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A

AADF/cofilin, W231
A bands, muscle, W212
Abdominal-A gene (Abd-A; Drosophila),
W130
Abdominal-B gene (Abd-B; Drosophila),
W130
Abdominal segments, Drosophila embryo,
W124
abx mutant (anteriobithorax; Drosophila),
W125F, W126, W130
Abzymes, W257
Accessory factors, blood clotting, W166
Accessory proteins, bacteriophage , W23
Ac-DEVD-CHO (acetyl-Asp-Glu-Val-Asp-
CHO) inhibitor, W148F, W154
O-Acetyl-ADP-ribose, W115
Acetylation, of histones, W111W114
Acetylcholine, W182
Acquired immune deficiency syndrome
(AIDS), W181
ACTH (adrenocorticotropic hormone),
W120, W120F
Actins, W149
binding site in myosin subfragment 1,
W215
complex with ATP and Ca
2
ions, W218F
interaction with myosin, W222, W222F
and microfilament dynamics, W230W231
movement of myosin along filaments,
W222W224
and myosin ATPase activity, W221W222
in nonmuscle cells, W228W232
structure, W218
in thin filaments, W216W217
Activated protein C (APC), W177
Activating transcription factor 2
(ATF-2), W104
Activation domains, W95W96
Activation-induced deaminase (AID),
W194, W196
Activation unit, of complement system,
W206, W208
Actomyosin, W221, W221F, W224
ADA (transcriptional adaptor), W112, W113
Ada2, W112
Ada3, W112
Adaptive immune response, W179W182,
W180F
Adaptive immune system, W179
Addisons disease, W182
Adenovirus, W2F, W144W145
ADP-ribosylation, of histones, W111
A gene, W23T
AID (activation-induced deaminase), W194,
W196
AIDS (acquired immune deficiency
syndrome), W181
Akey, C., W152
Alber, T., W101
Allelic exclusion, W194
Allis, D., W111
Allograft rejection, W204W205
Allotransplantation, W204W205
-Actinin, W219

2
-Antiplasmin, W178
-Thrombin, W171. See also Thrombin
-Tubulin, W236W237, W237F
Alternative pathway, of complement system,
W205, W205F, W210W211
Alternative splicing, W119
Alu family, W73, W73T
AluI, W73
Alzheimers disease (AD), W146
Amanita phalloides, W230
amber mutants, W27
Amerinds, mortality of infectious disease
for, W204
Amphibian embryo, W121F, W122, W122F
-Amylase, in mice, W119, W120F
Anaphylactic shock, W208
Anaphylatoxins, W208
Anatomy, W165
Androgens, nuclear receptor superfamily
and, W97
Anhidrotic ectodermal dysplasia, W84
Animals, restriction point of, W135W136.
See also specific species
Aniridia gene, W132
ANT-C complex (Drosophila), W130
Antenna, Drosophila embryo, W124, W124F
Antennapedia complex (ANT-C;
Drosophila), W130
Antennapedia mutant (antp; Drosophila),
W125F, W126, W130, W131F, W132
anteriobithorax mutant (abx; Drosophila),
W126
Anterior compartment, Drosophila embryo,
W123F
Anti-apoptotic proteins, W147
Antibodies, W179
antigen cross-linking, W184F
in chromatin immunoprecipitation, W110
diversity, W189W196
monoclonal, W185W186
neutralizing, W183
structure, W182W189
Antibody diversity, W189W196
and allelic exclusion, W194
heavy chain genes, W191W192
immunoglobin isotype switching,
W195W196
light chain genes, W189W190
light chain genes, W191
membrane-bound to secreted antibody
switching, W194W195
RAG1 and RAG2 in V(D)J recombinase,
W192W193
and recombinational flexibility,
W190W191
and somatic mutation, W193W194
somatic recombination and somatic
hypermutation hypotheses, W189
Antibody structures, W182W189
antigen-binding sites, W187W189
homology units, W186W187
isotypes, W182F, W182W184
light and heavy chain regions,
W184W185
monoclonal antibodies, W185W186
proteolytic separation of functional
segments, W184
Antigens, W179
and antigen-binding sites, W187W189
cross-linking of, W184F
Antigen-binding sites, W187W189
Antigenic drift, W43
Antigenic shift, W43
Antigenic variation, influenza virus,
W43W47
and HA, W43W45
and NA, W46W47
and surface residue changes, W45W46
Antigen-presenting cells (APCs), W179
Antihemophilic factor (VIII
a
), W176
Antimitotic drugs, W239W240
Anti-oncogene protein, W135
Antitermination complex, bacteriophage ,
W24W26, W25F
Antithrombin III (ATIII), W177
antp mutant (Antennapedia; Drosophila),
W125F, W126, W130, W131F, W132
Apaf-1 (apoptotic protease-activating
factor-1), W147, W151F, W152
APC (activated protein C), W177
APC (anaphase-promoting complex), W137
APCs (antigen-presenting cells), W179
Apo1, W150
Apoptosis, W136, W145W155
Apoptosome, W151F, W152, W153F
Apoptotic bodies, W147
Arabidopsis thaliana:
TBP, W90
transcription factor binding, W90W91
ARC/DRIP, W105
Archaeopterix, W122
Architectural proteins, W96, W106W107
Arp2, W231
Arp2/3 complex, W231W232, W232F
Arp3, W231
Artemis, W193
Asf1 (molecular chaperone), W60F,
W60W61
Asian flu of 1957, W40
Aspergillus oryzae, S1 nuclease, W71
Asthma, W228
Asturias, F., W105
WI-1
INDEX
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WI-2 Index
Ataxia telangiectasia, W140
ATF-2 (activating transcription factor 2),
W104
Atherosclerotic plaque, W175W176
AT hooks, W106W107, W107F
ATIII (antithrombin III), W177
ATM (ataxia telangiectasia mutated), W140
ATP:
in actin and Ca
2
complex, W218F
and ciliary motion, W246W247
and DNA packing in phage head,
W29W30
kinesin-1 and hydrolysis of, W241W242
ATPase, myosin as, W221W222
ATR (ATM and RAD3-related), W140
attB gene, W23T, W31
attL gene, W23T, W31
attP gene, W23T, W31, W32
attR gene, W23T, W31
Auditory hair cells, W235, W235F
Autoimmune disease, W182, W211
Avian leukosis virus, W134W135
Axonemal dyneins, W242
Axoneme, W245, W245F, W246F
Axons, W243
B
Bacillus subtilis, bacteriophage 29
infection, W29
Bacteria:
endotoxins, W207
flagella, W248W251, W249F
gene identification, W74
Bacteriophages, temperate, W20
Bacteriophage , W2F, W3, W20W39
assembly, W27F, W27W31
control of gene expression, W33F
control sites, W24F
Cro protein, W131
genes and genetic sites, W23T
genetic map, W22F
switch mechanism, W34W39, W39F
life cycle, W20W21, W21F
lysogenic mode, W20W21, W21F,
W31W34
lytic mode, W20W26, W21F, W24F
operator regions, W34F
protein component locations, W20F
site-specific recombination, W31F
turbid (cloudy) plaques on bacterial
lawn, W52
Bacteriophage 434, W52
Bacteriophage 434 Cro protein, W34
Bacteriophage 434 repressor, W34
Bacteriophage MS2, W2F, W16,
W16F, W70F
Bacteriophage P22, W25, W25F, W31
Bacteriophage 29, W29F, W29W30, W30F
Bacteriophage X174, W2F, W16
Bacteriophage SP6, W107
Bacteriophage T4, W2F, W31, W70F
Bacteriophage T7, W28F, W28W29
Bad, W151F, W152
Bak, W152, W154, W154F
Baker, T., W18, W29
Baltimore, D., W192
Banner, D., W150
Barbed end, of actin, W218
Barr bodies, W84F, W84W85
Basal body, flagella, W248
Basic helixloophelix (bHLH), W102
Basic region leucine zipper (bZIP) proteins,
W101W102
Bateson, W., W130
Bax, W151F, W152
bcd mutant (bicoid; Drosophila), W125F,
W126, W127F
B cells, see B lymphocytes
Bcl-2, W147, W151F, W151W152, W154
Bcl-2 family, W147, W151F, W151W152
Bcl-x
L
, W151, W151F, W152, W153F,
W154, W154F
BEAF-32 (boundary element-associated
factor of 32 kD), W110
Becker muscular dystrophy (BMD), W220
Benacerraf B., W200
Bence Jones, H., W184
Bence Jones proteins, W184
Bennett, C., W189
-Actinin, W219
Barrel, of icosahedral viruses, W10W11,
W15, W17, W18

2
-Microglobulin (
2
m), W199
Pleated sheets, of TBSV, W11
-Thymosin, W230
-Tubulin, W236W237
B gene, W23T
b gene, W23T
BH1, W151
BH2, W151
BH3, W151
BH3-only proteins, W152
BH4, W151
BHA, W44, W47, W48F
bHLH (basic helixloophelix), W102
bHLH/Z proteins, W102
bicaudal mutation, Drosophila embryo,
W124, W125F
bicoid mutant (bcd; Drosophila), W125F,
W126, W127F
Bicoid protein (Drosophila), W126, W126F
Bid, W152
Bik, W152
Bim, W152
BIR1, W154
BIR2, W154, W155F
BIR3, W154
Birds:
histone genes, W77
influenza viruses, W43, W44
mouse inducers activating genes of, W122
Bird flu, W44
BIR domains, W154
Birth, frog, W121F
Bisubstrate inhibitor, GCN5 and,
W113, W113F
Bithorax complex (BX-C; Drosophila),
W130, W130F
bithorax mutant (bx; Drosophila), W125F,
W126, W130
Black beetle virus, W16
Blastocoel, frog, W121F
Blastopore, frog, W121F
Blastula, W121, W121F
Blk, W152
Blood clotting, W165W179, W166
blood clots, W167F
clot lysis, W178W179
control of, W176W178
defined, W165W167
extrinsic pathway, W175W176
fibrinogen and fibrin conversion,
W167W170
human coagulation factors, W167T
in humans, W166F
intrinsic pathway, W176
thrombin activation and vitamin K,
W170W175
Bluetongue virus, W16W18, W17FW19F
B lymphocytes (B cells), W54F, W179,
W181, W194W196
BMD (Becker muscular dystrophy), W220
Bode, W., W148, W174, W177
Borrelia burgdorferi, evasion of
complement system by, W211
Botstein, D., W86
Boundary element-associated factor of 32
kD (BEAF-2), W110
boxA, W24, W26
boxB, W24, W25, W25F
Bradykinin, W176
Brain:
development in embryogenesis, W122
liver-specific genes not transcribed by
brain or kidney cells, W86
BRCA1, W134
BRCA2, W134
BRE (TFIIB recognition element), W91
Bre1, W117
Breast cancer, W134, W141
b region gene transcripts, W23
BRG1 (Brahma-related gene 1), W145
BRM (Brahma protein homolog), W145
Bromelain, W44
Bromodomains, W113W114
Brown, P., W86
BTV (bluetongue virus), W17FW19F,
W17W18
Bunick, G., W57
Buratowski, S., W93
Burkitts lymphoma, W134
Burley, S., W90W92, W102
Burnet, M., W179
Burtnick, L., W218
BX-C complex (Bithorax; Drosophila),
W130, W130F
bx mutation (Drosophila melanogaster),
W125F, W126, W130
bZIP (basic region leucine zipper) proteins,
W101W102
C
C. reinhardtii, microtubules, W246F
C
0
t curves, W69W70, W71F
C1, W206W208
cI gene, W23T, W33
C1INH (C1 inhibitor), W211
C1 inhibitor (C1INH), W211
cI repressor, W33
C1q, W206W208, W207F
C1r, W206W208
C1s, W206W208
C2, W208
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Index WI-3
C2b, W208
cII gene, W22, W23T
C3, W208, W209F, W210
C3a, W208
C3a receptor, W211
C3b, W208, W209F, W210, W211
C3 convertase, W208, W210, W211
C3dg, W210
cIII gene, W23, W23T
C4, W208
C4a, W208
C4b, W208, W211
C4b-binding protein, W211
C5, W208
C5a, W208
C5a receptor, W211
C5b, W208
C5 convertase, W208, W210
C6, W208
C7, W208
C8, W208
C9, W208, W209F
Ca
2
, see Calcium ion
CAD (caspase-activated DNase), W149
Caenorhabditis elegans:
apoptotic pathways, W145, W147, W147F
structural gene distribution, W75
CAF-1 (molecular chaperone), W60
CAK (Cdk-activating kinase), W136
Calcineurin (CaN), W152
Calcium ion (Ca
2
):
complex with actin and ATP, W218F
and prothrombin activation, W173F,
W173W174
in regulation of muscle contraction,
W224W225
release from sarcoplasmic reticulum,
W225W226
in smooth muscle contraction,
W227W228
and tropomyosin, W225F
Calico cats, W84W85, W85F
Calmodulin (CaM), myosin light chain and,
W215W216, W227
Calsequestrin, W226
cAMP response binding element protein
(CBP), W112
CaN (calcineurin), W152
Cancer, W121
and apoptosis, W146, W147
molecular basis, W134W135
and p53, W135
and viruses, W134W135
Cancer borealis, SSR, W72
Canine lymphoma, murine antibody against,
W186F
CAP (catabolite gene activator protein),
W59W60, W96
cap gene, W23T
Capping proteins, W232
Capsids, W1
BTV, W17
human rhinovirus, W14F
icosahedral viruses, W8W10
influenza virus, W41
PBCV-1, W19F, W20
picornaviruses, W14, W14F
poliovirus, W14F
SV40, W15W16
TBSV, W11F
CapZ, W219
Carba-NAD

