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Online slides of the endocrine system -- normal | pathology

These specimens at the Virtual Slidebox (University of Iowa Department of
Pathology) may be examined with full range of magnification and movement.
Requires Java and fast internet connection.
Link to LUMEN (Loyola University Medical Education Network), click on "Part 14: Endocrine Glands".
Link to Blue Histology. Click on "Notes", then "Endocrines".

INTRODUCTION TO ENDOCRINE GLANDS

Many of the body's cells secrete substances which influence other cells, either locally or at some distance.
Cells which are conspicuously specialized for this function are called endocrine cells. (The suffix -crine
refers to secretion; the prefix endo- tells us that the secretory product stays inside the body.) All
endocrine cells share certain characteristics.
Most obviously, endocrine cells are all specialized for secretion. Their specific appearance depends
on the nature of the secretory product and on the cellular machinery need to manufacture and store
that product.
Also, their secretory products are secreted into interstitial fluid from whence they can diffuse into
blood. Therefore, endocrine secretion does not involve ducts but requires close proximity to blood
vessels, usually either capillary networks or vascular sinusoids.
Endocrine cells are commonly arranged into cords or small clumps, with each cell closely associated
with adjacent vessels.
To faciliate diffusion of hormones into blood, vessels associated with endocrine glands have
fenestrated endothelium.
The various endocrine cells of the human body are organized in a few distinctive patterns.

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EPITHELIAL TISSUE forms the parenchyma of thyroid, parathyroid, anterior pituitary

(adenohypophysis), adrenal cortex, pancreatic islets, and liver.
The epithelial nature of these cells is reflected in their organization into cords or clumps, with cells attached
laterally to neighboring cells as in surface epithelium. But because there is typically no lumenal surface for
endocrine secretion, there is no apical/basal polarization of cytoplasm. (An exception is the thyroid, where
proper cuboidal epithelium does form follicles into whose lumens thyroglobulin is secreted for storage.)
With the exception of adrenal cortex (which is mesodermally derived), these glands are all of ectodermal or
endodermal origin. Remnants of embryonic origin may occur in the form of displaced glandular tissue or
ducts, especially with the adenohypophysis or the thyroid.

NERVOUS TISSUE, derived from neuroectoderm or neural crest, comprises the posterior pituitary
(neurohypophysis), adrenal medulla, and pineal.
Both neurohypophysis and pineal originate from the diencephalon and have organization typical of nervous
tissue. Secretion is from axon terminals. Secretory cells (neurons) are supported by glial cells.
The adrenal medulla is essentially a sympathetic ganglion originating from neural crest and innervated by
preganglionic sympathetic axons. The adrenal medullary cells lack axons but are otherwise functionally
similar to sympathetic axons.

Mesodermally derived endocrine cells, with organizational pattern more like CONNECTIVE
TISSUE, are represented by testicular Leydig cells and ovarian stromal cells. Ovarian
granulosa and luteal cells defy easy classification but are probably best placed in this class as
well.
Finally, INDIVIDUAL CELLS may have significant endocrine function. Examples include
the epithelial enteroendocrine cells of the GI tract and the juxtaglomular cells (modified
smooth muscle) of the renal cortex.

Overview of Individual Endocrine Glands

The pituitary gland (or hypophysis) consists of two distinct parts, the anterior pituitary
(adenohypophysis) and the posterior pituitary (neurohypophysis).
The anterior pituitary appears glandular (hence adenohypophysis), with clumps of
epithelial cells with varying staining properties. Cells of several species each
secrete one of several hormones (e.g., GH, ACTH, FSH, LH, TSH, etc.) Such secretion from
this "master gland" regulates most other endocrine glands and is, in turn, regulated by factors
secreted by hypothalamic neurons and delivered to the anterior pituitary by the hypophyseal
portal vessels.
The posterior pituitary consists of secretory endings of axons from nerve cells (hence
neurohypophysis) whose cell bodies are located in the hypothalamus. These secretory
processes of the posterior pituitary secrete oxytocin and ADH.
Pituitary adenomas may be "benign" (i.e., not malignant) but can nevertheless cause significant problems either from excess
hormone production or from mass effect (e.g., crowding the optic chiasm). For illustration, see WebPath.

The thyroid consists of characteristic follicles, each with a large lumen surrounded by a
simple cuboidal epithelium. The appearance (as well as evolutionary origin) is that of an
exocrine gland which has lost its outlet so that secretory product accumulates in the

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follicles. Follicular cells store thyroglobulin in the follicles for subsequent use in
production and endocrine secretion of T3 (thyroxin) and T4. Parafollicular cells (C cells) produce
calcitonin.
For some examples of thyroid pathology, see WebPath (thyroiditis, inflammation), WebPath (Grave's disease,
hyperthyroid), and WebPath (goiter), or Milikowski & Berman's Color Atlas of Basic Histopathology, pp. 452-461.

The parathyroid consists of several discrete glands, each organized into tangled
curvilinear cords of chief cells. These cells secrete parathyroid hormone, which works in
opposition to calcitonin (from thyroid C cells) to regulate blood calcium levels.

The pancreatic islets are nests of endocrine cells scattered within the pancreas. Each
islet consists of several cell types which secrete insulin, glucagon, somatostatin, and
pancreatic peptide. The cells are arranged into tangled cords.
Diabetes may result from immunological destruction of islet cells. For images, see WebPath (diabetes
I) and WebPath (diabetes II), or Milikowski & Berman's Color Atlas of Basic Histopathology, p. 469.

The adrenal consists of two distinct parts, an outer cortex and an inner medulla.
The cortex consists of cords of steroid-secreting epithelial cells, separated by
parallel sinusoids. The cords are organized into poorly defined zones. From the
outside inward, these zones secrete mineral corticoids (e.g., aldosterone),
glucocorticoids (e.g., cortisol), and androgenic steroids.
For images of tumors leading to Cushing's disease, see WebPath (gross) and WebPath (microscopic), or
Milikowski & Berman's Color Atlas of Basic Histopathology, p. 466.
For gross images of adrenal hyperplasia (e.g., subsequent to Cushing's disease or ectopic ACTH
production) and also adrenal atrophy, see WebPath.

The medulla consists of cells similar to sympathetic neurons which secrete catecholamines
(epinephrine and norepinephrine).

The testis contains clusters of interstitial Leydig cells which secrete testosterone.

The ovary includes steroid secreting cells of the theca

interna and of the corpus luteum.

The pineal consists of pinealocytes, neuron-like cells which secrete melatonin. Calcium accumulation in
the pineal gland makes this structure a useful landmark in x-rays. (Histology of the pineal will not be
evaluated. It is mentioned here for completeness.)

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According to Rene Decartes, it is through the pineal that the soul controls the body.

Comments and questions: dgking@siu.edu

SIUC / School of Medicine / Anatomy / David King
http://www.siumed.edu/~dking2/erg/enguide.htm
Last updated: 31 March 2004 / dgk

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