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SAFC PHARMA® ANNOUNCES COMPLETION OF $12M CONTRACT

MANUFACTURING FACILITY EXPANSION IN CARLSBAD, CALIF.
Addition Enhances Capabilities and Capacity Bolsters Biologics and Viral Manufacturing;
Reinforces Support for Secure, Successful Customer Launches

ST. LOUIS, MO., October 13, 2009 – SAFC Pharma®, a business segment of SAFC®, a
member of the Sigma-Aldrich® Group (NASDAQ: SIAL), today announced the completion of an
addition to its Carlsbad, Calif., facility that expands the Company’s contract manufacturing
services for its late phase and commercial clients. The $12 million project includes the addition
of two fully segregated state-of-the-art viral product manufacturing suites, built to employ the
latest in disposable bioreactor technologies, expanding SAFC Pharma’s biologics, viral vaccines
and gene therapy manufacturing to commercial-scale quantities.

SAFC Pharma’s Carlsbad site specializes in the process development and manufacturing of
viral vaccines and viral therapeutics, including a full menu of support services, from preclinical
process and analytical development to final fill/finish and commercial bulk drug supplies. The
new expansion, designed for multi-lot campaigns, includes dedicated cell expansion, bioreactor
production, purification and cleanroom suites. Adding 8,000 sq. ft. of manufacturing space to the
existing 44,000 sq. ft. site, the addition enables both 100-liter batch production in stirred tank

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bioreactors and 1,000-liter batch manufacturing in disposable bioreactors, and is Biosafety
Level 2 compliant, allowing manipulation of human pathogens. Designed from the outset as a
containment facility, the expansion space allows clients to secure a dedicated suite of
cleanrooms for larger scale manufacturing.

“We are delighted to announce this expansion of our capabilities at our Carlsbad facility,
particularly when the economic environment has been so challenging,” commented David
Feldker, Vice President SAFC Pharma. “We expect to see a great deal of value in the biologics
and viral manufacturing marketplace in the next three to five years generated by two main
customer types - those with late clinical phase opportunities but without any in-house
manufacturing capability and those with late clinical phase opportunities that have some
manufacturing capabilities but may be seeking an additional ‘safety net’ or wish to avoid
additional capital expansion until their technology and drug has proven itself. By adding and
extending our capabilities at Carlsbad, we are providing customers with an attractive, clear
pathway that adds value and supports secure, successful product launches.”

“The expansion at our Carlsbad campus underlines SAFC’s strategy to continue to invest in
building world class capabilities that serve and enhance our leadership in important emerging
new technologies such as niche biologics production and viral manufacturing - areas where we
see great potential and traction,” added SAFC President Gilles Cottier. “Our investment in large
capacity manufacturing, our financial stability, experience and quality systems differentiates us
in the market and enhances our abilities to securely support our customers all the way to
successful product launch.”

Facility validation studies are currently underway, with an expected start of cGMP
manufacturing operations by the end of December 2009. The site added numerous utility
support systems to allow for continuous operation and will now utilize its new Water For
Injection (WFI) system. The Company has enjoyed a close relationship with a number of clients
developing an exciting array of cancer therapeutics, gene therapies and mammalian and insect
cell-based viral vaccines.
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SAFC has announced worldwide investments totalling $90 million in the past two years to
expand capacity for active pharmaceutical ingredients (API) production and biologic drug
products. These investments build on the Company’s strengths in complex emerging
technologies such as high potency manufacturing and viral vaccines manufacturing, further
expanding its capabilities to serve customers in these growing areas. The expansion in
Carlsbad follows the acquisition in 2007 of Molecular Medicine BioServices, Inc.

About SAFC®: SAFC is the custom manufacturing and services group within Sigma-Aldrich that focuses
on high-purity inorganics for high technology applications, cell culture products and services for
biopharmaceutical manufacturing, biochemical production and the manufacturing of complex, multi-step
organic synthesis of APIs and key intermediates. SAFC has manufacturing facilities around the world
dedicated to providing manufacturing services for companies requiring a reliable partner to produce their
custom manufactured materials. SAFC has four focus areas – SAFC Pharma®, SAFC Supply Solutions®,
SAFC Biosciences®, and SAFC Hitech® – and had annual sales of over $600 million in 2008. SAFC is
one of the world’s 10 largest fine chemical businesses. For more information about SAFC, visit
www.safcglobal.com.

About SAFC Pharma®: SAFC Pharma is a complete pipeline partner for the development and cGMP
custom manufacturing of complex small-molecule APIs and biologic drug products. It combines world-
class project management and chemistry support for all stages of the drug discovery and development
process from research and discovery, through pre-clinical and clinical development to commercialization,
with a focus on reducing the drug development time-line. SAFC has the widest range of raw materials,
highly qualified and experienced staff, state-of-the-art facilities and an integrated portfolio of services,
including full analytical and regulatory support and is a leader in emerging technologies, including high-
potency APIs, solid-state chemistry, viral products and chemical-biologic API conjugates. For more
information visit www.safcpharma.com.

About Sigma-Aldrich®: Sigma-Aldrich is a leading Life Science and High Technology company. Its
biochemical and organic chemical products and kits are used in scientific research, including genomic
and proteomic research, biotechnology, pharmaceutical development and as key components in
pharmaceutical, diagnostic and other high technology manufacturing. The Company has customers in life
science companies, university and government institutions, hospitals, and in industry. Over one million
scientists and technologists use its products. Sigma-Aldrich operates in 38 countries and has 7,800
employees providing excellent service worldwide. Sigma-Aldrich is committed to Accelerating Customer
Success through Innovation and Leadership in Life Science, High Technology and Service. For more
information about Sigma-Aldrich, please visit its award-winning Web site at http://www.sigma-aldrich.com.

Cautionary Statement: This release contains forward-looking statements relating to future strategic
actions and initiatives and similar intentions and beliefs and other statements regarding the Company’s
expectations, beliefs, intentions and the like, which involve assumptions regarding the Company’s
operations and conditions in the markets the Company serves. The Company does not undertake any
obligation to update these forward-looking statements.

Sigma-Aldrich, SAFC, SAFC Pharma, SAFC Biosciences, SAFC Supply Solutions and SAFC Hitech are registered trademarks of
Sigma-Aldrich Biotechnology L.P. and Sigma-Aldrich Co.
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