, W115, W115F
Carcinoma, W134
CARD (caspase recruitment domain),
W148, W150, W150F, W152, W153F
Cardiac muscle, W226
Carsonella ruddii, mimivirus and, W1
Caspar, D., W9, W10, W15
Caspases, W147W149, W148F,
W154W155, W181
Caspase-1, W148
Caspase-3, W148, W149F, W151F
Caspase-6, W148
Caspase-7, W148, W148F
Caspase-8, W148, W149F, W151F
Caspase-9, W148, W151F, W152
Caspase-10, W148
CAT (chloramphenicol acetyltransferase),
W93
Catabolite repression system, E. coli, W33
Catharanthus roseus, W239
CBP (cAMP response binding element
protein), W112
CCAAT/enhancer binding protein
(C/EBP), W101
CD3, W202, W203F
CD4, T cell receptors and, W201W202,
W202F, W203F
CD4

T cells, W201
CD8, T cell receptors and, W201W202,
W202F, W203F
CD8

T cells, W201
CD95, W150
Cdc2 (cell division cycle 2), W136
Cdc25C, W136, W141
Cdc42, W232
Cdks (cyclin-dependent protein kinases),
W136W140
Cdk1 (cyclin-dependent protein kinase 1),
W136W137, W137F
Cdk2 (cyclin-dependent protein kinase 2),
W137F, W137W140
and cyclin A/p27
Kip1
, W139F
and pRb, W144
structure, W137W138, W138F
Cdk4 (cyclin-dependent protein kinase 4),
W137, W140, W144
Cdk6 (cyclin-dependent protein kinase 6),
W137, W140, W140F, W144
Cdk7, W136
Cdk inhibitors, W139W140
CDRs (complementarity-determining
regions), W185
C/EBP (CCAAT/enhancer binding
protein), W101
CED-3 protein, W147
CED-4 protein, W147
CED-9 protein, W147
ced gene, W147
Celiac disease, W204
Cell biology, W165
Cell cycle, regulation of, W135W145
Cell differentiation, W53
and developmental signals, W122W123
eukaryotes, W121W155
Cell division:
chromosomes in, W53
regulation, W135
Cell growth, eukaryotes, W122W155
Cell motility, W230, W230F
Cell proliferation, in organogenesis, W121
Cellular blastoderm, W123F, W124, W129
Cellular immunity, W179W181
CenH3, W55
CENP-A, W55
Centrioles, W239
Centromeres, W71W72, W84
Cetuximab (Erbitux), W185
c-FLIP (cellular FLICE inhibitory protein),
W150
c-fos protooncogene, W134
C gene, W23T
C
H
(constant region, heavy chain), W184
C
H
1, W184
C
H
2, W184
C
H
3, W184
Charifson, P., W148
CHD (chromodomain, helicase,
DNA binding), W118
Checkpoints, W136
Chickens:
DNase I cleavage of chromatin in, W106
embryo, W122
histone H1, W55
HS4 insulator, W117
myosin subfragment-1, W216F
nucleosome core particle, W57
presumptive thigh tissue bud,
W123, W123F
sex hormones in, W96
skeletal muscle troponin, W218F
vitellogenin production, W120
ChIP (chromatin immunoprecipitation),
W109W110
ChIP assay, W110
ChIP-seq, W110
Chk1, W140
Chk2, W140
chk2 gene, W141
Chloramphenicol acetyltransferase
(CAT), W93
Chlorovirus, W18
Cho, Y., W145
Choe, S., W231
Chorion proteins, W79
Christmas, S., W176
Christmas factor, W176
Chromatin, W59F, W84
calf thymus, W56F
in eukaryote chromosomes, W53W54
and modified histones, W111
nuclease digestion, W105W106
organization in 30-nm filaments,
W61FW62F, W61W62
organization in nucleosomes, W55W61
organization in radial loops, W63W66
role in cancer, W135
Chromatin immunoprecipitation (ChIP),
W109W110
Chromatin map, W112F
Chromatin-remodeling complexes,
W118W119, W119F
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WI-4 Index
Chromatin-unfolding domain
(CHUD), W107
Chromatosomes, W56
Chromodomains, W117
Chromomeres, W66
Chromosomal rearrangements,
cancer and, W134
Chromosomes:
double minute, W79
minichromosome, W15, W109,
W109F, W164
polytene, see Polytene chromosomes
structure of eukaryotic, W53W68
Chromosome puffs, W85, W85F
CHUD (chromatin-unfolding domain), W107
Churchill, M., W60
Chymotrypsin, W68, W166
Cilia, W245F, W245W248, W247F
c-Jun, W95F, W104, W134
CKIs (cyclin-dependent kinase inhibitors),
W139W140
C
L
(constant region, light chain), W184
Classes, immunoglobin, W182. See also
Isotypes, antibody
Class I core promoters, TBP and, W93
Class I MHC proteins, W179, W181,
W198W200, W199F
Class II core promoters, W88, W93W95
Class II MHC proteins, W179, W198,
W200F, W200W201
Class III core promoters, TBP and, W93
Classical pathway, of complement system,
W205, W205F, W206W210
Class switching, immunoglobin, W195F,
W195W196
Cleavage, W121
Cleavage furrow, W233
CLIP, W120F, W121
Clonal deletion, W182
Clonal selection, W179
Clore, M., W106
Clot lysis, W178W179
Clypeo-labrum, Drosophila embryo, W124F
c-myc proto-oncogene, W134
Coactivators, W96, W113W114
Coagulation, W166. See also Blood clotting
Coat proteins, W1
bacteriophage MS2, W16
human rhinovirus, W13F
SBMV, W13F, W14
TBSV, W10F, W10W11, W11F, W14
TMV, W3F, W3W6, W4F
Cohen, C., W224
Cohesin, W63W66, W65F
Colchicine, W239
Colchicum autumnale, W239
Coliphage, W20
Colman, P., W46W47
Color blindness, red-green, W164
Common cold, W1, W12
Complementarity-determining regions
(CDRs), W185
Complementation, in vitro, W27
Complement fixation, W205
Complement receptor-1 (CR1), W211
Complement receptor-2 (CR2), W211
Complement regulator-acquiring surface
protein (CRASP), W211
Complement system, W205W211
activation unit, W208
alternative pathway, W205, W205F,
W210W211
C3b as opsonin, W211
classical pathway, W205F, W205W210
evasion by pathogens, W211
function, W205W206
and humoral immune system, W181
MAC, W208W210
MB-lectin pathway, W205, W205F, W210
protein components, W26T
recognition unit, W206W208
regulation of, W211
Complexity, of DNA, W69W70
Conalbumin, hen egg, W203F
Condensin, W64, W65F
Connective tissue, W122
Constant region, heavy chain (C
H
), W184
Constant region, light chain (C
L
), W184
Constitutive chromatin, W84
Contact system, W176
Contractile ring, W233
Contraction:
smooth muscle, W227W228
striated muscle, W220W224
Conventional kinesin, W240
Conventional myosins, W223
Corces, V., W110
Coreceptors, W201W202, W202F, W203F
Corepressors, W96, W115
Core promoters, W88, W89F, W93
CoREST, W115
Cortex, Drosophila embryo, W124
Cortical cytoplasm, W124
cos gene, W23T, W26, W29, W30
Coumadin, see Warfarin
Covalent modification, of polypeptides, W120
Cow:
Arp2/3 complex, W232F
C
0
t curve of calf, W70F
calf thymus chromatin, W56F
calf thymus histones, W55F, W55T, W56F
histone H4, W54
prothrombin fragment 1, W173, W173F
CP1, W94
CpG islands, W74
C-protein, W220
CR1 (complement receptor-1), W211
CR2 (complement receptor-2), W211
Cramer, P., W91
CRASP (complement regulator-acquiring
surface protein), W211
CRDs (cysteine-rich domains), W150F
c-Rel, W103
Crick, F., W1
Critical concentration, W229
cRNAs, W42
Croce, C., W134
cro gene, W22, W23T, W24, W38
Crohns disease, W182, W185
Cro protein, W23, W33
Bacteriophage , W131
binding to o
R
, W38, W38F
structure, W34, W35F
Crossbridges, striated muscle, W212
CRSP, W105
Cryptic splice sites, W83
C

