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13
th
June , 2014 Volume No.: 34 Issue No.: 03
Vision
TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIELD
OF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BASED
LEARNING AND PRACTICE
Contents
Message from
PRINCIPAL
Editorial board
Historical article
News Update
Knowledge based Article
Disease Related
Breaking News
Upcoming Events
Drugs Update
Campus News
Students Section
Editors Note
Archive


GNIPST Photo Gallery
For your comments/contribution
OR For Back-Issues,
mailto:gnipstbulletin@gmail.com

GURU NANAK INSTITUTE OF PHARMACEUTICAL
SCIENCE AND TECHNOLOGY
Website: http://gnipst.ac.in






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MESSAGE FROM PRINCIPAL
























"It can happen. It does happen.
But it can't happen if you quit." Lauren Dane.


We are what we repeatedly do.
Excellence then is not an act, but a habit. Aristotle


It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank the
last years editors and congratulate the newly selected editors for the current year.

Our first consideration is always in the best interest of the students. Our goal is to promote academic
excellence and continuous improvement.

I believe that excellence in education is aided by creating a learning environment in which all learners are
supported in maximizing their potential and talents. Education needs to focus on personalized learning
and instruction, while promoting an education system that is impartial, universally accessible, and meeting
the needs of all students.

It is of paramount importance that our learners have sufficient motivation and encouragement in order to
achieve their aims. We are all very proud of you, our students, and your accomplishments and look
forward to watching as you put your mark on the profession in the years ahead.

The call of the time is to progress, not merely to move ahead. Our progressive Management is looking
forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken in
this direction and fruits of these efforts will be received by our students in the near future. Our Teachers
are committed and dedicated for the development of the institution by imparting their knowledge and play
the role of facilitator as well as role model to our students.

The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positive
challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holistic
needs of our students.

I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of the
opportunities and meet the challenges with purpose and determination.

Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us on
this path.

My best wishes to all.

Dr. A. Sengupta


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EDITORIAL BOARD
CHIEF EDITOR DR. ABHIJIT SENGUPTA
EDITOR MS. JEENATARA BEGUM
ASSOCIATE EDITOR MR. DIPANJAN MANDAL

HISTORICAL ARTICLE
HISTORICAL NOTES ON PHARMACY:
The beginnings of pharmacy are ancient. When the first person
expressed juice from a succulent leaf to apply to a wound, this art
was being practiced. In the Greek legend, Asclepius, the god of the
healing art, delegated to Hygieia the duty of compounding his
remedies. She was his apothecary or pharmacist. The physician-
priests of Egypt were divided into two classes: those who visited
the sick and those who remained in the temple and prepared
remedies for the patients.
In ancient Greece and Rome and during the Middle Ages in
Europe, the art of healing recognized a separation between the
duties of the physician and those of the herbalist, who supplied
the physician with the raw materials from which to make
medicines. The Arabian influence in Europe during the 8th
century AD, however, brought about the practice of separate duties
for the pharmacist and physician. The trend toward specialization
was later reinforced by a law enacted by the city council of Bruges
in 1683, forbidding physicians to prepare medications for their
patients. In America, Benjamin Franklin took a pivotal step in
keeping the two professions separate when he appointed an
apothecary to the Pennsylvania Hospital. The development of
the pharmaceutical industry since World War II led to the
discovery and use of new and effective drug substances. It also
changed the role of the pharmacist. The scope for extemporaneous
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compounding of medicines was much diminished and with it the
need for the manipulative skills that were previously applied by
the pharmacist to the preparation of bougies, cachets, pills,
plasters, and potions. The pharmacist continues, however, to fulfill
the prescribers intentions by providing advice and information; by
formulating, storing, and providing correct dosage forms; and by
assuring the efficacy and quality of the dispensed or supplied
medicinal product.
The first college of pharmacy was founded in the United States in
1821 and is now known as the Philadelphia College of Pharmacy
and Science. Other institutes and colleges were established soon
after in the United States, Great Britain, and continental Europe.
Colleges of pharmacy as independent organizations or as schools
of universities now operate in most developed countries of the
world.

NEWS UPDATE
'Tomato pill' improves function of blood vessels
in patients with cardiovascular disease:
(9
th
June, 2014)
A daily supplement of an extract found in tomatoes may improve
the function of blood vessels in patients with cardiovascular
disease, according to new research. The incidence of
cardiovascular is notably where a 'Mediterranean diet' consisting
of a larger consumption of fruit, vegetables and olive oil
predominates. Recent dietary studies suggest that this diet
reduces the incidence of events related to the disease, including
heart attack and stroke, in patients at high cardiovascular risk, or
those who have previously had the disease. One component of the
Mediterranean diet thought to play a role in reducing this risk is
lycopene, a powerful antioxidant which is ten times more potent
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than vitamin E. Lycopene is found in tomatoes and other fruits,
and its potency appears to be enhanced when it is consumed
pureed, in ketchup or in the presence of olive oil. Whilst there is
strong epidemiological evidence to support the role of lycopene in
reducing cardiovascular risk, the mechanism by which it does so is
unclear.

