This review aimed to search the literature for data on the prevalence, psychopathologic aspects, and comorbidity of body dysmorphic disorder. Patients with BDD often have been observed in aesthetic surgery settings seeking surgical enhancement at a reported prevalence of 6% to 15%.
This review aimed to search the literature for data on the prevalence, psychopathologic aspects, and comorbidity of body dysmorphic disorder. Patients with BDD often have been observed in aesthetic surgery settings seeking surgical enhancement at a reported prevalence of 6% to 15%.
This review aimed to search the literature for data on the prevalence, psychopathologic aspects, and comorbidity of body dysmorphic disorder. Patients with BDD often have been observed in aesthetic surgery settings seeking surgical enhancement at a reported prevalence of 6% to 15%.
Psychopathologic Aspects of Body Dysmorphic Disorder:
A Literature Review C. Pavan P. Simonato M. Marini F. Mazzoleni L. Pavan V. Vindigni Published online: 26 January 2008 Springer Science+Business Media, LLC 2008 Abstract Body dysmorphic disorder (BDD) is a so- matoform disorder characterized by the patients excessive concern with an imagined or minor defect in physical appearance. Patients with BDD often have been observed in aesthetic surgery settings seeking surgical enhancement at a reported prevalence of 6% to 15%. Published studies in the general population tend to aggregate a prevalence of 0.7% to 2.3%. This review aimed to search the literature for data on the prevalence, psychopathologic aspects, and comorbidity of BDD, and to provide an update on current BDD research. Relevant literature was identied by searching the Medline, PubMed, PsycINFO, and EMBASE databases. The following search words were used alone or in combination when appropriate: body dysmorphic dis- order, somatoform disorder, obsessive compulsive spectrum disorder, personality disorders, presurgical counseling, aesthetic surgery, cosmetic surgery, and plastic surgery. Further articles were sourced from the reference lists of the articles ascertained through the search. Recent ndings include the relationship between BDD and the obsessive-compulsive spectrum, treatment of BDD based on pharmacologic and psychological approa- ches, and the hypothesis that the often distinguished delusional and nondelusional variants of BDD very likely are the expression of a single disorder with varying degrees of severity. Retrospective outcome studies suggest that patients affected by BDD typically do not benet from surgical treatment. In contrast, serotonin reuptake inhibi- tors and cognitive-behavior therapy appear to be good practice in addressing the disorder. Further research is needed to identify effective interventions for patients who do not respond to these treatment methods. Keywords Aesthetic surgery Body dysmorphic disorder Comorbidity Etiology Obsessive compulsive spectrum disorder Somatoform disorder Individuals increasingly feel an inner need for their appearance to reect a certain aesthetic model as contem- porary social customs attribute increasing importance to a persons looks in his or her daily interactions, in both the private and the professional spheres. The demand to improve ones features or to retain their youthfulness in later life is constantly on the rise, as society has come to believe that improvement on nature is acceptable. It is, however, important to understand that the dividing line between this common wish to improve ones looks and neurosis can sometimes become very ne. Extreme dissatisfaction with ones appearance may conceal psy- chopathologic traits that are not always easy to recognize, and which if neglected may involve serious iatrogenic and medicolegal consequences. A plastic surgeon was recently accused of malpractice for not taking into due consider- ation the psychiatric problems of his patient, who was judged incapable of giving her informed consent for the scheduled operation because she had a diagnosis of body dysmorphic disorder (BDD) [1]. Plastic surgery constitutes a privileged vantage point for the analysis of BDD because it is strategically situated with C. Pavan (&) P. Simonato M. Marini L. Pavan Psychiatric Clinic, University of Padova, Via Giustiniani 2, 35122 Padova, Italy e-mail: chiara.pavan@unipd.it F. Mazzoleni V. Vindigni Unit of Plastic and Reconstructive Surgery, University of Padova, Via Giustiniani 2, 35122 Padova, Italy 1 3 Aesth Plast Surg (2008) 32:473484 DOI 10.1007/s00266-008-9113-2 regard to the study of the body image among BDD patients. In fact, BDD is a pathology that psychiatrists often are not informed to observe because the patients, who do not understand the true nature of their problem, turn to der- matologists and above all to plastic surgeons. It must be stressed that such a patient may benet from psychiatric treatment alone. An operation, even if perfectly performed, is incapable of resolving the psychological discomfort stemming from the supposed physical defect and leads more often than not to a lawsuit [210]. This review includes the history of BDD, the current diagnostic criteria, etiologic theories, clinical and demo- graphic features, comorbidity, and treatment. This article aims to stress to plastic surgeons and other physicians who offer aesthetic procedures the importance of promptly recognizing and properly treating patients with BDD. The relevant literature was identied by searching the Medline, PubMed, PsycINFO, and EMBASE databases. The following search words were used alone or in combi- nation when appropriate: body dysmorphic disorder, somatoform