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23 January 2012
Bacterial Break-in
The dangerous food-borne pathogen Listeria monocytogenes (the specks of green) enters the body via the gut, specifically at
the tips of tiny finger-like projections that line the intestine, called villi (http://en.wikipedia.org/wiki/Intestinal_villus) (red,
seen here from above). Cells at the villi tips are regularly shed, which exposes a protein that the bacteria use to get inside the
cells. The E-cadherin (http://en.wikipedia.org/wiki/E-cadherin) protein sticks cells together like grout between tiles. How
Listeria manage to reach that grout had long perplexed scientists but they now know that it is the continuous replacement of
the cellular tiles at the villi tips that gives the bugs the perfect opportunity.
Written by Ruth Williams
Mickey Pentecost
Department of Microbiology and Immunology, Stanford University, USA (http://stanford.edu)
Originally published under Creative Commons (CC-BY 2.0)
PLoS Pathogens (http://dx.doi.org/10.1371/journal.ppat.0020003)
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