Drug Information

1. Generic name: Mebeverine Hydrocholride

Description of drug Mebeverine is a musculotropic antispasmodic
drug, mainly used to treat irritable bowel
syndrome (IBS) and the associated abdominal
cramping. It works by relaxing the muscles in
and around the gut.
Dose & overdose Adult dose: 400mg/ day
Overdose: > 405mg/day
Child dose: Not recommended
Indications/ Disease 1. For symptomatic treatment of irritable bowel
syndrome
2. Chronic irritable colon
3. Spastic constipation
4. Mucous colitis
5. Colicky abdominal pain
6. Persistent non-specific diarrhea
Side effects & Adverse effects 1. Allergic reactions
2. Hypersensitivity
3. Urticaria
4. Angioedema
5. Face oedema
6. Exanthema
Contraindication If you are allergic to mebeverine hydrochloride
or any of the excipients.

Warning DO NOT TAKE MEBEVERINE IF:
1. You have liver or kidney problems
2. You are over 40 years
3. Have passed blood form the bowel
4. You are feeling sick or vomiting
5. You are looking pale and feeling tired
6. You are suffering from severe constipation
7. You have a fever
8. You have recently travelled abroad
9. You are or may be pregnant
10. You have abnormal vaginal bleeding or
discharge
11. You have difficulty or pain passing urine
Clinical experience Mebeverine should not given to children and
adolescents
Group Synthetic anticholinergics, esters with tertiary
amino group, musculotropic antispasmodic

Advice to patient 1. If you forget a single dose do not take a
consequent double dose to make up for it.
2. Keep away from children
3. Keep in original packaging
4. Do not store above 30C
Reference Medicines.org.uk
Brand
name
Manufacturer Dosage
form
Dose Price Pack
EVARIN Delta Pharma
Limited
Tablet 135mg 299.98
MRP
50s
IRBAN Incepta
Pharmaceuticals
Ltd
Tablet 135mg 300.00
MRP
50s
MANIL Gaco
Phamaceutical
Ltd
Tablet 135mg 303.43
MRP
50s
MAVE Opsonin
Pharma Ltd
Tablet 135mg 300.00
MRP
50s
MESPA Ambee
Pharmaceuticals
Ltd
Tablet 135mg 300.00
MRP
50s
MEVERINE Drug
International
Ltd
Tablet 135mg 300.00
MRP
50s
ROSTIL Beximco Tablet 135mg 300.00 50s

2. Generic name: Meclizine

Description Meclizine is a piperazine-derivative
antihistamine that is used as an antiemetic. It
has antiemetic, anticholinergic and
antihistaminic properties. It reduces the
sensitivity of the labyrinthine apparatus. The
action may be mediated through nerve
pathways to the vomiting center (VC) from the
chemoreceptor trigger zone (CTZ), peripheral
nerve pathways, the VC or other CNS centers.
Dose & overdose Adult dose for:
Motion sickness: Take an initial dose of 25-50
mg, 1 hour prior to travel. May repeat the dose
every 24 hours for the duration of the journey.
Radiation sickness: 50 mg administered 2-12
hours prior to radiation treatment.
Vertigo: 25-100 mg daily in divided doses.
Emergency contraception: 25-50 mg, 1 hour
before first ECP dose; repeat if needed in 24
hours.
Children <12 dose: Not established
Overdose: >100mg
Indications/ Disease 1. Nausea
2. Vomiting
3. Dizziness
4. Motion sickness
5. Vertigo associated with diseases of
vestibular system.
Side effects & Adverse
effects
1. Drowsiness
2. Dry mouth
3. Blurred vision
4. Constipation
Pharmaceuticals
Ltd
MRP
VERON Eskayef
Bangladesh Ltd
Tablet 135mg 304.00
MRP
50s
Contraindications Contraindicated in patients who have
hypersensitivity to Meclizine and those who
are breastfeeding
Warning 1. Patients should be warned that Meclizine
may impair their ability to perform hazardous
activities requiring mental alertness or
physical coordination (e.g., operating
machinery, driving a motor vehicle). 2.
Patients should avoid alcoholic beverages
while taking this drug. Due to its potential
anticholinergic action, this drug should be
used with caution in patients with asthma,
glaucoma, or enlargement of the prostate
gland.
Clinical experience 1. Shouldnt be used in children under 12.
Group Antiemetic;Histamine H1
Antagonist;Histamine H1 Antagonist, First
Generation;Piperazine Derivative
Advice to patient 1. Dry mouth may cause an increase in
cavities. Take good care of your teeth. See a
dentist regularly.
2. Do not take double or extra doses.
3. Do not share your medicine with others and
do not take anyone else's medicine.
4. Keep all medicine out of the reach of
children and pets.
Reference http://www.gthrifty.com



2. Brand name, manufacturer, dosage form, dose, pack & price

Brand
name
Manufacturer Dosage
form
Dose Price Pack
ACCLIZ Aristopharma
Ltd.
Tablet
(Film
Coated)
Meclizine hydrochloride
50mg/tablet
125 MRP 50s
ANOSEA IBN SINA
Tablet
(Film
Meclizine hydrochloride
50mg/tablet
1125 MRP 50s
Pharmaceutical
Industry Ltd.
Coated)
AVERT Bio-pharma
Laboratories Ltd
Tablet
(Film
Coated)
Meclizine hydrochloride
50mg/tablet
250 MRP 100s
CLIZIN Peoples Pharma
Ltd.
Tablet
(Film
Coated)
Meclizine hydrochloride
50mg/tablet
125MRP
250 MRP
50s
100s
EMEGO Opsonin
Pharma
Limited


Tablet
(Film
Coated)
Meclizine hydrochloride
50mg/tablet
125 MRP 50s
EMENIL Incepta
Pharmaceuticals
Ltd.
Tablet
(Film
Coated)
Meclizine hydrochloride
50mg/tablet
250 MRP 100s
EMEZIN Eskayef
Bangladesh Ltd.
Tablet
(Film
Coated)
Meclizine hydrochloride
50mg/tablet
125 MRP 50s
NOMOSIC Drug
International Ltd.
Tablet
(Film
Coated)
Meclizine hydrochloride
50mg/tablet
215 MRP 50s
VERTINA Square
Pharmaceuti
cals Ltd.


