Adnexal masses in pregnancy have a wide spectrum of imaging characteristics and clinical manifestations. Sonography is important in diagnosing, monitoring, and determining the malignant potential of these masses. Teratomas, endometriomas, hydrosalpinx, cystadenomas, and cystadenomas are often found incidentally.
Adnexal masses in pregnancy have a wide spectrum of imaging characteristics and clinical manifestations. Sonography is important in diagnosing, monitoring, and determining the malignant potential of these masses. Teratomas, endometriomas, hydrosalpinx, cystadenomas, and cystadenomas are often found incidentally.
Adnexal masses in pregnancy have a wide spectrum of imaging characteristics and clinical manifestations. Sonography is important in diagnosing, monitoring, and determining the malignant potential of these masses. Teratomas, endometriomas, hydrosalpinx, cystadenomas, and cystadenomas are often found incidentally.
Objective. To illustrate the imaging appearances of a variety of adnexal masses in pregnancy. Methods. Cases of adnexal masses in pregnancy were chosen to illustrate the appearance on ultra- sonography and magnetic resonance imaging. Results. Adnexal masses in pregnancy have a wide spectrum of imaging characteristics and clinical manifestations. Sonography is important in diag- nosing, monitoring, and determining the malignant potential of these masses. Common adnexal lesions seen in pregnancy include simple cysts, hemorrhagic cysts, leiomyomas, and hyperstimulat- ed ovaries in patients who have undergone assisted fertility. Uncommon adnexal lesions specific to pregnancy include hyperreactio luteinalis, theca lutein cysts with moles, and luteomas. Adnexal masses associated with pain include ovarian torsion and heterotopic pregnancy. Adnexal lesions that are found incidentally include teratomas, endometriomas, hydrosalpinx, cystadenomas, and cystadenocarcinomas. When the diagnosis of the adnexal mass cannot be made on the basis of sonographic appearance alone, magnetic resonance imaging may help. Conclusions. Familiarity with the clinicopathologic and sonographic features of common and uncommon adnexal masses in pregnancy is important for diagnosis and treatment. Key words: magnetic resonance imaging; neoplasm; ovary; pregnancy; sonography. Received December 28, 2003, from Harvard Medical School (G.C.) and Departments of Radiology and Obstetrics and Gynecology, Beth Israel Deaconess Medical Center (D.L.), Boston, Massachusetts USA. Revision requested January 21, 2004. Revised manuscript accepted for publication February 10, 2004. Address correspondence and reprint requests to Deborah Levine, MD, Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215. E-mail: dlevine@caregroup.harvard.edu. Abbreviations hCG, human chorionic gonadotropin; MR, magnetic resonance; T1, longitudinal relaxation time; T2, trans- verse relaxation time dnexal masses in pregnancy have a wide spec- trum of imaging characteristics and clinical manifestations. Between 1% and 2% of preg- nant women will have an adnexal mass that is sonographically detected and is persistent, and 1% to 3% of these will be malignant. 1,2 Sonography is impor- tant in diagnosing, monitoring, and determining the malignant potential of these masses. Common adnexal lesions associated with pregnancy include simple cysts, hemorrhagic cysts, leiomyomas, and hyperstimulated ovaries in patients who have undergone assisted fertility. Uncommon adnexal lesions specific to pregnancy include hyperreactio luteinalis, theca lutein cysts with moles, and luteomas. Adnexal masses associat- ed with pain include ovarian torsion and heterotopic pregnancy. Some adnexal entities are found incidentally, such as teratomas, endometriomas, hydrosalpinx, cys- tadenomas, and cystadenocarcinomas. Although the diagnosis of most adnexal pathologic conditions can be made on the basis of sonographic appearance alone, magnetic resonance (MR) imaging may help when the 2004 by the American Institute of Ultrasound in Medicine J Ultrasound Med 2004; 23:805819 0278-4297/04/$3.50 A Image Presentation sonographic appearance is not specific. Familiarity with the clinicopathologic and sono- graphic features of common and uncommon adnexal masses in pregnancy is important for diagnosis and treatment. In this image presenta- tion, we illustrate common and uncommon types of adnexal masses in pregnancy. Cysts and More Cysts Simple Cysts Most adnexal masses detected on sonography during pregnancy are simple cysts or hemor- rhagic corpus luteum cysts. Simple cysts are unilocular and anechoic and have a smooth, thin wall (Figures 1 and 2). Corpus luteum cysts enlarge during the first trimester, regress by the 12th week of gestation, and disappear later on in the pregnancy. 