BiomaterialsLecture11

SourceInformationforthefollowingslides: 1)B.Ratner,A.Hoffman,F.Schoen,andJ.Lemons:BiomaterialsScience, 2nd edition(SanDiego:ElsevierAcademicPress.2004).

Definitions Biotextile: structurescomposedoftextilefibersdesignedforusein specificbiologicalenvironments;particularlyasimplantablematerials Medicaltextiles: abroadergroupoftextilesincludingbandages,wound dressings,hospitallinen,preventiveclothing,etc

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 87.

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 88.

MeltSpinningFibers

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 88.

WetSpinning

Typicallyusedforpolymerswithlowdegradationtemperaturesorthat containtemperaturesensitivecomponents(i.e.drugs)

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 89.

Electrospinning
http://nano.mtu.edu/documents/Electrospinning.swf

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 89.

Electrospinning

30,000Volt

10micron

SEMimageofelectrospun PETfibers. Fiberdiametersareintherangeof1.5 4

Electronmicrographof 300nmpolybenzimidazole nanofibers

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 90.

Wovenpolyesterfabric

Nanofibers havelargesurfaceareapergram

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 91.

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 91.

WovenFabrics

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 93.

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 93.

KnitFabrics

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 94.

BraidedFabrics/Fibers

Usedinthemanufactureofsuturematerialsandanteriorcruciate ligaments(ACL)prostheses

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 95.

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 96.

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 96.

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 96.

B. Ratner, A. Hoffman, F. Schoen, and J. Lemons: Biomaterials Science, 2nd edition (San Diego: Elsevier Academic Press. 2004). 98.

MaterialsUsedforHemostais
Surgicalcelluloseisa materialthatiscomesin thinsheetsofinterwoven speciallytreatedcellulose thatprovidesamatrixto whichplateletsandclotting factorscanadhereleading toformationonthe celluloseofadenseclot whichcanactasapatch overanareaofbleeding.

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HollowFibers
Definition materialscapableofconductingflowinanaxial directionorprovidingaconduittoguidetheregenerationof tissue,andgenerallycapableofseparatingsolublemolecules onthebasisofsizeandincertainspecializedcasesonthe basisofcharge(semipermeable),inothercasesthe separationisnotmolecularbutcellular.

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Filtration
HollowFiberMembranes (HFM); SelectiveSeparation;

Materials
ThermoplasticsPS,PAN,PAN PVC,CA,CN Polyurethane

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Applications
Bloodgasoxygenators Plasmapheresis Dialysis Liquidsterilization Bioartificialliver Bioartificialkidney Drugdeliverycellencapsulation Biotechnologybioreactors Vasculargrafts Nerverepair
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Hemodialysis
Externalprocedure 3sessionsof4hrsaweek Filtrationprocessonly

Hollow Fiber Dialyzer Blood flows in and is cleaned using the process of diffusion and ultrafiltration.

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DryJetWetSpinning
Spinnerette

Nonsolvent Stream
Note: Picture not drawn to scale Nonsolvent Stream

Polymer Solution Stream

Polymer Solution Stream

Outflow Stream

Nonsolvent Bath
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OnaLargerScaleVariousStructuresareApparentandcanbecontrolled bychangingFabricationsconditions

F A C D B
APANPVCLietal.1998 BPANPVCLietal.1998 CPolyimideChungetal.1992 DPolysulfoneValetteetal.1999 ECelluloseacetateHaoetal.1996 FPANcopolymerValetteetal.1999 GAN69Valetteetal.1999 HPMMAValetteetal.1999
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