BIO 198 PRINCIPLES OF GENETICS Fall 2014

Lectures: MWF 9:00-9:50 AM

Hoyt Auditorium
Instructors:
Elaine Sia Jennifer Brisson
Hutchison Hall 332 Hutchison Hall 326B
275-9275 275-8392
elaine.sia@rochester.edu jbrisso3@ur.rochester.edu
Office hrs: T & R 1:00-2:00 By appointment only
Please come during office hours or make an appointment via email.
Recitations: You are strongly encouraged to regularly attend one of the recitation sections. Part of these
sessions will be devoted to solving workshop problems, which will be helpful in preparing for exams.
Teaching Assistants:
Ramya Kaushik (rkaushik@u.rochester.edu) Sarah Allen (sallen24@u.rochester.edu)
Zach Prebel (wprebel@u.rochester.edu) Nina Fogel (nfogel@u.rochester.edu)
Hiba Zafar (hzafar@u.rochester.edu) Eric Wilson (ewils13@u.rochester.edu)
Jake Kloeber (jkloeber@u.rochester.edu) Christine Ziegler (c.ziegler@rochester.edu)
Abby Ritter (aritter@u.rochester.edu) Logan Schwartz (lschwar9@u.rochester.edu)
Required Reading: Assigned chapters from Introduction to Genetic Analysis, 10
th
edition, Griffiths,
Wessler, Lewontin, & Carroll. (Freeman)
Grades will be based on practice problems, quizzes and three exams.
Practice Problems: Questions are available at the end of each chapter and some of these will be assigned
in lecture each week. Problem sets will be collected by the TAs during recitations sections. Completed
assignments are worth 5 points/week, for a total of 60 points in the semester. A Solutions Manual (W.D.
Fixsen) is available. In addition, some problems will be given out and discussed during recitations.
Quizzes: Several unannounced quizzes will be given throughout the semester resulting in a total of 50
points from quizzes. NO makeups will be given for quizzes! Each student will be allowed to miss ONE
quiz without penalty.
Examinations: Two exams will be given during the common exam times (10/9 & 11/11) from 8:00-9:30
AM (100 points each), and a comprehensive three hour final (location to be announced) on Saturday,
December 20, 8:30-11:30 AM (200 points). The examinations will cover information and concepts
discussed in the lectures and in the assigned readings. All three exams are required. Students with an
excused absence from one of the two midterm exams will be given a make-up exam in essay format.
Excused absences should be requested before the missed exam. The final exam is required of all students.
Academic Honesty: All assignments and activities associated with this course must be performed in
accordance with the University of Rochester's Academic Honesty Policy. All work for this course
including exams and homework assignments must represent each students individual effort. Turning in
homework assignments that are identical or nearly so to the solutions manual or another students work
will be considered an infringement on the honesty policy of this course. More information is available
at: www.rochester.edu/college/honesty/.
LECTURE SCHEDULE
Lecture Day Date Topic Chapter
1 W 9/3 Introduction, Chromatin & The Central Dogma 1
2 F 9/5 Single Gene Traits, Mitosis & Meiosis 2
3 M 9/8 Genetic Approaches & Sex-linked Traits 2
4 W 9/9 Human Pedigree Analysis 2
5 F 9/12 Independent Assortment 3
6 M 9/15 Cytoplasmic Inheritance 3
7 W 9/17 Gene Interactions I 6
8 F 9/19 Gene Interactions II 6
9 M 9/22 Synthetic Lethals, Linkage & Recombination 6, 4
10 W 9/24 Recombination & Mapping 4
11 F 9/26 Recombination & Mapping 4
12 M 9/29 Bacterial Conjugation 5
13 W 10/1 Bacterial Conjugation 5
14 F 10/3 Bacterial Transformation & Phage Recombination 5
15 M 10/6 Lysogeny & Transduction 5
16 W 10/8 DNA Structure & Replication 7
THURSDAY 10/9 EXAM I (LECTURES 1 TO 14) 8:00-9:30 AM
17 F 10/10 DNA Polymerases &Origins 7
M 10/13 ****FALL BREAK****
18 W 10/15 Telomeres & RNA Structure & Transcription 7, 8
19 F 10/17 RNA Processing, Splicing & Introns 8
20 M 10/20 Protein Structure & Cracking the Genetic Code 8, 9
21 W 10/22 Protein Synthesis 9
22 F 10/24 Regulation of Transcription in Bacteria; The Lac Operon 9, 11
23 M 10/27 Trp operon and Two Component Systems 11
24 W 10/29 Bacteriophage Gene Regulation 11
25 F 10/31 Transcriptional Regulation in Eukaryotes 12
26 M 11/3 Role of Chromatin Structure & Remodeling 12
27 W 11/5 Recombinant DNA; Constructing Libraries 10
27 F 11/7 Screening Libraries 10
28 M 11/10 Blots, Sequencing & PCR I 10, 14
TUESDAY 11/11 EXAM II (LECTURES 15 TO 27) 8:00-9:30 AM
29 W 11/12 Blots, Sequencing & PCR II 10, 14
30 F 11/14 NO CLASS
31 M 11/17 Genomics 14
32 W 11/19 Genetic Engineering; Transgenes & Knockouts I 10
33 F 11/21 Genetic Engineering; Transgenes & Knockouts II 10
34 M 11/24 DNA Damage & Error Prone Polymerases 16
35 W 11/26 ****NO LECTURE****
F 11/28 ****THANKSGIVING****
M 12/1 DNA Repair Mechanisms 16
36 W 12/3 Population Genetics 18
37 F 12/5 Population Genetics 18
38 M 12/8 Population Genetics 18
39 W 12/10 Population Genetics 18
40 F 12/12 Natural Selection 20
SATURDAY 12/20 8:30-11:30 AM COMPREHENSIVE FINAL EXAM