segment, W189
CTCF, W111
C value, W68
C-value paradox, W68F, W68W70, W74
cya gene, W23T
Cyclins, W136
Cyclin A, W137F, W137W140,
W139F, W144
Cyclin B, W136, W137, W137F
Cyclin box, W136
Cyclin D1, W137
Cyclin D2, W137
Cyclin D3, W137
Cyclin D group, W137, W137F
Cyclin E, W137, W137F, W144
Cyclin H, W136
Cysteine proteases, W147
Cysteine-rich domains (CRDs), W150F
Cystic acne, W133
Cytochalasin B, W230
Cytochrome c, apoptosis and, W152, W154
Cytokines, W103, W179
Cytokinesis, W230
Cytoplasm, W53
Cytoplasmic dyneins, W242
Cytotoxic T (T
C
) cells, W179, W181
D
DAF (decay-accelerating factor), W211
Darnell, J., W86
Davies, D., W186
DD (death domain), W150, W150F
Death ligands, W150
Death receptors, W150
Debiquitinating enzymes (DUBs), W118
Decay-accelerating factor (DAF), W211
DEDs (death effector domains), W148,
W150, W150F
Degradation signals, protein, W134
Delayed early transcription phase (lytic
mode), W23
-Tubulin, W239
Demethylation, of histones, W117
Dendritic cells, W179
Desmin, W219
Development, W53
embryological, W121W123
genes and patterns in Drosophila,
W124W126
molecular basis in Drosophila, W123F,
W123W134
Developmental signals:
in combination, W123
role in cell differentiation, W122
D gene, W23T
DHFR gene, mouse, W94F
DHS (DNase I hypersensitive site), W109,
W109F, W110, W112F
D
H
(diversity) segment, W191
DIABLO, W155
Diarrhea, W16
dicephalic mutation, Drosophila
embryo, W124
Dicoumarol, W171, W171F, W173
Dictyostelium, W233F
Dictyostelium discoideum, dynein heavy
chain, W247F
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Index WI-5
Dif, W103
2,4-Dinitrophenyl (DNP) group, W185
Diptheria toxin, W153F
DISC (death-inducing signal complex),
W149F, W150
Diversity (D
H
) segment, W191
DMD (Duchenne muscular dystrophy), W220
DMS (dimethyl sulfate) footprinting, W94
DNA. See also related topics, e.g.: DNA
replication
complexity, W69W70
degradation by caspases, W149
in eukaryote chromosomes, W53
homeodomain binding, W130W132
insertion by bacteriophage , W20
organization in metaphase
chromosome, W64F
p53 binding, W142
in phage head of bacteriophage ,
W28W30
repetitive sequences, W70W74
transcription factor binding,
W90W91, W91F
unexpressed, W69, W74
dnaA gene, W23T
DnaA protein, in replication, W26
dnaB gene, W23T
DnaB protein, in replication, W26
DNA chips, W86
DnaC protein, in replication, W26
DNA-dependent protein kinase
(DNA-PK), W193
DNA gyrase, in replication, W20
DNA ligase, in replication, W20
DNA looping, W38
DNA microarrays, W86
DNA-PK (DNA-dependent protein kinase),
W193
DNA replication:
bacteriophage , W26, W26F
nucleosome transfer, W60
viruses, W1, W3
DNase I, cleavage of chromatin with, W106
DNase I footprinting, W94
DNase I hypersensitive sites (DHS), W109,
W109F, W110, W112F
DNA transposons, W73, W73T
DNA viruses, W1, W3. See also specific
viruses
DNP (2,4-dinitrophenyl) group, W185
Doolittle, R., W167
Dorsal, W103
Dorsal ectoderm, amphibian embryo,
W122, W122F
Dorsal position, of Drosophila embryo,
W123F
Dosage compensation, W84
Double minute chromosomes, W79
Downing, K., W236
Downstream core promoter element
(DPE), W93
DP-1, W144
DP-2, W144
DPE (downstream core promoter element),
W93
DP (E2F dimerization partner)
family, W144
Dreyer, W., W189
Drosophila melanogaster:
chromatin electron micrograph, W55F
chromosome puffs, W85F
gene amplification, W79, W79F
haploid genome size, W69
histone genes, W77, W77F
histone ubiquitination, W118
HMG-D, W106
homeodomains of five genes, W131F
insulators, W110W111
linker DNA, W57
molecular basis of development in,
W123F, W123W134
morphogen proteins, W103
polytene chromosomes, W66F, W66W67,
W67F, W110, W111F
structural gene distribution, W75
TBP, W89
TFIID, W92
zinc fingers, W97
Drosophila virilis, satellite bands,
W72, W72F
Drug resistance, W79
dsDNA:
histone affinity and sequence of, W61
packing inside phage head, W28F,
W28W30
phages, W31
dsRNA-dependent RNA capping enzyme
[VP4(Cap)], W16
dsRNA-dependent RNA helicase
[VP6(Hel)], W16
dsRNA-dependent RNA polymerase
[VP1(Pol)], W16
dTAF6, W92, W92F
dTAF9, W92, W92F
dTAF
II
20, W92
dTAF
II
42, W92
dTAF
II
60, W92
dTAF
II
135, W92
D-type cyclins, W140, W144
DUBs (deubiquitinating enzymes), W118
Duchenne muscular dystrophy (DMD), W220
Dynamic instability, W238W239
Dyneins, W242W248
in ciliary motion, W246W247
conformational changes, W248F
heavy chain head, W247F
mechanism, W247W248
structure, W244F
in vesicle transport, W243W245
Dystrophin, W220
E
E. coli:
adsorption of bacteriophage , W20
and bacteriophage P22, W25W26
C
0
t curve, W70F
catabolite repression system, W33
DNA complexity, W69
flagellar rotation, W251
gene expression control, W83
haploid genome size, W69
K12 strain, W20
transcriptional initiation regulation,
W86, W88
trp repressor, W130
E1A, W135
E1B protein, W141
E2F, W135, W144, W145, W145F
E2F-1, W144
E2F-2, W144
E2F-3, W144
E2F-4, W144
E2F dimerization partner (DP)
family, W144
E2F family, W144, W145
E2 gene, W135, W144, W145
E2 promoter, W135, W145
E4, W145
E4 gene, W135, W144
E4 protein, W135
E6 protein, W141
E7, W145
Early transcription phase (lytic mode),
W22W23
Ebashi, S., W224
Ecdysone, W96
Ectoderm, frog, W121F, W122, W122F
Edelman, G., W182
Edgar, R., W27
Edmondson, A., W186
Effector caspases, W148W149
E gene, W23T
EGFR (epidermal growth factor receptor)
cancer treatment and, W185
Egg, directionality of Drosophila, W126
EGL-1, W147, W152
Elastase, blood clotting proteases and, W166
ELC (essential light chains), W213W216
Electrostatic forces, TMV assembly
and, W8
Elephant Man, W135
Embryogenesis, W53, W121F
Embryological development, W121F,
W121W123
-END (-endorphin), W120F, W121
Endoderm, frog, W121F
Endogenous retroviruses (ERVs),
W73, W73T
Endothelial cell protein C receptor
(EPCR), W177
Endotoxins, W207
engrailed mutant (en; Drosophila), W126,
W129, W129F, W131F, W131W132
Enhanceosome, W96, W104, W104F
en mutant (engrailed; Drosophila), W126,
W129, W129F, W131F, W131W132
Envelope, viruses, W1
Enveloped virus, W40
Envelope glycoprotein 120 (gp 120), W203F
EPCR (endothelial cell protein C receptor),
W177
Epidermal growth factor receptor (EGFR),
cancer treatment and, W185
Epidermis, development in
embryogenesis, W122
Epitopes, W188
ER (estrogen receptor), W99
Erbitux (cetuximab), W185
ERE (estrogen response element), W99
ERV-class I, W73T
ERV(K)-class II, W73T
ERV(L)-class III, W73T
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WI-6 Index
ERVs (endogenous retroviruses),
W73, W73T
Erythropoiesis, W80F
Essential light chains (ELC), W213W216
-Estradiol, W96
Estrogens, W96
and nuclear receptor superfamily, W97
and vitellogenin, W120
Estrogen receptor (ER), W99
Estrogen response element (ERE), W99
ESTs (expressed sequence tags), W74
Etf (extracellular fibrinogen-binding
protein), W211
Euchromatin, W53, W84, W105
Eukaryotes, W53
activation domains of transcription
factors, W95W96
DNA-binding motifs of transcription
factors, W97
flagella and cilia, W245W248
inducible transcription factors, W96W97
molecular genetic analyses of single-
celled, W84
Eukaryotic flagella, W245W248
Eukaryotic gene expression:
cell differentiation and growth,
W121W155
chromosome structure, W53W68
control, W83W121
genomic organization, W68W83
Eukaryotic molecular biology, W53
eve gene (even-skipped; Drosophila),
W127F, W127W128, W128F
even-skipped gene (eve; Drosophila),
W127F, W127W128, W128F
Eve protein, W129, W129F
Evolutionary stability, of histones, W54
Excisionase, W32
Exons, W74, W80
Expressed sequence tags (ESTs), W74
Extracellular fibrinogen-binding protein
(Etf), W211
Extrinsic pathway:
apoptosis, W149F, W149W150
blood clotting, W175W176
Eye:
Drosophila embryo, W124, W124F
ectopic formation in Drosophila,
W132W133
Eye lens, development, W122
eyeless gene (ey; Drosophila),
W132W133, W133F
F
FI gene, W23T
FII gene, W23T
Fab fragments, W184, W188F, W188W189,
W189F
FACT, W108W109
F-actin, W216F, W216W217, W232F
in microfilament formation, W228W229
in myofibril assembly, W219W220
structure, W218, W219F
Factor I, see Fibrinogen
Factor II, see Prothrombin
Factor III (TF; tissue factor), W175W176
Factor VII (proconvertin), W175, W176
Factor VIII
a
(antihemophilic factor), W176
Factor X
a
(Stuart factor), W171,
W173, W176
Factor XII
a
(Hageman factor), W175,
W176, W178
Factor XIII
a
(fibrin-stabilizing factor),
W169W170, W170F
Factor B, W210
Factor D, W210
Factor H, W210
Factor I, W210
Factor P (properdin), W210
Facultative chromatin, W84
FADD (Fas-associating death domain-
containing protein), W149F, W150
FADD-like ICE (FLICE), W150
Fas, W149F, W149W150
Fas-associating death domain-containing
protein (FADD), W149F, W150
Fas ligand (FasL), W149F,
W149W150, W181
Fc fragment, antibody, W184
Fc receptors, W184
Feigon, J., W106
Felsenfeld, G., W107
Female mammalian cells, W84, W84F
Fertilized ovum, W68, W121
Fesik, S., W154
Fibrin:
aggregation, W168W169
and clot lysis, W178
cross-linking of, W169W170
protofibril, W168F
Fibrinogen (factor I), W167W170
charge distribution, W169F
concentration, W176
cross-linking of, W170F
human, W167F
structure, W167W169, W168F
Fibrinolysis, W178
Fibrinopeptides, W167
Fibrin-stabilizing factor (FSF), W169W170
Fibronectin, W220
FISH (fluorescence in situ hybridization),
W67F, W67W68
Fis protein, W32
Flagella:
bacterial, W248W251
eukaryotic cilia and, W245W248
Flagellar filament, W248W250
Flagellar hook, W248
Flagellin, W248, W249
Fletterick, R., W218, W232
FlgE (hook protein), W248
FliC, W248
FLICE (FADD-like ICE), W150
FliD, W248
FliF, W251
FliG, W251
Fluorescence in situ hybridization (FISH),
W67F, W67W68
Fluorophores, W67
FMDV (foot-and-mouth disease virus), W14
Foldback structures, W71, W71F
Foot-and-mouth disease, W12
Formaldehyde, in chromatin
immunoprecipitation, W110
Fos, W134
14-3-3, W141
14-3-3 family, W141
Frog, embryogenesis, W121F
FSF (fibrin-stabilizing factor),
W169W170
ftz mutant (fushi tarazu; Drosophila),
W125F, W126, W127F, W128,
W130, W131F
Ftz protein, W129, W129F
Fuller, B., W10
Functional domains, W106
fushi tarazu mutant (ftz; Drosophila),
W125F, W126, W127F, W128,
W130, W131F
Fusion peptide, W47
Fv fragments, W184
Fyn, W194
G
G
1
phase:
and pRB, W144W145
regulation, W135, W136
G
2
phase:
checkpoints, W140F, W140W141
and p53, W141W142
regulation, W135, W136
G-actin, W216, W218, W228W229
GAL4, W99W101, W100F
-Galactosidase, W36
Gall, J., W66
Gamblin, M., W145
Gamblin, S., W116
Gametogenesis, frog, W121F
-Carboxyglutamate, see Gla
gene, W23T
Gamma globulin, W257
-LPH, W120F, W121
Protein, W26
-tubulin, W238W239
Gap genes, W126W127
Garden peas, histones, W54
Gastroenteritis, W16
Gastrula, W121, W121F
Gastrulation, W121, W124
GATA-1, W83, W94W95
GC boxes, promoters and, W94F
GCN4, W101F, W101W102, W102F
Gcn5, W112W114, W113F
Gcn5L, W112
Gehring, W., W128, W130, W132
Gelsolin, W232
Genes:
alterations as basis for malignancy,
W134W135
distribution of eukaryotic, W74W76
and Drosophila development,
W124W130
sequences of developmental, W130
Gene amplification, W78W79, W134
Gene clusters, tandem, W76W78
Gene conversion, W78, W78F
Gene families, clustered, W79W82
General transcription factors (GTFs),
W88, W88T
Gene superfamily, W196F, W199
Genitalia, Drosophila embryo, W124F
Genome, organization of eukaryotic,
W63W83
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Index WI-7
Genome size, C-value paradox and,
W68F, W69T
Genomics, W76
Genomic organization:
C-value paradox, W68W70
eukaryotic, W63W83
repetitive sequences, W70W74
Geodesic domes, W9W10, W10F
Germ cells, W121F, W124
Germline hypothesis, W189
Germ plasm, frog, W121F
G gene, W23T, W31
GH5, W59F, W59W60
Ghosh, G., W103, W104
giant gene Drosophila, W126, W127F, W128
Gla (-carboxyglutamate), W171W173,
W172F
Gla domain, W171, W172F
Globin family:
gene cluster, W80, W80F
locus control regions, W109, W109F
-Globin gene cluster, W80
-Globin gene cluster, W80, W94, W109,
W109F, W110
Glucocorticoids, W96, W97
Glucocorticoid response elements
(GREs), W96
Glycoproteins:
HA, W44W45
NA, W46W47
Glycoprotein Ib (GPIb), W165
GNAT family, W112
Goblet cells, W245F
Goldman, Y., W234
Gonad, frog, W121F
Goodwin, H.M., W106
gp 120 (envelope glycoprotein 120), W203F
gpA protein, W26
gpB protein, W27, W28
gpB* protein, W28
gpcIII protein, W33
gpcII protein, W33W34
gpC protein, W27
gpcro protein, W23
gpD protein, W27, W28
gpE protein, W27, W28
gpFI protein, W30
gpFII protein, W27, W28
gpG protein, W27
gphflA protein, W33
gphflB protein, W33
gpH protein, W27, W31
GPIb (Glycoprotein Ib), W165
gpI protein, W31
gpJ protein, W27, W31
gpK protein, W31
gpL protein, W27
gpM protein, W27
gpN protein, W23W25, W25F
gpNu1 protein, W26
gpNu3 protein, W27, W28
gpO protein, W23, W26
gpP protein, W23, W26
gpQ protein, W23, W24, W26
gpR protein, W23
gpR
z
protein, W23
gpS protein, W23W24
gpU protein, W27, W31
gpV protein, W27, W31
gpW protein, W27, W28
gpZ protein, W27, W31
GR (glucocorticoid receptor),
W98W99, W99F
Graft rejection, W198
Gram-negative bacteria, flagella, W249F
Granzyme A, W181
Granzyme B, W147W148, W181
GREs (glucocorticoid response elements),
W96, W98W99
Griscelli syndrome, W234
GroEL, in replication, W27W28
groEL gene, W23T
GroES, in replication, W27W28
groES gene, W23T
Gronenborn, A., W106
Gros, P., W208
Growth:
embryo, W121
frog, W121F
in TMV assembly, W6
GTFs (general transcription factors),
W88, W88T
GTP:
microtubules and hydrolysis of, W238
tubulin binding of, W236W237
gyrA gene, W23T
gyrB gene, W23T
H
H, see Immunoglobin heavy chains
H1N1 influenza virus, W43W44, W198F
H-2 loci, W198
H2N2 influenza virus, W43W44
H3N2 influenza virus, W43
H5N1 influenza virus, W44
HA (hemagglutinin), W40
and antigenic variation, W42W43
structure, W44F, W44W45, W45F
HA1, W44
HA2, W44
Hageman factor (XII
a
), W175, W176, W178
hairy gene (Drosophila), W127
Haltere, Drosophila embryo, W124F
Hanson, J., W221
Haploid genome sizes, W68, W68F
Haptens, W185
Harrison, S., W10, W15, W100, W101, W104
Hartwell, L., W136
HATs (histone acetyltransferases),
W112W113, W117
Hat1, W112
Hatching (birth), frog, W121F
HAT complexes, W112, W113
HAT group, W73T
HAT medium, W186F
HbA, W79W80
HbA
2
, W80
Hb anti-Lepore, W83
Hb Barts, W82
Hb Constant Spring, W82
Hb Gower 1, W79, W80
Hb Gower 2, W80
HbH, W82
Hb Kenya, W164
Hb Lepore, W83
hb mutant (hunchback; Drosophila),
W126, W127F
Hb Portland, W80
Hb Quong Sze, W82
HCC (hepatocellular carcinoma),
W86, W87F
HDAC1, W115, W145
HDAC2, W115, W145
HDAC3, W115
HDAC4, W115
HDAC5, W115
HDAC6, W115
HDAC7, W115
HDAC8, W115
HDAC9, W115
HDAC10, W115
HDAC11, W115
HDACs (histone deacetylases), W115, W145
Head-tail connector, W27W29, W29F
Heart, cardiac muscle, W226
Heart attacks:
and blood clotting, W175W176
and streptokinase, W178
Heavy chains:
dynein, W247F, W247W248
immunoglobin, see Immunoglobin heavy
chains (H)
myosin, W213
Heavy meromyosin (HMM), W214W215
Helical viruses, W1
Helixturnhelix (HTH) motif:
homeodomain, W130W132
transcription factors, W97
Helper T (T
H
) cells, W179
Hemagglutinin, see HA
Hemoglobin:
diseases of hemoglobin synthesis,
W82W83
gene organization, W79W82, W81F
Hemoglobin H disease, W82
Hemophilia A, W176
Hemophilia B, W176
Hemostasis, W165
Hen egg white lysozyme (HEW),
monoclonal antibodies against,
W188, W188F
Hens tooth, W122, W122F
Heparin, W177
Hepatitis A, W12
Hepatocellular carcinoma (HCC),
W86, W87F
Hereditary persistence of fetal hemoglobin
(HPFH), W82, W95
Heterochromatin, W53W54, W84, W106,
W110
Heterochromatin protein 1 (HP1),
W117, W117F
Heterogeneous nuclear ribonucleoprotein
K (hnRNP-K), W142
HEW (hen egg white lysozyme),
monoclonal antibodies against,
W188, W188F
hflA gene, W23T
hflB gene, W23T
H gene, W23T, W31
Highly repetitive DNA, W70W72
Highly repetitive sequences, W70
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WI-8 Index
High mobility group (HMG), W106W107
High molecular weight kininogen
(HMK), W176
himA gene, W23T
himD gene, W23T
Hinge region, immunoglobin, W184
Hippocrates, W40
HIRA (molecular chaperone), W60
Hirudin, W177W178, W178F
Hirudo medicinalis, clot prevention
by, W177
Hispanic deletion, in -globin cluster, W109
Histones, W54W55
acetylation, W111W114
calf thymus, W55F, W55T, W56F
methylation and demethylation,
W116W117
modifications of, W54W55, W111F,
W111W112
reiterated genes of, W77W78
ubiquitination, W117W118
Histone acetyltransferases (HATs),
W112W113, W117
Histone arginine demethylases, W117
Histone code, W113
Histone deacetylases (HDACs),
W115, W145
Histone-depleted metaphase chromosomes,
W63
Histone fold, W57
Histone H1, W54W56, W58F, W58W59
Histone H1, W59
Histone H2A, W54, W55, W58
Histone H2A.X, W55
Histone H2A.Z, W55
Histone H2B, W54, W55, W58, W117W118
Histone H3, W54, W55, W58
association with H4, W56F
association with H4 and Asf1, W60F,
W60W61
methylation, W116, W117
modification, W113
and X-chromosome inactivation, W85
Histone H4, W54, W55, W58
association with H3, W56F
association with H3 and Asf1, W60F,
W60W61
methylation, W116
modification, W113
Histone H5, W55, W59W60
Histone lysine demethylases, W117
Histone methyltransferase (HMTs),
W116W117
Histone octamer, W56W58, W57F, W61
HIV (human immunodeficiency virus),
W181, W211
HLA-A, W197
HLA-B, W197
HLA-C, W197
HLA-DR1 protein, W200F, W200W201
HMG (high mobility group), W106W107
HMG-14, W107
HMG-17, W107
HMG1, W106
HMG2, W106
HMGA, W106W107
HMGA1a, W106, W107F
HMGA1b, W106
HMGA1c, W106
HMGA2, W106
HMGB, W106
HMGB1, W106
HMGB2, W106
HMG boxes, W106
HMG-C, W106
HMG-D, W106
HMG-I, W106
HMGN, W106, W107
HMGN1, W107
HMGN2, W107
HMG proteins, W106W107
HMK (high molecular weight kininogen),
W176
HMM (heavy meromyosin), W214W215
HMTs (histone methyltransferases),
W116W117
Hogle, J., W12
Holden, H., W215, W222
Holmes, K., W4
Homeobox, W130
Homeodomain, W130W132
Homeotic selector genes, W126,
W129W130
Homology units, antibody, W186W187
Hong Kong flu of 1968, W40, W44,
W44F, W45
Hood, L., W189
Hook protein (FlgE), W248
Hormones, smooth muscle and, W228
Hormone response elements (HREs),
W96, W99
Horvitz, R., W147
Host range, viruses, W1
Houdusse, A., W224
Hox-1.1 gene, W132
Hox-3.1 gene, W132, W133F
Hox genes, W132W133
HP1 (heterochromatin protein 1),
W117, W117F
HPFH (hereditary persistence of fetal
hemoglobin), W82, W95
HREs (hormone response elements),
W96, W99
HS4 (hypersensitive site 4), W110, W117
hsp70 gene, W110
Hst2, W115, W115F
hTAF4, W92, W92F
hTAF12, W92, W92F
HTH motif, see Helix-turn-helix motif
Huber, R., W174, W177, W186
Humans:
alternative splicing, W119
Aniridia gene, W132
apoptosome, W153F
blood clotting cascade, W166F
blood coagulation factors, W167T
C3 and C3b, W209F
Cdk2, W138F
chromosomal organization, W67F
cilia of bronchial tube, W245F
Class II MHC protein, W200F
complement system proteins, W26T
fibrinogen, W167F
genealogy inferred from DNA polymor-
phisms, W81F, W81W82
gene identification, W74W76
Gla domain, W172F
globin gene cluster, W80, W80F
GTF properties compared to yeast, W88T
haploid genome size, W69
heavy chain genes, W192F
histone-depleted metaphase
chromosome, W63F
HLA-B protein, W198F
influenza viruses, W40, W43W44
Light chain genes, W190F
heavy chain genes, W192
light chain genes, W191
metaphase chromosome, W64F
MHC genetic map, W197F
moderately repetitive sequences,
W73, W73T
prothrombin, W171, W171F
SET7/9, W116, W116F
SIRT2, W115
skeletal muscle organization, W212F
TAF1 bromodomain, W114F
TBP, W89
TFIID, W92W93
thrombin, W174F, W178F
transcription factor binding, W90W91
yeast Mediator vs., W105, W105F
Human genome, W74W76
CTCF-binding sites, W111
STRs in, W72
structural gene distribution, W75, W75F
variants for transcriptional factors, W93
Human immunodeficiency virus (HIV),
W181, W211
Human rhinovirus, W13F, W14, W14F
Humoral immunity, W179, W181W182
hunchback mutant (hb; Drosophila),
W126, W127F
Hunchback protein (Drosophila),
W126W127, W127F
Hunt, T., W136
Huntingtons disease, apoptosis and, W147
hus1 gene, W140
Huxley, A., W221
Huxley, H., W221
Hybridoma, W185
Hydrops fetalis, W82
Hydroxyapatite chromatography, for C
0
t
curve analysis, W70
Hypernatremia, W177
Hypersensitive site 4 (HS4), W110
Hypervariable sequences, W185, W185F
Hyponatremia, W177
H zone, muscle, W212
I
IAPs (inhibitors of apoptosis), W154W155
I bands, muscle, W212
IB kinase (IKK), W103
IBs (inhibitor-Bs), W103W104
iC3b, W210
ICAD (inhibitor of CAD), W149
ICE (interleukin-1-converting enzyme),
W148
Icosadeltahedron, W9F, W9W10
Icosahedral viruses, W1, W3, W8W20
architecture, W8W10
bacteriophage MS2, W16
JWCL281_ndx_WI1-WI17.qxd 5/5/11 10:48 AM Page WI-8
Index WI-9
bluetongue virus, W16W18
PBCV-1, W18W20
picornaviruses, W12W14
SV40, W15W16
TBSV, W10W12
Icosahedron, W9, W9F
IgA, W182, W183, W183F, W184
Ig, W194
Ig, W194
IgD, W182W184
IgE, W182W184
I gene, W23T, W31
IgG, W182, W183, W183F
constant and variable regions of,
W184W185
functional segments, W184
structure, W186W187
IgM, W182W184, W183F, W194
IHF (integration host factor), in
replication, W29, W32, W32F
IKK (IkB kinase), W103
Imaginal disks, Drosophila embryo,
W124, W124F
Imago, Drosophila embryo, W124
Immature larval stages, frog, W121F
Immotile cilia syndrome, W248
Immune lysogens, W20
Immune response (Ir) genes, W200
Immune system, W179
apoptotic pathways, W146
cellular, W179W181
humoral, W181W182
innate and adaptive, W179
self-tolerance of, W182
Immunity, W179W211
adaptive immune response, W179W182
antibody diversity, W189W196
antibody structures, W182W189
complement system, W205W211
MHC, W197W205
T cell receptors, W196W197
Immunoglobins, W179. See also Antibodies
gene superfamily, W196F
isotype switching, W195F, W195W196
Immunoglobin fold, W186W187
Immunoglobin heavy chains (H):
genes, W191W192, W192F
and immunoglobin isotypes, W182
polyadenylation site, W194W195, W195F
structure, W184W185
Immunoglobin light chains (L):
and immunoglobin isotypes, W182
light chain genes, W189W190
light chain genes, W191
myeloma protein, W187F
structure, W184W185
Immunoprecipitation, chromatin,
W109W110
Immunoproteasomes, W179
Immunoreceptor tyrosine-based activation
motif (ITAM), W194
Immunosuppressants, W181
Inducible transcription factors, W88,
W96W97
Induction, W20
Infectious diseases, mortality of, W204
Infectious rhinitis, W12
Infliximab (Remicade), W185
Influenza, W40
Influenza A viruses, W43W44
Influenza B viruses, W43
Influenza C viruses, W43
Influenza hemagglutinin, W189F
Influenza virus, W2F, W3, W40W48
antigenic variation mechanism, W43W47
budding of, W40F, W42F
genome, W41T
life cycle, W41W43
membrane fusion mechanism, W47W48
nucleocapsids, W43F
RNA synthesis, W41F
structure, W40F, W40W41
Inhibitor-B (IB), W103
Inhibitor-Bs (IBs), W103W104
Initiation, translational initiation
rates, W120
Initiation complex, TMV RNA, W7,
W7F, W8
Initiation sites, alternative, W119, W120F
Initiator caspases, W148
Initiator (Inr) element, W93
INK4 family, W139W140
Innate immune system, W179
Inner dynein arm, W246
INO80 (inositol-requiring protein 80), W118
Inr (initiator) element, W93
In silico gene identification, eukaryotes, W83
In situ hybridization, W66, W67F
Insulators, W110W111
Insulin, W68
Insulin-dependent diabetes mellitus, W146,
W182, W204
Integration host factor (IHF), in
replication, W29, W32, W32F
Integrin
IIb

