Q'
Nf4'I(M'
64f4'I(M'
5fN7'I(M'
e5'I(M'
N6f7'
NeY'IOM'
_fN''
`ZV'

l;&,'&+9',;9'$9%9@@&+-'<*$#,*+#$?'
D&+&<9,9+@Q'8+*D9+'<&$&?9<9$,Q''

`6'

`4'

!*<D"9,9'="**A'!*1$,'I!=!M'
!=!'#$%"1A9@\'
B9A')"**A'%9""@'IB=!M'
O9<*?"*)#$'IO?)M'
O9<&,*%+#,'IO%,M'
l;#,9')"**A'%9""@'Il=!M'
b9&$'%*+D1@%1"&+'0*"1<9'Ib!aM'
b9&$'%*+D1@%1"&+';9<*?"*)#$'Ib!OM'
b9&$'%*+D1@%1"&+';9<*?"*)#$'%*$%9$,+&2*$'Ib!O!M'
8"&,9"9,'%*1$,'
l=!'A#m9+9$2&"'

!*<D"9,9'="**A'!*1$,'

`N'

b9&$'!*+D1@%1"&+'a*"1<9'Ib!aM'

O9<*?"*)#$'&$A'O9<&,*%+#,'

/@2<&,9'*F',;9'/9,3/7,&9"0;>,&*F',;9'9+-,;+*%-,9'

O9<*?"*)#$'IO?)M'
CU-?9$'%&++-#$?'%*<D*1$A'#$'B=!@'
O9<&,*%+#,'IO%,M'
'''''a*"1<9'*F')"**A'*%%1D#9A')-'B=!@'

'!C8.'
'!;+*$#%'@<*R9+@'''
''''j,;"9,9@'
B9@#A9$,@'#$'&+9&@'*F'
;#?;'&"2,1A9@'
8*"-%-,;9<#&'09+&'

`7'

'(,*-+7-$><+,*6,35,?$

3*"&,9'A9X%#9$%-'
a#,f)64'A9X%#9$%-'
j"%*;*"#@<'
!;+*$#%'"#09+'A#@9&@9'
O-D*,;-+*#A#@<'
j$*+9U#&'
b9A#%&2*$@'

="**A'"*@@'
O9<*"-@#@'
j$9<#&''
'
>*<92<9@\'8+9?$&$%-'
&$A'#$%+9&@9A'w1#A'
#$,&R9'

D-,*-+7-$><=,*6,35,?$

8*#@*$#$?'
G;&"&@@9<#&'
H+*$'A9X%#9$%-'&$9<#&'
O9<*"-2%'&$9<#&'
(9&A'8*#@*$#$?'

a&"D+*#%'&%#A:'
n#A*01A#$9:'@,&01A#$9'
`Z'

`_'

j$&9<#&'*F'!;+*$#%'.#@*+A9+'a>''
H+*$'.9X%#9$%-''
!ED$
O)'
b!a'
>9+1<'H+*$''
GH=!'
39++#2$''
b&++*P'39'@,*+9'
B9@D*$@9',*',+#&"'*F'
H+*$''

'B92%1"*%-,9@'

'D!$

'Y'?cA(h'+&+9"-'q'e'?cA('

a&+#&)"9'

J*+<&"'*+'@"#?;,"-'"*P'

(*P'

(*P'

(*P'

J*+<&"'*+'@"#?;,"-'"*P'

O#?;'

O#?;'

(*P'

J*+<&"'*+'#$%+9&@9A'

j)@9$,'

J*'

x9@'

;pD\ccPPPfF<@;Rf%*<f;Rc;R&),;c9<c1"4556f;,<'

H<<&,1+9'B=!@'
H$%+9&@9'&@@*%#&,9A'P#,;\'
O9<*"-2%'&$9<#&'
O9<*++;&?9'
>#%R"9'%9""'A#@9&@9'

.9%+9&@9'&@@*%#&,9A'P#,;\'
H$F9%2*$@'
j"%*;*"#@<'
B9$&"'A#@9&@9'

``'

'l;#,9'="**A'!9""@'

`e'