3 Size is the best indicator of whether the mass requires surgical intervention: 90% to 100% of masses smaller than 5 cm in diameter will resolve spontaneously. 4 Because larger cysts have an increased risk of torsion, rup- ture, and labor obstruction, close monitoring and sometimes surgery are necessary. 4,5 Hemorrhagic Cysts Hemorrhagic corpus luteum cysts can have a variety of sonographic appearances due to the changing appearance of the blood clot. Hemorrhagic cysts appear as predominantly anechoic masses that contain hypoechoic material within them (Figures 3 and 4). They exhibit increased sound through-transmission because of their fluid nature. Most resolve by the second trimester. 6 Acutely hemorrhagic cysts can appear as echogenic masses with internal echoes more hyperechoic than surrounding normal ovarian parenchyma (Figure 5). Hyperstimulated Ovaries Hyperstimulated ovaries are typically diagnosed in patients who have undergone ovulation induc- tion. The ovaries are enlarged with multiple cysts (Figures 68). More than 90% of patients who have hyperstimulation will have spontaneous resolution of these benign cysts. Ovarian hyper- stimulation syndrome appears as markedly enlarged ovaries containing multiple, large, peripherally located, thin-walled cysts that some- times exude fluid from hemorrhage or ascites. 7 The large ovaries are at risk of torsion (Figure 9) and hemorrhage, but usually they regress sponta- neously later in pregnancy or after delivery. 7 Masses Unique to Pregnancy Hyperreactio Luteinalis A similar appearance of hyperstimulated ovaries can be seen in patients who have not undergone ovulation induction. It is thought to result from hypersensitivity of the ovary to circulating human chorionic gonadotropin (hCG), which may or may not be high (Figures 10 and 11). 5,8 806 J Ultrasound Med 23:805819, 2004 Imaging of Adnexal Masses in Pregnancy Figure 1. Corpus luteum cyst in a 29 year-old woman, 8 weeks pregnant, with an 8-cm thin-walled anechoic cyst (calipers). The cyst resolved after first-trimester therapeutic abortion. Figure 2. Corpus luteum cyst in a 24 year-old woman at 19 weeks gestation being scanned for fetal anomalies, with inci- dental note of a 4.5-cm left adnexal cyst. On MR imaging, this has the characteristics of a benign cyst, being thin walled, with fluid signal intensity on a T2-weighted image, and having no nodular elements. This cyst was present slightly later in gestation than the typical corpus luteum cyst. However, it had resolved at the time of postpartum imaging. Because this is commonly mistaken for an ovari- an neoplasm, MR imaging can be used to better visualize the predicted sites for peritoneal implants that are associated with ovarian malig- nancy and to decrease the likelihood of this pos- sibility. 5 The lesions usually spontaneously involute after delivery. 5 This condition can be seen in a normal preg- nancy but has also been associated with polycys- tic ovary disease and triplet pregnancies (due to high levels of hCG). 5,810 Clinical manifestations J Ultrasound Med 23:805819, 2004 807 Chiang and Levine Figure 5. Acutely hemorrhagic cyst. Transvaginal scan from a 35-year-old woman shows a 5.5-cm echogenic mass with internal echoes more hyperechoic than surrounding ovarian parenchyma and with echogenicity greater than that seen in the typical hemorrhagic cyst, consistent with an acutely hem- orrhagic cyst. Figure 4. Hemorrhagic cyst, 38-year-old woman with a 5-cm multiloculated cyst with thick septations in the right ovary (calipers), consistent with the classic cobweb appearance of a hemorrhagic cyst. Figure 3. Ruptured hemorrhagic cyst in a 34 