TUGAS EBM PICO

NAMA : MARLENI NPM : 1102010156 KELOMPOK : B-1

FAKULTAS KEDOKTERAN UNIVERSITAS YARSI 2010

KASUS Seorang wanita berusia 22 tahun menderita sakit kepala sebelah (migrain). Sebagai obat pereda nyeri kepalanya dokter meresepkan aspirin, namun, pasien tersebut mengatakan bahwa sebelumnya dia telah mengkonsumsi ibuprofen. PERTANYAAN Apakah penggunaan ibuprofen pada penderita sakit kepala sebelah (migrain) lebih efektif meredakan sakit kepala dibanding dengan penggunaan aspirin? PICO Population Intervention Comparison Objection : Penderita sakit kepala sebelah (migrain) : Ibuprofen : Aspirin : Cepat reda/sembuh sakit kepala

KATA KUNCI Migraine AND ibuprofen AND aspirin PEMILIHAN SITUS http://www.yarsi.ac.id/web.ebscohost.com/ehost/resultsadvanced HASIL PENCARIAN 1. 9

Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, singledose, placebo-controlled study.Full Text Available (eng; includes abstract) By Goldstein J, Silberstein SD, Saper JR, Ryan RE Jr, Lipton RB, Headache [Headache], ISSN: 0017-8748, 2006 Mar; Vol. 46 (3), pp. 444-53; PMID: 16618262

Subjects: Acetaminophen administration & dosage; Analgesics, Non-Narcotic administration & dosage; Anti-Inflammatory Agents, Non-Steroidal administration & dosage; Aspirin administration & dosage; Caffeine administration & dosage; Central Nervous System Stimulants administration & dosage; Ibuprofen therapeutic use; Migraine Disorders drug therapy; Adult: 19-44 years; All Adult: 19+ years; Female; Male 2. OTC analgesics in headache treatment: open-label phase vs randomized double-blind phase of a large clinical trial.Full Text Available (eng; includes abstract) By Pfaffenrath V, Diener HC, Pageler L, Peil H, Aicher B, Headache [Headache], ISSN: 1526-4610, 2009 May; Vol. 49 (5), pp. 638-45; PMID: 19472437 Subjects: Acetaminophen administration & dosage; Aspirin administration & dosage; Caffeine administration & dosage; Headache Disorders drug therapy; Nonprescription Drugs

