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INTRODUCTION
Distinct from obsessive-compulsive disorder
(OCD), obsessive-compulsive personality disorder
* Correspondence to: Dr Laura Southgate, PhD, Eating Disorders Research Unit (PO59), Institute of Psychiatry, Kings
College London, De Crespigny Park, SE5 8AF, UK. Tel: 0207
8480134. Fax: 0207 8480181.
E-mail: l.southgate@iop.kcl.ac.uk
Copyright # 2008 John Wiley & Sons, Ltd and Eating Disorders Association.
Published online 28 April 2008 in Wiley InterScience (www.interscience.wiley.com) DOI: 10.1002/erv.870
L. Southgate et al.
452
prevalence of obsessive-compulsive personality
traits (OCPTs) amongst first-degree relatives of
individuals with EDs and their pattern of transmission highlights their potential aetiological significance (Lilenfeld et al., 1998; 2000).
It is generally accepted that premorbid personality can be involved in the development
and expression of psychiatric disorders (Duggan,
Milton, Egan, McCarthy, Palmer, & Lee, 2003). In a
systematic review of risk factor research in ED
(Jacobi, Hayward, de Zwaan, Kraemer, & Agras,
2004) OCPTs that developed in childhood were
identified as medium potency risk factors. The
importance of these premorbid features emphasises the need for a reliable measurement tool
that could be used to screen for phenotypic
traits in childhood and for use in prospective
longitudinal research. With this goal in mind,
we developed a short retrospective self-report
measure of childhood OCPT, utilising items
from the EATATE semi-structured interview
assessment of these traits (Anderluh et al., 2003).
To minimise the biases associated with retrospective self-report data and also to test methodology suitable for informant reports in childhood,
we also developed an informant report version of
the questionnaire.
The aims of the current study were to investigate
the psychometric properties of this novel retrospective questionnaire; to explore the prevalence
and predictive validity of premorbid traits suggestive of obsessive-compulsive personality, in a large
sample of females with a lifetime history of either
anorexia nervosa (AN) or bulimia nervosa (BN)
based upon both self and informant report data; and
to retrospectively examine the relationship between
childhood OCPTs and the development of an ED.
The construct validity of this measure relied on the
involvement of ED experts, including individuals
with a personal experience of an ED, in its development (see Anderluh et al., 2003). The reliability of
the questionnaire was explored through the
measurement of testretest and inter-rater reliability. The informant report questionnaire consisted of
identical items to the proband version that related to
clearly observable behaviours. Concurrent validity
was evaluated by comparing the data obtained from
the questionnaire with that elicited in the EATATE
semi-structured interview, from which the questionnaire was derived.
In line with prior studies of childhood OCPTs
in women with EDs (Anderluh et al., 2003;
Gillberg, Rastam, & Gillberg, 1995; Karwautz,
Rabe-Hesketh, Collier, & Treasure, 2002), our
METHOD
Participants
Two hundred and forty-six female participants with
a lifetime history (thus including individuals at
acute and recovered illness states) of AN (n 170)
or BN (n 76) were recruited from clinical settings
(inpatient and outpatient services) and the community, by way of a volunteer database maintained
by the eating disorder research unit at the Institute
of Psychiatry, London. In order to join the database,
individuals are required to provide baseline information with regards to their current and lifetime
symptom history, taking into account duration and
severity. Lifetime diagnoses were determined for
each participant based upon knowledge of current
and past diagnoses and were assigned according to
a formal diagnostic hierarchy, ensuring that their
full range of pathology was taken into account
(Kaye et al., 2000; Lilenfeld et al., 1998). For example
if participants had pure histories of AN (incorporating all sub-types) or BN (bingepurge behaviour
with no history of low weight) they were given that
lifetime diagnosis as appropriate. If a participant
had a symptom history containing discrete episodes
of AN and BN, they were given the lifetime
diagnosis of BN.
The control group consisted of 89 females who did
not have a history of an ED, recruited from the local
community.
Ninety-three informants also took part in this
study, limited to one informant per proband. They
consisted of family members or close friends of the
probands recruited into the study, who were invited
by the proband to complete (independently) an
informant version of the CHIRP questionnaire.
