S USAN R UTH M ARENGO , P H .D.

Wilmington, DE 19810 marengo125@gmail.com Cell: (302) 437-6369 Linkedin.SusanRuthMarengo

BIOMEDICAL SCIENCE RESEARCH SCIENTIST, PHD Industry Concentrations Biotechnology Healthcare Pharmaceutical Research QUALIFICATIONS SUMMARY
Project & Program Management Biomedical Research Laboratory Director Protocol and Model Development Funding Grant Development Grant Review Panels Teaching, Training and Mentorship Regulatory Compliance Molecular & Cell Biology Techniques Microarray Analysis Protein Isolation & Purification In Vivo (Large/Small Animals) & In Vitro (Primary /Established Cell Line Tissue Culture) Models Steroid Metabolism High Pressure Liquid Chromatography Light and Electron Microscopy Morphometric Analysis General Assays (ELISA, RIA, etc.)

PROFILE
Intelligent, well-educated, and self-motivated professional with a unique set of skills and career experience in the field of science; multifaceted background as a biomedical researcher, laboratory director, and educator. Excellent logistical, planning, organizational and presentation skills; skilled at managing concurrently running initiatives and at explaining concepts to both technical and non-technical audiences. Outstanding at oral and written communications; 33 publications in peer reviewed journals, invited reviews and book chapters combined with 70+ presentations and invited editorials. Effective at working both independently and as a member of a team; takes initiative and builds respectful relationships with individuals in other departments and support staff to further project goals. Successfully developed and funded projects in kidney stone disease, prostate cancer, and prostatitis. Principal investigator on three grants from the National Institutes of Health and other foundations; also served on 22 grant review panels for individual and program project grants. Experienced at working across regulatory and safety departments to ensure compliance.

PROFESSIONAL EXPERIENCE
BRANDYWINE SCHOOL DISTRICT / OHIO SCHOOL DISTRICTS Wilmington, DE / Cleveland, OH 2010 2013
Teacher Mount Pleasant High School (2012-2013) Long-Term Substitute Teacher Northeast Ohio School Districts (2010-2011) Taught Honors Biology, College Preparatory Chemistry, and Conceptual Chemistry at Mount Pleasant. Served as a long-term substitute for biology and chemistry in Northeast Ohio. Teaching honed skills at explaining scientific concepts to people without a scientific background, presenting information multiple ways, and persuading people to buy-in to an idea.

SCHOOL OF MEDICINE, CASE RESERVE UNIVERSITY Cleveland, OH 1993 2009

Senior Research Associate, PhD / Principal Investigator Dept. of Physiology (20072009) Carried out research initiatives at the largest biomedical research medical school in Ohio. Conducted investigations to determine whether oxalate plays an active role in calcium oxalate kidney disease (the most common type of kidney stone) versus a bystander role. Produced findings that are acknowledged to have a direct impact on patient care and health.

Research Findings
Established the first concrete evidence that transient surges of oxalate, undetectable in the urine, are sufficient to induce stone disease in rats; this is the most likely explanation of stone disease in idiopathic stone formers. Demonstrated that oxalate deposits itself throughout the body when oxalate in the urine is minimally elevated, potentially effecting patient health. For example, oxalate crystals in the vasculature may be the link between hypertension and stone disease. Oxalate deposition is of special concern to patients having weight loss surgery as they may be moderately hyperoxaluric for decades postsurgery.

S U S A N R U T H M A R E N G O , P H .D .

srmarengo@gmail.com Cell: (302) 437-6369

Medical Research Director, PhD, Jim & Eilleen Dicke Research Laboratory Dept. of Urology (1995 2007) Associate Professor (2001 2007) / Assistant Professor Dept. of Urology (1993 2001) Completely equipped and directed the Jim and Eilleen Dicke Research Laboratory which supported basic and clinical research in urology. Received the Merck Young Investigator Award from Society for Basic Urologic Research and was elected in 2001 to the Research on Calculous Kinetics Society (ROCK). Responsible for continuously funding the lab for 14 years.

