Sikkim Manipal University Model Question Paper MSc CRRA program III semester Sub: Clinical Studies (2-credits)

Sub Code: MR0017

PART A (20x1=20 marks)

PART B (11x2=22 marks)

PART C (7x4=28 marks)

PART A (20x1=20 marks) 1. Insulin is administered by ____________ route a. Sublingual b. Subcutaneous c. Intra venous d. Intra arterial 2. Which of the following forms of drug is most easily absorbed? a. Solid b. Liquid c. Semisolid d. Suspensions 3. In vitro dissolution time estimation of a tablet dosage form is carried out in _________ a. 0.1M NaOH b. 0.1M H2SO4 c. 0.1N NaOH d. 0.1N H 4. Sulfonamides after metabolism lead to ____________ a. Crystalluria b. Grey baby syndrome c. Renal toxicity d. Hepatotoxicity 5. Bioequivalence Requirement means a requirement imposed by the ____________. a. FDA b. IND c. FD and C d. NDA 6. FDA stands for____________ a. Food and Drug Application b. Food and Drug Administration

c. Food and Drug Amendment d. Federal and Drug Administration 7. Cmax is proportional to ___________ a. Rate of absorption b. Rate of elimination c. Half life d. Both a and b 8. Bioavailability is denoted as __________ a. F b. Cp c. AUC d. Kel 9. ANDA stands for___________ a. Applied New Drug Application b. Abbreviated New Dosage Application c. Abbreviated New Drug Application d. Appreciated New Drug Application 10. _____________ is a polar adsorbent material. a. Alumina b. Hydrocarbons c. Squalene d. Nujol 11. _____________ is a non polar adsorbent material. a. Silica b. Hydrocarbons c. Carbowaxes d. PEG 12. ________ is the volume of mobile phase needed to move an unretained solute from the point of injection to the detector. a. Void volume

b. Retention volume c. Recession volume d. Reversal volume 13. Distance between peaks of waves in cm is _______ a. Wave length b. Wave number c. Frequency d. Amplitude 14. Emission following the absorption of a photon is also called as ________________ a. Flourescence b. Phosphorescence c. Photoluminescence d. Chemiluminescence 15. A good example of atomic spectroscopy is ____________ a. UV spectroscopy b. Fluorimetry c. Colorimetry d. Flamephotometry 16. A good example of emission spectroscopy is ____________ a. UV spectroscopy b. Fluorimetry c. Colorimetry d. Flourimetry 17. a. 104 Ao b. 103 Ao c. 102 Ao d. 106 Ao 18. Hinge Point Gradient Development is a method in ________ a. HPLC b. HPTLC

c. GC d. LC-MS 19. The lighter the mass, the _____________ that will occur at a given charge. a. More deflection b. Less deflection c. No deflection d. More reflection 20. SIM stands for a. Single Ion Monitoring b. Single Ion Movement c. Sample Ion Monitoring d. Sample Ion Movement

PART B (11x2=22 marks) 21. In a mass spectrometer ____________ is followed by __________ a. Mass selector by magnetic sector b. Magnetic sector by mass selector c. Electrostatic sector by mass selector d. Mass selector by electrostatic sector 22. Interferometers provide two significant advantages ________ and ___________ a. Jacqunots and Felgets b. Jacqunots and Felgetts c. Jacqunots and Fellgets d. Jacquinots and Fellgetts 23. Consequently __________ and __________ methods have come to be known as classical methods of analysis. a. Gravimetry and volumetry b. Turbidometry and nephelometry c. Flourescence and phosphorescence d. Spectrometry and absorptiometry 24. Fermi resonance is ____________ and _____________ a. Multiple of two frequencies and sum of given vibrations b. Multiple of given vibrations and sum of two frequencies c. Multiple of two vibrations and sum of all the given frequency d. Multiple of given frequency and sum of two vibrations 25. Functional group region and finger print region in IR is __________ and _________ respectively a. 4000cm-1 to 130cm-1 and 1300cm-1 to 4000cm-1 b. 1300cm-1 to 4000cm-1 and 4000cm-1 to 130cm-1 c. 4000cm-1 to 1300cm-1 and 1300cm-1 to 400cm-1 d. 1300cm-1 to 400cm-1 and 4000cm-1 to 1300cm-1 26. Interferogram is ____________ and normal spectrum is _____________ a. Frequency domain spectrum and time domain spectrum b. Time domain spectrum and frequency domain spectrum

