The document summarizes an expert presentation on evidence-based approaches to treatment-resistant schizophrenia. It discusses definitions of treatment resistance, guidelines and algorithms for antipsychotic treatment sequences, strategies for augmenting clozapine such as with antidepressants or mood stabilizers, and the evidence for antipsychotic polypharmacy. While clozapine remains the gold standard for treatment-resistant cases, it has side effects and is not effective for all. The presenter advocates a bottom-up, evidence-based approach focusing on agreed upon priority outcomes and systematically modifying interventions.
Original Description:
Resistant Schizophrenia
Treatment
Original Title
An Evidenced-/based approach to Treatment- Resistant Schizophrenia Flaum
The document summarizes an expert presentation on evidence-based approaches to treatment-resistant schizophrenia. It discusses definitions of treatment resistance, guidelines and algorithms for antipsychotic treatment sequences, strategies for augmenting clozapine such as with antidepressants or mood stabilizers, and the evidence for antipsychotic polypharmacy. While clozapine remains the gold standard for treatment-resistant cases, it has side effects and is not effective for all. The presenter advocates a bottom-up, evidence-based approach focusing on agreed upon priority outcomes and systematically modifying interventions.
The document summarizes an expert presentation on evidence-based approaches to treatment-resistant schizophrenia. It discusses definitions of treatment resistance, guidelines and algorithms for antipsychotic treatment sequences, strategies for augmenting clozapine such as with antidepressants or mood stabilizers, and the evidence for antipsychotic polypharmacy. While clozapine remains the gold standard for treatment-resistant cases, it has side effects and is not effective for all. The presenter advocates a bottom-up, evidence-based approach focusing on agreed upon priority outcomes and systematically modifying interventions.