year-old woman, 7 weeks pregnant, with sudden onset of lower abdominal pain, nausea, and loss of consciousness. Hematocrit was 36% and subsequently dropped to 28% after intravenous fluid resuscita- tion. A, Transabdominal scan shows an intrauterine gestational sac (g), with subchorionic hemorrhage (arrow) and a moderate amount of free fluid (ff) in the pelvis compatible with hemor- rhage. B, Sagittal view of the right upper quadrant shows fluid (arrowheads) with debris (D), consistent with a large amount of blood around the liver. C, Transvaginal scan shows a 6-cm het- erogeneous right adnexal mass (M). This appearance was consis- tent with either a ruptured hemorrhagic cyst or heterotopic preg- nancy. A ruptured hemorrhagic cyst was found on laparoscopy. A B C include maternal abdominal pain, excessive abdominal distention, abnormal liver function test results, respiratory difficulties, and hir- sutism. 5 Patients with this condition may also be asymptomatic. These lesions may be found incidentally during routine obstetric imaging or cesarean delivery. Theca Lutein Cysts With Moles Molar pregnancy complicates about 0.1% of pregnancies. 11 Theca lutein cysts are reported with complete hydatidiform moles 14% to 30% of the time. 12 They appear as anechoic, multi- loculated, ovarian cysts (Figure 12). The pres- ence of a uterus filled with echogenic tissue with small cysts is the key to the diagnosis. These cysts are typically not seen in the first trimester of molar pregnancies because of rela- tively low -hCG values at that time. 13 Partial molar pregnancy is not likely to have theca lutein cysts. 808 J Ultrasound Med 23:805819, 2004 Imaging of Adnexal Masses in Pregnancy Figure 6. Hyperstimulated ovaries in a 32-year-old woman, 19 weeks pregnant, with twins conceived by in vitro fertilization. A and B, Transvaginal views show enlarged ovaries measuring up to 11 cm, with the largest cyst being 8 cm. The cysts resolved during pregnancy and were no longer pre- sent at the time of cesarean delivery. A B Figure 7. Hyperstimulated ovaries in a 36-year-old woman, 18 weeks pregnant, with twins conceived by in vitro fertilization. A and B, Transabdominal scans show 9-cm ovaries with multiple cysts, the largest of which was 11 cm. Ovaries were normal at the time of cesarean delivery at 32 weeks. A B Luteomas Luteomas are rare solid ovarian lesions that occur in pregnancy. Fewer than 200 cases of luteoma have been reported in the literature. 14 Luteomas cause maternal virilization in 25% to 30% of cases and carry a 50% risk of virilizing a female fetus. 15,16 Luteomas are usually asymp- tomatic and are found incidentally at cesarean delivery. 15,16 They are thought to result from ele- vated plasma androgens after stromal cell prolif- eration during pregnancy and to involute post- partum with falling androgen levels. 14,15 On sonography, they appear as heterogeneous solid masses, predominantly hypoechoic com- pared with normal ovarian tissue, with thick walls and irregular internal contours in an enlarged ovary (Figure 13). 14,15 They are often highly vascular and mimic ovarian neoplasms. 14 The appearance of virilizing symptoms in the pregnant patient leads to this diagnosis. When a luteoma is suspected, laparotomy can be avoid- ed during pregnancy because the lesions regress after delivery. Masses Associated With Pain Leiomyomas Leiomyomas are the most common solid masses in pregnancy. 3 They are seen on sonography in 1.4% of pregnancies. 17 Most are within the body of the uterus, but pedunculated and broad-ligament myomas can simulate an ovarian neoplasm. They appear on sonography as hypoechoic, round, persistent masses (Figure 14). Leiomyo- mas may enlarge during pregnancy and may cause focal pain. When the leiomyoma outgrows its blood supply, it may undergo red degenera- tion, which results in the development of cystic spaces, an echogenic rim, or a coarse heteroge- neous pattern consisting of hyperechoic clusters with focal areas of distal shadowing. 