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Journal List > Am J Pathol > v.170(2); Feb 2007


Abstract
Am J Pathol. 2007 February; 170(2): 557– PMCID: PMC1851853
Full Text
566.
PDF (933K) doi: 10.2353/ajpath.2007.060893.
Copyright © American Society for Investigative Pathology
Contents
Archive
Exacerbated Pathology of Viral Encephalitis
Related material:
in Mice with Central Nervous System-
Specific Autoantibodies
PubMed articles by:
Renaud Burrer,* Michael J. Buchmeier,* Tom Wolfe,† Joey
P.C. Ting,* Ralph Feuer,* Antonio Iglesias,‡ and Matthias G.
Burrer, R.
von Herrath†
Buchmeier, M.
From the Molecular and Integrative Neurosciences Department,*The Scripps
Wolfe, T. Research Institute, La Jolla, California; the La Jolla Institute of Allergy and
von Herrath, M. Immunology,†Immune Regulation Lab, La Jolla, California; and the Roche
Center for Medical Genomics,‡Basel, Switzerland

Top Accepted October 31, 2006.


Abstract
Materials and Methods This article has been cited by other articles in PMC.
Results
Discussion Abstract
References We examine here the outcome of viral encephalomyelitis
[mouse hepatitis virus (MHV) A59, Theiler’s
Top
encephalomyelitis virus, and Coxsackievirus B3] in mice
Abstract with autoantibodies to a central nervous system (CNS)-
specific antigen, myelin oligodendrocyte glycoprotein, that
Materials and Methods
usually develop no clinical disease. Morbidity and mortality
Results of the acute viral CNS disease was augmented by the
presence of the autoantibodies in all three viral infections.
Discussion Transfer of serum containing the autoantibodies at the time
of infection with MHV was sufficient to reproduce the
References
exacerbated disease. The presence of the autoantibodies was
found to result in increased infiltration of mononuclear cells
Top into the brain. Early demyelination was severely augmented
in brains and spinal cords of MHV-infected mice with CNS-
Abstract
specific autoantibodies. The antibody-mediated
Materials and Methods exacerbation was shown to be independent of the
complement system but to require expression of Fc
Results
receptors, because it was observed in C′-3-deficient but not
Discussion in Fc receptor-deficient mice. Our study illustrates the
possibility that infections can lead to much more profound
References immunopathology in the presence of an otherwise latent
autoimmune condition.
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Abstract
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