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Basophils
Neurons (CNS)
Platelets
Biosynthesis and metabolism
Decarboxilase
diaminooxidase N-methyltransferase
Histamine
CH 2 -CH2 -NH2
CH 2 -COOH
N N
N N CH 3
B cell (plasma)
Symptoms
1 2 3
4 5 6
Histamine in allergic response
Histamine releasing agents
- Morphine
- Substance P, bradikinine.
Types H1 H2 H3
PLC AC AC
↑Ca++ ↑AMPc ↓cAMP
NO
↑GMPc
Histamine
Stomach (H2 )
Itching, pain
Respiratory (H1)
Inflammation
Induce IL-10 secretion
Pharmacological actions of histamine
3
1
2
Antihistaminic drugs H1
1) Allergies
Rhinitis/ Allergic conjunctivitis
Urticaria/ dermatitis
First generation
3) Sedation
Second generation
First generation
- Sedation (if cross blood brain barrier). (Tolerance)
Second generation
Ranitidine Cimetidine
H1?
Respiratory tract alergies Allergie inhibition
Histamine Difenhydramine
H2?
stomach wall HCl secretion
HCl secretion
persist
~1976
PGE
2
H+ PG PGI 2
Célula parietal
Histamina
G
MOCO
PG
HCO-
3 Célula epitelial
M1 ACh
Célula paracrina
Cimetidina
Cimetidina
Inhibitors of Histamine release
Pharmacological action: prophylaxis of the brocoespasmo
induced by histamine
(I) Histamine