3,18 J Ultrasound Med 23:805819, 2004 809 Chiang and Levine Figure 9. Hyperstimulated ovary with torsion in a 31-year-old woman at 11 weeks gestation with hyperstimulated ovaries and severe right lower quadrant pain. A, Transabdominal scan shows an enlarged ovary, mea- suring up to 11 cm. B, Transvaginal scan shows an arterial waveform pre- sent in the solid portion of the ovary. Venous flow was present. Because of extreme pain, the patient was taken to surgery, during which the ovary was found to be twisted 3 times about its pedicle. A B Figure 8. Hyperstimulated ovaries in a 36-year-old woman, 12 weeks pregnant, with in vitro fertilization gestation. Transvaginal scan shows 6-cm ovaries with multiple cysts, some of which con- tain debris, consistent with hemorrhagic corpus luteum cysts. LO indicates left ovary; and RO, right ovary. Sonography is the mainstay of leiomyoma diag- nosis. However, MR imaging can be helpful in confirming the diagnosis of a large degenerating leiomyoma, which can simulate an ovarian neo- plasm on sonography (Figure 15). On longitudi- nal relaxation time (T1)-weighted images, degenerated leiomyomas appear heterogeneous with central low intensity. When red degenera- tion has occurred, the T1-weighted images can show high signal intensity. On transverse relax- ation time (T2)-weighted images, they can appear heterogeneously bright centrally, with punctate areas of hyperintensity and a thin band of myometrium around them. 19,20 When blood products are present, the T2-weighted appear- ance can be variable. Magnetic resonance imag- ing can clearly delineate the uterine origin of leiomyomas, which can help differentiate them from solid ovarian tumors, thereby avoiding surgery during pregnancy. 21 Heterotopic Pregnancy Heterotopic pregnancy occurs in 1 per 7000 pregnancies and is increasing because of the ris- ing prevalence of ectopic pregnancies and increased use of ovulation-inducing agents. 22 The reference standard is being able to identify cardiac motion in intrauterine and extrauterine pregnancies, but this only occurs in about 14% of cases. 23 Heterotopic pregnancy should be con- sidered in patients who have undergone ovula- tion induction or in vitro fertilization but can also occur spontaneously (Figure 16). Ovarian Torsion About 1% of large and complex masses have torsion (Figures 1719). 2,25 Torsion of an ovarian mass most frequently occurs in the mid to late first trimester, when the gravid uterus is enlarg- ing most rapidly. 26 Lack of flow on 2-dimensional Doppler sonography of the ovarian vessels on the ipsilateral side of the clinical condition is the classic finding of ovarian torsion. 27 Care must be taken in making the diagnosis of torsion because blood flow may be present even in the presence of torsion. This is due to the dual blood supply of the ovary, with the ovarian artery perfusing the ovary laterally and a branch of the uterine artery perfusing the ovary medial- ly. The presence of venous flow is predictive of ovarian viability. 28 When an adnexal mass is seen and the patient has severe pain, torsion should be considered. 810 J Ultrasound Med 23:805819, 2004 Imaging of Adnexal Masses in Pregnancy Figure 10. Hyperreactio luteinalis in a 34-year-old woman with diamniotic dichorionic twins at 19 weeks. A, Transabdominal scan shows the twins. B and C, Transvaginal scans show bilater- al enlarged ovaries measuring up to 14 cm with multiple cysts. Six weeks after vaginal delivery of twins, the ovaries had decreased dramatically in size, but cysts were still present. The woman was not taking hyperstimulating agents. A B C J Ultrasound Med 23:805819, 2004 811 Chiang and Levine Figure 11. Hyperreactio luteinalis in a 38-year-old woman at 18 weeks gestation with large adnexal cysts noted on routine obstetric sonography. The patient had not taken any hyperstim- ulating agents. A, Right upper quadrant scan shows a portion of the adnexal cyst (C). This was anechoic, measured 12 10 5 cm, and had thin septations versus adjacent cysts. B and C, Axial and coronal T2-weighted MR images show the enlarged cysts (C) in bilateral ovaries crossing the midline. No other abnormality was visualized. The cysts resolved after delivery. A B C Figure 12. Complete hydatidiform mole with theca lutein cysts in a 19-year-old woman, 11 weeks pregnant, with vaginal bleeding and an hCG level of 400,000 U/L. A, Transabdominal scan shows an enlarged