3
, W165
Intercellular interactions, W122
Interferon enhancer, W104, W104F, W107
Interferon response factors, W104
Interleukin-1, W179, W181
Interleukin-1, W148
Interleukin-2, W181
Interleukin-2 receptor, W181
Intermediate filaments, W236
Interphase, chromosomes in, W53,
W66W68
int gene, W23, W23T, W32
Intragenic sequences, W74
Intrinsic pathway:
apoptosis, W149W152, W151F
blood clotting, W175, W176
Introns, W74, W80
Inverted repeats, W70, W71
In vitro complementation, W27
IPTG (isopropylthiogalactoside),
bacteriophage and, W36
IQ motif, myosin, W216
IRF-3, W104
IRF-7, W104
Ir (immune response) genes, W200
Isopropylthiogalactoside (IPTG),
bacteriophage and, W36
Isotypes, antibody, W182F, W182W184
Isotype switching, immunoglobin, W195F,
W195W196
ISWI (imitation switch) complexes, W118
ITAM (immunoreceptor tyrosine-based
activation motif), W194
Iwanowsky, D., W3
IXCXE sequence motif, W145
J
J (joining chain), W183
Jerne, N. K., W179
J gene, W23T
JHDM (jumonji histone demethylase)
family, W117
J
H
segment, W191
Joining chain (J), W183
Joining (J

) segment, W189
J

(joining) segment, W189W191,


W190F, W191F
Jumonji histone demethylase (JHDM)
family, W117
Junk DNA, W74
K
K12 strain, E. coli, W20
Kabat, E., W185
Kallikrein, W176
Kaposis sarcoma-associated herpes
virus, W139
Light chain genes, W189W190, W190F
Kawaoka, Y., W42
K-cyclin, W139, W140, W140F
Kerr, J., W145
K gene, W23T, W31
Kidney, liver-specific genes not transcribed
in, W86
Kim, P., W47, W101
Kim, S.-H., W138
Kinesins, W240W245, W243F
Kinesin-1, W240F, W240W242, W241F
Kinesin-14, W242
Kip/Cip family, W139
Kleinsin, W64, W65F
Klug, A., W5, W9, W10, W58, W97
knirps mutant (Drosophila), W126,
W127, W127F
Knirps protein (Drosophila), W127
Knudsen, A., W135
Khler, G., W185
Kornberg, R., W55, W56, W90, W91, W105
Kornberg, T., W129, W131
Kossel, A., W54
Kringles, of prothrombin, W171
Krppel mutant (Drosophila), W126,
W127, W127F
Krppel protein (Drosophila), W127
Ku protein, W193
L
L, see Immunoglobin light chains
L. pictus, histone genes, W77F
Labia, Drosophila embryo, W124F
Labial (Lb) segment, Drosophila
embryo, W124
lacI gene, W36
lac operators, W88
lac repressor, W36, W39F
lacZ gene, W36, W128, W128F
5 protein, W194
integrase, W32
int gene, W32
JWCL281_ndx_WI1-WI17.qxd 5/5/11 10:48 AM Page WI-9
WI-10 Index
Light chain genes, W191, W191F
repressor:
binding of o
R
, W36F
and phage life cycle, W33W34
and p
RM
, W36F, W37F
and RNA polymerase, W37F
and SOS response, W38
structure, W34, W35F
synthesis, W36W37
and upstream transcription factors, W95
Switch, bacteriophage , W34W39, W39F
cooperative interactions in, W38
Cro protein binding, W38
repressor and Cro protein structure,
W34W35
repressor synthesis, W36W37
o
R
gene, W34
SOS response, W38
xis gene, W32
lamB gene, W20, W23T
Lamellipoda, W233F
Lamins, W149, W181
Lampbrush chromosomes, W86, W86F
Lamprey, fibrogen, W170F
Large intergenic noncoding RNA
(lincRNA), W141
Large T antigen, W141
Larva:
Drosophila embryo, W124
immature larval stage frog, W121F
Laskey, R., W60
Late transcription phase (lytic mode),
W23W24
Laue, E., W117
Laver, G., W47
Lb segment, Drosophila embryo (labial),
W124
Lck, W202W204, W203F
LCR (locus control region), W109, W110
Leader (L

) segment, W189
Leder, P., W189
Lederberg, E., W20
Lederberg, J., W179
Leg, Drosophila embryo, W124, W124F
Leghemoglobin, W80
Leucine zipper, W100W101, W101F
Leukocytes, W179
Lewis, E. B., W130
Lewis, M., W34
L gene, W23T, W31
Liddington, R., W154
Lifeboat response, bacteriophage , W21
Li-Fraumeni syndrome, W141
lig gene, W23T
Light chains:
immunoglobin, see Immunoglobin light
chains (L)
myosin, W213, W224
Light meromyosin (LMM), W214
Liljas, L., W16
LIM kinase, W231
lincRNA (large intergenic noncoding
RNA), W141W142
lincRNA-p21, W141W142
LINEs (long interspersed nuclear
elements), W73, W73T
LINE-1 (L1), W73, W73T
LINE-2 (L2), W73, W73T
LINE-3 (L3), W73, W73T
Linker DNA, W57
Linker histones, W59
Liver, genes not transcribed by brain or
kidney cells, W86
LMM (light meromyosin), W214
Local symmetry, of icosadeltahedron,
W9W10
Lockwashers, W3
Locus control region (LCR), W109, W110
Long interspersed nuclear elements
(LINEs), W73, W73T
-LPH, W120, W120F
LSD1 (lysine-specific demethylase 1), W117
L

(leader) segment, W189


LTR retrotransposons, W73, W73T
Luger, K., W57
LXCXE sequence motif, W144W145
Lymphocytes, W179
Lymphoid tissue, W179
Lyn, W194
Lysine-specific demethylase 1
(LSD1), W117
Lysis, blood clot, W178W179
Lysogens, W20
Lysogenic mode, bacteriophage , W21F
Cro protein and cI repressor, W33
DNA integration and excision,
W32, W32F
gpcII in, W33W34
in phage life cycle, W20W21
Lysogeny, W20W21, W31
Lytic mode, bacteriophage ,
W20W26, W21F
antitermination, W24W26
DNA replication, W26, W26F
gene expression, W24F
in phage life cycle, W20W21
phases, W22W24
M
M1 (matrix protein 1), W40W41
M2 (matrix protein 2), W40, W41
MAC (membrane attack complex), W206,
W208W210
McKnight, S., W101
McPherson, A., W12
MacroH2A1, W85
Macrophages, W147, W179
Major histocompatibility complex (MHC),
W179, W197W205
class II MHC proteins, W200W201
class I MHC proteins, W198W200
and fatality of infectious diseases, W204
genetic map, W197F
polymorphism, W197W198, W204
and T cell receptors, W201F, W201W204
and tissue/organ transplant rejection,
W204W205
Makowski, L., W169
Malaria:
and MHC polymorphism, W204
thalassemia and resistance to, W82
Male mammalian cells, W84, W84F
Malignancy, W134W135
MaLR, W73T
Maltoporin, W20
Mammals. See also specific species
apoptotic pathways, W145W146
evolution, W122
female and male cells, W84, W84F
globin gene cluster, W80
histone genes, W77
HMG proteins, W107
influenza viruses, W43
Mandelkow, E., W240
Mandelkow, E.-M., W240
Mandibulary (Md) segment, Drosophila
embryo, W124
Maniatis, T., W104
Mannose-binding lectin, see MB-lectin
pathway, of complement system
Mannose-binding lectin (MBL), W210
MAPs (microtubule-associated proteins),
W238
MAP (mitogen activated protein) kinase,
W144, W152
Marmorstein, R., W100, W113, W115,
W142, W145
MARs (matrix-associated regions), W63,
W110W111
MASP-1 (MBL-associated serine
protease 1), W210
MASP-2, W210
Maternal effect genes, W124, W125F
Matrix-associated regions (MARs), W63,
W110W111
Matrix protein 1 (M1), W40W41
Matrix protein 2 (M2), W40, W41
Matthews, B., W34
Mattick, J., W76
Maturation, W121, W121F
Max DNA-binding domain, W102, W103F
Maxillary (Mx) segment, Drosophila
embryo, W124
MBL (mannose-binding lectin), W210
MBL-associated serine protease 1
(MASP-1), W210
MB-lectin (mannose-binding lectin)
pathway, of complement system, W205,
W205F, W210
MCP (membrane cofactor of
proteolysis), W211
M disks (M lines), muscle, W212, W220
mdm2 gene, W141
Mdm2 protein, W141, W142
Md segment, Drosophila embryo
(mandibulary), W124
Mediator, W105, W105F
Megakaryocytes, W165
Melanocytes, W234
-Melanocyte stimulating hormone
(-MSH), W120F, W121
Melanosomes, W234
Membrane-attack complex, see MAC
Membrane-bound antibodies, W194W195
Membrane cofactor of proteolysis
(MCP), W211
Membrane fusion, influenza virus, W47W48
Memory B cells, W181
Memory T cells, W181
Menadione (Vitamin K
3
), W171F
Menaquinone (Vitamin K
2
), W171F, W173
Menstruation, W146
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Index WI-11
Mesenchyme, W122
Mesoderm, frog, W121F
Metallothionein I
A
, W94
Metallothionein II
A
, W94, W94F
Metamorphosis:
Drosophila embryo, W124
frog, W121F
Metaphase:
chromosomes in, W54, W54F
cohesin and condensin in metaphase
chromosome, W63W66
histone-depleted metaphase
chromosome, W63F
human metaphase chromosome, W64F
Metazoans, foreign gene expression,
W83W84
Methanothermus fervidus, histones, W58
Methotrexate, gene amplification and, W79
Methylation, of histones, W111, W112,
W116W117
5-Methylcytosine (m
5
C) residue, W74
M gene, W23T, W31
MHC, see Major histocompatibility complex
Mice:
-amylase production, W119, W120F
apoptosis in embryonic paws, W146F
C
0
t curve, W70F
DHFR gene, W94, W94F
ectoderm, W122
homeodomains of five genes, W131F
Hox-3.1 gene, W132, W133F
HP1 chromodomain, W117, W117F
kinesin, W241F
light chain genes, W191
MHC, W198
perforin, W210F
Small eye gene, W132
STR DNA, W72, W72F
T cell receptor, W197F
transcriptional initiation regulation, W86
Zif268 protein, W97
Micrococcal nuclease, W56, W56F
Microfilaments, W228F, W228W232, W229F
Micropyle, W123F
microRNAs (miRNAs), W141
Microsatellites, W72
Microtubules, W236F, W236W240
and antimitotic drugs, W239W240
in cilia and eukaryotic flagella, W245W248
and dyneins, W242W248
instability, W238W239
and kinesins, W240W245
microtubule-associated motors,
W240W248
organelles in microtubule track, W244F
structure and assembly, W237F,
W237W238, W238F
tubulin, W236W237
Microtubule-associated proteins
(MAPs), W238
Microvilli, W230
Milligan, R., W222
Milstein, C., W185
Mimivirus, W1
Mineralocorticoids, W97
Minichromosome, SV40, W15, W109,
W109F, W164
Minisatellites, W72
() end, of actin, W218
MIR, W73T
MIR3, W73T
miR-34a, W141
Mitochondrial porin, W154
Mitogens, W136, W144
Mitosis, W135W137
Mitotic spindle, W72
MLCK (myosin light chain kinase), W227
MM3 gene, W130, W131F
mMED, W105
MO-10 gene, W130
Mod(mdg4), W110, W111F
Moderately repetitive sequences, W70,
W72W74, W73T
Molecular chaperones, nucleosomes and,
W60W61
Molecular cloning, W83
Molecular physiology:
blood clotting, W165W179
immunity, W179W211
motility, W211W251
Molting, Drosophila embryo, W124
Monoclonal antibodies, W185W186
against hen egg white lysozyme,
W188, W188F
production of, W186F
Moras, D., W93
Morphogens, W122, W133W134
Morphogen proteins, W103
MORT1 (mediator of receptor-induced
toxicity 1), W150
Morula, frog, W121F
MotA, W251
MotB, W251
Motif ten element (MTE), W93
Motility, W211W251
actins in nonmuscle cells, W228W232
bacterial flagella, W248W251
microtubule-associated motors,
W240W248
microtubules, W236W240
myosins in nonmuscle cells, W233W236
smooth muscle, W226W228
striated muscle contraction, W220W226
striated muscle structure, W211W220
MOZ, W112
MPF (maturation promoting factor), W136
M phase, W53, W135, W136
M-protein, W220
mRNA:
control of degradation, W120
Drosophila embryo, W124
-MSH (-melanocyte stimulating
hormone), W120F, W121
-MSH, W120F, W121
MTE (motif ten element), W93
Multicellular organisms:
difficulty of studying gene expression
in, W83
histone modifications, W112
Multiple myeloma, W184
Multiple sclerosis, W182
Multiplicity of infection, W33
Murine antibody against canine lymphoma,
W186F
Murine H-2K
b
Class I MHC, W199, W199F
Murzina, N., W117
Muscle, W122. See also Smooth muscle;
Striated muscle
Muscle fibers, W212, W212F, W213F
Mx segment, Drosophila embryo
(maxillary), W124
Myasthenia gravis, W182
MyBP-C (myosin-binding protein C), W220
Myc, W112, W134
and bHLH, W102
and p53, W142
Myeloma protein, W184
antigen binding in, W187
folding of light chain, W187F
Myofibrils, W213F, W226F
anatomy, W213F
assembly and integrity, W219W220
contraction of, W221F
defined, W212
thick and thin filaments, W213F
Myohemerythrin, W188
Myomesin, W220
Myosins:
ATPase activity, W221W222
enzymatic cleavage pattern, W215F
interaction with actin, W222, W222F
movement along actin filaments,
W222W224
and muscle contraction rate, W224
myosin molecule, W214F
myosin subfragment-1, W215W216
in nonmuscle cells, W233W236
in smooth muscle, W227
in thick filaments, W213W215
Myosin I, W223
Myosin II, W233
Myosin V, W223, W233W234, W234F
Myosin Va, W234
Myosin VI, W223
Myosin VIIa, W235
Myosin VIII, W223
Myosin X, W223
Myosin XI, W223
Myosin XIII, W223
Myosin-binding protein C (MyBP-C), W220
Myosin light chain kinase (MLCK), W227
Myosin light chain phosphatase, W228
MYST family, W112
Myt1, W136
N
NA (neuraminidase), W40, W42, W43,
W46F, W46W47
Na

