Curriculum Vitae Clayton K. Trimmer, D.O., M.S. 2005 Cottonwood Valley Circle S. Irving, TX. 75038 clayton.trimmer@utsouthwestern.

edu

EDUCATION

1979-1983

Bachelor of Science, Biology, Stephen F. Austin State University, Nacogdoches, Texas Masters Candidate, Master of Science Graduate Assistant, Chemistry, Stephen F. Austin State University, Nacogdoches, Texas Doctor of Osteopathy, University of North Texas Health Science Center, Texas College of Osteopathic Medicine, Fort Worth, Texas Intern, Pontiac Osteopathic Hospital, Pontiac, Michigan Diagnostic Radiology Resident, Michigan State University, Pontiac-Oakland Division, Pontiac, Michigan Fellow, Vascular and Interventional Radiology, Parkland Memorial Hospital, Dallas, Texas Advanced Specialty Training Program Fellow, Vascular and Interventional Radiology, Johns Hopkins University Hospital, Baltimore, Maryland Master of Science in Healthcare Management, University of Texas at Dallas, Richardson, Texas

1983-1985

1985-1989

1989-1990

1990-1994

1994-1995

2001-2002

2003-2007

EMPLOYMENT

1995-2001

Diagnostic & Vascular and Interventional Radiologist, Mineral Area Regional Medical Center, Farmington, MO. Medical Director, Open MRI Center Mineral Area Regional Medical Center, Farmington, MO. Clinical Assistant Professor, Section of Vascular and Interventional Radiology, St. Louis University, St. Louis, MO. Clinical Instructor, Cardiovascular and Interventional Radiology, Johns Hopkins University School of Medicine, Baltimore, MD. Assistant Professor of Radiology, Section of Interventional Radiology, University of Texas Southwestern Medical Center, Dallas, TX. Medical Director Interventional Radiology, Parkland Memorial Hospital

1999-2001

2000-2001

2001-2002

2002-2008

2007-2011

2007-present Director of Interventional Oncology, Parkland Memorial Hospital 2008-present Associate Professor of Radiology, Section of Interventional Radiology, University of Texas Southwestern Medical Center, Dallas, TX.

LICENSURE

1990

Texas H8469

CERTIFICATION

1994

Diplomate Diagnostic Radiology American Osteopathic Board of Radiology Certificate of Added Qualifications Vascular and Interventional Radiology American Osteopathic Board of Radiology

1995

ACTIVITIES AND PROFESSIONAL SOCIETIES

1985-present Member, American Osteopathic Association 1987-present Member, Phi Beta Pi Medical Fraternity (Officer 1987-1988) 1990-present Member, American Osteopathic College of Radiology 1990-present Member, Radiological Society of North America 1992-1993 Chief Resident, Diagnostic Radiology, Michigan State University, Pontiac-Oakland Division Member, Steering Committee, Diagnostic Radiology, Michigan State University

1992-1993

1992-present Member, American College of Radiology 1995-present Member, Society of Interventional Radiology 1996-1997 1998-1999 1998-2001 1999-2000 2000-2001 2005-2009 2005-2007 Chairman, Infection Control Committee Chairman, Quality Assurance/Improvement Committee Member Board of Trustees, Mineral Area Regional Medical Center Chairman, Mineral Area Health Group Board of Directors Chief of Staff, Mineral Area Regional Medical Center Alternate Councilor, Board of Governors, American College of Radiology Alternate Senator, Faculty Senate, University of Texas Southwestern Medical Center

2006-present Interventional Radiology Reviewer, Radiographics Journal 2006-2010 Member, Policy Review Committee, American Osteopathic College of Radiology

ACTIVITIES (CONT.)

2007-2012 Member, RSNA-ACR Public Information Website Committee

2007-present Peer-reviewed Interventional Radiology manuscript reviewer, Journal of Vascular and Interventional Radiology 2007-2008 Member, Health Information Management Committee, University Hospital, Southwestern Medical Center Member, Radiology on-line Questionnaire Committee, University Hospital, Southwestern Medical Center Committee Member, American Registry of Radiologic Technologists, Examination Committee Committee Member, Continuing Post-Graduate Education Committee, American Osteopathic College of Radiology

2007-2009

2008-2012

2009-2012

2009-present Councilor, Board of Governors, Texas Radiologic Society, American College of Radiology, Texas Chapter 2011-present Peer-reviewed Interventional Radiology reviewer, Radiology, 2011-present Vice Chief Councilor, Board of Governors, Texas Radiologic Society, American College of Radiology 2011-present Committee Member, ACR E-Learning Subcommittee, American College of Radiology 2011-2012 Committee Member, Editorial Committee, American Osteopathic College of Radiology Committee Member, Scientific Exhibit Committee, American Osteopathic College of Radiology

2011-2012

PEER-REVIEWED MANUSCRIPTS

1.