Tablet
(Film
Coated)
Meclizine hydrochloride
50mg/tablet
125 MRP 50s
VOMEC Beximco
Pharmaceuti
cals Ltd.


Tablet
(Film
Coated)
Meclizine hydrochloride
50mg/tablet
125 MRP 50s
ACZIL
plus
Aristopharm
a Ltd.


Tablet
(Film
Coated)
Meclizine hydrochloride
USP 25mg & Pyridoxine
hydrochloride BP
50mg/tablet
150 MRP 50s
DEVOMIT Silva
Pharmaceuticals
Limited
Tablet
(Film
Coated)
Meclizine hydrochloride
USP 25mg & Pyridoxine
hydrochloride BP
50mg/tablet
150 MRP 50s
EMEGO
plus
Opsonin
Pharma
Limited


Tablet
(Film
Coated)
Meclizine hydrochloride
USP 25mg & Pyridoxine
hydrochloride BP
50mg/tablet
150 MRP 50s
EMENTIL
plus
Incepta
Pharmaceuti

Tablet
(Film
Coated)
Meclizine hydrochloride
USP 25mg & Pyridoxine
hydrochloride BP
300 MRP 100s
cals Ltd.
50mg/tablet
EMENOR Apex
Pharmaceuticals
Ltd
Tablet
(Film
Coated)
Meclizine hydrochloride
USP 25mg & Pyridoxine
hydrochlori1de BP
50mg/tablet
125 MRP 50s
EMEZIN
plus
Eskayef
Bangladesh Ltd.
Tablet
(Film
Coated)
Meclizine hydrochloride
USP 25mg & Pyridoxine
hydrochloride BP
50mg/tablet
150 MRP 50s
MEC-P Navana
Pharmaceuticals
Ltd.
Tablet
(Film
Coated)
Meclizine hydrochloride
USP 25mg & Pyridoxine
hydrochloride BP
50mg/tablet
150 MRP 50s
MECLIZIN General
Pharmaceuti
cals Ltd.


Tablet
(Film
Coated)
Meclizine hydrochloride
USP 25mg & Pyridoxine
hydrochloride BP
50mg/tablet
125 MRP 50s
PYRIMAC ACI Limited
Tablet
(Film
Coated)
Meclizine hydrochloride
USP 25mg & Pyridoxine
hydrochloride BP
50mg/tablet
150 MRP 50s
XMEC Beacon
Pharmaceuti
cals Ltd.


Tablet
(Film
Coated)
Meclizine hydrochloride
USP 25mg & Pyridoxine
hydrochloride BP
50mg/tablet
150 MRP 50s



3. Generic name: Metformin
Description of drug
Metformin is a biguanide type oral antihyperglycemic drug used in the
management of type 2 diabetes. It lowers both basal and postprandial
plasma glucose. Its mechanism of action is different from those of
sulfonylureas and it does not produce hypoglycemia. Nobesit decreases
hepatic glucose production, decreases intestinal absorption of glucose
and improves insulin sensitivity by an increase in peripheral glucose
uptake and utilization.
Dose & overdose
Adult tablet dose: 500mg twice a dat
Adult extended release dose: 500mg once a day
Overdose: > 2550mg
Children over 10: 500mg twice a day
Indications/
Disease
1. To improve glycemic control in type 2 diabetes
2. To help hormone balance
3. Lowers blood sugar & helps insulin work better
Side effects &
Adverse effects
1. Anorexia
2. Flatulence
3. Loss of appetite
4. Diarrhea
5. Nausea
6. Vomiting
Contraindication
Metformin is contraindicated in patients with:
1. Renal dysfunction
2. Cardiovascular collapse
3. Acute myocardial infarction
4. Diabetic ketoacidosis
5. Hypersensitivity to Metformin
Warning
Metformin is known to be substantially excreted by the kidney and the
risk of Metformin accumulation and lactic acidosis increases with the
degree of impairment of renal function. Thus, patients with serum
creatinine levels above the upper limit of normal for their age should not
receive Metformin.
Clinical experience
Rarely lactic acidosis (approximately 0.03 cases/1000 patient-year) can
occur due to Metformin accumulation during treatment with Metformin.
Group Antidiabetic Agent, Biguanide
Advice to patient
1. Keep out of reach of children
2. Store away from water and light
3. Do not take double doses
4. Consult doctor in case of pregnancy
Reference
www.gthrifty.com, www.inceptapharma.com


2. Brand name, manufacturer, dosage form, dose, pack & price

Brand name Manufacturer Dosage form Dose Price &Pack
BIGMET
Renata Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg /tablet
500mg x 100s
pack: 200.00
MRP; 850mg x
100s pack:
250.00 MRP

COMET
Square
Tablet
Metformin hydrochloride 500mg x 100s

Pharmaceuticals
Ltd.
500mg, 750mg &
850mg/tablet
pack: 200.00
MRP; 750mg x
60s pack:
150.00 MRP;
850mg x 50s
pack: 150.00
MRP
COMET XR
500
Square
Pharmaceuticals
Ltd.
Tablet(Extended
Release)
Metformin hydrochloride
500mg/tablet
500mg x 50s
pack: 200.00
MRP