!&@9'_'
j'D&29$,'#@'D+9@9$2$?'P#,;'l=!'*F'6e'v'65N'c<<N'&$A'
&')&%,9+#&"'%&1@9'#@'@1@D9%,9Af'l;#%;'*F',;9'F*""*P#$?'
&+9')&%,9+#&"'#$F9%2*$@',;&,'%&1@9'*$"-'9"90&,9A'l=!'
"909"'I$*,'"*P9+9A'l=!'"909"@MQ''''
jf g+&<'W09'+9@D#+&,*+-'#$F9%2*$'
=f g+&<']'09'@9D@#@'
!f b#"#&+-'G=''
.f G-D;*#A'F909+'I"&,9'D;&@9M''
/f j'K'='*$"-''
3f j'K'!'*$"-'
gf j""'*F',;9'&)*09''
`Y'

e5'

!&1@9@'F*+'"91R*%-,*@#@'

!&@9'`'

=&%,9+#&"'H$F9%2*$@:'9U%9D,''
,;*@9'P#,;'&$'#$@#A#*1@'*$@9,'&$A'%&1@9'@D"9$*<9?&"-'I9?f'
,-D;*#A'F909+'&$A')+1%9""*@#@M''
H$'9&+"-'K'A#@@9<#$&,9A'D;&@9@'<&-'%&1@9'"91R*%-,*@#@'

g<'i09'@9D@#@'

j'D&29$,'#@'D+9@9$2$?'P#,;'l=!'*F'4f6'v'65N'c
<<Nf'l;#%;'*F',;9'F*""*P#$?'&+9'D*,9$2&"'
%&1@9@Q'
jf
=f
!f
.f
/f
3f

<&-'%&1@9'"91R*%-,*@#@'*+'$91,+*D9$#&'
J91,+*D9$#&'A19',*'l=!@'$*,'<&,1+#$?'F&@,'9$*1?;'I"9z'@;#z'<&-')9'
&DD&+9$,M'
j%%*<D&$#9A')-',;+*<)*%-,*D9$#&'K'%"*$?'F&%,*+'&)$*+<&"#29@'

.+1?@'
/?f'%*+2%*@,9+*#A:'"#,;#1<'1@9'

(91R9<#&'
G;-+*#A'@,*+<''

H$F9%2*1@'<*$*$1%"9*@#@''
H$F9%2*1@';9D&22@''
!ba'#$F9%2*$''
b9&@"9@''
G='%;+*$#%'#$F9%2*$'
j""'*F',;9'&)*09'''''

e6'

!&@9'`'

e4'

C,;9+'%&1@9@'F*+'"91R*D9$#&'

j'D&29$,'#@'D+9@9$2$?'P#,;'l=!'*F'4f6'v'65N'c
<<Nf'l;#%;'*F',;9'F*""*P#$?'&+9'D*,9$2&"'
%&1@9@Q'
jf H$F9%2*1@'<*$*$1%"9*@#@\'A#+9%,'A&<&?9'*F',;9'
;&9<&,*D*#92%'D+9%1+@*+'%9""@'''
=f H$F9%2*1@';9D&22@''
!f !ba'#$F9%2*$\'&m9%,',;9')*$9'<&++*P'
<#%+*9$0#+*$<9$,',;+*1?;'#$F9%2*$'*F'X)+*)"&@,'''
.f b9&@"9@\'#$%+9&@9'$91,+*D;#"'&A;9+9$%9',*'A&<&?9A'
9$A*,;9"#&"'%9""@'''
/f G='%;+*$#%'#$F9%2*$\'@D"9$#%'@9^19@,+&2*$'&$A'
D*@@#)"-')*$9'<&++*P'@1DD+9@@#*$'
eN'

jD"&@2%'&$9<#&''
j$2%*$01"@&$,@''
!;9<*,;9+&D-]#$A1%9A')*$9'<&++*P'
@1DD+9@@#*$'

e7'

C,;9+'l=!'9"9<9$,@'
(-<D;*%-,9@'

C,;9+'l=!'9"9<9$,@'
b*$*%-,9@'K'/*@#$*D;#"@'

(-<D;*%-,*@#@'

b*$*%-,*@#@''

