Adrenergic agonists Action drug

Receptor

Pharmacologic use Rapid relief of allergic rxn, bronchodilator, prolong action of local anaesthetics, restoring cardiac rhythm, vasopressor, topical hemostatic agent, lower ioc in glaucoma Increase pvr in shock, hypotension Obesity, narcolepsy, adhd Obesity, narcolepsy, adhd Narcolepsy, adhd Topical hemostatic and local anasthetic Narcolepsy, obesity Emergency heart block, emergency bradycardia, or pacemaker in torsades de pointes Acute cardiac failure, chf, post op or post mi Different types of shock, profound hypotension, chf, incr urine output (dopa vs beta effect) Bronchodilator used in asthma Bronchodilater and uterine relaxation Uterine relaxation Bronchodilator used in asthma Mydriatic used to faciliate retina exam, cariothoracic surgery to increase pvr with minimal/controllable cardiac effects, nasal decongestant Hypotension, psvt (stimulates vagal effect) Hypotension, psvt (stimulate vagal effect) Nasal decongestant Antihypertensive agent, withdrawl syndromes, analgesic Opthalmic drops in glaucoma Opthalmic drops used in gluacoma Antihypertensive Antihypertensive Antihypertensive

Epinephrine

Direct

Alpha and beta catecholamine Alpha and beta catecholamines Alpha and beta Alpha and beta Alpha and beta Alpha and beta Alpha and beta Beta selective catecholamine Beta 1 selective catecholamine Beta 1 selective, d1 receptor renal, alpha 1 selective (high) Beta 2 selective Beta 2 selective Beta 2 selective Beta 2 selective Alpha 1 selective Alpha 1 selective Alpha 1 selective Alpha 1 selective Alpha 2 selective Alpha 2 selective Alpha 2 selective Alpha 2 selective Alpha 2 selective Alpha 2 selective

Norepinephrine Amphetamine Dextroamphetamine Methylphenidate Cocaine Ephedrine Isoproterenol Dobutamine

Direct Indirect Indirect Indirect Indirect Mixed Direct Direct

Dopamine Metaproterenol Terbutaline Ritodrine Albuterol Phenylephrine Methoxamine Metaraminol Pseudoephedrine Clonidine Apraclonidine Brimonidine Guanfacine Guanabenz Alpha-methyl-ne (methyldopa)

Mixed Direct Direct Direct Direct Direct Direct Mixed Direct Direct Direct Direct Direct Direct Direct