uterus (calipers) with a thickened endometrium and multiple small cysts. B and C, Transvaginal scans show bilateral enlarged ovaries (calipers), the left up to 6 cm and the right up to 9 cm, with multiple cysts. The findings are consistent with a complete hydatidiform molar pregnancy with bilateral theca lutein cysts. A B C Massive ovarian edema occurs when there is intermittent torsion of an ovary, which interferes with venous and lymphatic drainage and causes ovarian enlargement. It is usually unilateral and involves the right ovary in two thirds of cases. On sonography, it appears as a solid mass with a cys- tic component and heterogeneous internal echo texture (Figure 19). Magnetic resonance imaging exhibits homogeneous low signal intensity on T1-weighted imaging and high signal intensity on T2-weighted imaging that becomes brighter on more heavily T2-weighted images. 29,30 812 J Ultrasound Med 23:805819, 2004 Imaging of Adnexal Masses in Pregnancy Figure 13. Luteoma in a 33-year-old woman, 28 weeks pregnant, with hirsutism and a 6-cm solid right adnexal mass. Serum androgen levels were ele- vated. The mass decreased in size to 2 cm after delivery (not shown). Hirsutism resolved 6 months after delivery. A, Transvaginal scan shows a 5-cm solid mass arising from normal-appearing ovarian tissue (arrowheads). B, Color Doppler image shows flow within the solid mass. Reproduced with permis- sion from the Journal of Ultrasound in Medicine. 14 A B Figure 14. Leiomyoma in a 33-year-old woman, 32 weeks preg- nant, with a 7-cm complex right adnexal mass (calipers) with a broad base in the myometrium, consistent with exophytic leiomyoma. At first glance, it may look like a hemorrhagic cyst, but hemorrhagic corpus luteum cysts do not persist into the third trimester. Figure 15. Degenerated leiomyoma in a 39-year-old woman, 16 weeks pregnant, with a 14-cm complex mass superior to the uterus and separate from the ovaries on sonography. T2-weight- ed MR image shows a broad base with the myometrium, low signal intensity peripherally, and extensive high T2 signal areas centrally, consistent with an exophytic degenerated leiomyoma. This was of low signal intensity on T1-weighted imaging (not shown), consistent with cystic degeneration. Incidental Findings Teratomas Teratomas show a complex echo pattern due to the presence of fat, solid components and calci- fied material (Figure 20). 3,31 Acoustic shadowing due to the dense calcification is also seen. 25 Most ovarian teratomas have a typical sono- graphic appearance and can be correctly diag- nosed by sonography. In the rare cases in which the diagnosis is unclear, MR imaging is often helpful in highlighting the fat within the mass. 21 Magnetic resonance imaging can also help determine the size of the mass if surgical removal is contemplated during pregnancy. Teratomas may be pedunculated and are prone to undergoing torsion and rupture, leading to peritonitis. 3 Hydrosalpinx Hydrosalpinx appears as anechoic tubular fluid collections (Figure 21). They typically do not change in size or appearance throughout pregnancy. 31 J Ultrasound Med 23:805819, 2004 813 Chiang and Levine Figure 16. Heterotopic pregnancy in a 32-year-old woman at 7 weeks gestation with abdominal pain. A, Transabdominal scan shows a live intrauter- ine pregnancy with surrounding fluid with debris, consistent with blood. B, Transvaginal scan shows a 6-cm complex heterogeneous left adnexal mass (arrowheads) that was separate from the ovary and a moderate amount of free fluid with debris. Histology showed ectopic pregnancy. A B Figure 17. Corpus luteum cyst with torsion in a 29-year-old woman, 9 weeks pregnant, with acute right lower quadrant pain. A, Transabdominal scan shows a 12-cm ovary (calipers) containing 2 cysts with debris. B, No flow was seen in the walls of the cysts or adjacent ovarian tissue. At surgery, torsion of 360 was noted. Histologic examination revealed corpus luteum cysts. A B Endometriomas Because endometriosis is a cause of infertility, it is uncommon to find an unsuspected endometrioma at routine obstetric imaging. Endometriomas have a classic appearance of a chocolate cyst with diffuse low-level internal echoes (Figure 