, thrombin and, W177


Namba, K., W218, W249
NANA (N-acetylneuraminic acid), Relenza
and, W47
nanos gene (Drosophila), W126, W127F
Nanos protein (Drosophila), W126
NAP1 (molecular chaperone), W60
Nash, H., W32
NAT, W105
NBD (nucleosome-binding domain), W107
N-CAM (neuronal cell-adhesion molecule),
W196F
N-CoR, W115
ncRNAs (noncoding RNAs), W74, W76
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WI-12 Index
Nebulin, W220
Necrosis, W147
Nei, M., W81
NEP (nuclear export protein), W41, W42
Nerve impulses, calcium ion release and,
W225W226
Nervous system, apoptosis in, W145W146
Neuraminidase, see NA
Neurofibromatosis type 1 (NF1) protein,
Elephant Man condition and, W135
Neuromuscular junction, W225
Neuronal cell-adhesion molecule
(N-CAM), W196F
Neutralizing antibodies, W183
Nexin, W246
NF1 (neurofibromatosis type 1) protein,
Elephant Man condition and, W135
NF-B (nuclear factor B), W102W105,
W104F
NF-E2 (nuclear factor erythroid 2), W95
NF-E3 (nuclear factor erythroid 3), W95
NF-E4 (nuclear factor erythroid 4), W95
NFR (nucleosome free regions), W112F
N gene, W22, W23T, W24
NHP6A, W106, W106F
Niedergerke, R., W221
9 2 array, W245
Nitric oxide, smooth muscle and, W228
p-Nitrophenyldiazonium, W185
NOD (nucleotide oligomerization domain),
W152
Nogales, E., W91, W94, W118, W236
Noncoding RNAs (ncRNAs), W74, W76
Nonstructural protein 1 (NS1), W41
Nonstructural protein 2 (NS2), W41
Norwalk virus, W16
Notophthalmus viridescens:
histone genes, W77F
lampbrush chromosome, W86F
tandem gene clusters, W77F
Noxa, W152
NP (nucleocapsid protein), W41, W42
N regions, of antibodies, W193W194
NS1 (nonstructural protein 1), W41
NS2 (nonstructural protein 2), W41
Nu1 gene, W23T
Nu3 gene, W23T
NuA3, W112
NuA4, W112
Nuclear export protein (NEP), W41, W42
Nuclear factor erythroid 2 (NF-E2), W95
Nuclear factor erythroid 3 (NF-E3), W95
Nuclear factor erythroid 4 (NF-E4), W95
Nuclear factor B (NF-B), W102W105,
W104F
Nuclear matrix, W110
Nuclear membrane, W53
Nuclear receptor superfamily, W97W99
Nucleation, in TMV assembly, W6
Nucleic acids, of viruses, W1
Nucleocapsids, W41W43
Nucleocapsid protein (NP), W41, W42
Nucleolus, rRNA synthesis in, W76W77
Nucleoplasmin, W60
Nucleosome:
in DNA replication, W60
and DNase I hypersensitive areas, W109
Nucleosomes, W15, W56
chromatin organization in, W55W61
and Histone H1, W58W59
remodeling of, W118W119, W119F
and transcription of RNAP through,
W107W109, W108F
Nucleosome-binding domain (NBD), W107
Nucleosome core particle:
formation of, W56W58
histone modifications on, W111, W112
Nucleosome free regions (NFR), W112F
Nucleotide oligomerization domain
(NOD), W152
Nucleus:
Drosophila embryo, W123F
territories of interphase chromosomes,
W67W68
Nudaurelia Capensis virus, W16
NuRD, W115
Nurse, P., W136
Nurse cells, Drosophila embryo, W124
nusA gene, W23T
NusA protein, W25, W26
nusB gene, W23T
NusB protein, W25
nusE gene, W23T
NusE protein, W25
NusG protein, W25
Nus proteins, W25F, W25W26
Nsslein-Volhard, C., W126
nutL gene, W23T, W24
nutR gene, W23T, W24
O
Oda, T., W218
O gene, W22, W23T
o
L1
gene, W34, W38
o
L2
gene, W34, W38
o
L3
gene, W34
o
L
gene, W23T, W33, W34
OMIM (Online Mendelian Inheritance in
Man), W76
Oncogenes, W134
One-start helix, W62
Online Mendelian Inheritance in Man
(OMIM), W76
Oocyte, frog, W121F
Oogenesis, rRNA amplification and,
W78W79
Opsonins, W208, W211
Opsonization, W205
o
R1
gene, W34, W36W38
o
R2
gene, W34, W36, W37, W37F, W38
o
R3
gene, W34, W36W38
Orbivirus, W16
Organogenesis, W121, W121F, W124
Organ transplants, rejection of,
W204W205
o
R
gene, W23T, W33, W36
Cro protein binding, W38, W38F
and PIC, W95
subsites, W34
ori gene, W23T, W26
Orphan genes, W75
Orphan receptors, W97W99
Outer dynein arm, W246
Ovalbumin, W106
Ovarian cancer, W135
Ovum, information in fertilized, W121
Oxidative stress, IBs and, W103
P
P. miliaris, histone genes, W77F
p14
ARF
, W142
p16
INK4a
, W139, W142
p18
INK4c
, W140, W140F
p19
ARF
, W142
p21, W144
p21
Cip1
, W139
p27
Cip2
, W139
p27
Kip1
, W139, W139F, W144
p35, W154
p50, W102W104, W104F
p52, W103
p53, W95F, W141W144
and cancer, W135
and G
2
phase, W141W142
information integration by, W142, W144
oncogenic mutations, W142
structure, W142, W143F
p65, W102W104, W104F
p105, W103
p300, W112
p300/CBP-associated factor (PCAF), W112
p300/CBP family, W112
PA (polymerase acidic protein), W41, W42
Pabo, C., W34, W97, W131
Packing ratio, W54
PAF65, W113
PAF65, W113
Pair-rule genes, W126W128
Pancreatic cells, W68
Pancreatic aciner cells, W68
Pancreatic serine protease, thrombin
structure and, W174
Papain, W34
Papovavirus, W74
PAR1 (protease-activated receptor 1),
W175, W175F
PAR4, W175
Paramecium bursaria Chlorella virus type 1
(PBCV-1), W18W20, W19F
Paramyosin, W220
Parasegments, W129
Pardue, M. L., W66
Parkinsons disease, apoptosis and, W147
PARs (protease-activated receptors), W175
Patel, D., W25
Pathogens, evasion of complement
system, W211
Pavletich, N., W138, W139, W142, W145
Pax-6 gene (mouse), W132
PB1 (polymerase basic protein 1), W41, W42
PB2 (polymerase basic protein 2), W41, W42
PBCV-1 (Paramecium bursaria Chlorella
virus type 1), W18W20, W19F
pbx mutation (Drosophila melanogaster),
W125F, W126, W130
PC2, W105
PCAF (p300/CBP-associated factor), W112
PCAF complex, W112, W113
PCD (primary ciliary dyskinesia), W248
PCR, in chromatin immunoprecipitation,
W110
Pentasymmetrons, W20
Perforin, W181, W208, W210F
JWCL281_ndx_WI1-WI17.qxd 5/5/11 10:48 AM Page WI-12
Index WI-13
P gene, W22, W23T
Phage 434 Cro protein, W34
Phage head, W27W30
assembly, W27W28
DNA in, W28W29
DNA packing process, W28F, W29W30
Phagocytes, W181
Phagocytosis, W179
Phagocytotic cells, W147
Phalloidin, W230
Phorbol esters, IBs and, W103
Phosphoprotein phosphatase-1 (PP1), W152
Phosphorylation, of histones, W111
Phylloquinone (Vitamin K
1
), W171F, W173
Physical stress, IBs and, W103
Physiology, W165
PIC (preinitiation complex), W88, W89
assembly of, W89F
and Mediator, W105
and upstream transcription factors,
W95W96
Picornaviruses, W12W14
Pigs, influenza viruses, W44
p
I
gene, W23T, W33
Pigmented epithelial cells, W235
Plasma cells, W181
Plasma thromboplastin antecedent
(PTA; XI), W176
Plasmin, W178
Plasminogen, W178W179
Plasmodia species, Class I MHC proteins
and, W199
Platelets, W165, W175
p
L
gene, W23T, W24, W33
plk1, W136
() end, of actin, W218
Pocket domain, W145, W145F
Pointed end, of actin, W218
Point mutations, -thalassemias and, W83
Pol I (RNAP I; RNA polymerase I), W76,
W93
Pol II, see RNAP II (RNA polymerase II)
Pol III (RNAP III; RNA polymerase III),
W77, W93, W108
Pole cells, W123F, W124
Poliomyelitis, W12
Poliovirus, W12, W14, W14F
Poljak, R., W186
Pollard, T., W231
Polo kinase, W136
Poly(A):
C
0
t curve, W70F
and mRNA degradation, W120
Polymerase acidic protein (PA), W41, W42
Polymerase basic protein 1 (PB1), W41, W42
Polymerase basic protein 2 (PB2), W41, W42
Polymorphisms:
genealogies from, W80W82
MHC, W197W198, W204
Polyomavirus, W15
Polypeptides, processing of, W120
Polyproteins, W120
Polytene chromosomes:
chromosome puffs in, W85
of Drosophila melanogaster, W66F, W67F,
W110, W111F
parallel DNA strands in, W66W67
Poly(dA:dt) tracts, W61
Poly(U), C
0
t curve, W70F
POMC (proopiomelanocortin), W120F,
W120W121
Porter, R., W182, W184
Position effect, W109
postbithorax mutant (pbx; Drosophila),
W125F, W126
Posterior compartment, Drosophila
embryo, W123F
Post-translational processing, W120W121
PP1 (phosphoprotein phosphatase-1), W152
pRb, W135
pRB (retinoblastoma-associated protein),
W144W145, W145F
Pre-B cell, W194
Pre-B cell receptor, W194
Precipitin reaction, W184
p
RE
gene, W23T, W33
Preinitiation complex, see PIC
Prekallikrein, W176
p
R
gene, W23T, W26
p
R
gene, W23T, W33, W36, W37, W37F,
W38, W39F
Primary ciliary dyskinesia (PCD), W248
Primary immune response, W181F
Primary pair-rule genes, W127W128
p
RM
gene, W23T, W33, W36, W37, W37F,
W38, W38F
pRNA, W30
Proaccelerin (V
a
), W171, W173, W174
Pro-apoptotic proteins, W147
Pro-C3, W208
Procaspases, W147W149
Procaspase-3, W149F, W151F
Procaspase-7, W148W149
Procaspase-8, W149F, W150
Procaspase-9, W151F, W152, W153F
Procaspase-10, W150
Proconvertin (VII), W175, W176
Profilin, W230W231
Progesterone, W97
Programmed cell death, W145
Prohead, W28W30, W30F
Promoters, GC boxes and, W94F
Promyelocytic leukemia, W135
Pronase, W46
Proopiomelanocortin (POMC), W120F,
W120W121
Properdin (factor P), W210
Prophage, W20, W21
Protease-activated receptor 1, W175, W175F
Protease-activated receptors (PARs), W175
Proteins:
alterations as basis for cancer, W134
cleavage by caspases, W149
in viruses, W1
Protein A, W110
Protein C, W171, W174, W177
Protein C pathway, control of clot formation
and, W177
Protein families, W79
Protein kinase A:
and BH3-only proteins, W152
Cdk2 structure and, W138
Protein S, W171, W177
Proteolytic cleavage, polypeptides, W120
Prothrombin (factor II), W167
activation, W173W174
concentration, W176
human, W171, W171F
Prothrombinase, W171
Prothrombin fragment 1, W173, W173F
Protofilaments, W237W238
Protohelices, TMV, W3W4, W4F, W6W8
Proto-oncogenes, zinc fingers, W97
Pseudogene, W77, W80
Psoriasis, W182
PSTAIRE sequence, W139, W140
PTA (plasma thromboplastin antecedent;
XI), W176
Ptashne, M., W34, W100
PTB domain, W113
PTEN, W135
PUMA (p53 upregulated modulator of
apoptosis), W152
Pupate, Drosophila embryo, W124
pX1 protein, W28
pX2 protein, W28
Q
Q gene, W23T
Quasi-equivalent viral subunits, W8
qut gene, W23T, W26
R
RA (retinoic acid), as morphogen,
W133W134
Rabbit:
actin complex, W218F
cardiac muscle tropomyosin, W217F
Rabies, W1
Rac, W232
rad1 gene, W140
Rad3, W140
rad3 gene, W140
Rad6, W117
rad9 gene, W140
rad17 gene, W140
rad26 gene, W140
Radial loops, chromatin, W63W66
Raff, M., W146
RAG, W192W193
RAG1, W192
RAG1 protein, W192, W193
RAG2, W192
RAG2 protein, W192
RAIDD, W150F
Ramakrishnan, V., W59
RAR (retinoic acid receptor), W135
RAREs (retinoic acid response
elements), W135
Ras, W142
Rats:
kinesin-1, W240W241, W241F
POMC in, W120W121
Rayment, I., W215, W222
Rb gene, W135
rDNA, W76, W78W79
RecA, W38
recA gene, W23T
Recognition unit, of complement system,
W206W208
Recombination activating genes, W192
Recombination signal sequences (RSSs),
W190
JWCL281_ndx_WI1-WI17.qxd 5/5/11 10:48 AM Page WI-13
WI-14 Index
Red-green color blindness, W164
Regulatory light chains (RLC), W213W215
Regulatory proteins, W75
Regulatory sequences, protein, W134
Regulatory T cells, W181
Reinberg, D., W108
Reiterated sequences, W77W78
RelA, W102
Relenza, W47
Rel homology region (RHR), W102W103
rel oncogene, W102
Rel proteins, W103
Remicade (infliximab), W185
Reoviridae, W16
Repetitive sequences, in genome, W70W74
REST, W115
Restriction point, W135W136
Retinitis pigmentosa, W235
Retinoblast, W135
Retinoblastoma, W135
13-cis-Retinoic acid, W133
Retinoids, W97
Retinol, W133
R gene, W23T
Rheumatoid arthritis, W146, W182, W185
Rhinovirus, W12, W13F, W14, W14F
Rhodes, D., W62, W99
rho gene, W23T
RHR (Rel homology region), W102W103
Ribosomes, assembly of, W76W77
Rice, P., W32
Richmond, T., W57, W61, W90
Rigor complex, W222
Rigor mortis, W222
Rigor state, W257
Ringer, S., W224
Rinn, J., W142
RLC (regulatory light chains), W213W215
RNA:
of bacteriophage , W24
in BTV, W19F
in eukaryote chromosomes, W53
of TBSV, W12
of TMV, W4W8, W5F
5S RNA, gene clustering for, W77, W77F
RNAP (RNA polymerase):
in antitermination complex of
bacteriophage , W25F
bacteriophage , W22, W24, W25,
W37, W37F
interaction with repressor, W37F
transcription through nucleosomes,
W107W109, W108F
RNAP I (RNA polymerase I; Pol I),
W76, W93
RNAP II (RNA polymerase II; Pol II):
core promoter sequences, W89F
and Mediator, W105
and PIC, W95
TATA-less promoters, W93
transcriptional initiation regulation,
W88, W89
transcription factor binding,
W90W91, W91F
transcription through nucleosome, W108
RNAP II holoenzyme, W105, W105F
RNAP III (RNA polymerase III; Pol III),
W77, W93, W108
RNase, in TMV assembly, W7
RNase P, noncoding RNAs and, W74
RNA viruses, W1, W3, W12. See also specific
viruses
Rod cells, W235
Roeder, R., W90, W92
Rossman, M., W12, W18, W29
Rotaviruses, W16
Rowboat model of muscle contractile cycle,
W222W224
rpoA gene, W23T
rpoB gene, W23T, W24
rpoC gene, W23T
rRNA, W76F
gene amplification, W78W79
genes organized into repeating sets, W76
as noncoding RNA, W74
nucleolus site of synthesis, W76W77
5S rRNA:
gene clustering for, W77F
and RNAP III, W95
RSC, W118, W118F
RSSs (recombination signal sequences),
W190
Rubinstein-Tabi syndrome, W135
runt gene (Drosophila), W127
Russian flu of 1977, W40
Rutter, W., W93
Ryania speciosa, W226
Ryanodine, W226
Ryanodine receptors, W226
R
z
gene, W23T
S
S. purpratus, histone genes, W77F
S1, see Subfragment-1, myosin
S1 nuclease, W71
S2 (subfragment-2), myosin, W215
Saccharomyces cerevisiae (Bakers yeast),
W57, W84
SAGA (Spt/Ada/Gcn5L acetyltransferase),
W112, W113
Salmonella typhimurium:
bacteriophage P22 on, W25
flagella, W249, W249F, W250F
Salvesen, G., W154
SAM (S-adenosylmethionine), histone
methyltransferase and, W116W117
Sarcomas, W141
Sarcomeres, W212
Sarcoplasmic reticulum (SR) calcium ion
release from, W225W226
SARs (scaffold-attachment regions), W63
SAS, W112
Sas2, W112
Satellite DNAs, W72
Satellite tobacco mosaic virus, see STMV
Sauer, R., W34
SBMV (southern bean mosaic virus),
W12, W13F
Scaffold-attachment regions (SARs), W63
Scallops, myosin subfragment 1, W224F
Scott, M., W130
scs sequence, W110
scs sequence, W110
Sea urchins, histone genes, W77
Secondary immune response, W181, W181F
Secondary pair-rule genes, W128
Secreted antibodies, W194W195
Segmental duplications, W70
Segmentation genes, W124, W126
Segment polarity genes, W126, W129
Selfish DNA, W74
Self-tolerance, immunological, W182
Selvin, P., W234
Senda, T., W60
Sendai virus, W199F
Sensor proteins, W140
Separase, W66
Serotonin, platelet activation and, W165
Serpins, W177, W178
SET7/9, W116F, W116W117
SET domain, W116
Sex hormones, W96
Sexually mature adult frog, W121F
Sey gene (mouse), W132
S gene, W23T
SH2 domain, W113
Shi, W., W148
Short interspersed nuclear elements
(SINEs), W73, W73T
Short tandem repeats (STRs), W71W72
Sialic acid, NA and, W47
Sickle-cell anemia, W82
Sigler, P., W90, W98
Silencers, W95
Silent-carrier state, of -thalassemia, W82
Simian virus 40, see SV40
Simple sequence repeats (SSRs), W71W72
Sin3, W115
SINEs (short interspersed nuclear
elements), W73, W73T
Single nucleotide polymorphisms
(SNPs), W76
SIRT1, W115
SIRT2, W115
SIRT3, W115
SIRT4, W115
SIRT5, W115
SIRT6, W115
SIRT7, W115
Sirtuins, W115
Situs inversus, W248
Situs solitus, W248
60-loop, thrombin, W175
Skehel, J., W44, W47
Skeletal muscle:
myofibrils, W213F
organization, W212F
Skeleton, W122
SLI, W93
Sliding filament model of muscle
contraction, W221
Smac, W155
Small eye gene (mouse), W132
Smallpox, W1
Smc1, W64
Smc2, W64
Smc3, W64
Smc4, W64
SMC (structural maintenance of
chromosomes) proteins, W63W64,
W65F
Smooth muscle, W226W228, W227F
SMRT, W115
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Index WI-15
snake mutation, Drosophila embryo, W124
snoRNAs, as noncoding RNA, W74
SNPs (single nucleotide polymorphisms),
W76
snRNAs, as noncoding RNA, W74
Sodium ion (Na

