!Pain is "hat the patient says hurts# - M$%affery &'() !Pain is perfe$t misery, the "orst of evils, and e*$essive, overturns all patien$e+# - ,ohn Milton PAIN An unpleasant sensory and emotional e*perien$e asso$iated "ith a$tual or potential tissue damage, or des$ribed in terms of su$h damage- .Mers/ey, &'0', 1nternational Asso$iation for the Study of Pain 2eady 3 4d"ards &''56 DEFINITIONS OF PAIN TEMINO!O"# Allodynia 7 per$eption of non-no*ious stimulus as pain Anal$esia 7 absen$e of pain per$eption Anesthesia 7 absen$e of all sensations Dysesthesia - unpleasant sensation "ith or "ithout stimulus Hy%oal$esia 7 diminished response to no*ious stimulus Hy%eral$esia - in$reased response to no*ious stimulus Hy%eresthesia 7 in$reased response to mild stimulus Hy%oesthesia - redu$ed $utaneous sensation Ne&ral$ia 7 pain in the distribution of a nerve Ne&ritis 7 inflammation of a nerve or nerves Ne&ro%athy - disturban$e of fun$tion or pathologi$ $hange in a nerve Pain %erce%tion 7 point "hi$h the person be$omes a"are of pain Pain threshold 7 least e*perien$e of pain that a patient $an re$ogni8e Pain tolerance 7 greatest level of pain a patient $an tolerate Paresthesia 7 abnormal sensation "hether spontaneous9evo/ed PH#SIO!O"# OF PAIN Ma'or Mechanis(s: Nocice%ti)e *sensory+ - inflammatory pain due to $hemi$al, me$hani$al and thermal stimuli at the no$i$eptors Ne&ro%athic - initiated or $aused by a primary lesion or dysfun$tion in the nervous system .Mers/ey &'':6; a$utely o$$urs after trauma and surgery+ TIAD OF PAIN PECEPTION Pain rece%tors 7 no$i$eptors; free nerve endings that respond to intense, potentially damaging stimuli Pain sti(&li 7 me$hani$al; thermal; $hemi$al o Me$hani$al 7 pressure, s<uee8e, pin pri$/ o =hermal 7 heat9free8ing o %hemi$al 7 !P# fa$tors- brady/inin, serotonin, histamine, prostaglandin, substan$e P Pain ,ibers o Myelinated A-delta small diameter rapidly transmit .fast pain6; initial pain sharp pain sensation o .n(yelinated C very small diameter slo"er .slo" pain6; delayed pain diffuse burning9a$hing sensation deep throbbing pain, vis$eral, $hroni$ pain NOCICEPTION ability to dete$t no*ious and potentially tissue- damaging stimuli prote$tive me$hanism involves multiple intera$ting peripheral 3 $entral me$hanisms multifa$torial influen$ed by psy$hologi$al 3 environmental fa$tors PHASES OF NOCICEPTION Transd&ction - translation of no*ious stimuli into ele$tri$al energy at peripheral no$i$eptors+ Trans(ission - propagation of impulse from no$i$eptors to the dorsal spinal $ord Mod&lation - alteration of no$i$eptive information to attenuate9amplify the signal Perce%tion - sensory dis$rimination 9lo$ali8ation of no$i$eptive information in the thalamus and $orte* resulting into the emotional and physi$al pain e*perien$e "ATE CONTO! THEO# onald Mel/ac0 1 Patric0 2all 7 peripheral nerve fibers $arrying pain to the spinal $ord $an have their input modified at the spinal $ord level before transmission to the brain %on$ept: a non-painful stimulus $an blo$/ the transmission of a no*ious stimulus; based on the premise that the gate lo$ated in the dorsal horn modulates afferent nerve impulses Small diameter nerve fibers $arry pain stimuli through same gate >arge diameter fibers that $arry non-pain impulses go through same gate and inhibit transmission of pain impulses, that is, $lose the gate 4*ample: o Bumping the head o 1nitial trauma a$tivates A-delta