COMET XR
1gm
Square
Pharmaceuticals
Ltd.
Tablet(Extended
Release)
Metformin hydrochloride
1gm/tablet
1gm x 30s
pack: 210.00
MRP

DAOMIN
ACME Laboratories
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 200.00
MRP; 850mg x
40s pack:
120.00 MRP

D-FO
Decent Pharma
Laboratories Ltd.
Tablet
Metformin hydrochloride
850mg/tablet
850mg x 30s
pack: 75.00
MRP

DIABEX
Gaco
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 55.50
MRP; 850mg x
30s pack:
82.68 MRP

DIAFRE
Mystic
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 150.00
MRP; 850mg x
50s pack:
150.00

DIA-M
Medimet
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 55.00
MRP; 850mg x
50s pack:
125.00 MRP

DIA-M-SR
Medimet
Pharmaceuticals
Ltd.
Tablet(Sustained
Release)
Metformin hydrochloride
500mg/tablet
500mg x 50s
pack: 100.00
MRP

ETFORM
Sandoz/Novartis
(Bangladesh) Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 200.00
MRP; 850mg x
50s pack:
150.00 MRP

ETFORMIN
Elixir
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg/tablet
500mg x 100s
pack: 110.00
MRP; 850mg x
50s pack:

125.00 MRP
FORMET
Bio-pharma
Laboratories Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 110.00
MRP; 850mg x
50s pack:
125.00 MRP

FORMIN
Skylab
Pharmaceuticals
Ltd
Tablet
Metformin hydrochloride
850mg/tablet
850mg x 30s
pack: 90.00
MRP

FORMIN
Zenith
Pharmaceuticals
Ltd
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 150.00
MRP; 850mg x
100s pack:
300.00 MRP

GLUCOMET
Aristopharma Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 200.00
MRP; 850mg x
50s pack:
150.00 MRP

GLUNOR XR
Eskayef Bangladesh
Ltd
Tablet(Extended
Release)
Metformin
hydrochloride
500mg/tablet


500mg x 50s
pack: 200.00
MRP

GLUCOMET
XR 500
Aristopharma Ltd.
Tablet(Extended
Release)
Metformin
hydrochloride
500mg/tablet


500mg x 50s
pack: 200.00
MRP

GLUCOMET
750 XR
Aristopharma Ltd.
Tablet(Extended
Release)
Metformin hydrochloride
750mg/tablet
750mg x 30s
pack: 180.00
MRP

GLUNOR
Eskayef Bangladesh
Ltd
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 100.00
MRP; 850mg x
50s pack:
150.00 MRP

GLUPHAGE
XR
Silva
Pharmaceuticals
Limited
Tablet(Extended
Release)
Metformin
hydrochloride
400mg/tablet


400mg x 50s
pack: 185.00
MRP

GLYMIN
Healthcare
Pharmaceuticals
Limited
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 75.00
MRP; 850mg x
50s pack:
150.00 MRP

GLYMIN 500
XR
Healthcare
Pharmaceuticals
Limited
Tablet(Extended
Release)
Metformin hydrochloride
500mg/tablet
500mg x 50s
pack: 230.00
MRP

G-PHASE
Edruc Limited
Tablet
Metformin hydrochloride
850mg/tablet
850mg x 30s
pack: 90.00
MRP

HI-MET
Hudson
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
850mg/tablet
850mg x 100s
pack: 300.00
IP

INFO
Bristol Pharma
Limited
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 100.00
MRP; 850mg x
50s pack:
150.00 MRP

INFORMET
Beximco
Pharmaceuticals
Ltd.


Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 300.00
IP; 850mg x
60s pack:
270.00 IP

INFORMET
LA
Beximco
Pharmaceuticals
Ltd.


Tablet(Long
Acting)
Metformin hydrochloride
500mg/tablet
500mg x 100s
pack: 500.00
IP

INSIMET
IBN SINA
Pharmaceutical
Industry Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 250.00
MRP; 850mg x
50s pack:
175.00 MRP

KEMIN
Kemiko
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 100.00
MRP; 850mg x
50s pack:
150.00 MRP

MEFOREX
Jayson
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 55.00
IP; 850mg x
30s pack:
75.00 IP

MEFORIN XR
RAK
Pharmaceuticals
Pvt. Ltd.
Tablet(Extended
Release)
Metformin hydrochloride
500mg/tablet
500mg x 30s
pack: 150.00
MRP

MEFORIN
850
RAK
Pharmaceuticals
Pvt. Ltd.
Tablet
Metformin hydrochloride
850mg/tablet
850mg x 50s
pack: 200.00
MRP

MEGLU
Unimed &
Unihealth
Manufacturers
Ltd.


Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 30s
pack: 60.00
MRP; 850mg x
30s pack:
90.00 MRP

MEGLU ER
500
Unimed &
Unihealth
Manufacturers
Ltd.


Tablet(Extended
Release)
Metformin hydrochloride
500mg/tablet
500mg x 30s
pack: 150.00
MRP

MET
Opsonin Pharma
Tablet
Metformin hydrochloride 500mg x 30s

Limited 500mg & 850mg/tablet pack: 60.00
MRP; 850mg x
30s pack:
90.00 MRP
METARIN
Popular
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 30s
pack: 60.00
IP; 850mg x
30s pack:
90.00 IP

METFAR
White Horse
Pharmaceutical Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 100.00
MRP; 850mg x
50s pack:
150.00 MRP

METFAR SR
White Horse
Pharmaceutical Ltd.
Tablet(Sustained
Release)
Metformin hydrochloride
1000mg & 850mg/tablet
500mg x 50s
pack: 200.00
MRP; 1000mg
x 30s pack:
210.00 MRP

METFAST ER
500
Aexim
Pharmaceuticals
Ltd.