Human stem cells used to create light-sensitive
retina:(10
th
June,2014)
Like many processes in the body, vision depends on many different
types of cells working in concert, in this case to turn light into
something that can be recognized by the brain as an image.
Photoreceptors are only part of the story in the complex eye-brain
process of vision. Using a type of human stem cell, researchers say
they have created a three-dimensional complement of human
retinal tissue in the laboratory, which notably includes
functioning photoreceptor cells capable of responding to light, the
first step in the process of converting it into visual images.
'Onion' vesicles for drug deliver developed:
(10
th
June, 2014)
One of the defining features of cells is their membranes. Each cell's
repository of DNA and protein-making machinery must be kept
stable and secure from invaders and toxins. Scientists have
attempted to replicate these properties, but, despite decades of
research, even the most basic membrane structures, known as
vesicles, still face many problems when made in the lab. They are
difficult to make at consistent sizes and lack the stability of their
biological counterparts.A certain kind of dendrimer, a molecule
that features tree-like branches, offers a simple way of creating
vesicles and tailoring their diameter and thickness, researchers
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report. Moreover, these dendrimer-based vesicles self-assemble
with concentric layers of membranes, much like an onion.

Malaria-carrying mosquitoes wiped out in lab
with genetic method that creates male-only
offspring: (10
th
June, 2014)
Since 2000, increased prevention and control measures have
reduced global malaria mortality rates by 42 per cent, but the
disease remains a prevalent killer especially in vulnerable sub-
Saharan African regions. Malaria control has also been threatened
by the spread of insecticide resistant mosquitoes and malaria
parasites resistant to drugs. Scientists have modified mosquitoes
to produce sperm that will only create males, pioneering a fresh
approach to eradicating malaria. Since 2000, increased prevention
and control measures have reduced global malaria mortality rates
by 42 per cent, but the disease remains a prevalent killer especially
in vulnerable sub-Saharan African regions. Malaria control has
also been threatened by the spread of insecticide resistant
mosquitoes and malaria parasites resistant to drugs.
Limiting carbohydrates could reduce breast
cancer recurrence in women with positive IGF1
receptor:(10
th
June, 2014)
Receptors for IGF1 have been found in breast tumor tissue, and
expression of those receptors may contribute to treatment
resistance among breast cancer survivors. Since diet can influence
insulin activation, the researchers wondered whether diet could
impact breast cancer prognosis based on expression of the IGF1
receptor in the primary breast tumor tissue. Using an unusual
approach, this study assessed the combined association of two
factors implicated in tumor growth -- carbohydrate intake and
IGF1 receptor status -- to test whether activating the
insulin/insulin-like growth-factor axis can impact breast cancer.
Since carbohydrates stimulate the biological pathway that can
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increase concentrations of IGF1, the researchers focused on
carbohydrate intake.

'All systems go' for a paralyzed person to kick
off the World Cup: (10
th
June, 2014)
All systems are go for a bold demonstration of neuroscience and
cognitive technology in action: on June 12, during the opening of
the FIFA 2014 World Cup in Brazil, a paralyzed person wearing a
brain-controlled robotic exoskeleton is expected to make the first
kick. The system records electrical activity in the patient's brain
and translates that to action. It also gives the patient tactile
feedback using sensitive artificial skin.

MRI shows brain abnormalities in late preterm
infants: (10
th
June, 2014)
Babies born 32 to 36 weeks into gestation may have smaller brains
and other brain abnormalities that could lead to long-term
developmental problems, according to a new study. Researchers
focused on moderate and late preterm (MLPT) babies -- those
born between 32 weeks, zero days, and 36 weeks, six days, into
gestation. MLPT babies account for approximately 80 percent of
all preterm births and are responsible for much of the rise in the
rates of preterm birth over the last 20 years.

Infection prevention implanted directly into
bones: (11
th
June,2014)
Hospital germs can be fatal, since they are resistant to antibiotics.
As a result, alternative methods of defense against bacteria are in
demand. A research team has been able to develop bone implants
that keep the germs at bay. At first glance, the fine-grained
implant looks like flour. Only under the microscope can one see
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what is inside: The individual grains of the granules consist of
apatite crystals. These are similar in composition and structure to
natural bone material, which is formed of the same chemical
elements-calcium and phosphorus. The granules make it an ideal
material for implants. To prevent complications, some
manufacturers coat their bone substitute material with
antibiotics.