Retz K.C., Trimmer, C.K., Forester, M., Lal, H: Motor Responses of Autoimmune NZB/BINJ and C57B1/6Nnia mice to arecoline and nicotine: Pharmacology Biochemistry and Behavior, Vol. 28, January 1987. Trimmer, CK, Percutaneous Thrombin injection of Pseudoaneurysms: Does it work? Is it safe?, American Heart Association, Cardiovascular Radiology Council Newsletter, Fall 2002 Matsumoto E, Johnson B, Ogan K, Trimmer C, Sagalowsky A, Margulis V, Caddedu J, Short-Term Efficacy of temperature-based radiofrequency ablation of small renal tumors. Urology, 65 (5), 2005 877-881. Trimmer CK, Pro/ConClotted AVF-Worth Fixing? DNR-DOA, Journal of Vascular Access, October-December 2006, Vol 7,. No. 4, pp 181-182 Trimmer CK, Pro/ConAngioplasty of AV Graft Anastomotic Stenosis: Worth Doing? Journal Of Vascular Access, October-December 2006, Vol. 7, No. 4, pp 190. Trimmer CK, What Data Supports Adjunctive Techniques and Devices for AV Shunt Intervention? Cryoplasty: Snowballs Chance? Journal of Vascular Access, OctoberDecember 2006, Vol. 7, No. 4, pp 194. McDougal JL, Valentine RJ, Josephs SC, Trimmer CK, Clagett GP, Modrall JG, Computed Tomographic Angiography has added Value in patients with vascular disease, Journal of Vascular Surgery, Nov 2006 Vol. 44, No. 5 998-1001 Auchus RJ, Chandler DW, Singeetham S, Chokshi N, Nwariaku FE, Dolmatch BL, Holt SA, Wians, Jr. FH, Josephs SC, Trimmer CK, Lopera J, Vongpatanasin W, Nesbitt SD, Leonard D , Victor RG, Inverse 18-Hydroxycorticosterone/ Aldosterone Gradients From Adrenal Vein Sampling Confirm Unilateral Aldosterone Production, Journal of Clinical Endocrinology and Metabolism. October 2006

2.

3.

4.

5.

6.

7.

8.

9.

Auchus RJ, Chandler DW, Singeetham S, Chokshi N, Nwariaku F, Dolmatch B, Holt S, Wians F, Josephs SC, Trimmer CK, Lopera J, Vongpatanasin W, Nesbitt S, Leonard D, Victor R. Measurement of 18-Hydroxycorticosterone during Adrenal Vein Sampling for Primary Aldosteronism, J Clin Endocrinol Metab 92(7):2648-2651 July 2007.

10. Baker M, Anderson JK, Jaffer O, Trimmer C, Cadeddu JA, Pain after percutaneous radiofrequency ablation of renal tumors. Journal of Endourology, 21(6): 606-609, June 2007

MANUSCRIPTS (Cont.)