Tablet(Extended
Release)
Metformin hydrochloride
500mg/tablet
500mg x 50s
pack: 200.00
MRP

METFEN
Doctors
Chemical
Works Ltd.


Tablet
Metformin hydrochloride
850mg/tablet
850mg x 50s
pack: 125.00
MRP

METFO
Pacific
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 125.00
MRP; 850mg x
30s pack:
120.00 MRP

METFO XR
500
Pacific
Pharmaceuticals
Ltd.
Tablet(Extended
Release)
Metformin hydrochloride
500mg/tablet
500mg x 30s
pack: 150.00
MRP

GLYMIN plus
Health Care
Pharmaceuticals
Ltd.
Tablet(film
coated)
Glipizide 2.5mg +
Metformin hydrochloride
500mg/tablet
30s pack:
97.50 MRP

MEFOGLIP
250
Incepta
Pharmaceuticals
Ltd.
Tablet(film
coated)
Glipizide 2.5mg +
Metformin hydrochloride
250mg/tablet
50s pack:
95.00 IP

MEFOGLIP
500
Incepta
Pharmaceuticals
Ltd.
Tablet(film
coated)
Glipizide 2.5mg +
Metformin hydrochloride
500mg/tablet
30s pack:
84.00 IP

MEFOGLIP
DS
Incepta
Pharmaceuticals
Ltd.
Tablet(film
coated)
Glipizide 5mg +
Metformin hydrochloride
500mg/tablet
30spack:
111.00 MRP

METAZID
Popular
Pharmaceuticals
Tablet(film
coated)
Glipizide 2.5mg +
Metformin hydrochloride
30s pack:
75.00 IP

Ltd. 500mg/tablet
METGLIP
Pacific
Pharmaceuticals
Ltd.
Tablet(film
coated)
Glipizide 2.5mg +
Metformin hydrochloride
250mg/tablet
50s pack:
95.00 MRP

METGLIP
plus
Pacific
Pharmaceuticals
Ltd.
Tablet(film
coated)
Glipizide 2.5mg +
Metformin hydrochloride
500mg/tablet
30s pack:
89.40 MRP

METGLIP DS
Pacific
Pharmaceuticals
Ltd.
Tablet(film
coated)
Glipizide 5mg +
Metformin hydrochloride
500mg/tablet
30s pack:
120.00 MRP

ATOMEG 500
Unimed & Unihealth
Manufacturers Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
500mg/tablet
20s pack:
180.00 MRP

ATOMEG 850
Unimed & Unihealth
Manufacturers Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
850mg/tablet
20s pack:
200.00 MRP

COMPIMET
500
Incepta
Pharmaceuticals
Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
500mg/tablet
30s pack:
270.00 MRP

COMPIMET
850
Incepta
Pharmaceuticals
Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
850mg/tablet
30s pack:
300.00 MRP

GLITAMIN
500
White Horse
Pharmaceutical Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
500mg/tablet
30s pack:
270.00 MRP

GLITAMIN
850
White Horse
Pharmaceutical Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
850mg/tablet
30s pack:
300.00 MRP

METOPA
Eskayef Bangladesh
Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
500mg/tablet
30s pack:
270.00 MRP

PIOL-M 500
Opsonin Pharma
Limited
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
500mg/tablet
20s pack:
180.00 MRP

PIOL-M 850
Opsonin Pharma
Limited
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
850mg/tablet
20s pack:
200.00 MRP

PIOMET 500
Silva
Pharmaceuticals
Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
500mg/tablet
30s pack:
180.00 MRP

PIOMET 850
Silva
Pharmaceuticals
Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
850mg/tablet
50s pack:
210.00MRP

PIOMIN 500
Pacific
Pharmaceuticals
Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
500mg/tablet
30s pack:
300.00 MRP

PIOMIN 850
Pacific
Tablet(film
Pioglitazone 15mg + 50s pack:

Pharmaceuticals
Ltd.
coated) Metformin hydrochloride
850mg/tablet
345.00 MRP
POLITOR
500
ACI Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
500mg/tablet
50s pack:
270.00 IP

POLITOR
850
ACI Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
850mg/tablet
30s pack:
300.00 IP

REZULIN
500
Square
Pharmaceutical Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
500mg/tablet
50s pack:
270.00 MRP

REZULIN
850
Square
Pharmaceutical Ltd.
Tablet(film
coated)
Pioglitazone 15mg +
Metformin hydrochloride
850mg/tablet
30s pack:
300.00 MRP

AROMET-1
Aristopharma Ltd.
Tablet(film
coated)
Rosiglitazone 1mg +
Metformin hydrochloride
500mg/tablet
30s pack:
120.00 MRP

AROMET-2
Aristopharma Ltd.
Tablet(film
coated)
Rosiglitazone 2mg +
Metformin hydrochloride
500mg/tablet
30s pack:
180.00 MRP

METARIN
plus
Popular
Pharmaceuticals
Ltd.
Tablet(film
coated)
Rosiglitazone 1mg +
Metformin hydrochloride
500mg/tablet
30s pack:
120.00 MRP

METIGLIT 1
General
Pharmaceutical Ltd.
Tablet(film
coated)
Rosiglitazone 1mg +
Metformin hydrochloride
500mg/tablet
30s pack:
120.00 MRP

METIGLIT 2
General
Pharmaceutical Ltd.
Tablet(film
coated)
Rosiglitazone 2mg +
Metformin hydrochloride
500mg/tablet
30s pack:
180.00 MRP

