FC Path(SA) Chem

THE COLLEGES OF MEDICINE OF SOUTH AFRICA

Incorporated Association not for gain
Reg No 1955/000003/08

Examination for the Fellowship of the
College of Pathologists of South Africa - Chemical

31 August 2011

Paper 1 Laboratory Management and Practice (3 hours)

Answer FOUR questions only. Each question to be answered in a separate book (or books if more than one
is required for the one answer)
Beantwoord slegs VIER vrae. Elke vraag moet in n aparte boek (of boeke indien meer as een nodig is vir n
vraag) geskryf word

1 Write short notes on all of the following
a) Laboratory diagnosis of Cutaneous Hepatic Porphyria.
b) Insulin-like Growth Factor-1.
c) Impact of water quality on test performance.
d) Pyrosequencing. [25]

1 Skryf kort aantekeninge oor die volgende
a) Die laboratorium diagnose van Kutane Hepatiese Porfirie.
b) Insulienagtige groeifaktoor-1.
c) Die impak van waterkwaliteit op toets resultate en uitkoms.
d) Volgordebepaling volgens pirofosfaat vrystelling. [25]

2 Provide a critical discussion on the ISO 15189 requirement for measurement of
uncertainty. [25]

2 Bespreek krities die ISO 15189 vereistes vir bepaling van onsekerheid. [25]

3 Laboratory errors are common and often expected due to the high work volumes
what is your opinion on this statement and how would you improve the situation
can we learn from our mistakes? In your answer give some examples of how you
could have learnt from an error or mistake. [25]

3 Laboratorium foute is algemeen en word baie keer verwag te wyte aan n ho
werkslading. Wat is u opinie aangaande die stelling en hoe sou u die situasie
verbeter. Kan ons leer uit ons foute? Gee voorbeelde in u antwoord van hoe u sou
kon leer uit foute begaan. [25]

4 a) Discuss recent advances in the HbA1c assay with special reference
to standardisation. (15)
b) Discuss hepcidin and its association with disease. (10)
[25]

4 a) Bespreek onlangse ontwikkelinge betreffende die HbA1c essai met
spesiale verwysing na standardisasie. (15)
b) Bespreek hepsidien en sy assosoiasie met siekteprosesse. (10)
[25]

OR

5 Write short notes on
a) The value of antibody testing with special emphasis on thyroid function and
diabetes mellitus. (10)
b) Bonemarkers. (15)
[25]

5 Skryf kort notas aangaande
a) Die belang van antiliggaam bepaling met die klem op tiroed funksie en
diabetes mellitus. (10)
b) Beenmerkers. (15)
[25]







































FC Path(SA) Chem

THE COLLEGES OF MEDICINE OF SOUTH AFRICA
Incorporated Association not for gain
Reg No 1955/000003/08

Examination for the Fellowship of the
College of Pathologists of South Africa - Chemical

1 September 2011

Paper 2 Applied Clinical Biochemistry (3 hours)

Answer FOUR questions only. Each question to be answered in a separate book (or books if more than one
is required for the one answer)
Beantwoord slegs VIER vrae. Elke vraag moet in n aparte boek (of boeke indien meer as een nodig is vir n
vraag) geskryf word

1 Discuss how you would assess vitamin B12 status in the elderly paying particular
attention to diagnostic accuracy and limitations of the tests used. [25]

1 Bespreek hoe u vitamien B12 status in n bejaarde sal beoordeel. L klem op die
diagnostiese akkuraatheid en beperkings van die toetse. [25]

2 Discuss briefly the molecular basis of glucose homeostasis and response to hypoglycaemia
in childhood. How can the laboratory assist in investigating hypoglycaemia in the neonatal
period? [25]

2 Bespreek kortliks die molekulre basis van glukose homeostase en die respons op
hipoglukemie in kinders. Hoe kan die laboratorium gebruik word om te help in die
ondersoek van hipoglukemie in die neonaat? [25]

3 Discuss the clinico-pathological approach to and investigation of a 65-year-old female
patient who has developed confusion and hyponatraemia post-hip replacement surgery
[25]

3 Bespreek die klinies-patologiese benadering tot en ondersoek van n 65-jarige vroulike
pasint wat verwardheid en hiponatremie ontwikkel na heupvervangings chirurgie. [25]

4 Discuss the following
a) High Sensitivity Cardiac Troponin I measurement for risk stratification.
b) Current state of and future applications of using saliva for screening and diagnostic
testing.
c) The use of plasma renin mass versus renin activity to detect primary
hyperaldosteronism. [25]

4 Bespreek die volgende
a) Hoogs sensitiewe Kardiale Troponien I meting vir risiko bepaling.
b) Die huidige stand en toekomstige toepasings van die gebruik van speeksel vir sifting
en diagnostiese toetse.
c) Die gebruik van plasma renien massa teenoor renien aktiwiteit vir die opsporing van
primre hiperaldosteronisme. [25]

OR

5 Write short notes on the following
a) Single molecule ELISA.
b) Use of genetic information to partition reference intervals.
c) Non-HDL-cholesterol and cardiovascular risk.
d) Fractionated urine collection. [25]

5 Skyf kort notas aangaande die volgende
a) Enkel molekuul ELISA.
b) Die gebruik van genetiese inligting vir die partisie van verwysingsintervalle.
c) Non-HDL cholesterol en kardiovaskulre risiko.
d) Gefraksioneerde urine versameling. [25]