), thrombin and, W177


Somatic hypermutation hypothesis, W189
Somatic hypermutation process, W194
Somatic mutations, antibody diversity and,
W193W194
Somatic recombination hypothesis, W189
SOS response, W38
Southern bean mosaic virus (SBMV),
W12, W13F
Southern blotting (Southern transfer
technique), W83
Sp1, W93W94, W94F
Spanish flu of 1918, W40
Sperm cell, frog, W121F
S phase:
and pRB, W144W145
regulation, W135, W136
Spherical viruses, W1. See also Icosahedral
viruses
Spine of hydration, W61
Spokes, W246
Spoke head, W246
S protein (vitronectin), W211
Spt3/TAF/Gcn5L acetyltransferase
(STAGA), W112
Spt16, W108
Spt/Ada/Gcn5L acetyltransferase (SAGA),
W112, W113
Spudich, J., W232
Squelching, W96
SR (sarcoplasmic reticulum), calcium ion
release from, W225W226
SRC (steroid receptor coactivator)
family, W112
S regions, W196
SSRs (simple sequence repeats), W71W72
ssRNA, viruses, W3
SSRP1, W108
STAGA (Spt3/TAF/Gcn5L
acetyltransferase), W112
Stanley, W., W3
Staphylococcus aureus:
evasion of complement system by, W211
Protein A, W110
START, W135
Stem cells, W179
Stereocilia, W235, W235F
Steric interactions, TMV assembly and, W8
Steroids, W96W97
Steroid receptors, W98
Sth1, W118F
STMV (satellite tobacco mosaic virus), W1,
W12, W13F
Streptokinase, W178
Streptomyces griseus, pronase, W46
Stress, IBs and, W103
Striated muscle:
actin structure, W218
contraction, W220W224
control, W224W226
mechanism of force generation, W223F
myofibril assembly and integrity,
W219W220
myosin subfragment-1, W215W216
organization, W211W212
proteins of, W214T
structure, W211W220
thick filaments, W213W215
thin filaments, W216W218
Stroke, blood clotting and, W175W176
Strominger, J., W200
Strongylocentrotus purpuratus,
C
0
t curve, W71F
STRs (short tandem repeats), W71W72
Structural genes, W69
distribution of, W75, W75F
transcription factors for, W88
Structural maintenance of chromosomes
(SMC) proteins, W63W64, W65F
Struhl, K., W101
Stuart, D., W14, W17
Stuart factor, see Factor X
a
Stubbs, G., W4
Studs, W251
Subfiber A, W245, W246
Subfiber B, W245W247
Subfragment-1, myosin (S1), W214W216,
W216F, W217F
conformational changes in, W224
in muscle contraction, W222W224
Subfragment-2, myosin (S2), W215
Su(Hw), W110, W111F
Suppressor T cells, W181
Surrogate light chain, W194
Suv39h, W117
SV40 (Simian virus 40), W2F, W15W16
large T antigen, W141
minichromosome, W109, W109F, W164
Sp1-binding sites, W94F, W95
structure, W15F
symmetry, W52
Swi2/Snf2, W118
Swine flu of 2009, W40
SWI/SNF complex, W118
Switch I, kinesin, W241F,
W241W242, W242F
Switch II, kinesin, W241F,
W241W242, W242F
Switch regions, W196
Syncytial blastoderm, W123F, W124
Syncytium, W123F, W124
Systemic lupus erythematosus, W182
Szent-Gyrgyi, A., W214, W221, W224
T
T1 thoracic segment, Drosophila embryo,
W124
T2 thoracic segment, Drosophila embryo,
W124
T3 thoracic segment, Drosophila embryo,
W124
TAFs (TBP-associated factors), W88T, W89
TAF
II
250, W112
TAF1, W112, W114, W114F, W118
TAF1 family, W112
TAF5, W113
TAF6, W113
TAF9, W113
TAF10, W113
TAF11, W93
TAF12, W113
TAF13, W93
Tail, bacteriophage, W27, W31
Talmage, D., W179
Tang, S., W93
TATA box, W88W90
in assembly of PIC, W89F
class II core promoters lacking, W93
transcription factor binding, W91F
TATA box-binding protein, see TBP
Taxol, W239W240
Taylor, E., W221
TBHA
2
, W47W48, W48F
tBid, W151F, W152
TBP (TATA box-binding protein), W88T,
W89W90
and core promoters, W93
transcription factor binding,
W90W91, W91F
X-ray structure, W90F
TBP-associated factors (TAFs), W88T, W89
TBSV (tomato bushy stunt virus), W2F,
W10W12
capsid, W11, W11F
coat protein subunit, W10F, W10W11,
W11F, W14
radial organization, W12F
RNA, W12
Tc-1 group, W73T
T cell receptors (TCRs), W179,
W196W197
CD4 and CD8 coreceptors,
W201W202, W202F
and MHC, W201F, W201W204
mouse, W197F
and T cell proliferation, W202W204
TdT (terminal deoxynucleotidyl
transferase), W193W194
Telomerase, noncoding RNAs and, W74
Telomeres:
constitutive chromatin, W84
highly repetitive DNA clustered at,
W71W72
Temperate phages, W20
Tenases, W175
Terminal deoxynucleotidyl transferase
(TdT), W193W194
Terminase, W26, W29
Territories, nuclear, W67W68
Tetrahymena thermophila, HAT domain,
W113, W113F
TF (tissue factor; factor III), W175W176
TFIIA, W88, W88T, W89
binding to DNA, W90W91, W91F
and TFIID/TFIIB, W91W93, W92F
TFIIA-TFIIB-TBP-DNA quaternary
complex, W90W91, W91F
TFIIB, W88, W88T, W89
binding to DNA, W90W91, W91F
and Mediator, W105
and TFIID/TFIIA, W91W93, W92F
TFIIB
C
, W90W91
TFIIB
N
, W90
TFIIB recognition element (BRE), W91
TFIID, W88, W88T, W89, W91W93
and activators, W95F
and bromodomains, W114, W114F
and HATs, W112
and Mediator, W105
JWCL281_ndx_WI1-WI17.qxd 5/5/11 10:48 AM Page WI-15
WI-16 Index
TFIID-TFIIA-TFIIB complex,
W91W93, W92F
TFIIE, W88, W88T, W89
TFIIF, W88, W88T, W89
TFIIH, W88, W88T, W89, W105
TFIIIA, W97
TFIIIB, W93, W97
TFIIIC, W97
TFTC, W112
TF-VII
a
complex, W175
TGF (transforming growth factor), W139
-Thalassemias, W82
-Thalassemias, W82W83
-Thalassemia, W82
Thalassemias, W82W83, W109
()
0
-Thalassemia, W109
Thalassemia major, W82
Thalassemia minor, W82
-Thalassemia trait, W82
Thick filaments, W212, W213F, W215F
in muscle contraction, W220W221
myosins in, W213W215
Thin filaments, W212, W213F
actin, tropomyosin, and troponin in,
W216W218
in muscle contraction, W220W221
and myosin S1, W217F
30-nm Chromatin filaments, W61FW62F,
W61W62
Thoracic segments, Drosophila
embryo, W124
Three-dimensional FISH, W67, W67F
Thrombin, W167
activation, W170W175
and hirudin, W177W178, W178F
human, W174F
and Na