ORAMET
plus
Drug International
Ltd.
Tablet(film
coated)
Rosiglitazone 2mg +
Metformin hydrochloride
500mg/tablet
50s pack:
350.00 MRP

ROGMET 2
Pacific
Pharmaceuticals
Ltd.
Tablet(film
coated)
Rosiglitazone 2mg +
Metformin hydrochloride
500mg/tablet
30s pack:
180.00 MRP

ROSIMET 1
Delta Pharma Ltd.
Tablet(film
coated)
Rosiglitazone 1mg +
Metformin hydrochloride
500mg/tablet
30s pack:
120.00 MRP

ROSIMET 2
Delta Pharma Ltd.
Tablet(film
coated)
Rosiglitazone 2mg +
Metformin hydrochloride
500mg/tablet
30s pack:
180.00 MRP

ROSIMIN 1
White Horse
Pharmaceutical Ltd.
Tablet(film
coated)
Rosiglitazone 1mg +
Metformin hydrochloride
500mg/tablet
30s pack:
120.00 MRP

ROSIMIN 2
White Horse
Pharmaceutical Ltd.
Tablet(film
coated)
Rosiglitazone 2mg +
Metformin hydrochloride
500mg/tablet
50s pack:
350.00 MRP

ROTAMIN 2
ACI Ltd.
Tablet(film
coated)
Rosiglitazone 2mg +
Metformin hydrochloride
500mg/tablet
30s pack:
180.00 IP

ROTAMIN 2
DS
ACI Ltd.
Tablet(film
coated)
Rosiglitazone 2mg +
Metformin hydrochloride
1000mg/tablet
32s pack:
240.00 IP

ROTAMIN 4
ACI Ltd.
Tablet(film
coated)
Rosiglitazone
4mg +
Metformin
hydrochloride
500mg/tablet


50s pack:
255.00 IP

ROTAMIN 4
DS
ACI Ltd.
Tablet(film
coated)
Rosiglitazone 4mg +
Metformin hydrochloride
1000mg/tablet
32s pack:
320.00 IP

SENSIMET 1
Square
Pharmaceutical Ltd.
Tablet(film
coated)
Rosiglitazone 1mg +
Metformin hydrochloride
500mg/tablet
30s pack:
120.00 MRP

SENSIMET 1
DS
Square
Pharmaceutical Ltd.
Tablet(film
coated)
Rosiglitazone
1mg +
Metformin
hydrochloride
1000mg/tablet


30s pack:
225.00 MRP

SENSIMET 2
Square
Pharmaceutical Ltd.
Tablet(film
coated)
Rosiglitazone
2mg +
Metformin
hydrochloride
500mg/tablet


30s pack:
180.00 MRP

SENSIMET 2
DS
Square
Pharmaceutical Ltd.
Tablet(film
coated)
Rosiglitazone 4mg +
Metformin hydrochloride
1000mg/tablet
30s pack:
300.00 MRP

SENSIMET 4
Square
Pharmaceutical Ltd.
Tablet(film
coated)
Rosiglitazone 4mg +
Metformin hydrochloride
500mg/tablet
30s pack:
255.00 MRP

METFORM
ACI Limited
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 200.00
MRP; 850mg x
50s pack:
200.00 MRP

METFORM
ER
ACI Limited
Tablet(Extended
Release)
Metformin hydrochloride
1000mg/tablet
1000mg x 32s
pack: 224.00
IP

METIN
Supreme
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 75.00
MRP; 850mg x
30s pack:
90.00 MRP

METMIN 850
Alco
Tablet
Metformin hydrochloride 100s pack:

Pharma
Ltd.
850mg/tablet 225.00 MRP
MINIFOR
Rephco
Laboratories Ltd.
Tablet
Metformin hydrochloride
850mg/tablet
100s pack:
380.00 MRP

NOBESIT
Incepta
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 100.00
MRP; 850mg x
50s pack:
150.00 MRP

NOBESIT XR
500
Incepta
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg/tablet
500mg x 50s
pack: 200.00
IP

NV MET
Navana
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 100.00
MRP; 850mg x
50s pack:
150.00 MRP

NV MET 500
SR
Navana
Pharmaceuticals
Ltd.
Tablet(Sustained
Release)
Metformin hydrochloride
500mg/tablet
500mg x 50s
pack: 150.00
MRP

OBID
Delta Pharma
Limited
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 199.94
MRP; 850mg x
30s pack:
89.99 MRP

ORAMET
Drug International
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 200.00
MRP; 850mg x
100s pack:
300.00 MRP

ORAMET SR
Drug International
Ltd.
Tablet(Sustained
Release)
Metformin hydrochloride
500mg/tablet
500mg x 50s
pack: 200.00
MRP

ORMIN
Orion Laboratories
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 50s
pack: 100.00
MRP; 850mg x
50s pack:
150.00 MRP

P-MIN
Pharmadesh
Laboratories Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 110.00
MRP; 850mg x
30s pack:
90.00 MRP

PREFORM
850
Apex Pharma Ltd.
Tablet
Metformin hydrochloride
850mg/tablet
850mg x 100s
pack: 250.00
MRP

PREFORM SR
Apex Pharma Ltd.
Tablet(Sustained
Metformin hydrochloride 500mg x 50s

Release) 500mg/tablet pack: 200.00
MRP
SUCOMET
Globe
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg/tablet
500mg x 100s
pack: 100.00
MRP

SUGAMET
General
Pharmaceuticals
Ltd.
Tablet
Metformin hydrochloride
500mg & 850mg/tablet
500mg x 100s
pack: 200.00
MRP; 850mg x
40s pack:
120.00 MRP