and % fibers o 2ubbing traumati8ed area stimulates A- beta fibers "hi$h a$tivate the S? to $lose the spinal gate o 1nhibiting transmission of painful stimulus =he theory led to re$ognition that PA1@ $an be redu$ed or modulated at : points: &+ Peripheral site 5+ Spinal $ord A+ Brainstem :+ %erebral $orte* 4le$tri$al stimulation of s/in-s sensory nerve fibers inhibits pain 2elease of endogenous opioids from the %@S .en/ephalins, endorphins,dynorphins6 have morphine-li/e a$tions Pain gate at the substan$ia gelatinosa in the dorsal horn of the spinal $ord $an be shut by stimulation of tou$h-fibers .rubbing, stro/ing, massage, vibration, liniments6 @ormal9e*$essive sensory stimuli may relieve pain by $ompeting "ith pain stimuli .musi$, heat9$old, imagery, video games6 $an $lose the pain gate T#PES OF PAIN Accordin$ to location3ori$in o Superfi$ial $utaneous 7body surfa$e or s/in segments o Deep somati$- ligaments, tendons, bones, blood vessels, nerves o Bis$eral 7 abdominal $avity, thora*, $ranium Accordin$ to d&ration3intensity S&r$ical tra&(a - produ$es an initial afferent barrage of pain signals and subse<uently generate a se$ondary inflammatory response releasing inflammatory mediators .sensiti8ing soup6 at the site of inCury and surrounding uninCured tissue+ =hese signals initiate $hanges in the peripheral and %@S that amplify and prolong pain+ Peri%heral sensiti/ation results due to redu$tion in the threshold of no$i$eptor afferent terminals brought by inflammation at the site of inCury+ Central sensiti/ation3s%inal 4ind-&% - a$tivity- dependent in$rease in the e*$itability of spinal neurons due to persistent e*posure to afferent input from peripheral neurons+ %ombined, the pain signals and inflammation $ontribute to the hypersensitivity state responsible for a de$rease in pain threshold, at the site of inCury as primary hyperalgesia and in the surrounding uninCured tissue as se$ondary hyperalgesia; and e*plains "hy pain may be prolonged beyond the duration normally e*pe$ted "ith an a$ute insult li/e surgery+ The %rolon$ed central sensiti/ation $an result to permanent alterations in the %@S in$luding death of inhibitory neurons, repla$ement "ith ne" afferent e*$itatory neurons, and the establishment of aberrant e*$itatory synapti$ $onne$tions+ =his is the reason for the intra$table post-surgi$al pain unresponsive to many analgesi$s+ PAIN SENSITI5ATION =he impa$t of a$ute postoperative pain $an therefore e*tend beyond the time of surgi$al inCury and healing and imprint indelibly on the nervous system amplifying the response to subse<uent no*ious stimuli+ PS#CHOSOCIA! FACTOS IN PAIN STESS o Per$eption influen$ed by stress o Stress leads to behaviors .teeth grinding, mus$le tensing6 o Stress-indu$ed analgesia .in$reased toleran$e via endogenous opioids6 !EANIN" o Modeling o Se$ondary gain9reinfor$ement o %ulturally learned CO"NITION o Anti$ipation is "orse than pain itself o 4*pe$tations of ability to $ope ASSESSMENT TOO!S Self-2eport !=he ?old Standard# Dnidimensional Pain S$ales o Eong-Ba/er FA%4S Pain 2ating S$ale o Berbal 2ating S$ale .B2S6 o @umeri$al 2ating S$ale .@2S6 o Bisual Analogue S$ale .BAS6 Multidimensional Pain S$ales o Brief Pain 1nventory o M$?ill Pain Guestionnaire o Memorial pain Assessment %ard o @europathi$ Pain S$ale o >eeds Assessment of @europathi$ Symptoms and Signs .>A@SS6 Physiologi$9Biologi$ Parameters Behavioral Observations