11. Raman JD, Thomas J, Lucas SM, Bensalah K, Lotan Y, Trimmer C, Cadeddu JA, Radiofrequency ablation for T1a tumors in a solitary kidney: promising intermediate oncologic and renal function outcomes, Canadian Journal of Urology, 2008 April, 15 (2), 3980-3985. 12. Lopera JE, Trimmer CK, Josephs SC, Anderson ME, Schuber S, Li R, Dolmatch B, Toursarkissian B. Multidetector CT angiography of infrainguinal arterial bypass. Radiographics. 28 (2): 529-548 discussion 549, 2008 Mar-Apr 13. Lopera JE, Trimmer CK, Josephs S, Dolmatch B, Valentine RJ, Clagett GP, Neoaortoiliac Reconstructions Using Femoropopliteal Veins: MDCT Angiography Findings, American Journal of Roentgenology, 191, August 2008, 569-572. 14. Gupta A, Raman JD, Leveillee RJ, Wingo MS, Zeltser IS, Lotan Y, Trimmer C, Stern J, Cadeddu JA, General Anesthesia and Contrast Enhanced Computed Tomography To Optimize Renal Percutaneous Radiofrequency Ablation: Multi-Institutional Intermediate Term Results, British Journal of Urology, Submitted June 2008. 15. Lopera JE, Alvarez A, Trimmer C, Josephs S, Anderson M, Dolmatch B, Stability of balloon-retention gastrostomy tubes with different concentrations of contrast material: in vitro study. Cardiovascular and Interventional Radiology. 2009 Jan; 32(1): 127-131 16. Auchus RJ, Michaelis C, Wians FH Jr, Dolmatch BL, Josephs SC, Trimmer CK, Anderson ME. Rapid cortisol assays improve the success rate of adrenal vein sampling for primary aldosteronism. Ann Surg. 2009 Feb;249(2):318-21. PMID: 19212188 17. Modrall JG, Timaran CH, Dolmatch BL, Clagett GP, Trimmer C, Preoperative Clinical Determinants of Response to Renal Artery Stenting: Who Will Benefit? Journal of Vascular Surgery, May 2009 16S-17S 18. Gupta A, Raman JD, Leveillee RJ, Wingo MS, Zeltser IS, Lotan Y, Trimmer C, Stern JM, Cadeddu JA, General Anesthesia and Contrast-Enhanced Computed Tomography to Optimize Renal Percutaneous Radiofrequency Ablation: Multi-Institutional Intermediate-Term Results, Journal of Endourology June 16, 2009. 19. Trimmer CK, Song J, Endovascular Management of Upper Gastrointestinal Hemorrhage, Endovascular Forum, Published on-line June 17, 2009. 20. Murphy EH, Arko FA, Trimmer CK, Phangureh VS, Fogarty TJ, Zarins CK, Volume associated dynamic geometry and spatial orientation of the inferior vena cava; Journal of Vascular Surgery, August 2009

MANUSCRIPTS (Cont.)

21. Lopera J, Trimmer CK, Lamba R, Suri R, Cura MA, El-Merhi FM, Kroma G; MDCT Angiography of Mesenteric Bypass Surgery for the Treatment of Chronic Mesenteric Ischemia, American Journal of Roentgenology, 193, November 2009 1439-1445 22. Echeverri S, Lopera J, Trimmer C; Pseudoaneurysm of the Pulmonary Artery after Blunt Chest Trauma, Intervencionismo, April-June 2009; 9,2: 75-79 23. Haskal Z, Dolmatch BD, Trimmer CK, Endovascular Stent Graft versus Balloon Angioplasty for Treatment of Dialysis Access Graft Failure, New England Journal of Medicine, 09-02045, February 11, 2010 24. Auchus RJ, Wians FH Jr, Anderson ME, Dolmatch BL, Trimmer CK, Josephs SC, Chan D, Toomay SM, Nwariaku FE, What we still do not know about Adrenal Vein Sampling for Primary Aldosteronism, Hormone & Metabolic Research, 42(6): 411-5, 2010 June 25. Modrall JG, Valentine RJ, Timaran CH, Rosero EB, Anthony T, Clagett GP, Trimmer C, Renal Volume and Blood Pressure Response to Renal Artery Stenting, Journal of Vascular Surgery, Volume 51, Issue 6, Supplement 1, June 2010, Pages 13S-14S. 26. Tracy C, Raman JD, Donnally C, Trimmer CK, Cadeddu JA, Durable Oncologic Outcomes following Radiofrequency Ablation (RFA): Experience from treating 243 small renal masses over 7.5 years, Cancer, 116(13): 3135-42, 2010 Jul 1 27. Lopera JE, Restrepo CS, Gonzales A, Trimmer CK, Arko F. Aortoiliac Vascular Injuries after Misplacement of Fixation Screws. J Trauma 69 (4): 870-5, 2010 October

28. Modrall JG, Timaran CH, Rosero EB, Chung J, Arko FA, Valentine RJ, Clagett GP, Trimmer CK, Renal Artery Stenting for Salvage of Renal Function: Preoperative Redictors of Outcome Guide Patient Selection, Journal of Vascular Surgery, Volume 52, Issue 6, December 2010, Page 1732. 29. Georgiades CS, Rodriquez R, Littrup PJ, Frangakis CE, Leveille R Ahrar K, Atwell TD, Cadeddu J, Trimmer CK, Durack JC, Hammers HJ, Meng MV, Raman S, Solomon SB,Zagoria RJ, McLennan G, LaBerge, JM, Gervais DA, Kee ST; Development of a Research Agenda for Percutaneous Renal Tumor Ablation: Proceedings from a Multidisciplinary Research Consensus Panel, Journal of Vascular Interventional Radiology, Dec 2010; 21:1807-1816

MANUSCRIPTS(Cont.)