4. Generic name: Metoprolol

De Description of drug
Metoprolol tartrate BP, is a selective 1- adrenoreceptor blocking agent.
Metoprolol tartrate is ()-1- (isopropylamino)-3-[p-(2-
methoxyethyl)phenoxy]-2-propanol L-(+)-tartrate (2:1) salt. It is a white,
practically odorless, crystalline powder with a molecular weight of 684.82.
It is very soluble in water;freely soluble in methylene chloride, in
chloroform, and in alcohol, slightly soluble in acetone; and insoluble in
ether.
Dose & overdose
Adult dose:
1. Hypertension: initially 100mg daily, maintenance 100-200mg daily in
1-2 divided doses
2. Angina Pectoris: 50-100mg 2-3 times daily.
3. Myocardial Infarction: After early intravenous treatment for 48 hours,
patients should receive a maintenance dose of 100mg twice daily.
4. Arrhythmias: usually 50mg 2-3 times daily; up to 300mg daily in
divided doses if necessary.
5. Hyperthyroidism: (adjunct), 50mg 4 times daily
6. Migraine Prophylaxis: 100-200mg daily in divided doses.

Pediatric dose:
1. Immediate release: 1 to 2mg/kg/day
Overdose: >200mg/day
2. Extended release: 1mg/kg/day
Overdose: 50mg

Indications/
Disease
1. Hypertension
2. Angina Pectoris
3. Myocardial infarction
4. Arrythmias
5. Hyperthyroidism
6. Migraine prophylaxis
Side effects &
Adverse effects
1. Bradycardia
2. Heart failure
3. Hypotension
4. Conduction disorder
5. Bronchospasm
6. Peripheral vasoconstriction
7. Gastrointestinal disturbances
8. Fatigue
9. Sleep disturbances
10. Rash
11. Dry eye
12. Sexual dysfunction
13. Exacerbation of psoriasis
Contraindication
Hypertension and Angina: Metoprolol is contraindicated in sinus
bradycardia, heart block greater than first degree, cardiogenic shock, and
overt cardiac failure.

Myocardial Infarction: Metoprolol is contraindicated in patients with a
heart rate<45 beats/min; second and third-degree heart block; significant
first-degree heart block; systolic blood pressure <100 mmHg; or
moderate-to-severe cardiac failure.
Warning
Metoprolol should be used with caution in patients with impaired hepatic
function.
Clinical experience
Metoprolol should not be used in women more than 12 weeks
pregnant and those with Raynauds disease.
Group
Beta Blocker, Beta-1 Selective
Advice to patient
Patients should be advised to take Metoprolol regularly and continuously,
as directed, with or immediately following meals. If a dose missed, the
patient should take only the next scheduled dose (without doubling it).
Patient should not discontinue Metoprolol without consulting the physician.
Patients should be advised to
avoid operating automobiles and machinery or engaging in other tasks
requiring alertness until the
patient's response to therapy with Metoprolol has been determined.
contact the physician if any difficulty in breathing occurs.
inform the physician or dentist before any type of surgery that he or she
is taking Metoprolol.
Reference
www.gthrifty.com, www.inceptapharma.com




5. Generic name: Metronidazole

Description of drug
Metronidazole is a member of the imidazole class of antibacterial agents
and is classified therapeutically as an antiprotozoal and antibacterial
agent. The intracellular targets of action of metronidazole on anaerobes
are largely unknown. The 5-nitro group of metronidazole is reduced by
metabolically active anaerobes, and studies have demonstrated that the
reduced form of the drug interacts with bacterial DNA. However, it is
not clear whether interaction with DNA alone is an important component
in the bactericidal action of metronidazole on anaerobic organisms.
Dose & overdose
Adult Dosing
1. Trichomonasis: 2g one day
2. Amebiasis: 750mg three times a day
3. Anerobic bacterial infection: 7.5mg/kg every 6 hours

Pediatric doses
1. Amebiasis: 35-50mg/kg/day
2.Anerobix bacterial infection: 30mg/kg/day

Overdose: >4g/day
Indications/ Disease
1. The prevention of post-operative infections due to anaerobic bacteria,
particularly species of bacteroides and anaerobic streptococci.
2. The treatment of septicaemia, bacteraemia, peritonitis, brain
abscess, necrotising pneumonia, osteomyelitis, puerperal sepsis, pelvic
abscess, pelvic cellulitis and post-operative wound infections from which
pathogenic anaerobes have been isolated.
3. Urogenital trichomoniasis in the female (trichomonal vaginitis) and in
the male.
4. Bacterial vaginosis (also known as non-specific vaginitis, anaerobic
vaginosis or Gardnerella vaginitis).
5. All forms of amoebiasis (intestinal and extra-intestinal disease and
that of symptomless cyst passers).
6. Giardiasis.
7. Acute ulcerative gingivitis.
8. Anaerobically-infected leg ulcers and pressure sores.
9. Acute dental infections due to anaerobic organisms (eg. acute
pericoronitis and acute apical infections).
10. H. pylori infection
11. Antibiotic Associated Pseudomembranus colitis
Side effects &
Adverse effects
1. Pain
2. Tenderness
3. Redness or swelling over vein in which medicine is given
4. Unsteadiness
5. Fever
6. Sore throat
7. Chills
8. Headache
9. Numbness
10.Weakness in hands & feet
11. Skin itching
12. Vaginal irritation
13. Seizures
14. Unusual tiredness
Contraindication
Metronidazole is contraindicated in patients with a history of
hypersensitivity to Metronidazole or other Nitroimidazole derivatives.
Warning
Metronidazole should be given with caution in the following conditions-
anaemia or other blood disorders, liver disease, disease of the nervous
system, seizures etc.
Clinical experience
Nil
Group
Antiiprotozoal
Advice to patient
1.Nursing mothers shouldnt take metronidazole
2. Keep away from reach of children
Reference
www.inceptapharma.com



6. Generic name: Midazolam

Description of
drug
Midazolam is a sleep inducing agent characterized by a rapid
onset and short duration of action. It also exerts an anxiolytic,
anticonvulsant and muscle-relaxant effect.
Dose & overdose
Oral dosage: For adults 7.5-15 mg daily. In elderly and debilitated
patients, the recommended dose is 7.5 mg. In premedication, 15 mg of
Midazolam should be given 30-60 minutes before the procedure.