disorder, obsessive compulsive spectrum disorder, personality disorders, presurgical counsel- ing, aesthetic surgery, cosmetic surgery, and plastic surgery. Further articles were sourced from the reference lists of the articles ascertained through the search. History The rst clinical description of BDD dates back to Enrico Morselli [11], who in 1891 introduced the term dysmor- phophobia to describe a subjective feeling of ugliness or of a physical defect, which makes the patient believe he or she is observed by others despite a normal appearance. Pierre Janets [12] subsequent descriptions of the disorder indicated the presence of an obsession with shame of the body (obsession de la hontu du corps), whereas Kraepelin [13] maintained that the disorder stemmed from obsessive neurosis. Jaspers [14], on the other hand, stressed that the patients preoccupation could assume different forms and become an obsession, a prevalent idea, or a secondary delusion. Etymologically speaking, the term dysmorphophobia derives from the Greek dysmorphia, which indicates ugliness, particularly in relation to the face. The disorder is not, however, characterized simply by the fear of having a physical defect, as the sufx phobia might suggest. Rather, the patient manifests what can be described as a polarization of attention, charged with an emotional par- ticipation that focuses on a specic part of the body. The subject develops repulsion for that part of the body, which interferes to a varying degree with relations with others and with social functioning. Dysmorphophobia rst became a distinct diagnostic category in 1980 in the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition (DSM-III) [15], but only in DSM-III-R [16] was the term dysmorphophobia abandoned in favor of body dysmorphic disorder to avoid an emphasis on the phobic aspects of avoidance and to classify it among the group of somatoform disorders. Relationship of BDD to the Obsessive-Compulsive Spectrum The classication of BDD is a debated issue. According to DSM-IV-TR [17], BDD is subsumed under the somatoform disorders, but this classication has been criticized. Some researchers assert that BDD has commonalities with the obsessive-compulsive spectrum [18]. Morselli [11], Janet [12], and Kraepelin [13] identied psychopathologic analogies between the two disorders related to the presence of intrusive thoughts and repetitive behavior. The study by Phillips [19] that investigated 200 cases of BDD showed at least one repetitive behavior for each patient aimed at reducing levels of anxiety about physical appearance. The most frequently encountered behaviors were camouaging, comparing the imagined abnormal part with that of others, mirror checking, glancing in reective surfaces, excessive grooming, frequent changes in dress, skin picking [20], dieting, and excessive physical exercise. There is indeed some clinical and pathologic overlap between obsessive-compulsive disorder (OCD) and BDD such as obsessive thoughts and the performance of ritual behavior (safety behavior). Other characteristics fre- quently encountered in both are the desire for symmetry (in the positioning of objects or in ones own body), the search for perfection, and the patients need to control the envi- ronment surrounding his or her appearance. Both disorders are characterized by frequent requests for reassurance [21]. There is further overlap between the two disorders in age of onset, sex distribution, chronic course, family his- tory of psychiatric disorders, and type of treatment. Reports in the literature suggest that some personality traits such as asthenia/hyposthenia, a robust tendency toward self-criti- cism, insecurity, and perfectionism may be considered premorbid factors predisposing to the development of BDD and OCD. Among patients with a primary diagnosis of OCD, ndings have shown BDD to be a comorbidity in 8% to 37%, whereas among those with a primary diagnosis of BDD, the rate of OCD comorbidity is reportedly 20% to 30% [18, 2128]. Many other studies have described similarities in both symptomatology and therapeutic approach [18, 2128]. A study by Eisen et al. [29] compared a sample of 64 OCD patients with 85 BDD patients and discovered that 474 Aesth Plast Surg (2008) 32:473484 1 3 the latter had less insight and a worse clinical course, conrming the ndings of Phillips et al. [18] and Simeon et al. [30]. Conversely, the survey by Neziroglu et al. [22] suggested a higher tendency toward delusionality than found among patients with OCD. As observed by Phillips and Diaz [28], it seems that BDD patients are less frequently married, have greater suicidal ideation, are at greater risk for the development of major depression or social phobia, and are more frequently addicted to substance abuse than subjects with OCD. From a neurophysiologic standpoint, Neziroglu et al. [22] and Phillips et al. [31] reported serotonergic system involve- ment with both disorders, conrming the rationale behind the use of serotonin reuptake inhibitors. As observed [18, 29, 32], despite these analogies, it is appropriate to make a distinction between BDD and other obsessive-compulsive spectrum disorders, both clinically and in the research eld. This is illustrated by a recent Italian study conducted at Pisa University [33] that compared three different groups of patients, comprising those affected by BDD (n = 34), by BDD and OCD (n = 24), and by OCD (n = 79). The groups presenting with BDD or BDD and OCD were slightly younger, less fre- quently married, and more often unemployed, in addition to presenting with bulimia, substance abuse disorders, and social phobia. The authors conrmed that it was appro- priate to include BDD in the OCD spectrum, but, according to their ndings, it could not simply be con- sidered a variant. Rather, the copresence of BDD and OCD indicated a more severe syndrome with a greater psychopathologic load. Denition By denition, BDD consists of an excessive, dispropor- tionate preoccupation with an imagined or slight defect in physical appearance by a person of normal appearance. In particular, DSM-IV-TR [17] identies the following as essential diagnostic criteria: 1. Preoccupation with an imagined defect in physical appearance. If a slight physical anomaly is present, the persons concern is markedly excessive. 