CJC 1295 refers to a tetrasubstituted peptide hormone which contains 30 amino acids. The snthetic !ersion of this chemica" was de!e"oped b the Canadian biotechno"o# specia"t compan ConjuChem$ which a"so acts as the main distributor for this chemica" for those that are interested in usin# it in a research settin#. %ne of the main ad!anta#es researchers ha!e found in usin# CJC 1295 o!er usin# traditiona" app"ications of #rowth hormone re"easin# hormone is that CJC 1295 is capab"e of bioconju#atin# with the serum a"bumin within an anima"&s bod. This has si#nificant" increased the wor'in# window and the ha"f-"ife for this product when it is app"ied to "i!e anima" tissues. This a"teration was accomp"ished b creatin# protectin# #roups made up of amino acids$ de!e"oped from #rowth hormone producin# hormone which wou"d norma"" be susceptib"e to se#re#ation from en(mes. Bioconjucation of CJC 1295 The main benefit of usin# CJC 1295 o!er the natura"" occurrin# #rowth hormone re"easin# hormone in the bod is the e)tended ha"f-"ife of the substance which a""ows it to ha!e a #reater impact on the tissues it interacts with. The main reason that CJC 1295 is capab"e of "en#thenin# its ha"f-"ife when it reaches the acti!e a#ent re!o"!es around the bio"o#ica" process of bio-conju#ation. The bioconju#ation techno"o# is re"ati!e" new$ a""owin# scientists to har!est a reacti!e #roup and a""ow it to bond with a #i!en peptide. The attachment to this peptide a""ows for a reaction that creates a nuc"eophi"ic unit. This is tpica"" a partia" mo"ecu"e which can be found within an anima"&s b"oodstream and then trac'ed as research continues. The bioconju#ation reaction is particu"ar" !a"uab"e when wor'in# with peptides because this a""ows the bond to become more stab"e. *an snthesi(ed chemica"s ha!e a !er short ha"f-"ife or do not brea' down the same wa the natura" forms of these chemica"s mi#ht which can ma'e for "ess than re"iab"e test resu"ts that wi"" impact anima" test subjects in was that cou"d be ineffecti!e or dan#erous. CJC 1295 in particu"ar has a hi#h attraction to the chemica" a"bumin which is a #"obu"ar protein that is water so"ub"e. This bond prohibits the peptide from natura"" de#radin# when it is e)posed to other chemica"s and f"uids within an anima"&s bod which increases its o!era"" she"f-"ife. +n addition to this$ c"inica" research on anima" test subjects has current" shown consistent" that CJC 1295 does not show si#ns of ,---+. se#re#ation when it is introduced into an anima". -ro"on#ed /timu"ation of 0rowth 1ormone 2sin# #rowth-hormone re"easin# hormone in a specific manner is desi#ned to increase an anima"&s secretion of #rowth hormone but this is "imited$ due to the natura" chemica"&s "imited duration of action. The objecti!e of on#oin# studies is to e)amine the pharmacodnamics effects and pharmaco'inetic profi"e as we"" as the safet of usin# CJC 1295 as a "on# actin# #rowth hormone re"easin# hormone. +nitia"" this stud was performed on two in!esti#ationa" sites on hea"th adu"t anima" test subjects at a !ariet of a#e ran#es. These test subjects were e)posed to CJC 1295 or a p"acebo which was both app"ied in 1-3 different app"ication si(es durin# the first stud. ,urin# the second stud app"ications were #i!en in biwee'" or 2-3 da doses. The main outcome was to note the pea' concentrations of +04-1 and #rowth hormone and standard pharmaco'inetic parameters were used to measure CJC 1295 within the anima"&s sstem. 4o""owin# a sin#"e app"ication of CJC 1295 !ia injection there were sustained resu"ts which showed increases in +04-1 and #rowth hormone$ thou#h these resu"ts were c"ear" app"ication dependent. The anima"s appeared to to"erate the chemica" we"" and it appeared to be safe for use$ particu"ar" at 30-50 u#6'# app"ications. There was some e!idence that CJC 1295 cou"d pro!ide a cumu"ati!e effect after mu"tip"e app"ications were administered. The use of CJC 1295 in de!e"opin# anima"s or those in pubert has #enera"" been accepted as a potentia" practice. 0i!en the need for an un"imited supp" of #rowth hormone in those that are not de!e"opin# proper"$ it is be"ie!ed that there is more potentia" use for this chemica" in the de!e"opin# mar'et7 thou#h more research into the safet of this chemica" must be performed to #uarantee this use. CJC 1295 is a !er uni8ue chemica" with specific properties which differentiate it from other #rowth hormone re"easin# hormone on the mar'et for research stud toda. 0i!en the specific nature of these compounds it is important to wor' with companies that are appro!ed or partners with ConjuChem$ to ensure that the are usin# the patented formu"a to create research-#rade samp"es that are suitab"e for app"ication in "i!e anima" test subjects. This wi"" ensure accurate research that can be rep"icated b peers in the fie"d. 9esource Bo)7 http766en.wi'ipedia.or#6wi'i6CJC-1295 http766www.ma)impeptide.com6peptides6 :se!era" !ersions of Cjc-1295; http766press.endocrine.or#6doi6fu""610.12106jc.2005-1535
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