Intravenous administration:
Endoscopic or Cardiovascular Procedures
In healthy adults the initial dose is approximately 2.5 mg. In cases of
severe illness and in elderly patients, the initial dose must be reduced to
1 to 1.5 mg.

Induction of Anesthesia
The dose is 10-15 mg I. V.

Intramuscular administration:
Adult: 0.07-0.1 mg/kg bodyweight i. m. Usual dose is about 5 mg.
Children: 0.15-0.20 mg/kg.
Elderly and debilitated patients: 0.025-0.05 mg/kg

Rectal administration in children:
For preoperative sedation, rectal administration of the ampoule solution
(0.35-0.45 mg/kg) 20-30 min before induction of general anesthesia.
Overdose: >30mg in 24 hours
Indications/ Disease
1. Short term treatment of insomnia
2. Sedation in premedication before surgical or diagnostic
procedures.
Side effects &
Adverse effects
1. Drowsiness
2. Confusion
3. Fatigue
4. Headache
5. Muscle weakness
In IV or IM admisntration there can be respiratory depression,
apnoea, variations in blood pressure and pulse rate.
Contraindication
Midazolam must not be given to patients with severe respiratory
insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep
apnea syndrome and with known hypersensitivity to benzodiazepines or
to any component of the product.
Warning
Midazolam should be used with caution in:
patients over 60 years of age,
patients routinely short of breath,
myasthenia gravis (a disease causing muscle weakness),
a kidney, liver or heart condition,
a history of alcohol or drug abuse,
coma,
patients taking any other medicines including those not
prescribed by your doctor (make sure that your doctor knows what
other medicines you are taking, including ones you may have bought
without a prescription),
heart problems,
pregnancy,
personality disorder,
in babies or children. Let your doctor know if your child has a
heart condition.

It should not be used in:
allergies to midazolam, any other benzodiazepines or any of the
other ingredients;
severe difficulty in breathing or those who are very short of
breath and are to undergo conscious sedation (a state of calm or
drowsiness where you remain awake);
unstable myasthenia gravis (a condition causing muscle
weakness);
sleep apnoea (a condition causing frequent interrupted
breathing during sleep);
severe liver problems.
Clinical experience
Midazolam IV should be administered very slowly
Group
Anesthetic. Sedative Hypnotic, Benzodiazepines
Advice to patient
1. Before using this medication, tell your doctor or pharmacist your medical
history
2. Avoid drinking alcohol as it may increase the sedative effect and may
cause problems with your breathing.
Reference
www.drugs.webmd.boots.com, www.inceptapharma.com




7. Generic name: Minoxidil

Description of drug
Minoxidil can reverse the hair loss process of androgenetic alopecia by
the following means: increase the diameter of hair shaft; stimulate
anagen growth; prolong the anagen phase; stimulate anagen recovery
from telogen phase.

As a peripheral vasodilator Minoxidil enhances microcirculation of hair
follicles. The Vascular Endothelial growth factor (VEGF) is stimulated by
Minoxidil and VEGF is presumably responsible for the increased capillary
fenestration, indicative of a metabolic activity observed during the
anagen phase.
Dose & overdose
Adults
Male: Apply 1 mL of 2% or 5% solution to affected areas of scalp BID (qAM
& qHS); no more than 2 ml in 24 hours
Female: Apply 1 mL of 2% solution to affected areas of scalp BID (qAM &
qHS)
Pediatric
Not for children under 18
Indications/
Disease
Minoxidil indicated for the treatment of alopecia androgenetica in men
and women aged between 18 and 65.
Side effects &
Adverse effects
1. Hypertrichosis
2. Local erythema
3. Scalp flaking
4. Exacerbation of hairloss
Contraindication
inoxidil topical solution is contraindicated in patients with a history of
hypersensitivity to Minoxidil or any of the other ingredients in the
formulation such as propylene glycol or ethanol.
Warning
Before using Minoxidil, the user should determine that the scalp is
normal and healthy. Patients with known cardiovascular disease or
cardiac arrhythmia should contact a physician before using Minoxidil.
Minoxidil contains alcohol, which will cause burning and irritation of the
eye. In the event of accidental contact with sensitive surfaces (eye,
abraded skin and mucous membranes) the area should be bathed with
large amount of cool tap water.
Clinical experience
Do not use on sunburnt or irritated scalp.
Avoid guanethidine (hospitalize until stable if used)
Group
Vasodilator,
Advice to patient
Not recommended for lactating mothers
Reference
www.empr.com, www.inceptapharma.com,