administration & dosage; Adolescent: 13-18 years; Adult: 19-44 years; Aged: 65+ years; Middle Aged: 45-64 years; All Child: 0-18 years; All Adult: 19+ years; Female; Male 3. Intracranial hypotension following motor vehicle accident: an overlooked cause of post-traumatic head and neck pain?Full Text Available (eng; includes abstract) By Huntoon MA, Watson JC, Pain Practice: The Official Journal Of World Institute Of Pain [Pain Pract], ISSN: 1533-2500, 2007 Mar; Vol. 7 (1), pp. 47-52; PMID: 17305680 Subjects: Accidents, Traffic; Aspirin therapeutic use; Headache drug therapy; Intracranial Hypotension etiology; Intracranial Hypotension therapy; Middle Aged: 45-64 years; All Adult: 19+ years; Female 4. Placebo-controlled comparison of effervescent acetylsalicylic acid, sumatriptan and ibuprofen in the treatment of migraine attacks.Full Text Available (eng; includes abstract) By Diener HC, Bussone G, de Liano H, Eikermann A, Englert R, Floeter T, Gallai V, Gbel H, Hartung E, Jimenez MD, Lange R, Manzoni GC, MuellerSchwefe G, Nappi G, Pinessi L, Prat J, Puca FM, Titus F, Voelker M, EMSASI Study Group, Cephalalgia: An International Journal Of Headache [Cephalalgia], ISSN: 0333-1024, 2004 Nov; Vol. 24 (11), pp. 947-54; PMID: 15482357 Subjects: Aspirin therapeutic use; Ibuprofen therapeutic use; Migraine Disorders drug therapy; Sumatriptan therapeutic use; Adult: 19-44 years; Middle Aged: 45-64 years; All Adult: 19+ years; Female; Male 5. Over-the-counter analgesics and risk of ovarian cancer.Full Text Available (eng; includes abstract) By Cramer DW, Harlow BL, Titus-Ernstoff L, Bohlke K, Welch WR, Greenberg ER, Lancet [Lancet], ISSN: 0140-6736, 1998 Jan 10; Vol. 351 (9096), pp. 104-7; PMID: 9439495 Subjects: Analgesics, Non-Narcotic adverse effects; Anti-Inflammatory Agents, NonSteroidal adverse effects; Nonprescription Drugs adverse effects; Ovarian Neoplasms chemically induced; Adult: 19-44 years; Aged: 65+ years; Middle Aged: 45-64 years; All Adult: 19+ years; Female 6. Community pharmacy treatment of minor ailments in refugees.Full Text Available (eng; includes abstract) By Parmentier H, Golding S, Ashworth M, Rowlands G, Journal Of Clinical Pharmacy And Therapeutics [J Clin Pharm Ther], ISSN: 02694727, 2004 Oct; Vol. 29 (5), pp. 465-9; PMID: 15482391 Subjects: Community Pharmacy Services; Delivery of Health Care organization & administration; Nonprescription Drugs therapeutic use; Refugees 7. Efficacy of diclofenac sodium softgel 100 mg with or without caffeine 100 mg in migraine without aura: a randomized, double-blind, crossover study.Full Text Available (eng; includes abstract) By Peroutka SJ, Lyon JA, Swarbrick J, Lipton RB,

Kolodner K, Goldstein J, Headache [Headache], ISSN: 0017-8748, 2004 Feb; Vol. 44 (2), pp. 136-41; PMID: 14756851 Subjects: Anti-Inflammatory Agents, Non-Steroidal administration & dosage; Caffeine administration & dosage; Diclofenac administration & dosage; Migraine without Aura drug therapy; Adolescent: 13-18 years; Adult: 19-44 years; Middle Aged: 45-64 years; All Child: 0-18 years; All Adult: 19+ years; Female; Male 8. Elevated hepatic transaminases associated with telithromycin therapy: a case report and literature review.Full Text Available (eng; includes abstract) By Bolesta S, Roslund BP, American Journal Of Health-System Pharmacy: AJHP: Official Journal Of The American Society Of Health-System Pharmacists [Am J Health Syst Pharm], ISSN: 1535-2900, 2008 Jan 1; Vol. 65 (1), pp. 37-41; PMID: 18159037 Subjects: Alanine Transaminase blood; Anti-Bacterial Agents adverse effects; Aspartate Aminotransferases blood; Drug-Induced Liver Injury etiology; Ketolides adverse effects; Respiratory Tract Infections drug therapy; Adult: 19-44 years; All Adult: 19+ years; Male 9. Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis.Full Text Available (eng; includes abstract) By Hedner T, Samulesson O, Whrborg P, Wadenvik H, Ung KA, Ekbom A, Drugs [Drugs], ISSN: 0012-6667, 2004; Vol. 64 (20), pp. 2315-43; discussion 2344-5; PMID: 15456329 Subjects: Anti-Inflammatory Agents, Non-Steroidal metabolism; Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal therapeutic use; Arthritis, Rheumatoid drug therapy; Butanones metabolism; Butanones pharmacokinetics; Butanones therapeutic use; Cyclooxygenase Inhibitors adverse effects; Cyclooxygenase Inhibitors therapeutic use; Osteoarthritis drug therapy; Stomach Diseases chemically induced; Adolescent: 13-18 years; Adult: 19-44 years; Aged: 65+ years; Child: 612 years; Child, Preschool: 2-5 years; Middle Aged: 45-64 years; All Child: 0-18 years; All Adult: 19+ years ARTIKEL YANG DIPILIH Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebocontrolled study