Drug developers

Set your MIND for

pharmacology

Join the new course
15
th
to 19
th
November 2004

Course on Pharmacology (B-8104)

This course is a part of the compulsory curriculum for the professional masters programme
Master of Industrial Drug Development at the Danish University of Pharmaceutical Sciences.

Aim
The objective of the course is to give the students a fundamental concept of pharmacology, its
experimental tools and an insight in the major drug classes.

Who should attend?
Drug developers who wish to work in a more rational and systematic way within drug
development by improving their qualifications and thus securing a better understanding of the
drug development processes. It is suitable especially for current and prospective project
leaders/managers, group leaders, function managers, senior scientists or others who want to
get a grip on fundamental aspects of pharmacology and pharmacokinetics in a comprehensive
and suitable/practical way. The typical participant will have a background in chemistry,
biochemistry, pharmacy, engineering, health science or the like.

Course outline
The pharmacological concepts, methodologies and techniques are fundamental for the drug
development. As discipline it does not fit in for one particular part of the process but an
important feature is the translation of animal data to the human situation. Thus basic
pharmacological knowledge is important for those who want to possess an integrated view on
the effects and behaviour of the drug candidate from discovery to clinical development.
Pharmacodynamics and pharmacokinetics are addressed separately to be familiar with the
theoretical background behind these disciplines.

The course contains the following topics:
Pharmacology and the drug development process.
Classes of pharmacology targets.
Classification of receptors. Drug classes.
Measurement of pharmacologic effects.
In vitro pharmacology, concepts and methodology.
Pharmacokinetics I-V
Basic concepts
Extra vascular dosing
Non-compartment analysis
Toxicokinetics and exposure
Scaling
Metabolism
Biomarkers
High throughput techniques in exploratory pharmacology
Pharmacogenetics
In vivo pharmacology methodology
Animal models for cardiovascular diseases, obesity, bone and joint diseases and
pain.
Behavioural animal models.

The course contains the following practices:
Hands-on pharmacokinetics with computer simulation
Case studies as exercises
Laboratory demonstrations

Teachers
Johan Gabrielsson, AstraZeneca
Jrn Arnt, Lundbeck
Bjarke Ebert, Lundbeck
Frank Larsen, Lundbeck
Erik B. Nielsen, Lundbeck
Anders Gersel Pedersen, Lundbeck
Ole J. Bjerrum, DFU
Bjarne Fjalland, DFU
Arne Schousboe, DFU
Uffe Kristiansen, DFU
Anne-Marie Heegaard, DFU
Trine Meldgaard Lund, DFU
Huw Davies, Ciphergen Biosystems Inc.


Course material
Textbook of pharmacokinetics
Textbook of pharmacology
Folder with copies of relevant chapters and articles.

Deadline for application
1 September 2004

Course weight
2.5 ECTS-points (European Credit Transfer System)

Course fee
7.500 DKK + lunch and course materials
MIND students 5175 DKK + lunch and course materials

Further information

www.drugmaster.dk