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Zonisamide (Zonegran)
On 19 Feb 2009, the Food and Drug Administration (FDA) released an FDA Alert on
zonisamide (Zonegran). One of a number of newer anticonvulsants, zonisamide has been
causally related to metabolic acidosis, particularly in the pediatric age group. Zonisamide
is indicated as adjunctive therapy in the treatment of partial seizures in adults.
Zonisamide use in DoD beneficiaries was reviewed in the Pharmacy Data Transaction
System (PDTS). While use peaked in the 51-55 year old group, substantial use in the
pediatric age group, including use in children under one year of age, was documented.
Prepared by:
Geoffrey Rake, M.D.
Director, DoD Patient Safety Center
6 Mar 2009