30. Modrall JG, Rosero EB, Leonard D, Timaran CH, Anthony T, Arko FA, Valentine RJ, Clagett GP, Trimmer CK, Clinical and Kidney Morphological Predictors of Outcome for Renal Artery Stenting: Data to Inform Patient Selection, Journal of Vascular Surgery, May 2011, 53:1282-90.

31. Miller A, Pepe PE, Pechock R, Bhore R, Yancy CC, Xuan L Miller MM, Huet GR, Trimmer C, Davis R, Chason R, Kashner MT, Is Coronary CT Angiography a Resource Sparing Strategy in the Risk-Stratification and Evaluation of Acute Chest Pain? Results of a Randomized Controlled Trial. Academic Emergency Medicine Journal, 18 (5):458-67, May 2011

32. Modrall JG, Rosero E, Timaran CH, Anthony T, Chung J, Arko F, Clagett GP, Valentine RJ, Trimmer C, Assessing Outcomes to Deternime Which Symptoms Justify Renal Artery Stenting, Journal of Vascular Surgery, Volume 53, Issue 6, Supplement 1, June 2011, Pages 8S-9S 33. Plummer M, Timaran CH, Rosero E, Chng J, Arko F, Clagett GP, Valentine RJ, Trimmer C, Modrall JG, Changes in Kidney Volume After Renal Artery Stenting: Does Stenting Preserve Renal Mass?, Journal of Vascular Surgery, Volume 53, Issue 6, Supplement 1, June 2011, Pg. 5S 34. Modrall JG, Timaran CH, Rosero EB, Chung J, Arko FA III, Valentine RJ, Clagett GP, Trimmer C, Predictors of Outcome for Renal Artery Stenting Performed for Salvage of Renal Function. Journal of Vascular Surgery, July 2011, In Press 35. Modrall JG, Rosero EB, Timaran CH, Anthony T, Chung J, Arko FA III, Valentine RJ, Clagett GP, Trimmer C, Assessing Outcomes to Determine Whether Symptoms Related to Hypertentsion Justify Renal Artery Stenting, Journal of Vascular Surgery, July 2011, In Press

36. Hardman RL, Lopera JE, Cardan RA, Trimmer CK, Josephs SC, Common and Rare Collateral Pathways in Aortoiliac Occlusive Disease: A Pictorial Essay, American Journal of Roentgenology: 197:W519-W524, September 2011

SCIENTIFIC EXHIBITS

Trimmer, CK, Kelly, J.K., MRI of Cranial Nerves- Normal Anatomy. Annual Meeting-American Osteopathic College of Radiology, 1992. Dolmatch BL, Trimmer CK, Josephs SC, Siddiqi NH, Intra-and Inter-Observer Agreement of Aortic Aneurysm Measurements. Society of Interventional Radiology Annual Meeting, New Orleans, LA, 2004. Lopera JE, Trimmer CK, Josephs S, Anderson M, Dolmatch B, et al, CTA of infrainquinal bypass, Radiologic Society of North America, Chicago, IL. 2006. Lopera JE, Sheffield C, Trimmer C, Josephs S, Anderson A, Dolmatch B, Smith S, Valentine RJ, Clagett GP, CTA of Neo-Aorto-iliac Systems, Radiologic Society of North America, Chicago, IL. 2006. Lopera JE, Trimmer C, Josephs S, Anderson A, Dolmatch B. Stability of balloon-type gastrostomy tubes with different concentrations of contrast material: In-vitro study, Society of Interventional Radiology Annual Meeting, Seattle, WA. 2007 Lopera JE, Josephs S, Trimmer C, Anderson M, Dolmatch B, Tilting of Femoral GuntherTulip Filter: In-Vitro Study, Society of Interventional Radiology Annual Meeting, Seattle, WA 2007.