Mechanism explains complex brain wiring:
(11
th
June, 2014)
It is estimated that a person has 100 billion neurons, or nerve cells.
These neurons have thin, elongated, highly branched offshoots
called dendrites and axons. They are the body's information and
signal processors. The dendrites receive electrical impulses from
the other neurons and conduct these to the cell body. The cell
body then decides whether stimuli will or will not be transferred
to other cells via the axon. A researcher unravels a part of the
mystery by describing a mechanism that explains novel aspects of
how the wiring of highly branched neurons in the brain works.
These new insights into how complex neural networks are formed
are very important for understanding and treating neurological
diseases.

For detail mail to editor



KNOWLEDGE BASED ARTICLE
PHARMACEUTICAL WATER:
Water is the most widely used substance, raw material or starting
material in the production, processing and formulation of
pharmaceutical products. It has unique chemical properties due to
its polarity and hydrogen bonds. This means it is able to dissolve,
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absorb, adsorb or suspend many different compounds. These
include contaminants that may represent hazards in themselves or
that may be able to react with intended product substances,
resulting in hazards to health. Control of the quality of water
throughout the production, storage and distribution processes,
including microbiological and chemical quality, is a major concern.
Unlike other product and process ingredients, water is usually
drawn from a system on demand, and is not subject to testing and
batch or lot release before use. Assurance of quality to meet the
on-demand expectation is, therefore, essential. Additionally,
certain microbiological tests may require periods of incubation
and, therefore, the results are likely to lag behind the water use.
Different grades of water quality are required depending on the
route of administration of the pharmaceutical products. Other
sources of guidance about different grades of water can be found in
pharmacopoeias and related documents.
Drinking water:
Drinking-water should be supplied under continuous positive
pressure in a plumbing system free of any defects that could lead
to contamination of any product. If drinking-water is used directly
in certain stages of pharmaceutical manufacture or is the feed-
water for the production of higher qualities of WPU, then testing
should be carried out periodically by the water users site to con-
firm that the quality meets the standards required for drinking-
water.
Bulk Purified water:
Bulk purified water (BPW) should be prepared from a drinking-
water source as a minimum-quality feed-water. It should meet the
relevant pharmacopoeial specifications for chemical and
microbiological purity with appropriate action and alert limits. It
should also be protected from recontamination and microbial
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proliferation. BPW may be prepared by a combination of reverse
osmosis (RO) RO/electro-deionization (EDI) and vapour
compression (VC). Alert levels for the water system should be
determined from knowledge of the system and are not specified in
the pharmacopoeias.

Bulk Highly Purified water:
Bulk highly purified water (BHPW) should be prepared from
drinking water as a minimum-quality feed-water. BHPW is a
unique specification for water found only in the European
Pharmacopoeia. This grade of water must meet the same quality
standard as water for injections (WFI), including the limit for
endotoxins, but the water-treatment process used may be
different. Current production methods include, for example,
double-pass RO coupled with other
suitable techniques such as ultrafiltration and deionization.
BHPW may be prepared by a combination of different methods
such as RO, ultrafiltration and deionization.

Bulk water for Injections:
Bulk water for injections (BWFI) should be prepared from
drinking-water (usually with further treatment) or purified water
as a minimum-quality feedwater. BWFI is not sterile water and is
not a final dosage form. It is an intermediate bulk product and
suitable to be used as an ingredient during formulation. BWFI is
the highest quality of pharmacopoeial WPU. Certain
pharmacopoeias place constraints upon the permitted puri-
fication techniques as part of the specification of the BWFI. The
International Pharmacopoeia and the European Pharmacopoeia,
for example, allow only distillation as the final purification step.
BWFI should meet the relevant pharmacopoeial specifications for
chemical and microbiological purity (including endotoxin) with
appropriate action and
alert limits. BWFI should also be protected from recontamination
and microbial proliferation.
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Other Grades of water:
When a specific process requires a special non-pharmacopoeial
grade of water, its specification must be documented within the
company quality system. As a minimum it must meet the
pharmacopoeial requirements relating to the grade of WPU
required for the type of dosage form or process step.