2. The preoccupation causes clinically signicant distress or impairment in social, occupational, or other impor- tant areas of functioning. 3. The preoccupation is not better accounted for by another mental disorder (e.g., dissatisfaction with body shape and size in anorexia nervosa). The pathologic nucleus is preoccupation about a physical defect that generally concerns the face but may also involve other parts of the body. Attention may be focused on one portion or may transfer over time according to a pattern known as substitution [34]. Etiology The etiology of BDD is most likely multifactorial (bio- logic, psychological, and sociocultural). An impairment of the frontal-striatal and temporo-parietal-occipital circuits, which process facial images and emotional information, has been shown by neuropsychological and brain imaging studies [35], suggesting some evidence for genetic links and familiar aggregation [36] with OCD, although the lit- erature on these relationships is limited. A role for the serotonin system and receptors is sug- gested by the evidence of a therapeutic response to serotonergic antidepressants. Symptoms of BDD have been exacerbated after tryptophan depletion, and onset has occurred after abuse of a serotonin antagonist [35]. Few studies describe certain cognitive decits with BDD such as loss of executive function, memory, facial emotion perception, and attributional bias. Some authors [36] have shown that BDD patients had no difculty identifying facial features. They were less accurate than normal controls but more accurate than a group of patients with OCD in identifying facial expressions of emotion. Veale [37] suggests a cognitive-behavioral model of BDD based on an excessive self-focused attention to neg- ative body-related information. Veale et al. [38] have in fact shown that BDD patients have an unrealistic ideal for appearance, failing to achieve their own aesthetic standard. In summary the cognitive data suggest that abnormal per- ception and emotional processing decits have an important role in BDD, but further empiric testing is required. Epidemiology Currently available studies indicate a BDD prevalence of approximately 1% in the general population of the United States [39, 40]. A community survey in Florence, Italy by Faravelli et al. [41] demonstrated a BDD prevalence of 0.7%. Published studies in the general population aggre- gate a prevalence of 0.7% to 2.3% [36]. Certain groups of individuals have higher rates of BDD, such as those in plastic surgery and dermatologic settings, among whom the prevalence is 6% to 15% [4244]. A recent study based on administration of a questionnaire to 1,000 patients [45] conrmed an incidence of 3% to 8% in the same groups. According to a recent report, 20% of patients affected by BDD probably have at least one rst-degree relative affected by the same disorder [19], suggesting some form Aesth Plast Surg (2008) 32:473484 475 1 3 of heredity. However, this hypothesis warrants further investigation. Epidemiologically speaking, the incidence of BDD seems to present a bimodal distribution. The disorder tends to manifest primarily in adolescence and early adulthood, with a second incidence peak after menopause [46]. Most clinical series of patients describe an onset in the teenage years, but many patients with BDD describe sensitivity about their appearance throughout their lives. A survey conducted by Phillips et al. [19] with 200 subjects affected by BDD identied the mean age of onset to be 16.4 years. When subclinical forms were included in the analysis, the mean age of onset was lowered to 12.9 years. In some cases [47], the disorder also may be manifested in childhood. Overall, therefore, the mean age of BDD onset is estimated to be approximately 33.7 years [28, 42]. Many studies have shown BDD to be common among the student population, both male and female. In a ques- tionnaire study by Cansever et al. [48] that investigated a sample of 420 female college students, 43.8% of the respondents reported dissatisfaction with their appearance, and 4.8% met the DSM-IV diagnostic criteria for BDD. A similar survey by Bohne et al. [23], based on a sample of 133 students at a German college (73.3% women), identi- ed a 5.3% prevalence of BDD, associated with low self- esteem, depressive symptoms, and behavior characteristic of the obsessive-compulsive sphere. A study of 102 college students showed a prevalence of 13% [49]. In another college population study, Sarwer et al. [50] reported a BDD prevalence of 2.5%. Dening gender differences has been more difcult. Some authors [26] have observed a higher incidence of BDD among males, but others [27, 28] have reported the incidence to be unvaried. Studies conducted by Rosen et al. [51] and Biby [49] point to a greater presence of the dis- order among women. Specically, Cororve and Gleaves [52], by aggregating patients who voluntarily