This study was approved by the South London
and Maudsley NHS Trust and the Central and
North West London NHS Trust Research Ethics
Committees. Information sheets describing the
study were provided along with freepost envelopes
with which to return the questionnaires. The return
of questionnaires was taken to imply participant
consent in the study.
Copyright # 2008 John Wiley & Sons, Ltd and Eating Disorders Association.
Materials
Diagnostic measures As participants were recruited
by different means, two diagnostic instruments were
used to assign diagnoses. A common factor for each
measure was that they assessed and allocated ED
diagnoses according to DSM-IV criteria.
The EATATE interview, part 1 (Anderluh et al.,
2003). Participants who had completed the questionnaire as part of another ongoing study in the
research unit had their current and lifetime
diagnoses determined using the EATATE interview. This is a semi-structured clinical interview
based upon the Eating Disorders Examination
(Fairburn & Cooper, 1993) but adapted to assess
lifetime symptoms of ED following the Longitudinal Interval Follow-up Evaluation (Keller, Lavori, &
Friedman, 1987).
The eating disorder diagnostic scale (EDDS; Stice,
Telch, & Rizvi, 2000). The EDDS is a one page
self-report questionnaire that can distinguish
between full and sub-threshold diagnoses of AN
and BN, (Stice et al., 2000; Stice, Fisher, & Martinez,
2004). This diagnostic screen was sent to members
of the volunteer database along with the retrospective childhood OCPTs questionnaire.
453
the use of pronouns to denote the proband as the
reference for the responses. The informant had to be
someone who had good knowledge of the proband
in childhood (e.g. parent, sibling, good friend). This
was determined by eliciting the relationship
between the informant and the proband and the
number of childhood years (up to 12) that they had
known the proband. Informants are also asked to
rate as a percentage, how reliable they would
consider their answers to be.
Copyright # 2008 John Wiley & Sons, Ltd and Eating Disorders Association.
L. Southgate et al.
454
Proband questionnaire
A scoring system was designed to provide an
overall dimensional questionnaire score and to
obtain categorical childhood trait scores. The
dimensional score represented the number of
behaviours that each participant endorsed as being
relevant to them in childhood. Simply, every yes
response received a score of 1 and the total summed
(question 6c reversed scored). The endorsement of
particular behaviours was taken to reflect the
presence of specific traits. Table 1 details the
childhood traits assessed, the behaviours measured
to determine the presence or absence of these traits
and the scoring protocol. The scoring procedure
was kept as close as possible to that of the interview
used by Anderluh et al. (2003). The nature and the
quantity of traits present (03) was determined in
this way for each participant.
Informant questionnaire
The same scoring systems as used for the proband
questionnaire, were employed with the informant
questionnaire to (a) derive a dimensional score to
represent the number of behaviours relating to
obsessive-compulsive personality that was relevant
each proband and (b) produce an overall OCPT
score (03).
behaviours endorsed). Cohens k analyses investigated the inter-rater and testretest reliabilities based
on the presence/absence of each individual trait
assessed (perfectionism, inflexibility and symmetry), with weighted ks to determine the reliability
for the total number of childhood traits endorsed.
Between group analyses for normally distributed
continuous variables were conducted using oneway ANOVA with Bonferroni post-hoc analyses
where appropriate. Where the assumptions of
parametric testing were violated, non-parametric
tests were used; Kruskal Wallis to test for main
effects and MannWhitney U-tests for pairwise
analyses, applying Bonferroni correction procedure
to correct for multiple testing. x2 analyses explored
the prevalence of the childhood traits across the ED
and control participants. The association between
childhood personality features and the development of an ED was determined using logistic
regression analyses, with ED status as the dependent variable and (1) total CHIRP questionnaire
score as the independent (predictor) variable, (2)
total number of childhood traits present (03) as the
independent variable. Analyses were performed on
both the self-report and witness data, using
two-tailed tests with a 5% level of significance.
Analyses were conducted using SPSS version 12
and STATA 8.0.
Statistical Analysis
The psychometric properties of the CHIRP questionnaire were determined using intra-class correlation coefficients to explore testretest reliability
and inter-rater reliability, based upon the total
questionnaire score (representing the number of
RESULTS
Psychometric Properties of the Questionnaire
Complete reports were collected from 77 proband
informant participant pairs. The majority of
Table 1. Childhood traits reflecting obsessive-compulsive personality as measured by the CHIRP questionnaire
OCP trait
Perfectionism
Inflexibility
Copyright # 2008 John Wiley & Sons, Ltd and Eating Disorders Association.