Maintenance of water systems:
Water for Pharmaceutical Use or WPU systems should be
maintained in accordance with a controlled,
documented maintenance programme that takes into account the
following:
de"ned frequency for system elements;
the calibration programme;
SOPs for speci"c tasks;
control of approved spares;
issue of a clear maintenance plan and instructions;
review and approval of systems for use upon completion of work;
record and review of problems and faults during maintenance.
Inspection of water system:
WPU (BPW, BHPW and BWFI) systems are likely to be the
subject of regulatory inspection from time to time. Users should
consider conducting routine audit and self-inspection of
established water systems.
This GMP guidance can be used as the basis of inspection. A tour
of the water generation plant and visible pipework (including user
points) should be performed to ensure that the system is
appropriately designed, installed and maintained (e.g. that there
are no leaks and that the system matches the piping and
instrumentation diagram or drawing (P&ID).
The following list identifies items and a logical sequence for a
WPU
system inspection or audit:
a current drawing of the water system showing all equipment in
the system from the inlet to the points of use along with sampling
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points and their designations;
approved piping drawings (e.g. orthographic and/or isometric);
a sampling and monitoring plan with a drawing of all sample
points;
training programme for sample collection and testing;
the setting of monitoring alert and action levels;
monitoring results and evaluation of trends;
inspection of the last annual system review;
review of any changes made to the system since the last audit
and
a check that the change control has been implemented;
review of deviations recorded and their investigation;
general inspection of system for status and condition;
review of maintenance, failure and repair logs;
checking calibration and standardization of critical instruments.

DISEASE RELATED BREAKING NEWS
Middle East respiratory syndrome
coronavirus (11
th
June, 2014)
WHO encourages all Member States to continue their
surveillance for acute respiratory infections. Infection
prevention and control measures are critical to prevent the
possible spread of MERS-CoV in health care facilities. It is not
always possible to identify patients with MERS-CoV early
because like other respiratory infections, the early symptoms of
MERS-CoV are non-specific. Therefore, health-care workers
should always apply standard precautions consistently with all
patients, regardless of their diagnosis. Droplet precautions
should be added to the standard precautions when providing
care to patients with symptoms of acute respiratory infection;
contact precautions and eye protection should be added when
caring for probable or confirmed cases of MERS-CoV infection;
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airborne precautions should be applied when performing
aerosol generating procedures.Read more

UPCOMING EVENTS
5
th
International Conference on Stem Cells and Cancer 2014, JNU
Convention Centre, New Delhi,India from 8-10 November.2014

DRUGS UPDATES
FDA Approves Bunavail Buccal Film for the
Maintenance Treatment of Opioid Dependence: (9
th

June, 2014)
BUNAVAIL is the first and only formulation of buprenorphine and
naloxone for buccal (inside of the cheek) administration. The
ability of BUNAVAIL to stick on the inside of the cheek, unlike
sublingual products that need to be kept in place under the tongue
until they dissolve, allows patients to talk, swallow and go about
normal daily activities while the medication is being consistently
absorbed. BioDelivery Sciences International, Inc. (BDSI)
(NASDAQ: BDSI) received approval of the New Drug Application
(NDA) for BUNAVAIL (buprenorphine and naloxone) buccal
film (CIII) from the U.S. Food and Drug Administration (FDA).
BUNAVAIL is indicated for the maintenance treatment of opioid
dependence and should be used as part of a complete treatment
plan to include counseling and psychosocial support. BDSI
expects to launch BUNAVAIL late in the third quarter of 2014.
Read more


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CAMPUS NEWS
Reminiscence, 2014(GNIPST Reunion) was held in College
campus on 2
nd
February,2014.
1
st
Annual Sports of GNIPST was held on 3
rd
February,2014 in
College campus ground.
An industrial tour and biodiversity tour was conducted in Sikkim
for B.Pharm and B.Sc. students under the supervision of Mr. Asis
Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.
B.Pharm 3
rd
year won the GNIPST Football Champions trophy,
2013. B.Pharm 3
rd
year won the final match 1-0 against B.Pharm 2
nd

year. Deep Chakraborty was the only scorer of the final.
Students of GNIPST organized pre puja celebration programme,
Saaranya on 7
th
October, 2013 in college Auditorium.
GNIPST organized a garment distribution programme on 28
th