consulted a psychiatrist with those experiencing milder forms of BDD, found the prevalence rate decidedly higher in the female population. There are, however, clinically signicant gender dif- ferences in the body parts on which the patient focuses attention. Phillips and Diaz [28] and Perugi et al. [53, 54], for example, found that men were more concerned about their genitals, muscle mass, and hair, whereas women were more preoccupied with their breasts, thighs, and legs. These differences are likely to have sociocultural conno- tations and to be reinforced by models proposed by the mass media. A recent study by Phillips et al. [55] examined the similarities and differences in an extensive sample (n = 200) of subjects affected by BDD and found that in addi- tion to being older, the men were less frequently married than the women and also more prone to substance abuse. Conversely, the women tended to present repetitive behavior and to camouage their supposed defects. Con- sequently, although BDD is sometimes considered to be a female disorder, the gender ratio ranges from 1:1 to 3:2 (female:male), in contrast to eating disorders, which are essentially disorders of females (Tables 1 and 2). Clinical Symptoms of BDD Patients with BDD generally show an exaggerated preoc- cupation with imagined physical defects that have a highly disproportionate emotional and affective charge [56, 57]. Table 1 Prevalence of body dysmorphic disorder (BDD) among community, college student, cosmetic surgery, and dermatology populations Sample Authors Year Country Rate (%) Community Faravelli et al. [41] 1997 Italy 0.7 Cotterill & Cunliffe [39] 1997 United States 1 Patterson et al. [40] 2001 United States 1 Castle DJ [36] 2006 Australia 0.72.3 College students Biby [49] 1998 United States 13 Bohne et al. [23] 2002 Germany 5.3 Cansever et al. [48] 2003 Turkey 4.8 Sarwer et al. [50] 2005 United States 2.5 Cosmetic surgery and dermatology populations Vindigni et al. [87] 2002 Italy 53.6 Phillips et al. [42] 2000 United States 11.9 Vulink et al. [45] 2006 Netherlands 38 Veale et al. [38] 2003 United Kingdom 20.7 Crerand et al. [99] 2006 United States 653 Castle et al. [84] 2004 Australia 2.9 Pavan et al. [82] 2006 Italy 27 476 Aesth Plast Surg (2008) 32:473484 1 3 The fear experienced by these subjects is closer to shame than to a narcissistic desire to improve or perfect their body. In other words, they have a pervading sense of inadequacy about their body and would like to feel acceptable or simply normal. Anxiety arises particu- larly when they are exposed to others, producing strong social inhibition. A wide array of body parts may be involved, as shown by the extensive case set reported by Phillips et al. [55]. In reviewing 200 cases of BDD, these authors observed a mean involvement of ve to seven body parts and com- pulsive behavior in all subjects, including excessive mirror checking, grooming, or skin picking. Many patients express concern about their skin (e.g., color, marks, veins, pores, wrinkles) or face, describing it as hideous or awed because the ears are too low, the hairline is too high, or there is acne or blackheads. Others express a pervasive fear of resembling an animal or other members of the family with some physical defect (e.g., baldness, prominent nose). Another common complaint is lack of femininity (typ- ically small breasts) or masculinity (small penis, puny body). Great concern also is expressed about lack of symmetry, particularly of the face (number of moles, height of eyes or eyebrows, or shape of nose) and hair [28]. Cases of body parts that change appearance, shape, or prole also have been described [28], as well as parts that appear more delicate, as in the case of a patient who pre- ferred to have a tooth extracted without anesthesia to ensure that the dentist did not damage his fragile nose. Often, BDD is associated with accessory symptoms, such as reference ideas or delusions (73%) and tactile sensations (37%) [58]. Subjects with BDD manifest self-referential thinking. They assume that others can see the imagined physical defect and consider every phrase, glance, or laugh to be the expression of a judgment, a condemnation, or a sentence. Hence the condition is not a phobia but a disorder of body image because the subject is preoccupied solely with his or her own presumed defects [59] but tolerates those of others. This broad spectrum of manifestations may impair patients daily life, even to a severe degree. As Phillips and Diaz [28] observed in various case reports, when the dis- order becomes very pervasive, it can potentially disrupt the subjects entire social life. Conversely, if it remains cir- cumscript, taking on milder, less debilitating forms, it may be associated with high, almost compensatory social functioning. In their study of 200 patients affected by BDD, Phillips et al. [19] reported that in the previous month, 36% of the sample (n = 63) had been absent from work, and 32% (n = 56) had skipped school because of the disorder. They also reported that 11% had permanently left school. Hence, BDD impairs the social life of affected subjects. Hollander et al. [47] observed that 50% of a student sample was concerned about their appearance and that social functioning was affected in 25% of cases. In a study of 62 subjects affected by BDD [60] the quality of life experi- enced by BDD patients was assessed on the basis of various scales and compared with the general U. S. population. The ndings showed that the mental health status and quality of life experienced by BDD patients was far inferior to that of the general