PRESENTATIONS/INVITED LECTURES

Program Moderator, American Osteopathic College of Radiology annual Meeting, Advances in Radiology, 1998, The Present and Future. MIIT Interventional Radiology & Endovascular Therapy Seminar. Oak Brook, IL. The Bard PTFE Stent Graft Trial for Venous Anastomotic Stenosis of HD Access Grafts. September 12, 2003. MIIT Interventional Radiology & Endovascular Therapy Seminar. Oak Brook, IL. The Top Ten Things Your Surgeon Needs to Know About Failing Bypass Grafts. September 12, 2003. Texas Association of Peri-Anesthetic Nurses Annual Meeting. Dallas, TX. Emerging Trends in Embolotherapy: Hepatic Chemo-Embolization and Uterine Fibroid Embolization. September 13, 2003. Dallas-Fort Worth Radiologic Society Monthly Meeting. Dallas, TX. Hepatic Arterial ChemoEmbolization. September 15, 2003. Diagnostic Radiology Update Annual Course/University of Texas Southwestern Medical Center Dallas, TX. Abnormal CTA findings that require early follow-up and/or intervention. October 26, 2003 Access for Dialysis: Update & Controversies. Dallas, Texas. Pro/Con: Percutaneous Treatment of the Failing Shunt. Newer Catheter Techniques are Superior to Angioplasty. October 14-15, 2004. New Therapeutic Advances in the Battle with Cancer: Oncology Update for Primary Care Physicians. Dallas, Texas. Cookin with Clayton: Percutaneous Tumor Ablation. December 4, 2004. 19th Annual Cardiology Review, St. Louis University and Des Peres Hospital, St. Louis, MO. The Odd Aorta. December 9, 2004. Workshop Coordinator, Society of Interventional Radiology Annual Meeting, Vascular Imaging: CTA and MRA, non-Coronary applications, Toronto, Ontario, Canada, 2006. Diagnostic Radiology Annual Update/ University of Texas Southwestern Medical Center Dallas, TX. Balloon Kyphoplasty, The Straw that Fixed the Camels Back, March 3, 2006. 5th Annual Southwestern Dialysis/Transplant Update, Interventional Procedures For Vascular Access Problems, April 8th 2006, Dallas, TX.

PRESENTATIONS (Cont.)

Texas Association of Peri-anesthetic Nurses District Meeting, Treatment of Vertebral Compression Fractures, Dallas, TX. June 10, 2006. 3rd Annual Controversies in Dialysis Access, Cryoplasty of AV Graft Stenosis, Declot of Native AV Fistulas, Angioplasty of AV Graft stenosis, Nov 2-4, 2006, San Francisco, California. Workshop Coordinator, Society of Interventional Radiology Annual Meeting, Vascular Imaging: CTA and MRA, non-coronary applications, Seattle WA. 2007. Categorical Course in Trauma, Society of Interventional Radiology Annual Meeting, Blunt Extremity Trauma, Seattle, WA. 2007 Visiting Professor, Michigan State University Atis K. Freimanis Visiting Professor Program, Venous Interventions, Oncologic Interventions, September 17-18, 2007 Dallas County Internist Society, Interventional Radiology: Emerging Trends; Recognition and Treatment of Aortic Dissection, January 11, 2008. Association of Peri-Anesthetic Nurses Annual Convention, Percutaneous Radiofrequency Ablation of Renal Masses. Grapevine, TX, May 6, 2008. Texas Radiological Society Annual Meeting, Angiography and Embolization for Blunt Trauma: Abdomen, Pelvis, and Extremities, Fort Worth, Texas March 8, 2009. American Osteopathic College of Radiology Mid-Year Meeting, Imaging Guided Treatments for Renal Cancer, Royal Oak, Michigan, April 24, 2009. American Osteopathic College of Radiology Mid-Year Meeting, Embolization for Other Solid -Tumors, Royal Oak, Michigan, April 25, 2009. Association of Vascular Interventional Technologists, North Texas Chapter, Annual Meeting, Radiofrequency ablation, Cryotherapy and Ethanol Ablation of Renal Masses, Brookhaven College, August 1, 2009 14th Annual Physician CME Symposium at Hendrick Medical Center, Current Imaging-Guided Treatment for Renal Cancers, Abilene, TX., September 18-19, 2009 Texas Osteopathic Medical Association Annual Meeting, Image Guided Treatments for Renal Cancer, Fort Worth, Texas May 6, 2010

PRESENTATIONS(Cont.)