/*@#$*D;#"#&'
j""9+?#%'+9&%2*$@''
H<<1$9'+9@D*$@9',*'
D&+&@#,9@'K'F1$?&"'
#$F9%2*$'
G=''
!+-,*%*%%&"'#$F9%2*$'
.#1+$&"'0&+#&2*$@'

j%1,9')&%,9+#&"'#$F9%2*$h'
B9%*09+-'D;&@9'*F'&%1,9'
#$F9%2*$'
>1)&%1,9')&%,9+#&"'
9$A*%&+A#2@''
!;+*$#%'G=:',-D;*#A:'
)+1%9""*@#@'
!ba'
>-D;#"#@:'<&"&+#&'
(91R9<#&:'&$A'"-<D;*<&'

(-<D;*D+*"#F9+&209'A#@*+A9+'0@'B9&%209''
l&,%;'*1,'F*+'F909+'*+'*,;9+'A#@%*<F*+,'&%%*<D&$-#$?'
@-<D,*<@''

B9&%209'@99$'#$'/=a:'!ba:',*U*D"&@<*@#@:'0#+&"'
;9D&22@:'OHa''
G];9"D9+'%9""@',;&,'@;*P'&'A9"&-'#$'9U#,'F+*<')"**A'#$,*'
"-<D;*#A'2@@19''

(-<D;*%-,*D9$#&'
H<<1$*A9X%#9$%-'A#@*+A9+:'&%1,9'@9D@#@:'w1:'0#+&"'
#$F9%2*$@''
eZ'

!&@9'e'

e_'

'8"&,9"9,@'

j'D&29$,'D+9@9$,@'P#,;'&'D"&,9"9,'%*1$,'*F'ZZZ'v'
65Y'c'(f'l;#%;'*F',;9'F*""*P#$?'#@',;9'<*@,'"#R9"-''
%&1@9'P#,;'&DD+*D+#&,9'<&$&?9<9$,Q''
jf HG8'i'@,9+*#A',+9&,<9$,'
=f H$w&<<&2*$'I9?f'.19',*'>(/M'i'<*$#,*+'*$"-''
!f j%1,9',+&1<&'c')"99A#$?'i'D+*0#A9'&$2D"&,9"9,'
,+9&,<9$,''
.f (-<D;*D+*"#F9+&209'A#@9&@9'i'+9F9+'*$%*"*?-''
/f J*$9'*F',;9'&)*09''
e`'

'(,*-+7-$$
H$F9%2*$'
!;+*$#%'#$w&<<&,*+-'
A#@9&@9@'
O9<*++;&?9'
H+*$'A9X%#9$%-'&$9<#&'
b&"#?$&$%#9@'

D-,*-+7-$

j1,*#<<1$9'A#@*+A9+@'IHG8M''
jD"&@2%'&$9<#&'
B&A#&2*$'
=&%,9+#&"'*+'0#+&"'#$F9%2*$@'
.+1?'#$A1%9A\'
!;9<*,;9+&D-'
O9D&+#$'IOHGM''
a&"D+*#%'&%#A'

E@1&""-:'+#@R'*F')"99A#$?'#@'*$"-'
@#?$#X%&$,'P;9$'D"&,9"9,@'F&""'
)9"*P'45:555',*'Z5:555c('
ee'

j$2]#$w&<<&,*+-'b&+R9+@'
!]B9&%209'8+*,9#$'I!B8M'

j$2]#$w&<<&,*+-'b&+R9+@'
0*3)2*6,3)-$7-4=<-()+56($*+)-'

j%1,9'D;&@9'+9&%,&$,'
>9%+9,9A')-',;9'"#09+'#$'+9@D*$@9',*'#$w&<<&,*+-'
%-,*R#$9@'
a9+-'@9$@#209')1,'$*$'@D9%#X%'
B&D#A'#$%+9&@9'&@@*%#&,9A'P#,;'#$F9%2*$:',+&1<&:'
#$w&<<&2*$:'<&"#?$&$%#9@:'2@@19'$9%+*@#@'