population. Very often, self-esteem can be so low as to result in social isolation. One important nding emerging from some studies is that most patients with BDD are not mar- ried [28, 60, 61]. This brief discourse is a source for much reection and calls for future studies. It is not clear, for example, how patients choose the body part on which to concentrate their attention. Subjects undoubtedly present an anomalous perception of their own body image, but the mechanisms underlying the choice of one aspect to the exclusion of others is not known. It also is not certain how subjects judge details as being anomalous that most people consider irrelevant. Table 2 Comorbidity in body dysmorphic disorder (BDD) Comorbidity in BDD Prevalence among patients with BDD (%) Obsessive compulsive disorder (OCD) 630 [99] Depressive disorders 80 (lifetime) [58, 60, 71] Social phobia 12 [72]/39.3 (lifetime) [73] Substance abuse disorders 48.9 [78] Suicidal ideation 78 [74] Eating disorders 32.5 [79] s Anorexia nervosa 9.0 s Bulimia nervosa 6.5 s Not otherwise specied ED (eating disorders) 17.5 Personality disorders (cluster C) 1543 [22, 32] Aesth Plast Surg (2008) 32:473484 477 1 3 Delusional and Nondelusional Forms of BDD Patients complaints also can present delusional aspects. Although these generally are less severe than in other forms of delusion, they exceed mere attention to ones own physical appearance. Several studies have described some severe variants characterized by poor insight, in which the patient loses the capacity for realistic criticism of his or her own symptoms, as observed in four case reports by Lucchelli et al. [62]. Currently, approximately 35% to 40% of BDD cases are believed to present the delusional pattern [19, 63, 64]. The DSM-IV-TR [17] does in fact envisage an additional diagnosis of delusional disorder, somatic type, in which the patient presents absolutely unrealistic, primarily pathologic thinking that does not permit criticism [22, 65]. However, the delusional and nondelusional variants of BDD are very likely to be the expression of a single disorder with various degrees of severity. Numerous studies based on this hypothesis [27, 60, 66] have observed uctuations in delusional ideation in patients with BDD related to envi- ronmental stressors. Specically, Phillips et al. [60] noted an overlap between the two forms in terms of demographic factors, clinical presentation, natural history, comorbidity, family history, and response to pharmacologic treatment. Course of BDD Usually, BDD is lifelong, but the outlook for those who receive treatment is much more favorable. Phillips et al. [67] reported the chronic course of BDDin a study of 183 patients with a 12-month follow-up period. After 1 year, the proba- bility of complete spontaneous remission was 9%and that of partial remission was 21%, without signicant gender or ethnic differences. The authors stressed that BDD had an extremelylowprobabilityof remissioncomparedwithmood, personality, and anxiety disorders surveyed with similar methods. Moreover, a prospective study showed that the severity of symptoms at onset, the long duration of the dis- order, and the comorbidity with personality disorders are indices of the low probability for partial or spontaneous remission [68]. This study also evidenced that gender, eth- nicity, age of onset, socioeconomic status, adolescence or adulthood, comorbidity with social phobia, OCD, and eating disorders were not, however, predictors of remission proba- bility, nor was being a recipient of nonpsychiatric treatments. BDD Comorbidity Comorbidity with Depressive Disorders Findings show that BDD has a high rate of comorbidity with depressive disorders (estimated to be 80% of cases), as corroborated by our study. Various reports in the liter- ature have conrmed that subjects with BDD present with depressive symptoms marked by emotional lability, social withdrawal, loss of pleasure or interests, or comorbidity with axis 1 and 2 disorders [27, 6972]. A recent study [70] using the Symptom Questionnaire to compare 75 patients with a control group recorded high scores for the anxiety, depression, somatization, and anger and hostility scales. The literature reports major depression to be the disorder most frequently associated with BDD, with a lifetime prevalence exceeding 80% [58] [60, 71]. In many ways, BDD differs from depressive disorders, although it may be that feelings of low self-esteem about ones own body develop during an episode of major depression. Nonetheless, these feelings never focus on specic aspects of physical appearance, nor are they cor- related with compulsive behavior. Moreover, depression affects more women than men, with a later age of onset and a less chronic course than experienced with BDD. Thera- peutically, BDD also responds far less to serotonin reuptake inhibitor-type antidepressants. Currently, BDD appears to be correlated and often comorbid with depres- sive disorders, but to date the relationship between the two has not been fully understood. Patients with BDD also seem to be particularly exposed to suicidal ideation and suicide risk. A recent study by Phillips et al. [74] examined 200 subjects with BDD and found a 78% lifetime frequency of suicidal ideation and an attempted suicide rate of 27.5%. In addition, the study showed that BDD was the main reason for suicidal ideation experienced by 70.5% of patients and that it was correlated with a high suicidal risk, particu- larly in patients with comorbid depressive and substance abuse disorders. Conversely, Phillips and Menard [75] conducted the rst prospective study