455
Table 2. Reliability and validity analyses based upon the dimensional scoring procedure
Psychometric property
Testretest reliability
Inter-rater reliability
Concurrent validity
Sample size
Intra-class correlation
coefficient
95% CI
59
77y
81
0.73
0.60
0.60
0.580.83
0.440.73
0.450.73
Agreement rating
Substantial
Substantial
Substantial
y
Table 3. Reliability and validity analyses for the total data set based upon the categorical (trait) scoring procedure
Trait
Child Perfectionismy
Inflexibilityy
Drive for order and symmetryy
Total number of traits (03)z
y
z
Testretest
reliability (n 59)
0.46
0.67
0.49
0.54
p < 0.001
p < 0.001
p < 0.001
p < 0.001
Inter-rater
reliability (n 77)
Concurrent
validity (n 81)
Probandinformant pairs.
Unweighted k analysis.
Weighted k analysis.
Copyright # 2008 John Wiley & Sons, Ltd and Eating Disorders Association.
L. Southgate et al.
456
Table 4. Participant characteristics and total CHIRP questionnaire score (based on self- and informant report data)
Self-report
Age
BMI
CHIRP total
Informant report
CHIRP total
Control
n 89
AN
n 170
BN
n 76
F
(df 2, 332)
Pair-wise
comparisons
29.13 (9.40)
22.23 (2.47)
30.87 (11.47)
17.33 (2.80)
33.71 (11.99)
21.06 (3.64)
3.42
88.87
<0.05
<0.001
3.64 (3.48)
9.54 (4.57)
9.57 (5.12)
57.75
<0.001
Control
n 28
AN
n 45
BN
n 20
F
(df 2, 90)
Pair-wise
comparisons
4.04 (3.69)
9.31 (4.48)
9.25 (4.48)
<0.001
Bonferroni post-hoc tests. Results confirmed with non-parametric MannWhitney analyses with Bonferroni adjustment of the a level
( p < 0.017).
analyses were conducted to determine the discriminant validity of the CHIRP questionnaire. With
participant diagnostic category (lifetime ED or
control participant) as the dependent variable and
total questionnaire score (dimensional analyses) as
the predictor variable, both proband questionnaire
scores (l2 (1) 63.76, p < 0.001, OR 1.38, 95% CI
1.271.49) and witness questionnaire scores (l2
(1) 13.53, p < 0.001, OR 1.28, 95% CI 1.121.47)
could accurately predict participant diagnostic
category.
Similarly with the number of OCPTs endorsed
(03) as the predictor variable, both the proband
reports (l2 (1) 63.64, p < 0.001, OR 3.93, 95% CI
2.815.49) and witness reports (l2 (1) 12.05,
p 0.001, OR 2.79, 95% CI 1.564.97) were found
to be significant predictors of ED status. Thus the
strongest doseresponse relationships for the development of an ED were found when using the
questionnaire data categorically.
DISCUSSION
The aims of the current study were threefold; (1) to
investigate the psychometric properties of a novel
retrospective questionnaire measure of childhood
personality traits; (2) to investigate the prevalence of
childhood OCPTs in adults with a lifetime history of
an ED, measured by self- and informant report
questionnaires and (3) to determine the strength of
the relationship between OCPTs in childhood and
the development of an ED.
Copyright # 2008 John Wiley & Sons, Ltd and Eating Disorders Association.
457
Table 5. Prevalence of childhood traits reflecting obsessive-compulsive personality among participants with a history
of an ED and controls
x2 statistic
(ED vs. C)
Participant group
(lifetime diagnoses)
Self-report
Perfectionism
Inflexibility
Symmetry
Informant report
Perfectionism
Inflexibility
Symmetry
p-value
Odds ratio
(95% CI)
AN (n)
BN (n)
ED (n)
Control (n)
df 1
78.20% (129)
71.30% (117)
18.25% (31)
71.20% (52)
73.00% (54)
22.40% (17)
76.10% (181)
71.80% (171)
19.50% (48)
34.80% (31)
18.00% (16)
2.20% (2)
48.27
76.78
15.34
<0.001
<0.001
<0.001
6.00 (3.5010.07)
11.59 (6.3221.44)
12.00 (2.5144.37)
68.90% (31)
55.60% (25)
11.10% (5)
70.00% (14)
55.00% (11)
10.00% (2)
69.20% (45)
55.40% (36)
10.80% (7)
35.70% (10)
14.30% (4)
3.60% (1)
9.10
13.49
1.29
0.003
<0.001
>0.05
4.02 (1.6010.32)
7.29 (2.3223.90)
3.00 (0.3827.82)
Assumption of x2 violated therefore significance value determined using fishers exact test. 95% CI 95% confidence interval.