September, 2013 at Dakshineswar Kali Temple and Adyapith,
Kolkata. On this remarkable event about hundred people have
received garments. More than hundred students and most of the
faculties participated on that day with lot of enthusiasm.
GNIPST celebrated World Heart Day (29
th
September) and
Pharmacists Day (25
th
September) on 25
th
and 26
th
September,
2013 in GNIPST Auditorium. A seminar on Violence against
woman and female foeticide was held on GNIPST Auditorium on
25
th
September organized by JABALA Action Research
Organization. On 26
th
September an intra-college Oral and Poster
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presentation competition related to World Pharmacists day and
Heart day was held in GNIPST. Ms. Purbali Chakraborty of
B.Pharm 4
th
year won the first prize in Oral Presentation. The
winner of Poster presentation was the group of Ms. Utsa Sinha,
Mr. Koushik Saha and Mr. Niladri Banerjee (B.Pharm 4
th
year).
A good number of students have participated in both the
competition with their valuable views.
STUDENTS SECTION
WHO CAN ANSWER FIRST????
Who is the CEO of Dr Reddys Laboratories?
Which pharmaceutical company recently
acquired a UK-based firm called CP
Pharmaceuticals?

Answer of Previous Issues Questions:
A) Fuleco B)Armadillo
Identify the lady


Answer of Previous Issues Image:
Sunderlal Bahuguna

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Congrts Mr. Subhadeep Sengupta for the correct
answers

Send your thoughts/
Quiz/Puzzles/games/write-ups or any other
contributions for Students Section& answers
of this Section at gnipstbulletin@gmail.com



EDITORS NOTE
I am proud to publish the 3
rd
issue of 34
th
Volume of GNIPST
BULLETIN. GNIPST BULLETIN now connected globally
through facebook account GNIPST bulletin
I want to convey my thanks to all the GNIPST members and the
readers for their valuable comments, encouragement and supports.
I am thankful to Dr. Abhijit Sengupta, Director of GNIPST for
his valuable advice and encouragement. Special thanks to Dr.
Prerona Saha, Mr. Debabrata Ghosh Dastidar for their kind co-
operation and technical supports. An important part of the
improvement of the bulletin is the contribution of the readers. You
are invited to send in your write ups, notes, critiques or any kind of
contribution for the forthcoming special and regular issue.


ARCHIVE
Teachers day was celebrated on 5
th
September, 2013 by the
students of GNIPST in GNIPST Auditorium.
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Azalea (exotic flower ) , the fresher welcome programme for
newcomers of GNIPST in the session 2013-14 was held on 8
th

August in GNIPST Auditorium.
One day seminar cum teachers development programme for
school teachers on the theme of Recent Trends of Life Sciences
in Higher Education organized by GNIPST held on 29
th
June,
2013 at GNIPST auditorium. The programme was inaugurated by
Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy
Director of JIS Group and Dr. Abhijit Sengupta, Director cum
Principal of GNIPST with lamp lighting. The programme started
with an opening song performed by the B.Pharm students of this
institute. The seminar consists of a series of lectures, video
presentations and poster session. On the pre lunch session 4
lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata
Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty
respectively. On their presentation the speakers enlighten the
recent development of Pharmacy, Genetics and Microbiology and
their correlation with Life Sciences. On the post lunch session, Ms.
Saini Setua and Ms. Sanchari Bhattacharjee explained the recent
development and career opportunities in Biotechnology and
Hospital Management. The programme was concluded with
valedictory session and certificate distribution.
About 50 Higher secondary school teachers from different
schools of Kolkata and North& South 24 Parganas district of
West Bengal participated in this programme. A good interactive
session between participants and speakers was observed in the
seminar. The seminar was a great success with the effort of
faculties, staffs and students of our Institute. It was a unique
discussion platform for school teachers and professional of the
emerging and newer branches of Life Science.
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The general body meeting of APTI, Bengal Branch has been
conducted at GNIPST on 15
th
June, 2012. The program started
with a nice presentation by Dr. Pulok Kr. Mukherjee, School of
Natural Products, JU on the skill to write a good manuscript for
publication in impact journals. It was followed by nearly two hour
long discussion among more than thirty participants on different
aspects of pharmacy education. Five nonmember participants
applied for membership on that very day.
GNIPST is now approved by AICTE and affiliated to WBUT for
conducting the two years post graduate course (M.Pharm) in
PHARMACOLOGY. The approved number of seat is 18.
The number of seats in B.Pharm. has been increased from 60 to
120.
AICTE has sanctioned a release of grant under Research
Promotion Scheme (RPS) during the financial year 2012-13to
GNIPST as per the details below:
a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical
Science & Technology.
b. Principal Investigator: Dr. LopamudraDutta.
c. Grant-in-aid sanctioned:Rs. 16,25000/- only
d. Approved duration: 3 years
e. Title of the project: Screening and identification of potential
medicinal plant of Purulia & Bankura districts of West Bengal
with respect to diseases such as diabetes, rheumatism, Jaundice,
hypertension and developing biotechnological tools for enhancing
bioactive molecules in these plants.

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