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UNIVERSITY OF ILORIN FACULTY OF HEALTH SCIENCE DEPARTMENT OF PHARMACOLOGY AND THERAPEUTICS

INTRODUCTORY PHARMACOLOGY (PART A) CURRICULUM This aspect of subject is taught to 300 level students of Pre-clinical arm of faculty A. GENERAL PRINCIPLES OF PHARMACOLOGY a. Introduction to the basic concept and definition in pharmacology b. Introduction to the basic concept (principles of pharmacokinetics) c. Factors affecting absorption, distribution and excretions of drugs d. Drug metabolism/ biotransformation e. Mechanism of drug action f. Drug receptor theory g. Routes and methods of drug administration h. Bioassays qualitative measurements in pharmacology i. Dose-response relationships drug receptor theory B. AUTONOMIC NERVOUS SYSTEM PHARMACOLOGY a. Organisation of the autonomic nervous system b. Neurotransmitter theory/concept c. Metabolism (i.e. synthetic, storage, release, inactivation) of acetylcholine d. Metabolism of catecholamine (esp NOREPINEPHRINE) e. Sympathomimetic agents adrenoceptor (alpha and beta) agonists f. Cholinomimetic agents cholinoceptor agonist and anticholinesterases. g. Sympatholytic agents adrenoceptor (alpha and beta) antagonists h. Cholinoplegic agents i. Antimuscarinic drugs ii. Ganglion blockers iii. Neuromuscular/myoneural junction blockers i. An overview of effector organ responses to A.N.S. activity/stimulation

Corticosteroids the naturally occurring and synthetic analogues i. The antagonists of adrenocortical agents. e. Gonadotropins f. Oestrogens and progestagens g. Androgens and anabolic steroids h. Insulin and insulin preparations i. Oral contraceptive agents and fertility drug j. Oral hypoglycemic agents D. RENAL SYSTEM PHARMACOLOGY a. Introduction to/general principles of Diuresis and classification of diuretic agents b. Loop (High ceiling) diuretics c. Thiazide diuretics d. Potassium-sparing diuretics e. Carbonic anhydrase inhibitor f. Mercurial and osmotic diuretics/water diuresis E. GASTRO-INTESTINAL SYSTEM PHARMACOLOGY a. Basic pharmacology of Histamin and Histaminoceptor agonists b. Histaminoceptor Type-I antagonists c. Basic pharmacology of Emetic and anti-emetic drugs d. Therapeutics of vomiting Disorder (e.g. motion sickness, pregnancy-induced vomiting, vertigo, druginduced like Post-general anaesthesia, cytotoxic chemotherapy). e. Basic pharmacology of drugs used in the therapy of peptic ulcer Disease i. Introduction to classification ii. Antacid and mucosal-surface protective agents iii. Proton pump inhibitor iv. Antimuscarinic agents v. Histaminoceptor type-II antagonist vi. Miscellaneous agents e.g. octrectide, preglumede, vasoactive intestinal peptide (VIP), tricyclic antidepressant, algine antacids and glucagon f. Therapeutics of peptic ulcer disease g. Basic pharmacology of purgatives and laxatives h. Basic pharmacology of drugs used in the therapy of hypermotility disorders (diarrhea disease) of GIT i. Basic pharmacology of the drugs used in the therapy of hyperlipidemias j. Drug treatment of iron-deficiency anemia, anemic treatment of iron poisoining k. Ascorbic acid, folic acid and vitamin B12 therapy l. Antacids

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C. ENDOCRINE SYSTEM PHARMACOLOGY a. An overview of cellular mechanism of hormone action b. Posterior pituitary hormones (vasopressin, oxytocin) c. Thyroxin and anti-thyroid drugs

INTRODUCTORY PHRAMCOLOGY (PART-B) CURRICULUM The following basic pharmacology and therapeutics lecture topics together with topics for the seminar sessions make up the curriculum for the Part B of introductory Pharmacology which is taught to the 400 level students on commencement of the Clinical aspect of their undergraduate medical education. F. RESPIRATORY SYSTEM (RS) PHARMACOLOGY a. Basic pharmacology of the drugs used in the treatment of bronchial asthma b. Drug treatment/therapeutics of bronchial asthma c. Basic pharmacology of cough stimulant, cough suppressant mucolytics

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MISCELLANEOUS TOPICS a. Introduction of Clinical Pharmacokinetics b. Drug treatment/therapeutics of Common Clinical Conditions involving the Autonomic Nervous System (e.g. Myasthenia gravis, pheochromocytoma, etc.) c. Basic pharmacology of the Ergot Alkaloids d. Basic pharmacology of the Serotonergic agents (agonist and antagonist) e. Introduction to drug interactions SOME SEMINAR TOPICS a. Factors affecting absorption, distribution and elimination of drugs b. Drug metabolism and the factors affecting it c. Mechanism of drug action and factors affecting drug action/drug effect d. Route and method of drug administration e. Drug dependence and Drug/misuse f. Therapeutics and Toxic Potentials of Over-thecounter drugs g. The clinical uses/rational for use of steroids, complication/Problems of steroids therapy h. Common Toxic Agents/Poisons in the Environment and the Management of the Poisoned Patient: Heavy Metals and Chelating Agents

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G. CARDIOVASCULAR (CVS)/HEMOPOIETIC PHARMACOLOGY a. Basic pharmacology of antihypertensive drugs b. Basic pharmacology of the drugs used in the treatment of congestive cardiac failure c. Basic pharmacology of anti-angina drugs d. Basic pharmacology of the drugs used in the treatment of cardiac rhythm disorders e. Basic pharmacology of anticoagulants f. Basic pharmacology of the drugs used in the treatment of athereosclerosis/ hyperlipidemias g. Basic pharmacology of vasodilators, vasoconstrictors and the drug treatment/ therapeutics of peripheral vascular delsenlies h. Drug treatment/therapeutics of systemic hypertension i. Drug treatment/therapeutics of congestive cardiac failure j. Drug treatment/therapeutics of angina pectoris k. Drug treatment/therapeutics of Cardiac rhythm disorders. l. The Clinical uses/Rational for the use of Diuretics H. CENTRAL NERVOUS SYSTEM (CNS) PHARMACOLOGY a. Basic pharmacology of Sedatives/Hypnotics b. Basic Pharmacology of the Drugs used in the treatment of Seizure disorders c. Basic Pharmacology of the Drugs used in the treatment of Parkinsons dx d. Pharmacology of the Antiphsycotics. e. Basic Pharmacology of the antidepressants f. Basic Pharmacology of the CNS stimulants g. Basic Pharmacology of the Local anesthetics h. Basic Pharmacology of the General Anaesthetics i. Basic Pharmacology of the Analgesics j. Drug treatment/Therapeutics of Affective Disorders k. Drug treatment/Therapeutics of Seizure Disorders l. Drug treatment/Therapeutics of NSAIDS

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