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IN THE NAME OF GOD

FIRST NAME: Fatima LAST NAME: Poorrajab PHONE NUMBER: +98-351-8202660, +98-9123070076 POSTAL ADDRESS: No. 503, Block C1, Venous Building, Emam Ali Sq. Yazd, Iran, 8944118193. E. MAIL: mina_poorrajab@yahoo.com Present Position; Lecturing Molecular Biology, Biochemistry PhD in Molecular Biochemistry September 2009

Biochemistry and Biophysics Institute (I.B.B.), faculty of science, University of Tehran, Iran. With the average of 18.5 out of 20 and project excellent grade of 19.8 out of 20. Thesis subject: Investigation on leishmanicidal activities of some new synthetic thiadiazole compounds and their mechanism of action, Under supervising of Professor Susan K. Ardestani, ardestani@ibb.ut.ac.ir.

Master of Science in Molecular Biochemistry Iran. With the average of 17.98 out of 20. Thesis Subject:

June 2006

Biochemistry and Biophysics Institute (I.B.B.), faculty of science, University of Tehran,

Effect of lead (Pb) on Chromatin components specially Histone Proteins and PARP, DNA strand breaks - sensor enzyme, Under supervising of Professor Azra Rabbani, rabbani@ibb.ut.ac.ir. 1

Bachelor of Science in Cellular & Molecular Biology Biology department, faculty of science, University of Tehran, Iran. Thesis Subject:

June 2004

Cancer and Environment, Literature survey and investigating the effect of some agents on polyten chromosomes of drosophila melanogaster, with the average of 17.5 out of 20. Under supervising of Dr. Farideh sayedyazdani fyazdani@chamran.ut.ac.ir .

ABSTRACTS & ARTICLES Mina Begrouzi-F., Fatemeh Poorrajab, et al. Synthesis and in vitro antileishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines, Bioorg Med Chem. (2008). Fatemeh Poorrajab, Sussan K. Ardestani, et al. Nitroimidazolyl-1,3,4thiadiazole -based anti-leishmanial agents: synthesis and in vitro biological evaluation. Eur J Med Chem. (2008). Fatemeh Poorrajab, Alireza Foroumadi. Sussan K. Ardestani, et al. Selective leishmanicidal effect and mechanism of action of thiadiazole derivatives against Leishmania species, Exp. Para. (2008). Babak H. ALIZADEH, Alireza FOROUMADI, Susan K. ARDESTANI3, Fatemeh Poorrajab. Synthesis and Leishmanicidal Evaluation of Novel 4Substituted-2,2-Dimethyl-7-(prop-2-ynyloxy)Chromenes. Turk. J. Chem.(2009). Babak Heidary Alizadeh, Alireza Foroumadi, Susan K. Ardestani, Fatemeh Poorrajab, and Abass Shafiee. Leishmanicidal Evaluation of Novel Synthetic Chromenes. Arch. Pharm. Chem. (2008). And three are submitted under subjects of : Cell death features induced in Leishmania major by 1, 3, 4-thiadiazole derivatives, Fatemeh Poorrajab, Sussan K. Ardestani, et al. In Vivo Toxicity of New 1, 3, 4-Thiadiazole Derivatives with Leishmanicidal Activity, Fatemeh Poorrajab, Sussan K. Ardestani, et al.

In Vivo Efficacy and Immunomodulatory Effects of 1, 3, 4-Thiadiazole Derivatives for Treatment of Leishmaniasis in BALB/c mice, Fatemeh Poorrajab, Sussan K. Ardestani, et al.

Novel antileishmanial chalconoids: Synthesis and biological activity of 1- or 3(6-chloro-2H-chromen-3-yl)propen-1-ones, Zohreh Nazarian, Saeed Emami, Fatemeh Poorrajab et al. (2010). Euro. J. Medic. Chem.

Chromene-Based Synthetic Chalcones as Potent Antileishmanial Agents: Synthesis and Biological Activity. Alireza Foroumadi, Saeed Emami, Fatemeh Poorrajab, et al. (2010). Chem Biol Drug.

Synthesis and antileishmanial activity of 5-(5-nitroaryl)-2-substituted-thio1,3,4-thiadiazoles. (2010). Eskandar Alipour, Saeed Emami, Fatemeh Poorrajab, et al. Journal of Enzyme Inhibition and Medicinal Chemistry.

