40th COSPAR Scientic Assembly 2014

Life Sciences as Related to Space (F) Inuence of Spaceight Environments on Biological Systems (F4.4) Consider as poster only.

PRINCIPALS OF RADIATION TOXICOLOGY: IMPORTANT ASPECTS.

Dmitri Popov, dlpopov@rogers.com Advanced Medical Technologies and Systems, Richmond Hill, Canada Jerey Jones, jajones@bcm.edu Baylor College of Medicine, Houston, United States Slava Maliev, intervaccine@gmail.com Russian Academy of Science, Vladicaucas, Russia

All things are poison, and nothing is without poison; only the dose permits something not to be poisonous. Paracelsus Key Words: Radiation Toxins (RT), Radiation Toxicants (RTc), Radiation Poisons (RP), Radiation Exposure (RE), Radiation Toxicology is the science about radiation poisons. [D.Popov et al. 2012,J.Zhou et al. 2007,] Radiation Toxins is a specic proteins with high enzymatic activity produced by living irradiated mammals. [D.Popov et al. 2012,] Radiation Toxicants is a substances that produce radiomimetics eects, adverse biological eects which specic for radiation. [D.Popov et al. 2012,] Radiation Toxic agent is specic proteins that can produce pathological biological eects specic for physical form of radiation.[D.Popov et al. 1990,2012,V. Maliev 2007] Dierent Toxic Substances isolated from cells or from blood or lymph circulation. [Kudriashov I. et al. 1970, D.Popov et al. 1990,2012,V. Maliev et al. 2007,] Radiation Toxins may aects many organs or specic organ, tissue, specic group of cells. [Kudriashov I. et al. 1970, D.Popov et al. 1990,2012,V. Maliev et al. 2007] For example: Radiation Toxins could induce collective toxic clinical states to include: systemic inammatory response syndrome (SIRS),toxic multiple organ injury (TMOI), toxic multiple organ dysfunction syndromes (TMODS),and nally, toxic multiple organ failure (TMOF). [T. Azizova et al. 2005, Konchalovsky et al., 2005, D. Popov et al 2012] However, Radiation Toxins could induce specic injury of organs or tissue and induce Acute Radiation Syndromes such as Acute Radiation Cerebrovascular Syndrome, Acute Radiation Cardiovascular Syndrome, Acute Radiation Hematopoietic Syndrome, Acute Radiation GastroIntestinal Syndrome. [ D.Popov et al. 1990, 2012, V. Maliev et al. 2007] Radiation Toxins correlates with Radiation Exposure and the dose-response relationship is a fundamental and essential concept in classic Toxicology and Radiation Toxicology.[ D.Popov et al. 1990, 2012] Moderate and high doses of radiation induces necrosis of radiosensitive cells with the subsequent formation of radiation toxins and their induced acute inammatory processes.

Radiation necrosis is the most substantial and most severe form of radiation induced injury, and when widespread, has grave therapeutic implications. [D. Popov et al. 1990, 2012,Claudio A. et al. 2002, Robertson J. et al. 2002, ] Relatively small doses of Radiation Toxins induce apoptosis and high doses of Radiation Toxins induce necrosis. [Rastogi P. et al. 2009, D. Popov et al. 1990, 2012,] Threshold of Toxic Eects occurs and can be dened. [D. Popov et al. 2012, ] Radiation Toxins aects Somatic cells and Germ Cells. Radiation Toxins can induce teratogenic processes. Specic Toxicity of Radiation Toxins can aects developing fetus. Material and Methods, Results: http://www.intechopen.com/books/current-topics-in-ionizingradiation-research/radiation-toxins-molecular-mechanisms-of-toxicity-and-radiomimetic-propertiesConclusion: Radiation is a physical agent - induce activation of some secretory proteins with high enzymatic activity. This proteins called as Radiation Toxins can produce specic for radiation biological and toxic eects after administration to radiation naive mammals. [V. Maliev et al. 2007, D. Popov et al. 1990, 2012] Radiation Toxins are teratogenic and oncogenic. Radiation Toxins eects depend on Administered Dose and Radiation eects depend on Exposure Dose and Absorbed Dose. The levels of Radiation Toxins correlates with Radiation Exposure.