Laboratory Expansion, Regulatory Compliance & Savings

Fully equipped a lab to perform most techniques commonly used in animal and tissue culture studies of lower urinary tract diseases, including molecular biology, cell biology, immunological assays and protein isolation and detection. Started and funded projects in kidney stone disease, prostate cancer and prostatitis. Expanded the lab to three postdoctoral follows, six technicians and two faculty members. Ensured compliance with safety, animal, and radiation regulations. Saved $30K per year by performing cost analysis and then outsourcing in-house clinical testing. Developed protocols to work closely with the clinical staff to obtain samples from targeted populations of patients. Developed of minipump model of hyperoxaluria in rats that debunked two well accepted ideas about the ethylene glycol model of stone disease. Used microarray analysis to demonstrate that hyperoxaluria causes oxidative damage to the proximal and distal tubules of the rat kidney. Developed Western blot analysis on human urine samples; among the proteins tested, only inter--trypsin inhibitor is increased in the urine of stone formers. A cheap, simple procedure to isolate microgram quantities of the bikunin subunit was developed. Studies in prostate cancer involved differences in the expression of several oncogenes, especially erbB2/neu, during the progression of prostate cancer using cell lines, functional assays, gene and protein expression and microarray analysis. First to demonstrate that the prostate has a unique subset of lymphocytes and that induction of prostatits causes organ specific changes in this subset.

Laboratory Techniques & Protocol Development

Grants & Endowments

Secured multiple grants and endowments totaling $3M, thereby continuously funding lab for a 14-year period. Fostered formal collaborations and joint funding (two grants totaling $461K for lab) by persuading labs from multiple departments in an isolated part of the School of Medicine to operate as a research group. Successfully funded through NIH grants on kidney stone disease without any prior training in the area. Served as Principal Investigator on three NIH grants ($1.1M in total funding) and on smaller grants from other agencies. Served on 22 grant review panels for individual and program project grants for NIH and Department of Defense.

Abstracts, Symposiums & Committees

Co-Moderator of the animal model session at a National Institute of Diabetes, Digestive and Kidney Disease sponsored symposium on kidney stone disease. Member of Organizational Committee and Faculty, Addressing the Controversies of Prostate Cancer Management . Reviewed abstracts on kidney stone disease research for the American Urological Association (9 years). Initiated the departmental website and originated the first regular Visiting Speakers seminar series in the School of Medicine. Developed short course in reproductive toxicity and created a novel summer program for medical students interested in urology.

Laboratory Department Website, Seminars & Course/Program Development

S U S A N R U T H M A R E N G O , P H .D .

srmarengo@gmail.com Cell: (302) 437-6369

UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER Houston, TX 1990 1993 Postdoctoral Fellow Dept. of Urology (1990-1993) Fellowship in an internationally recognized laboratory for study of prostate cancer at a leading cancer center in the U.S. Received Hamilton Thorne Outstanding Original Research Award and Society for Basic Urologic Research Essay Contest Award for this research.

Laboratory Research, Regulatory Compliance & Productivity Improvements

Developed novel way to test the effects of substances (e.g., drugs or growth factors or the metastatic capabilities of cells) by orthotopic injection into the prostate of rats or mice. Worked with safety to comply with new regulations for positive air flow while reducing contamination. Fostered teamwork and persuaded support staff to increase productivity, add services, and resolve problems. Equipped and ran the labs dark room and purchased $20K microscope and camera system.

Prior Experience: Postdoctoral Fellow BAYLOR COLLEGE OF MEDICINE, DEPARTMENT OF UROLOGY (1989-1990), Houston, TX. Studied regulation of androgen-dependent gene in transfected cells from hamster ductus deferens.

EDUCATION
MEd, Teaching (Secondary Education) URSULINE COLLEGE, Pepper Pike, OH PhD, Physiology COLORADO STATE UNIVERSITY, Fort Collins MS, Animal Science UNIVERSITY OF FLORIDA, Gainesville BS, Animal Science (Honors) CORNELL UNIVERSITY, Ithaca, NY

SUMMARY OF HONORS & AWARDS

Election to Research on Calculous Kinetics Society, limited to 23 members at election Society for Basic Urologic Research, Merck Young Investigator Award Hamilton Thorne Outstanding Original Research Award American Urological Association Laboratory Research Award National Cancer Institute Fellow for the Training of Academic Urologic Oncologists Society for Basic Urologic Research Essay Contest National Institutes of Health Training Program Fellow Graduate and Professional Opportunities Program Fellow