c. Time domain spectrum and wave length domain spectrum d. Wave length domain spectrum and time domain spectrum 27. Emission following the absorption of a photon is also called ________________ and that following a chemical reaction is called _________________ a. Turbidimetry and nephelometry b. Fluorimetry and colorimetry c. Photoluminescence and chemiluminescence d. Fluorescence and phosphorescence 28. In normal phase chromatography, the stationary phase is ______ and mobile phase is __________ a. Polar and polar b. Non polar and non polar c. Polar and non polar d. Non polar and polar 29. In reverse phase chromatography, the stationary phase is ______ and mobile phase is __________ a. Polar and polar b. Non polar and non polar c. Polar and non polar d. Non polar and polar 30. Bioequivalence Requirement means a requirement imposed by the Food and Drug Administration for the ___________ testing of specified drug products. a. Both a and b b. Invitro c. Invivo d. Bioavailability 31. Complete drug absorption and no drug absorption are represented by _____________ and _________ respectively. a. F = 1, F = 0 b. F = 0, F = 1 c. F = 100, F = 0 d. F = 0, F = 100

PART C (7x4=28 marks) 32. Match the following:1. Brand name 2. Chemical name 3. Drug product 4. Generic name a. 1-D, 2-B, 3-C and 4-A b. 1-B, 2-A, 3-D and 4-C c. 1-A, 2-B, 3-C and 4-D d. 1-D, 2-C, 3-A and 4-B 33. Match the following 1. 1872-1919 2. 1931 3.1941 a. Martin and Synge b. Nobel prize c. Chromatography as an analytical technique d. Mikhail Tswett a. Trade name b. Chemical structure c. Dosage form d. Active drug name

4. 1952 a. 1-D, 2-B, 3-C and 4-A b. 1-A, 2-C, 3-B and 4-D c. 1-A, 2-B, 3-C and 4-D d. 1-D, 2-C, 3-A and 4-B

34. Match the following 1. Orientation forces 2. Debye forces 3.Non-polar forces 4. Specific interactions a. 1-D, 2-B, 3-C and 4-A b. 1-A, 2-C, 3-B and 4-D c. 1-A, 2-B, 3-C and 4-D d. 1-D, 2-C, 3-B and 4-A a. Hydrogen bond b. Dipole forces c. Weakest force d. Complex formation

35. Match the following 1. Spectroscopic technique 2. Electrochemical techniques 3. Chromatographic techniques 4. Hypenated techniques a. 1-D, 2-B, 3-C and 4-A b. 1-B, 2-A, 3-D and 4-C c. 1-A, 2-B, 3-C and 4-D d. 1-D, 2-C, 3-A and 4-B 36. Match the wavelengths 1. Radio waves 2. Micro wave 3. Infra red 4. Visible a. 1-D, 2-B, 3-C and 4-A b. 1-B, 2-A, 3-D and 4-C c. 1-A, 2-B, 3-C and 4-D d. 1-D, 2-C, 3-A and 4-B 37. Match the wavelength range: 1. Red 2. Yellow 3. Blue 4. Violet a. 1-D, 2-B, 3-C and 4-A b. 1-B, 2-A, 3-D and 4-C c. 1-A, 2-B, 3-C and 4-D d. 1-D, 2-C, 3-A and 4-B 38. Match the radiations to groups a. 620 760nm b. 570 590nm c. 450 500nm d. 400 450nm a. 380-780nm b. 0.1cm to 100cm c. 0.78 to0.1cm d. 1 to 1000m a. Voltammetry b. NMR c. GC-MS d. HPLC

1. Radio waves 2. Micro wave 3. Infra red 4. Visible a. 1-D, 2-B, 3-C and 4-A b. 1-B, 2-A, 3-D and 4-C c. 1-A, 2-B, 3-C and 4-D d. 1-D, 2-C, 3-A and 4-B

a. 1H and 13C b. Free radicals c. Functional group d. Chromophores-conjugations