Visiting Professor, University of Louisville, Renal RFA and other Techniques, February 17, 2011, Louisville, Kentucky Greater Louisville Radiologic Society, Oncologic Interventions and Therapy of Liver Masses, February 17, 2011, Louisville, Kentucky University of Texas Southwestern Gastrointestinal Oncology Symposium, Novel Ablative and Interventional Therapies of Liver Cancer, April 2011, Dallas, TX. Spring 2011 Metroplex Multidisciplinary Endovascular Case Conference, Co-Moderator, May 19, 2011, Dallas Texas Current Trends in IR: A Primer for Diagnostic Radiologists, Program Chair, American Osteopathic College of Radiology Mid-Year Meeting, Chicago IL , September 23-25, 2011

ABSTRACTS

Arepally A, Vasquez O, Hofmann LH, Kim HY, Trimmer CK, Eng J and Perler B. Catheter Directed Thrombolysis with t-PA: A Comparison of Two Dosages. RSNA Annual Meeting, Chicago, IL 2002. Trimmer CK, Arepally A, Fakhry C, Eng J. Hemobilia: A 7 Year Review of a Single-Center Clinical Experience. RSNA Annual Meeting, Chicago, IL, 2002. Lopera, J, Trimmer C, Aorto-iliac vascular Injuries after placement of Fixation Screws. SIR Annual Meeting, Tampa, FL 2010

BOOK CHAPTERS

Arepally A, Trimmer C, Georgiades C. Obstructive Jaundice: Transhepatic Interventions in: Current Surgical Therapy 8th Edition, Elsevier Mosby, Philadelphia, PA 2004.

Coldwell D, Trimmer C, Embolotherapy in the treatment of pelvic fractures, Embolotherapy, Ray C ed., Springer, Mauer Germany, 2009

RESEARCH/GRANTS

Principal Investigator UTSW A Prospective, Multi-Center, Evaluation of an IMPRA/Bard ePTFE Encapsulated Carbon Lined Nitinol Endoluminal Device for AV Access Graft Stenoses Academic Transition Award Recipient 2004, Cardiovascular and Interventional Radiology Research and Education Foundation (CIRREF), Society of Interventional Radiology. Principle Investigator: Cryoplasty to Treat Anastomotic Venous Stenosis of a Synthetic Arteriovenous (AV) Dialysis Graft. IRB No. 082005-001 Principle Investigator UTSW- A Prospective, Randomized, Concurrently-Controlled Post Approval Study of the FLAIR Endovascular Stent Graft Sub-Investigator: A Phase III Randomized, Double-Blind Trial of Chemoembolization with or without Sorafenib in Unresectable Hepatocellular Carcinoma (HCC) in Patients with and without Vascular Invasion , PI Udit Verma IRB No. 092010-198 Sub-Investigator: Utility of Preoperative FDG-PET/CT Scanning to Detect Retrooperable Lymph Node Metastasis in Patients with Locoreginally Advanced Carcinoma of the Cervix and High Risk Endometrial Cancer, PI David Miller, IRB No. 072010-012 Sub-Investigator: Renal Volume and Clinical Outcomes for Renal Artery Interventions, PI Gregg Modrall, IRB No. 092010-120 Sub-Investigator: Factors Predicting Retrievability of Removable Inferior Vena Cava Filter, PI Scott Schuber, M.D. IRB No. 012005-074 Sub-Investigator: ePTFE Coated vs. Covered Stents for Peripheral Vascular Disease, PI: Bart Dolmatch, M.D. APN 1003-04-01-1 Sub-Investigator: In-vivo Premarket Evaluation of Devices for Endovascular Applications, PI: Bart Dolmatch, M.D. APN 1003-07-02-102-1 Sub-Investigator: NIH Grant/ IRB No. 11205-014 CORAL Study, PI: Ramesh Saxena, M.D., Bart Dolmatch, M.D. Sub-Investigator: Rex Medical Option Vena Cava Filter, PI: Bart Dolmatch, M.D. IRB File No. Pending Sub-Investigator: A Randomized, Placebo-controlled, Double-blinded Study of the Efficacy and Safety of Cobiprostone in Patients with Portal Hypertension. IRB No. SPI/8811 SPH-0721