of 185 patients affected by BDD over a period of 4 years. The annual incidence was reported to be 57.8% for suicidal ideation and 2.6% for attempted sui- cides. Two subjects (0.3%) completed suicide. The authors emphasized that suicidal ideation was high with BDD and suggested that the frequency of completed suicides was probably also signicant. Comorbidity with Social Phobia Social phobia is another comorbidity of BDD, with an estimated rate of 12% [72]. An interesting study conducted by Coles et al. [73] examined the relationship between BDD and social phobia in a series of 178 patients with BDD. These patients showed comorbidity with social phobia at a lifetime rate of 39.3%, and 34.3% presented 478 Aesth Plast Surg (2008) 32:473484 1 3 ongoing comorbidity, sharing similar general characteris- tics (age, gender, degree of BDD severity, functional disability) and correlation with poorer social functioning. The authors also emphasized that comorbid patients pre- sented greater suicidal ideation than patients affected by BDD but not social phobia. Like BDD, social phobia is characterized by robust social anxiety and avoidance behavior, but there is no clear focus on a single feature of the body. Phillips and Diaz [28] maintained that social phobia develops secondarily in patients with BDD. Comorbidity with Substance Abuse Various studies have reported high rates of BDD comor- bidity with substance abuse disorders [32, 57, 71, 76, 77]. Grant et al. [78] examined 176 subjects affected by BDD and found a lifetime substance abuse disorder rate of 48.9% (n = 86) and a lifetime substance dependency rate of 35.8%, particularly alcohol dependency (29% lifetime rate). In 68% of these subjects, BDD was the main causal element of substance abuse. Comorbidity with Eating Disorders There is a signicant correlation between BDD and eating disorders, with moderate comorbidity. A recent research study [79] examined 200 subjects with BDD and found a 32.5% rate of lifetime comorbidity with eating disorders including anorexia nervosa (9%), bulimia nervosa (6.5%), and other unspecied disorder (17.5%). The ndings also showed that patients with eating disorders have received more mental health care than other subjects with BDD. Anorexia nervosa, BDD, and bulimia nervosa share the commonalities of compulsive behavior (mirror checking and measuring parts of the body) and an underlying pre- occupation with bodily appearance, accompanied by a distortion of ones own body image. However, important differences also exist. Subjects affected by BDD appear normal to other people, whereas anorexics have a cachetic appearance. The more emaciated they seem, the better they think they look. In addition, eating-disordered patients concentrate chiey on their weight rather than on a single part of the body, unlike those with BDD. Epidemiologi- cally, eating disorders differ from BDD in that they more frequently affect women [59]. However, Phillips and co- authors suggested [79] the presence of a gray area between eating disorders and BDD, maintaining that the overlap of symptoms hindered differential diagnosis and prevented clinicians from completely ruling out eating disorders as a form of BDD. Comorbidity with Personality Disorders Comorbidity in axis 2 is more frequent among patients with BDD, particularly cluster C personality disorders [43, 54, 80] including avoidance (43%), dependence (15%), and obsession-compulsion (14%). Several studies conducted in aesthetic surgery departments also have evidenced cluster A disorders [69], showing a high frequency of paranoid disorder (14%). Similarly, the survey by Maffei and Fossati [81] positively correlated BDD with avoidance and dependent personality disorders in a sample of 30 subjects seeking corrective aesthetic surgery. A study investigating a group of patients from the Plastic Surgery Department of Padova University surveyed not only the presence of BDD but also temperamental and personologic charactersitics using the Three-dimensional Personality Questionnaire (TPQ) and Neo Five-Factor Inventory (Neo-FFI) [82]. Subjects affected by BDD had elevated scores on the Harm Avoidance (HA) scale of the TPQ, suggesting greater behavioral inhibition, with high levels of anticipatory anxiety (HA1), fatigability and asthenia (HA4). Conversely, on the Neo-FFI, the patients with BDD presented lower scores on the Open to experi- ence (O), Agreeableness (A), Conscientiousness (C), and Extraversion (E) subscales, conrming greater introversion and hostility. Bellino et al. [69] examined a sample of 57 subjects presenting for plastic surgery. This study included testing with standardized instruments for the presence of BDD and personality disorders. The results showed an association between symptom severity and the number of cluster per- sonality traits (schizotypal and paranoid characteristics). The authors concluded that these personality traits, marked by a tendency toward suspiciousness, fear of the judgment of others, social anxiety, and an essentially fragile per- sonality, probably predisposed subjects to abnormal cognitive experiences, with amplication of bodily imperfections to the point of psychic decompensation. Surveys of personality and temperamental traits in patients with BDD have preliminary but important clinical impli- cations because patients who meet a high number of diagnostic criteria for personality disorders in perioperative assessment may constitute a risk group (Table 2). BDD and the Request for Aesthetic Surgery Body dysmorphic disorder is considered a relatively fre- quent disorder among patients seeking aesthetic