PT-141s Functionality And Orgins

Posted on October 4, 2013 by Maxim Peptide

PT-141 is a research cyclic peptide that is being examined for its
potential positive effects relating to hemorrhagic shoc and
reperfusion industry! "t commonly goes by the name #remelanotide!
PT-141s Functionality
PT-141 is designed to stimulate the melanocortin receptors $%&-'
and $%4-' in the central nervous system of animal test sub(ects!
The receptors that PT-141 targets )or to bloc and regulate specific
signals )hich are transmitted from the brain to the components of the
central nervous system relating to negative body functions lie
inflammation or blood flo) restriction! This type of receptor activation
results in a modulation of inflammation and a limiting of ischemia*
also no)n as a restriction in blood supply due to factors related to
blood vessels! As such* the functionality of PT-141 through as
derived through scientific studies is to limit bodily irritation caused by
various pathogens* as )ell as to curb damage or dysfunction of blood
vessels and associated tissues! #ecause the peptide acts through
the central nervous system* it does not express itself directly via the
bloodstream!
PT-141s Origins
Previous scientific studies determined that PT-141 induced lordosis amongst animal test sub(ects+ a sexual
response that in essence is defined by an animals )illingness and desire to mate! "t is also mared by aiding in the
copulation of animals through physical characteristics involving an animals hips and bac!
These scientific findings amongst animal test sub(ects )ere eventually balanced out by the discoveries of negative
side effects in regards to maintaining a state of lordosis for an extended period of time! ,pecifically* the peptide
)as lined to increases in blood pressures as )ell as various negative gastronomical events! Today* scientific
study is still using animal test sub(ects in order to test the peptides connection )ith male and female dysfunction*
including the activation of lessening sexual drive!
Other Current Scientific Study
%urrently* scientific study in regards to PT-141 is focused on managing hemorrhagic shoc and reperfusion in(ury!
-emorrhagic shoc is a potentially serious condition mared by decreased tissue perfusion* resulting in the
inade.uate delivery the oxygen and nutrients essential for proper cellular function!
There are four classes of cellular shoc! They are/
0eurogenic
%ardiogenic
-ypovolemic
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1asogenic 2also referred to as septic3
These classifications of shoc can result in several potentially dangerous scenarios in animal test sub(ects*
including serious issues tied to the cardiovascular system lie decreased cardiac output and decreased pulse
pressure! PT-141 theoretically aids in the stimulation of neural reflexes for purposes of elevating sympathetic
outflo) to the heart and other organs that may other)ise significantly slo) or cease operation as a result of
hemorrhagic shoc! This stimulation includes factors lie elevated heart rate* vascoconstriction* and a redistribution
of blood flo) a)ay from organs that a body )ould vie) as non-vital* such as idneys or sin!
'eperfusion in(ury refers to tissue damage caused by the blood supply reentering into the tissue after an ischemic
episode lie a stroe! The lac of nutrients and oxygen from blood during an ischemic period generates a condition
)here the restoration of circulation results in oxidative damage and inflammation through oxidative stress as
opposed to the restoration of proper functionality!
This type of in(ury plays a rather significant role in the brains ischemic cascade* )hich is the series of biochemicial
reactions that start in the brain and other aerobic tissues seconds or even minutes after an ischemic episode is
detected! These reactions can lead to stroes* cardiac arrest* and other traumatic in(uries! Additionally* reperfusion
in(ury can manifest in other forms of brain failure* such as the moments follo)ing the reversal of cardiac arrest! "f
forms of reperfusion in(ury occur on a multiple basis* other ailments such as the formation of chronic )ounds could
occur! Furthermore* the healing of such )ounds could also be slo)ed do)n! PT-141 )ors neurologically to lo)er
the inhibitions associated )ith blood flo) restriction to tissues as a result of the ischemic cascade! This )ould
hypothetically lessen or even halt the resultant damage that could come as a result from a limitation of blood flo) in
the areas that )ould be potentially affected!
Scientific Research
"t should be noted that PT-141 is still being in the scientific research phase* and that all of its documented findings
in relation to its mechanics* functionality* benefits* and side effects have been culled from studies done )ithin the
confines of a controlled environment! As such* the peptide should only be used and studied )ithin an strict
environment that is solely meant for further research* such as a laboratory or medical research facility!