8. Generic name: Montelukast

Description of drug
Montelukast is a selective and orally active leukotriene receptor
antagonist that inhibits the cysteinyl leukotriene CysLT1 receptor.
Cysteinyl leukotrienes and leukotriene receptor occupation have been
correlated with the pathophysiology of asthma ( such as, airway edema,
smooth muscle contraction and altered cellular activity associated with
the inflammatory process, which contribute to the signs and symptoms of
asthma).
Dose & overdose
Adults (15 years of age or over): 10 mg daily to be taken in the evening.
Children (6-14 years of age): 5 mg daily to be taken in the evening.
Children (6 months-5 years of age): 4 mg daily to be taken in the
evening.
Indications/
Disease
Montelukast is indicated for the prophylaxis and chronic treatment of
asthma in adults and pediatric patients from 6 months of age and older.
Side effects &
Adverse effects
1. Dizziness
2. Headache
3. Restlessness
4. Abdominal pain
5. Cough
6. Fever
7. Asthenia
8. Rash
9. Upper respiratory tract infection
Contraindication
Montelukast is contraindicated to patients with hypersensitivity to any
component of this product.
Warning
Patients with known aspirin sensitivity should continue avoidance of
aspirin or other NSAID, while taking Montelukast.
In rare cases, patients on therapy with Montelukast may present with
systemic eosinophilia, sometimes presenting with clinical features of
vasculitis consistent with churg-strauss syndrome, a condition which is
often treated with systemic corticosteroid therapy. Physician should be
alert to eosinophilia, vasculitic rash, worsening pulmonary symptoms,
cardiac complications, and/or neuropathy presenting in their patients. A
causal association between Montelukast and these underlying conditions
has not been established.
Clinical experience
The safety and efficacy of Montelukast was demonstrated in clinical trials
where it was administered in the evening without regard to the time of
food ingestion.
Group Anti Asthmatics, Leukotriene Receptor Antagonist
Advice to patient
Keep away from reach of children
Reference
www.inceptapharma.com




9. Generic name: Morphine

Description of drug Morphine is the most important alkaloid of opium and is a
phenanthrene derivative. It is available as the sulfate salt.
Dose & overdose
Adults: 2-10mg/70kg
<18: No available information
Overdose: 5mg/day
Indications/ Disease
1.Management of pain
2. Shortness of breath
3. Intractable pain
4. Sedative
5. Cancer pain
6. Severe neuralgia
7. Acute pulmonary edema
8. FRactures
Side effects &
Adverse effects
1. Constipation
2. Headache
3. Itchy skin
4. Dizziness
5. Nausea
Contraindication Morphine is contraindicated in: 1. Respiratory depression
2. Hypersensitivity
3. Paralytic ileus
4. Delayed gastric emptying
5. Obstructive airway disease 6. Acute hepatic disease
7. MAO Inhibitor
8. Pregnancy
9. Lactation and in children.
Warning Some of the adverse effects of morphine can be dangerous in CNS
disease, head injury, Emphysema, asthma, chronic lung disease,
enlarged prostate and in micturition difficulties. The chance of
adverse effects may be increased in Colitis, cardiac disease, renal
disease and in Hepatic disease.
Clinical experience Morphine will not be effective in people taking naltrexone. It can
increase the sedative effect of alcohol, increase the risk of
respiratory depression when used with MAO inhibitors and
Cimetidine. It antagonises the effects of diuretics.
Group
Opioid Analgesic
Advice to patient
Use as indicated by prescriber
Keep away from children
Reference
www.webhealthcarecentre.com




10. Generic name: Moxifloxacin

Description of drug
Moxifloxacin hydrochloride is a synthetic broad spectrum
antibacterial agent.
Dose & overdose Adult Dose
18yrs: 400mg once daily. Sinusitis: treat for 10 days. Bronchitis: treat
for 5 days. Pneumonia: treat for 714 days. Skin and skin structure:
treat for 7 days, if complicated: 721 days. Intra-abdominal: treat for
514 days; use IV form first. IV form: infuse over 60mins.
Childrens Dose: not established
Indications/ Disease
1. Sinus infection
2. Urinary tract infection
3. Gonorrhea
4. Acute bronchitis
5. Bacterial infection of the kidney
6. Diverticulitis
7. Bladder inflammation
8. Staphylococcus bacteria infection
9. Bacterial pneumonia
10. Salmonella infections
11. Pseudomonas infection
12. Streptococcus bacteria infection
13. Bacteroides infections
14. Proteus Infections
15. Klebsiella infection
16. E coli infection
17. Hemophilus infection
Side effects &
Adverse effects
1. Nausea
2. Diarrhea
3. Dizziness
4. Headache
5. Hypersensitivity reactions
6. Burning of eye
7. Dry eyes
8. Mild blurred vision
9. Skin rash
10. Numbness
11. Seizures
12. Yellow skin
13. Taste perversion
Contraindication
Moxifloxacin is contraindicated with NSAIDs and for people
with a history of hypersensitivity to moxifloxacin. It is alsi
contraindicated in pregnancy and pediatric populations.
Warning History of myasthenia gravis; avoid. Increased risk of tendinitis and
tendon rupture esp. in patients >60yrs, or those with kidney, heart or
lung transplants. CNS disorders (eg, seizures). Discontinue if tendon
pain, inflammation, or rupture occurs; or if allergic reaction or CNS
events occur. Severe hepatic impairment. History of QT prolongation
or proarrhythmic conditions (eg, hypokalemia, bradycardia, acute
myocardial ischemia).
Clinical experience
Concomitant NSAIDs may increase risk of seizure.
Increased risk of tendonitis & tendon rupture with
corticosteroids
Group
Quinolone antibiotic
Advice to patient Do not exceed recommended dose or infusion rate; may increase QT
prolongation. Discontinue immediately if symptoms of peripheral
neuropathy occur. Maintain adequate hydration. Avoid excessive sun
or UV light. Elderly. Pregnancy (Cat.C), nursing mothers: not
recommended.
Reference
www.empr.com