surgery, and these specialist departments often are the rst to make contact with these subjects. Reports published in the lit- erature indicate a high prevalence of BDD particularly in departments of dermatology and plastic surgery, with an Aesth Plast Surg (2008) 32:473484 479 1 3 estimated frequency of 6% to 15% [4244]. The study conducted by Vulink et al. [45] described an 8.5% preva- lence of patients affected by BDD in a plastic surgery population (n = 1,000). This conrms, as do other studies [83], that the rst treatment to be sought by patients with BDD is nonpsychiatric and that intervention often is multiple. Another study [26] found that 40% of assessed patients (n = 50) had received at least one aesthetic operation, but a research study [44] showed no differences among receivers and nonreceivers of nonpsychiatric treatment in terms of clinical or demographic characteristics. Still another study examined 268 patients awaiting dermatologic treatment and reported that 11.9% of patients were affected by BDD according to DSM-IV criteria [42]. A questionnaire administered by Castle et al. [84] to 137 patients awaiting aesthetic improvement identied 4 patients affected by BDD and many others with a sub- clinical level of dysmorphic preoccupation attributable to states of anxiety, manifestations of social anxiety, and a decline in social functioning. Phillips et al. [83] surveyed 289 subjects affected by BDD (250 adults and 39 adoles- cents) and found that 76.4% had received nonpsychiatric medical care including dermatologic (45.2%) and surgical (23.2%) treatment. These treatments were rarely able to improve the symptoms of the patient with BDD. In addition to these retrospective studies [19, 32, 83], the literature also contains an important prospective study demonstrating that medical or surgical treatment of patients with BDD is not associated with a high probability of remission from the disorder. Rather, the clinical results of these treatments are perceived as unsatisfactory to the point of exposing the attending physician to risk [43, 61, 85]. One article published in a specialist surgical journal [5] emphasized the urgent need for plastic surgeons to identify patients with BDD promptly despite the multiform nature of the disorder. These subjects are prone to a syndrome of overoperation. There is a risk that they will not be satised with the aesthetic procedure and may constitute a (poten- tially physical) threat to the attending surgeon. Indeed, many authors have suggested and stressed the importance of con- ducting preoperative psychiatric assessment to avoid subsequent psychopathologic decompensation [8688]. De Jongh and Adair [89], reporting on a patient with BDD who became enraged after dental treatment, emphasized the need to assess patient vulnerability and psychological problems, primarily to avoid exposure to potential treatment stressors. In the practice of liposuction, Glaser and Kaminer [90] highlighted the need to recognize patients with BDD and diagnose their condition because they were highly subject to dissatisfaction with the treatment received and difcult to manage postoperatively. A study conducted by Veale et al. [91] used a screening questionnaire to assess the presence of BDD among patients requesting rhinoplasty and obtained a frequency of 20.7%. The authors subse- quently compared patients with and without BDD undergoing the procedure, showing that the former were younger, more depressed, more anxious, and more preoc- cupied about their nose. Moreover, they were signicantly less functional at work, in their social life, and in personal relations besides being more avoidant. Finally, these sub- jects were more convinced that their life would dramatically change after the rhinoplasty. The authors suggested identifying patients with BDD, particularly those with the more serious variants, for whom the prognosis for aesthetic rhinoplasty is signicantly worse. BDD Treatment Individuals with BDD often refuse psychiatric referral because of poor insight into their underlying illness, but certain pharmacologic and psychological treatments have shown some success. Psychiatric treatment of BDD envisages the use of selective serotoninergic antidepres- sants (uoxetine and uvoxamine) and tricyclics (e.g., clomipramine). In particular, the retrospective study of 50 patients by Hollander et al. [26] demonstrated that improvement in symptoms was greater for subjects treated with clomipramine, uoxetine, or uvoxamine. Another study conrmed the greater efcacy of the aforementioned compounds in association with buspirone compared with other compounds (Tryciclic antidepressants (TCA), ben- zodiazepines, neuroleptics, or anticonvulsants) that showed minimal efcacy [92]. A double-blind study by Phillips et al. [93] conrmed the efcacy of uoxetine compared with placebo, whereas a survey by Hollander et al [72], conducted in double-blind fashion with 29 patients, correlated the use of clomipramine with an improvement in global symptoms and a return to social functioning. Conversely, Phillips et al [31] obtained a 63% response with uvoxamine in a study of 30 patients. A recent study showed good therapeutic efcacy with citalopram, but suspension of medication led to a relapse in 83.8% of cases after a mean period of 38 weeks [94]. As these studies [72, 94] indicate, the presence of delusional characteristics is apparently not a factor pre- dicting a negative response to serotoninergics. Patients respond to treatment with a reduction in preoccupations, a decrease in stress, a reduction in behavioral rituals, and signicant