Professional Documents
Culture Documents
NCM 104
• Definition of Cancer
o Cancer is the general name given to a large group of diseases characterized by:
a. uncontrolled growth and spread of abnormal cells.
b. proliferation ( i.e. rapid production by cell division)
c. metastasis ( i.e.., spread or transfer of cancer cells from one organ not directly
connected)
o It affects people of all ages, most cancer occur in people older than 65 years of age.
o It is higher in men than women and higher in industrialized sectors & nations.
o Is second only to cardiovascular disease as the leading cause of death in the United
States.
• Etiology of Cancer
o Healthy cells are transformed by unknown mechanisms or exposure to certain etiologic
agents, including:
a. viruses ( e.g. Epstein- Barr, herpes simplex type II, cytomegalovirus,
papillomavirus, hepa B)
b. chemical carcinogens ( e.g. chromium, cobalt , tar, soot, asphalt, nitrogen
mustard, certain plastics, aniline dyes, hydrocarbons in cigarettes smoke, air
pollutants from industry, crude paraffin oil, nickel, asbestos, arsenicals)
c. physical stressors ( e.g. excessive exposure to sunlight or radiation, chronic
irritation )
d. hormonal factors ( e.g. imbalance of endogenous or exogenous hormones, such as
estrogen or diethylstilbestrol)
e. genetic factors ( e.g. abnormal chromosomes patterns, such as in Burkitt’s
lymphoma, chronic myelogenous or acute leukemia and skin cancers; familial
predisposition, such as in breast, endometrial, colorectal, stomach, lung, colon,
and kidney cancers)
f. dietary factors (e.g. fats, alcohol, salt-cured or smoked meats, foods containing
nitrates and nitrites, and a high caloric dietary intake)
Begins when an abnormal cell is transformed by the genetic mutation of the cellular
DNA.
The abnormal cell forms a clone and begins to proliferate abnormally, ignoring growth-
regulating signals in the environment surrounding the cell.
The cell acquires invasive characteristics, and changes occur in surrounding tissues.
The cell infiltrates these tissues and gain access to lymph and blood vessels, which carry
the cell to other areas of the body.
Proliferative Patterns
o Neoplasm (new cell growth) has several proliferative patterns:
a. Benign (i.e. usually harmless, does not infiltrate other tissues) and malignant (i.e.
always harmful; may spread or metastasize to tissues far from the original site)
cells display different characteristic of cellular growth; the degree of
differentiation (i.e. anaplasia) determines the potential for malignancy.
b. Hyperplasia involves an increase in the number of cells in a tissue; it may be a
normal or abnormal cellular response.
c. Metaplasia refers to the conversion of one type of cell in a tissue to another type
not normal for that tissue. It results from an outside stimulus affecting parent stem
cells and may be reversible. It could also progress to dysplasia.
d. Dysplasia refers to change in size, shape, or arrangement of normal cells into
bizarre cells; it may precede an irreversible neoplastic change.
e. Anaplasia involves a change in the DNA cell structure and in their orientation to
one another, characterized by a loss of differentiation and a return to a more
primitive form. The resulting poorly differentiation, irregularly shaped cells
usually are malignant.
Mechanism of Metastasis
o Lymph and blood are key mechanisms by which cancer cells spread.
o Angiogenesis- is a mechanism by which the tumor cells are ensured a blood supply is
another important process.
Lymphatic Spread
o Lymphatic spread is the transport of tumor cells through the lymphatic
circulation; and the most common mechanism of metastasis.
o Malignant cells may also penetrate the lymphatic circulation by invasion.
Tumor emboli enter the lymph channels by way the interstitial fluid, which
communicate with lymphatic fluid.
Malignant Cells either lodge in the lymph nodes or pass between the lymphatic &
venous circulation.
Tumors arise in areas of the body with rapid and extensive lymphatic circulations
are high risks for metastasis through lymphatic channels.
Hematogenous Spread
o Hematogenous spread is the dissemination of malignant cells via the
bloodstream.
o It is directly related to the vascularity of the tumor.
o Few malignant cells can survive the turbulence of arterial circulation, insufficient
oxygenation, or destruction by the body’s immune system.
o The survived malignant cells are able to attach to endothelium and attract fibrin,
platelets, and clotting factors to seal themselves from immune system.
o The endothelium retracts that allows the malignant cells to enter the basement
membrane & secrete lysosomal enzymes.
o These enzymes destroy surrounding body tissues and allow implantation.
Angiogenesis
o Angiogenesis is the growth of new capillaries from the host tissue by the release
of growth factors and enzymes such as vascular endothelial growth factor
(VEGF).
o These proteins rapidly stimulate formation of new blood vessels, which help
malignant cells obtain the necessary nutrients and oxygen.
o Large tumor emboli that become trapped in the microcirculation of distant sites
may further metastasize to other sites.
Immunoincompetent patients
a. Organ transplant recipients (under immunosuppressive therapy to prevent
rejection of transplanted organ).
b. AIDS Patients
c. Patients under alkylating chemotherapeutic agents.
d. Patients with Auto immune diseases (such as Rheumatoid Athritis).
e. Patients with declining organ functions (age related).
Magnetic resonance imaging Use of magnetic fields and Neurologic, pelvic, abdominal,
(MRI) radiofrequency signals to create thoracic cancers
sectioned images of a various body
structures
Computed tomography Use of narrow beam x-ray to scan Neurologic, pelvic, skeletal,
successive layers of tissue for a abdominal, thoracic
cross-sectional view
Nuclear medicine imaging Uses intravenous injection or Bone, liver, kidney, spleen,
ingestion of radioisotope substances brain, thyroid cancers
followed by imaging of tissues that
have concentrated the radioisotopes
o Nursing Interventions
1. The nurse can help relieve the patient’s fear and anxiety by explaining the tests to be
performed, the sensations likely to be experienced, and the patient’s role in the test
procedures.
2. The nurse encourages the patient and family to voice their fears about the test results,
supports the patient and family throughout the test period, and reinforces and clarifies
information conveyed by the physician.
3. The nurse encourages the patient and family to communicate and share their concerns
and to discuss their questions and concerns with each other.