Fatemah Poorrajab, Mina Behrouzi-Fardmoghadam, Antileishmanial activity of some new synthetic thiadiazole components, 33rd FEBS Congress & 11th IUBMB Conference, June 28th July 3rd , 2008, Athens.

Azra Rabbani, Fatemeh Poorrajab, The Effects of Lead Nitrate on Chromatin Components of Alveolar Macrophages, 31st FEBS Congress, June 24-29, 2006, Istanbul.

Sussan K. Ardestani, Fatemeh Poorrajab, Alireza Foroumadi, Saeed Emami, Amina Kariminia, Mina Behrouzi-Fardmoghadam, Abbas Shafiee Antileishmanial Activity of 1, 3, 4-thiadiazoles with Nitroheteroaryl Substitutions, 4th Congress of world wiled Leishmania, Jan, 2009, Lacknow, India.

Azra Rabbani, Fatemeh Poorrajab, Marziyeh Masbough, Time - course study of Lead effect on Histone proteins from alveolar macrophages, 2nd International Biological Congress, 2006, Tarbiat Modarres Univ. Tehran.

Contributing in the writing of Molecular Genetics book, publishing in Tehran, Iran, (2008). Sussan K. Ardestani, Fatemeh Poorrajab, Alireza Foroumadi, Saeed Emami, Amina Kariminia, Mina Behrouzi-Fardmoghadam, Abbas Shafiee, Antileishmanial Activity of 1, 3, 4-thiadiazoles with Nitroheteroaryl Substitutions (2009), Nanotechnology Congress, Yazd.

Fatemeh Poorrajab, Sussan Kabudanian Ardestani, Alireza Foroumadi, Amina Kariminia, Mina Behrouzi-Fardmoghadam, Abbas Shafiee, 3

Cell death in Leishmania major induced by 1, 3, 4-thiadiazole derivatives: apoptosis or necrosis?, Keystone Symposia B3 Antibiotics and Resistance , Santa Fe, New Mexico, USA , 13th - 19th feb, 2010.Awarded to attend in the Keystone Symposia, Santa Fe/Historic Plaza, Santa Fe, USA.

Viruses as Nanobiocarriers for Gene therapy, (2011). The 1st national conference on Nano Science and thecnology. Fatemeh Pourrajab, Atef Atefi, Javad Mohiti Ardakani.

EXperiences Cell culture and Viability assays , Apoptosis or necrosis assay DNA laddering and TUNEL assay In vivo experiments on BALB/c mice, rat alveolar and mouse peritoneal lavaging and Giemsa staining for macrophages Immunology assays; ELIS, Immunoblotting and gel electrophoresis DNA proteins extractions and topoisomerase activity assay Some work on drosophila melanogaster polyten chromosomes in Genetic lab. PCR, DNA extraction experiences in Molecular Biology lab.

INTERESTS and LITRETURE SURVY Molecular mechanism of Cell cycle and Cancer. Drug investigation for Antimicrobial and anticancer agents and cellular targets Molecular mechanism of Cell death; necrosis and apoptosis (PARP & DNA damage) Immunomodulatory mechanisms for cancer therapy MicroRNAs and mechanism of actions.

REFERENCES Dr. Sussan K. Ardestani, ardestani@ibb.ut.ac.ir. Immunology lab, Institute of Biochemistry and Biophysics, Department of Biochemistry University of Tehran, P.O. Box: 13145-1365, Tehran, Iran. Tel: +98-21- 66956978, Fax: +98-2166404680. Professor Abdol Ali Ziaee, aaziaee@ibb.ut.ac.ir, Institute of Biochemistry and Biophysics, Department of Biochemistry University of Tehran, P.O. Box: 131451365, Tehran, Iran. Tel: +98-21- 66956975, Fax: +98-21-66404680.

Dr. Aliresa Foroumadi, aforoumadi@yahoo.com. Pharmaceutical Chemistry lab, Department of Medicinal Chemistry, Faculty of Pharmacy & Pharmaceutical Sciences Research Center, University of Tehran of Medical Sciences, Tehran 14174, Iran. Tel: +98-21-66954708.