Abstract Materials and Methods This article has been cited by other articles in PMC. Results Discussion Abstract References We examine here the outcome of viral encephalomyelitis [mouse hepatitis virus (MHV) A59, Theiler’s Top encephalomyelitis virus, and Coxsackievirus B3] in mice Abstract with autoantibodies to a central nervous system (CNS)- specific antigen, myelin oligodendrocyte glycoprotein, that Materials and Methods usually develop no clinical disease. Morbidity and mortality Results of the acute viral CNS disease was augmented by the presence of the autoantibodies in all three viral infections. Discussion Transfer of serum containing the autoantibodies at the time of infection with MHV was sufficient to reproduce the References exacerbated disease. The presence of the autoantibodies was found to result in increased infiltration of mononuclear cells Top into the brain. Early demyelination was severely augmented in brains and spinal cords of MHV-infected mice with CNS- Abstract specific autoantibodies. The antibody-mediated Materials and Methods exacerbation was shown to be independent of the complement system but to require expression of Fc Results receptors, because it was observed in C′-3-deficient but not Discussion in Fc receptor-deficient mice. Our study illustrates the possibility that infections can lead to much more profound References immunopathology in the presence of an otherwise latent autoimmune condition. Top
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Antonio Daniele Pinna, Giorgio Ercolani (Eds.) - Abdominal Solid Organ Transplantation - Immunology, Indications, Techniques, and Early Complications-Springer International Publishing (2015)