ion, W177
and platelet activation, W165, W175
in protein C pathway, W177
and prothrombin activation, W173W174
structure, W174W175
synthesis, W170W171
Thrombomodulin, W177
Thromboxane A
2
, platelet activation
and, W165
Thrombus, W166, W176
Thucydides, W182
Thyroid hormones, nuclear receptor
superfamily and, W97
Tijan, R., W91, W93, W94, W114
Tip60, W112
Tissue factor (Factor III; TF), W175W176
Tissue transplants, rejection of, W204W205
Tissue-type plasminogen activator (t-PA),
W178W179
Titin, W220
t
L1
gene, W23T, W24
T lymphocytes (T cells), W179
apoptosis of, W146
proliferation of, W202W204
regulatory and suppressor, W181
TMV (tobacco mosaic virus), W2F, W3W8
assembly, W6W8, W7F
RNA tails, W8F, W31
structure, W3F, W3W6
TMV coat protein, W3W6
aggregation state, W3F, W3W4
cross section, W6F
growth of rods, W4
and RNA, W4W6, W5F
subunit x-ray structure, W5F
TMV protein disk, W6, W6F
TnC, W217, W218, W224
TNF, W150
TNF, W150, W150F
TNF (tumor necrosis factor) family, W150
TNFR1 (TNF receptor 1), W150, W150F
TNFR (TNF receptor) family, W150
TnI, W217, W218, W224W225
TnT, W217
Tobacco mosaic virus, see TMV
Tomato bushy stunt virus, see TBSV
Tonegawa, S., W189
Totipotency, W68
t-PA (tissue-type plasminogen activator),
W178W179
t
R1
gene, W23T, W24
t
R2
gene, W23T, W24
t
R3
gene, W23T
Tra1, W112
Transactivation domains, W95W96
Transcription:
chromosome puffs and lampbrush
chromosomes in, W85W86
initiation regulation, W86, W87F
portion of human genome
transcribed, W76
Transcriptional adaptor (ADA),
W112, W113
Transcriptional antiterminator, W23
Transcriptional corepressors, W115
Transcription factors, W88. See also specific
factors, e.g.: TFIIIA
DNA-binding motifs, W97
properties of GTFs, W88T
types of, W88
Transgenic individuals, Xenopus laevis, W84
Transglutaminase, W169
Translation:
initiation rates, W120
post-translational processing, W120W121
Translocases, chromatin remodeling
complexes as, W118W119
Translocation:
control, W120
and nuclear territories, W67
Transplants, organ and tissue, W204W205
Transplantation antigens, W198
Transverse (T) tubules, W225
TRAP/SMCC, W105
Treadmilling, W229, W229F
t
R
gene, W23T, W26
Triangulation number, W10
Trisymmetrons, W20
tRNA, as noncoding RNA, W74
Tropomodulin, W220
Tropomyosin, W217, W217F
and Ca
2
ion, W225F
in regulation of muscle contraction,
W224W226, W225F
Troponin:
chicken skeletal muscle, W218F
and regulation of muscle contraction,
W224W225, W225F
in thin filaments, W217W218
trp repressor, E. coli, W130
Trypsin, W68, W166, W174W175
Tsix gene, W85, W141
T (transverse) tubules, W225
Tubulin, W236W237
Tulinsky, A., W173, W174, W177
Tumor necrosis factor , W185
Tumor suppressors, W135
Tumor suppressor genes, loss or
inactivation, W135
12/23 rule, W192F
Two-start helix, W61
Tyler, J., W60
Type 1 diabetes, W146
Type II myosins, W223
U
UASs (upstream activation sequences), W88
Ubiquitination, histones, W117W118
Ubx gene (Ultrabithorax; Drosophila),
W130, W131F
U gene, W23T
Ulcerative colitis, W182, W185
Ultrabithorax gene (Ubx; Drosophila),
W130, W131F
Unconventional myosins, W223
Unequal crossover, W78, W78F
Unexpressed DNA, W69, W74
Unique sequences, W71
Upstream transcription factors, W88,
W95W96
Urokinase, W178
Usher 1B syndrome, W235
UvrA protein, W97
V
Vaccines, W182
Vaccinia virus complement control protein
(VCP), W211
Valegrd, K., W16
van Holde, K., W62
Variable region, heavy chain (V
H
), W184
Variable region, light chain (V
L
), W184
Variant histones, W55
VCP (vaccinia virus complement control
protein), W211
VDAC (voltage-dependent anion
channel), W154
V(D)J joining, W191, W193F
V(D)J recombinase:
and RAG1/RAG2, W192W193
and T cell receptors, W197
Vegetative growth, W20
Ventral ectoderm, amphibian embryo,
W122, W122F
Ventral position, of Drosophila
embryo, W123F
Vertebrates. See also specific species
apoptotic pathways, W145W146
blood clotting, W166
homeodomains, W132
muscle types, W226
retinoic acid morphogen of,
W133W134
self-tolerance of immune system, W182
smooth muscle, W226W228
striated muscle, W211W226
Vesicle transport, W243W245
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Index WI-17
v-FLIP, W150
v-fos proto-oncogene, W134
V gene, W23T
V
H
(variable region, heavy chain),
W184W185
V
H
segment, W191
Video-enhanced contrast microscopy, W243
Vimentin, W219
Vinblastine, W239
Vinca alkaloids, W239
Vincristine, W239
VIPERdb (Virus Particle ExploreR
database), W16
Viral diseases, W1
Virions, W1
bacteriophage , W20
bacteriophage MS2, W16
influenza virus, W40F
SV40, W15F
Virulent phages, W20, W52
Viruses, W2F. See also specific viruses
bacteriophage , W20W39
and cancer, W134W135
defined, W1W3
enveloped, W40
helical, W1
icosahedral, W1, W8W20
influenza, W40W48
TMV, W3W8
Virus Particle ExploreR database
(VIPERdb), W16
Vitamin A, W133
Vitamin D, nuclear receptor superfamily
and, W97
Vitamin K:
in -carboxyglutamate synthesis,
W171W173, W172F
molecular formula, W171F
Vitamin K
1
(phylloquinone),
W171F, W173
Vitamin K
2
(menaquinone), W171F, W173
Vitamin K-2,3-epoxide, W172
Vitamin K
3
(menadione), W171F
Vitamin K-dependent carboxylase, W172
Vitamin K-epoxide reductase, W172
Vitamin K reductase, W172
Vitellogenin, W120
Vitronectin (S protein), W211
v-Jun, W134
V
L
(variable region, light chain),
W184W185
von Willebrandt factor, W165, W175
VP1:
human rhinovirus, W13F, W14F
picornaviruses, W12, W14
SBMV, W13F
SV40, W15W16
VP1(Pol) (dsRNA-dependent RNA
polymerase), W16
VP2:
BTV, W16
human rhinovirus, W13F, W14F
picornaviruses, W12, W14
SBMV, W13F
VP3:
human rhinovirus, W13F, W14F
picornaviruses, W12, W14
SBMV, W13F
VP3(T2), BTV, W16W18, W18F
VP4:
human rhinovirus, W13F
picornaviruses, W12, W14
SBMV, W13F
VP4(Cap) (dsRNA-dependent RNA
capping enzyme), W16
VP5, BTV, W16
VP6(Hel) (dsRNA-dependent RNA
helicase), W16
VP7(T13), BTV, W16W18, W17F
Vp54, W18, W19F, W20
VpreB, W194
vRNAs, influenza virus, W41W42
V

segment, W189W191, W190F, W191F


W
Wang, X., W152
Warfarin (Coumadin), W171, W171F, W173
WASP/WAVE protein, W231W232
Watson, J., W1
WD40 repeats, in apoptasomes, W152
Wee1, W136, W141
Weinberg, R., W134
Weintraub, H., W106
Weisel, J., W169
W gene, W23T
wg gene (wingless; Drosophila), W129,
W129F
Whiskers, W122
white gene, Drosophila, W110
Whole-genome tiling array, W110
Wieschaus, E., W126
Wiley, D., W44, W47, W200
Wilson, I., W188, W197
Wilson, K., W148
Wing, Drosophila embryo, W124, W124F
wingless gene (wg; Drosophila),
W129, W129F
WiskottAldrich syndrome, W232
Wood, W., W27
Wthrich, K., W132
X
X-actin, W232, W232F
X-activation center (XIC), W85
X chromosome, inactivation, W84W85
Xenopus, microfilaments, W231F
Xenopus laevis:
5S rRNA genes, W77, W77F
gene amplification in oocytes, W78, W79F
homeodomains of five genes, W131F
MM3 gene, W130
nucleoplasmin, W60
nucleosome core particle, W57
number of ribosomes synthesized, W164
TFIIIA, W97
transgenic, W84
XI (plasma thromboplastin
antecedent;PTA), W176
XIAP (X-linked IAP), W154, W155F
XIC (X-activation center), W85
XII
a
, see Hageman factor
xis gene, W23, W23T, W32
Xist gene, W85, W141
Y
Yamamoto, K., W98
Ybf2/Sas3, W112
Y chromosome, X activation and, W84
Yeast:
gene identification, W74
GTF properties compared to human,
W88T
histone ubiquitination, W117W118
Hst2 and carba-NAD

, W115F
Mediator, W105, W105F
molecular genetic analyses, W84
NHP6A, W106F
RSC, W118
START, W135
TBP, W89, W90
TFIID, W93
yellow gene, Drosophila, W110
Yolk, Drosophila embryo, W124
yTAF4, W93
yTAF6, W93
yTAF9, W93
yTAF12, W93
Z
Zanamivir, W47
ZAP70, W203F, W203W204
Z disks (Z lines), muscle, W212, W219,
W219F
Zebra-stripe expression pattern
(Drosophila), W127W128
Z gene, W23T
Zif268 protein, W97, W98F
Ziff, E., W102
Zinc fingers, W97F, W97W101
Zinc-finger DNA-binding motifs, W97
Zygote, W122
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