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Columbia University - Department of Biomedical Engineering

BMEN E3320: Fluid Biomechanics


Spring 2015

Time: Tuesday/Thursday 8:40am - 9:55am


Location: Mudd 337
Instructor: Prof. David Elad (de2219@columbia.edu)
Instructor office hours: Tuesday, 3:00pm - 4:00pm (or by appointment), ET 373
TA: Samuel Robinson (str2117@columbia.edu)
TA office hours: Friday 12:00pm -1:00pm, Room TBA
Recitation: Friday 11:00am -12:00pm, Room TBA
Course Description:
The course will provide basic knowledge of fluid flow in biological conduits. It is composed of a
comprehensive review of fundamental Fluid Mechanics and detailed models and techniques to
solve problems of blood flow in the cardiovascular system and airflow in the respiratory system.
Prerequisites: APMA E2101
Textbooks:
1) James A Fay, Introduction to Fluid Mechanics, MIT Press, Cambridge, MA, 1994.
2) George A Truskey, Fan Yuan, David F Katz, Transport Phenomena in Biological Systems,
2nd Edition, Pearson, Upper Saddle River, NJ, 2009.
Additional Literature:
Relevant articles and advanced material will be posted on the web site.
Lecture/Recitation Handouts:
The PDF files of the lecture slides will be posted on the web site prior to the lectures. You are
advised to bring the printed handouts in order to add on it your comments. You are also advised to
bring the printed handouts of the subsequent week in case we will be able to speed up the lectures.
Recitation problems and solutions will also be available online prior to the recitations.

Homework Assignments:
1. You must comply with the University Policy for Academic Integrity, which can be found at:

http://bulletin.columbia.edu/columbia-college/standards/
2. You are allowed to work on the problems in groups, but you are expected to submit your own
original work.
3. Homework assignments must be turned in by 5pm on the due date in the BME office.
Homework assignments will not be accepted after the due date.
4. Solutions for the homework assignments problems will be posted on the web site 24 hours after
the due date.
Mini-Project:
1. A computation project using MATLAB will also be required.
2. You can team up in groups of 2 students for the project.
3. Detailed instructions will be provided by the TA during the recitations.

Recitation:
1. The weekly recitation will be devoted to problem solving practice by the TA.
2. An attendance sheet will be passed at each recitation.
3. Attendance in 10 recitations will provide a 5% bonus.
Final Exam:
1. You are welcome to bring the lectures and recitations handouts, as well as your personal notes.
2. Books and solution manuals are not allowed.
Grading:
Homework sets (20%), Project (30%), Final Exam (50%).

Course Contents:
1

Introduction (Physics of fluids, Vector calculus)

2-6 Review (Fluid statics, Conservation of mass, Inviscid flow, Conservation of momentum,
Flow in real fluids)

Cardiovascular System (Engineering perspective Review)

Blood Flow in Large Arteries


Pressure and velocity waves
Steady state Rigid tube
Startup Flow Rigid tube
Pulsatile flow Rigid tube
Steady flow Elastic tube
Pulsatile flow Elastic tube
Wave propagation in Elastic tubes

Blood Rheology

10 Blood Flow in the Heart and the Coronaries


11 Respiratory Airflow
12 Fluid Flow in Collapsible Tubes

Tube law

Steady state flow

Transient flow

13 Analog Models

Windkessel model

Electrical analogs

14 Transcapillary Exchange

Mathematics of diffusion

Transport in capillaries (Krogh cylinder model, capillary filtration)

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