Copyright # 2008 John Wiley & Sons, Ltd and Eating Disorders Association.
L. Southgate et al.
458
et al., 1995). The fact that the findings reported here
were comparable with the consensus in the
literature, endorses the criterion validity of this
novel measure.
The inter-rater reliability based upon the presence/absence of each individual trait was smaller
than the agreement found when utilising the
dimensional score. These findings are typical
(Kraemer, Noda, & OHara, 2004), being found in
previous literature investigating self-informant
concordance regarding the presence of personality
traits and disorders (Bernstein et al., 1997; Riso,
Klein, Anderson, Ouimette, & Lizardi, 1994). Overall, the inter-rater concordance reflects an absence of
self-presentation biases in the ED participants,
defending the reliability of self-report data with
this clinical group.
The concordance of the data obtained from the
retrospective questionnaire with that determined
from the EATATE semi-structured interview,
confirmed the utility of this questionnaire as a
quick and easy measure of childhood personality
traits, allowing a large participant sample to be
tested. Whilst the use of the EATATE interview has
the advantage of eliciting greater detail and thus
allowing superior diagnostic sensitivity and specificity, its limitations lie in the time and costs
associated with interviewer training and administration. Literature suggests that OCPTs increase
individual vulnerability towards the development
of an ED. To confirm this, longitudinal prospective
risk factor studies are required (Jacobi et al., 2004),
research which is difficult and costly to conduct,
especially in EDs due to the relatively low incidence
of disorder. The potential for such research is made
increasingly possible with this quick and simple
questionnaire that reliably measures the construct
under study.
The instability of the ED diagnostic categories
poses a problem for research. This study utilised a
trait approach to diagnostic classification, following
a symptom hierarchy to derive lifetime diagnoses
for each ED participant. This methodology makes a
substantial attempt to overcome some of the short
comings associated with the conceptualisation of
current diagnoses, including their temporal
instability, the problem of state versus trait and
the heterogeneous nature of the phenotypes. Thus,
whilst the diagnosis of eating disorder not otherwise specified (EDNOS) is commonly found in the
clinical setting (Fairburn & Bohn, 2005) and may
have been a relevant current diagnosis for some
participants included in this study, EDNOS as a
lifetime diagnostic category was not relevant as
Copyright # 2008 John Wiley & Sons, Ltd and Eating Disorders Association.
ACKNOWLEDGEMENTS
The authors would like to acknowledge Sara Morgan for her help in re-rating the EATATE interviews
used in the assessment of concordant validity and
thank all those who participated in this research.
Support for this work has been received from the
Nina Jackson Research Into Eating Disorders (RIED)
in conjunction with the Psychiatry Research Trust
(registered charity no. 284286), The Wellcome Trust,
BIAL foundation (grant nos. 88/02: 61/04) and the
European Commission Framework 5 Project Factors in Healthy Eating QLK1-1999-916.
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However only judge if a behaviour was present if
you:
EITHER took longer than others doing things
because of attention to detail or high standards
and if in your judgement this interfered with
other activities (e.g. leisure time, school or hobbies)
OR this behaviour was so extreme that other
people (e.g. siblings, relatives, friends, teachers)
commented on it
I estimate that my account is . . .. . .. . .. . .. . ..% reliable (where 0% is not at all reliable and 100% is perfect).
Copyright # 2008 John Wiley & Sons, Ltd and Eating Disorders Association.
L. Southgate et al.
462
I estimate that my account is . . .. . .. . .. . .. . ..% reliable (where 0% is not at all reliable and 100% is perfect).
Copyright # 2008 John Wiley & Sons, Ltd and Eating Disorders Association.