improvement in social and occupational func- tioning. The defect is generally noted (it rarely is no longer perceived), but usually causes less distress. The most effective psychological intervention is cogni- tive-behavior therapy used to change specic beliefs and assumptions thought to underlie both BDD and 480 Aesth Plast Surg (2008) 32:473484 1 3 maladaptative behavior patterns [95]. Cognitive therapy aims to challenge dysfunctional thinking, replacing it with adaptive cognitive styles, whereas behavior therapy involves prolonged and graded exposure to distressing situations with prevention of compulsive overt and covert responses (e.g., rituals) [36]. The cognitive-behavioral approach involves self-monitoring of thoughts and behav- ior related to appearance, cognitive strategies, and behavioral exercises [96]. Other components of cognitive- behavior therapy in the treatment of BDD are social skills training, psychoeducation, and role-playing [36]. A recent metaanalysis [36] of trial and case series involving pharmacologic and psychological treatments for BDD suggests that cognitive-behavior therapy was signif- icantly more effective than treatment with medications. Medication associated with cognitive-behavioral psycho- therapy has proved to be an effective intervention [27, 51, 9699], although it currently is not possible to tease out the effects of combined treatments. The published literature has a paucity of combined psychological and pharmaco- logic treatments evaluated rigorously [36]. BDD: Probably an Underestimated Disorder In conclusion, BDD probably is an underestimated disor- der. First, it may escape notice because few psychiatrists or specialists who make rst contact with BDD patients know or recognize the condition [100]. By contrast, it is acknowledged that subjects affected by BDD consult der- matologists and plastic surgeons to change their appearance [65, 101], but the outcome of the procedure very often is unsatisfactory, with the patient requesting further (potentially unlimited) aesthetic interventions for the same or other parts of the body, to which there is a transfer in the focus of attention. However, few studies have been conducted to assess the outcome of any treat- ments received [43, 102, 103], although they were unlikely to cure the disorder. Second, patients with BDD often are reluctant to manifest their preoccupation openly to either their family or the psychiatrist, whom they tend to avoid consulting in any case [28]. This is linked to the fear of feeling that others will judge them to be absurdly vain and narcissistic, triggering a mechanism of social with- drawal, which very often is identied, diagnosed, and treated as major depression. Many studies conducted with these patients have noted an episode of major depression in their history. Paradoxically, the need to keep their preoccupation secret is sometimes fueled by the fear that their anxieties will be conrmed if they reveal them to others. Currently, it is believed that patients with BDD seek out psychiatric treatment after an average estimated delay of 11 years following onset of the disorder [103105]. How to Test for BDD in Clinical Practice Although psychological evaluation of patients is not stan- dard in clinical practice, it is very important for the plastic surgeon to diagnose BDD during preoperative consultation, not only for medicolegal reasons but also with a view to referring affected patients for proper treatment. The con- sultation should start with questions for the patients about their motivation for surgery, their personal expectations, and whether they are dissatised with how they look or worry considerably about their appearance [35, 106]. A group of authors has recently developed an algorithm to help lter out BDD patients preoperatively. The algo- rithm focuses attention on the severity of the deformity and the patients general behavior. The authors have identied three groups of patients with different characteristics. The rst group includes patients with unreasonable behavior but no deformity. Under these circumstances, the diagnosis of BDD has to be considered, and the patients should be referred to a psychiatrist. The second group consists of patients with a correctable deformity and reasonable expectations, to whom a surgical intervention could potentially be offered. The third is a risk group formed by patients with a minimal but correctable deformity and inadequate behavior. The surgeon must be extremely crit- ical when proposing a procedure in these cases. Risk group patients should at least be revaluated during a second preoperative consultation [106]. The tests that can be used to diagnose BDD are the Body Dysmorphic Disorder Questionnaire and the Body Dys- morphic Disorder Examination Self-Report. Diagnosis and follow-up evaluation of BDD can be simplied by a visual analog scale (VAS), but the VAS results should be cross- checked with the patient interview [107, 108]. Phillips developed the BDD-Yale-Brown Obsessive Compulsive Scale (YBOCS) [21] to determine the severity of BDD, but as suggested by Hodgkinson [107], this tool is more likely to be used as a clinical research tool by psychiatrists. In any event, the diagnosis of BDD must be conrmed by a psy- chiatrist in accordance with DSM-IV criteria and after a psychiatric interview. How to Inform BDD Patients Phillips and Dufresne [109] suggested adopting a psycho- education approach for patients with BDD. It is vitally important to inform patients that they seem to have a dis- turbance of body image known as BDD. 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