H$%+9&@#$?'&?9:'F9<&"9'?9$A9+:',9%;$#^19'*F'D9+F*+<#$?',;9',9@,:'
D+9?$&$%-:'&$&9<#&'&$A'D*@@#)"-'909$'*)9@#,-'<&-'%&1@9'&$'
9"90&2*$'
H$A#0#A1&"')*A-k@'A#m9+9$2&"'+9@D*$@9',*'#$F9%2*$'K'#""$9@@'%&$'%&1@9'
A#m9+9$%9'

(*P'D*P9+',*'D+9A#%,')&%,9+#&"'#$F9%2*$'P#,;'$*$@D9%#X%:'F9)+#"9'
#""$9@@9@'*F'@;*+,'A1+&2*$''
a9+-';#?;'0&"19'#@'#$A#%&209'*F''

B;91<&,*#A'&+,;+#2@''
G9<D*+&"'&+,9+#2@''
H$F9%2*$''
b&"#?$&$%-''
)1,'$*+<&"'0&"19'A*9@$k,'+1"9',;9<'*1,'

b#"A'i'<*A9+&,9"-'9"90&,9A'/>B'P#,;*1,'*)0#*1@'@-<D,*<@\';&+A'
,*'#$,9+D+9,]'D+*)&)"-'+9D9&,',9@,''
eY'

'G;-+*#A'31$%2*$'
#23*6=4$75</.+5(8$26*<6(-7$

F*--$#G
(*P

O#?;

O-D9+,;-+*#A#@<

J*+<&"

0/)23*6=4$7=,H$
73(4*6<-$
G7'&1,*&$2)*A#9@''
G;-+*#A';*+<*$9'
G;-+*#A';*+<*$9'
+9@#@,&$%9'@-$A+*<9'
+9@#@,&$%9'@-$A+*<9'
G>O]@9%+9,&+-'D#,1#,&+-' G>O]@9%+9,&+-'
D#,1#,&+-'&A9$*<&

&A9$*<&

J*+<&"
"/C,.=(=,+.$
/1,;-+*#A#@<

23;-*)23*6=4=7<$$
GN',;-+*,*U#%*@#@'
A*-8(+(,3$>I7)$)*=<-7)-*?$$
D*/87$>7)-*6=4J$
46;+<=(-J$!<=64+*6(-?

(*P'

!9$,+&"';-D*,;-+*#A#@<

O#?;'

"/C,.=(=,+.$
>,6<;-(7+)-4?$
23;6)23*6=4=7<$

!9$,+&"';-D*,;-+*#A#@<' 8+#<&+-'
O-D*,;-+*#A#@<'

/1,;-+*#A'@#%R'
Y6'
@-$A+*<9'

Y5'

G;-+*?"*)1"#$'&1,*&$2)*A-'K''
G;-+*#A'89+*U#A&@9'&1,*&$2)*A-'
$A*-K+.-(,-

Ggj):'V

G8Cj)'V

g+&09k@'A#@9&@9'

_`

e`

O&@;#<*,*k@',;-+*#A#2@

Y5]655

Y5]655'

J*$]@D9%#X%'&1,*#<<1$9'
A#@9&@9

NZ

Z5

J*+<&"'%*$,+*"@

65]6e

65]6e

Y4'
G9U,)**R'*F'!"#$#%&"'b9A#%#$9'F*+'j@#&'6YYY

81$?'#,'&""',*?9,;9+'
l;9$'&DD+*&%;#$?'&'D&29$,'P#,;'&)$*+<&"'"&)'
0&"19@:'&@R'-*1+@9"F',;9'F*""*P#$?'^19@2*$@\'
H@',;9+9'&$-,;#$?',;&,'%*1"A'&m9%,',;9'D+*A1%2*$:'
#$,&R9'*+'9"#<#$&2*$'*F',;9'@1)@,&$%9Q'
l;&,'&+9',;9'D*,9$2&"'%&1@9@'F*+',;9'&)$*+<&"#29@Q'
j$-'@1)@,&$%9'%*1"A';&09'&m9%,9A',;9'"909"Q''
.+1?:'"&):'9,%''

l;&,'#@',;9'"909"'*+'@909+#,-'*F'&)$*+<&"#,-Q'
O*P'P*1"A'#,'&m9%,',+9&,<9$,Q''
YN'