22). Cystadenomas and Cystadenocarcinomas When an ovarian cyst is complex (and not hem- orrhagic), the likelihood of neoplasm is increased. Cystadenomas may be simple cysts or have thin septations (Figures 2325). Serous cystadenomas tend to be anechoic, whereas mucinous tumors have low-level internal echoes. Irregular septations and mural nodules increase the likelihood of malignancy. When malignancy is suspected in utero, a minilaparo- tomy is typically performed in the second trimester (to avoid spontaneous miscarriage in the first trimester and the risk of precipitating preterm delivery in the third trimester; Figure 26). If diagnosis is not made until late in gesta- tion, surgical removal of the ovary can be per- formed at the time of cesarean delivery. 814 J Ultrasound Med 23:805819, 2004 Imaging of Adnexal Masses in Pregnancy Figure 18. Teratoma with torsion in a 28-year-old woman, 30 weeks pregnant, with acute right-sided pain. Sonography shows a 9-cm cyst (calipers) with heterogeneous internal echoes and a hyperechoic nodule, consistent with a teratoma. No Doppler flow was seen around the cyst. At surgery, 2 complete twists of the right adnexa were found. Histologic examination revealed a teratoma. It is common to not visualize flow around a teratoma. However, the amount of pain the patient has is the key to the diagnosis. Figure 19. Massive ovarian edema in a 33-year-old woman at 14 weeks gestation with quadruplets spontaneously reduced to twins. Sonography (not shown) showed an enlarging left adnexal mass. A, Transverse T2-weighted MR image shows a 14-cm solid-appearing left ovary (LO) with a high-signal-intensity stroma and peripheral cysts, some of which are hemorrhagic. B, Transverse T2-weighted MR image shows an enlarged hyperstimulated right ovary (RO) in the cul-de-sac. Histologic examination showed massive ovarian edema of the left ovary. Reproduced with permission from Abdominal Imaging. 24 A B Conclusions Adnexal masses exhibit a wide range of imaging characteristics. Knowledge of the clinical appearance and sonographic findings allows for correct diagnosis in most. Complex cystic mass- es include corpus luteum cysts, theca lutein cysts, cystadenomas, and teratomas. Solid mass- es are commonly uterine leiomyomas. Magnetic resonance imaging can be useful when the diag- nosis is not clear on sonography. J Ultrasound Med 23:805819, 2004 815 Chiang and Levine Figure 20. Teratoma in a 38-year-old woman, 12 weeks preg- nant, with incidental notation of a 4-cm echogenic left adnexal mass (calipers) on a transverse view of gravid uterus. The cyst was removed at the time of cesarean delivery, and histologic examination revealed a teratoma. Figure 21. Hydrosalpinx in a 19-year-old woman, 15 weeks pregnant, with an oblong fluid collection (A, arrows) posterior to the gravid uterus. B, Postpartum image showing a hydrosalpinx (H) and a normal ovary (O). A B Figure 22. Endometrioma in a 29-year-old woman with a 7 3 4-cm bilobed left adnexal mass with diffuse low-level internal echoes seen at 11 weeks (A) and again at 28 weeks (B) with no change. The cyst was removed after delivery, and histologic examination showed an endometrioma. A B 816 J Ultrasound Med 23:805819, 2004 Imaging of Adnexal Masses in Pregnancy Figure 23. Mucinous cystadenoma in a 41-year-old woman, 7 weeks pregnant, with a 16-mm cyst containing a 6-cm mural nodule. The cyst was removed laparoscopically after a miscarriage, and histologic examination revealed a mucinous cystadenoma. Figure 24. Mucinous cystadenoma in a 40-year-old woman, 17 weeks pregnant. A and B, Sonograms show an 8-cm predomi- nately anechoic cyst with septations and no nodularity (B, calipers). An MR examination was performed for further charac- terization. C, Axial T2-weighted MR image shows the cyst (C) with thin septations and no nodularity. Because both modalities suggested a benign neoplasm, the cyst was followed during pregnancy and was not removed until cesarean delivery. Histologic examination showed a mucinous cystadenoma. A C B J Ultrasound Med 23:805819, 2004 817 Chiang and Levine Figure 25. Serous cystadenoma in a 34-year-old woman with a cyst. 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