Professional standard of the Peoples Republic of China

HG

The Grades of Toxicity Harm and Explosion Danger of Chemical in Pressured Vessels

HG 20660-2000

Edited by: Huatai Engineering Corporation and Shanghai Determination Bureau of Chemical Toxicity Approved by: Petroleum and Chemical Industrial Bureau of China Effective from: July 1, 2001

The Edition Center of Standard for Chemical Engineering Construction of China

(The Edition Center of Standard for Chemical Engineering Construction of Pristine Chemical Engineering Department)

Beijing, 2001

Introduction According to assignment of petroleum and chemical industrial bureau of china, the center of chemical engineering equipment designing technology has established and revised the technological regulation and design standard for chemical engineering equipment, which will be the compulsive industrial standard for designing and manufacture of chemical engineering equipment. In this standard, hundreds of kinds of common chemical have got their grades of toxicity harm and explosion danger according to category and technological requirement of pressured vessels, and principles and basis for grading are established. This standard is edited by: Huatai Engineering Corporation (The Second design Bureau of Pristine Chemical Engineering Department) and Shanghai Determination Bureau of Chemical Toxicity. Chief editors are Linyunlan from Huatai Engineering Corporation (The Second Design Bureau of Pristine Chemical Engineering Department), Fuweizhu from Shanghai Determination Bureau of Chemical Toxicity. Chief revisers are Kangmaoxian from Huatai Engineering Corporation (The Second Design Bureau of Pristine Chemical Engineering Department, Jinyueqiu from Shanghai Determination Bureau of Chemical Toxicity. Revisers are Yuqingxiu from Fire Protection Science Research School of Public Security Department. All the drafts are compiled, revisedfixed and emended by Yingdaoyan from the Center of Chemical Engineering Equipment Designing Technology. This standard was censored by correspondence by a committee which was organized by the Center of Chemical Engineering Equipment Designing Technology, Shanghai Standardization Committee of Chemical Toxicity Evaluation, Shanghai Standardization Committee for Evaluation of Fire Danger Grade of Chemical and Material, which consisted of some designing, executing, researching and managing unites from Departments of Chemical Engineering, Petro-chemical-engineering, Labor, Sanitation and Public Security. It was passed on the technological committee meeting of the Center of Chemical Engineering Equipment Designing Technology. Some delegates from the Boiler Bureau of Labor Department took part in that meeting. Then the final version was got and approved by Petroleum and Chemical Industrial Bureau of China. The 1991 version is emended partly now. In the execution of this standard, if you feel some amendments are necessary, please inform us of that. That would be good reference for the next revision. The information about evaluation and consultation of toxic material is available form Shanghai Standardization Technologic Committee for Evaluation of Toxic Material and us. The Center of Chemical Engineering Equipment Designing Technology October 2000

CONTENT
1 Applicable Scope ......................................................................................................................4 2 Quoted standard ........................................................................................................................5 3 Principle of grading...................................................................................................................6 Annex A The basis of ascertaining of grades of toxic harm (*) ...................................................15 Introduction of edition ....................................................................................................................16 Accessory table 1 Data table of grade of toxicity harm of chemical.......................................19 Accessory table 2 Data table of chemical with explosion danger ...........................................29

1 Applicable Scope To ascertain the category and technological requirements of pressured vessels, the grades of toxicity harm and explosion danger of material was established in this standard. This standard is purposed to ascertain the grades of toxicity harm and explosion danger of material that is used or stored in pressured vessels of chemical engineering. The chemicals include raw materials, production, semi-production, intermediate, reaction material, side production of reaction and impurity. The category and technological requirements of compactness and airproof are ascertained accordingly.

Quoted standard

The category of harm grade of toxic material contacted in work, GB 5044-85 The regulations of inspection of technological requirements for safety of pressured vessels, (1999) issued by quality and technology inspection bureau of China.

Principle of grading

3.0.1 In this standard, the toxic harm and explosive danger of chemical is due to the chemical that are contacted with body massively and cause explosion when accident take place in the use of pressured vessels, or that cause professional chronic harm when often leak. 3.0.2 The grades of toxic harm of chemical are ascertained on the basis of the six indexes specified in GB 5044 (refer to Annex A The basis of ascertaining of grades of toxic harm) The grades of toxic harm include extremely high grade, high grade, and middle grade. (Refer to 1) 3.0.3 The category of pressured vessels are ascertained on the basis of state of accident, the grade of toxic harm of chemical contacted with body massively. In ascertaining main attention is taken to index of acute toxicity and highest allowed concentration, and other indexs attribution are taken into account, and comprehensive analyses are made. Some chemical are available in table 3.0.3-1~table 3.0.3-3 with extremely high, high and middle grade of toxicity harm. 3.0.4 In ascertaining technological requirements of compactness and airproof of pressured vessels, in addition of the state of accident, the potential chronic harm cause by frequent leak must be taken into account. So we take acute toxicity, highest allowed concentration and carcinogen as three main indexes, take other indexes attribution into account, and make comprehensive analyses, and then get the grades. As for some chemicals we take special attention to some outstanding harm, such as carcinogen. So we have made some adjustment on the grades in the table 3.0.3-1~table 3.0.3-3. Please refer to Note for more information. 3.0.5 The grades of chemical with explosive danger is listed according to the regulations of inspection of technological requirements for safety of pressured vessels. (Refer to Note 2). Chemical with explosive danger are those materials of which gaseity or steam, mist of liquid can form mixed explosive material mixed with air, and of which explosion low limit is less than 10 percent, or the difference between low and high limit is mort than or equal to 20 percent. Refer to table 3.0.5 for more information. 3.0.6 If more than one kind of chemical are involved, the chemical with highest grade of toxic harm or explosive danger must be taken as foundation. As for some trace dangerous chemical, the quantity and the grade of danger of it must all be taken into account, and designer or user can ascertain the grade. 3.0.7 As for chemical not involved in this standard, the grade can be got by the principle above and referring to similar kinds of chemical.

Table 3.0.3-1 the common chemical with extremely high grade of toxicity harm Number 1 2 3 4 5 6 7 8 9 10 Disyston Ethyleneimine Dimethylnitrosamine Diborane Schradan Tricthyl tin chloride Pentaborane Systox Tetraethyl lead Thimet Name Number 11 12 13 14 15 16 17 18 19 20 Parathion Phosgene Methylisocynate Mercury Benzo () pyrene Sulfur mustard Hydrogen cyanide Chloramethyl ether Nickel carbonyl Name Merhyl parathion

Note: when the grade of toxicity harm is applied for ascertaining the technological requirements of compactness and airproof of pressured vessels, vinyl chloride and-Naphthylamine should be listed in the table with extremely high grade of toxicity harm. Note 1: the chemical with low grade of danger is not listed. Note 2: in this standard, the chemical with explosion danger is the same as in the regulations of inspection of technological requirements for safety of pressured vessels.

Table 3.0.3-2 the common chemical with high grade of toxicity harm Number 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Name Dimethylhydrazine Toluene-2,4-diisoeyanate Oxygen difuoxide Dinitrobenzene (m,o,p) Chloro-dinitrobenezen 1,2-dibromoethane 1,2-dibromo-3-chloropropane Dichlorotetrafluroproptone Selenium oxychloride Allyleyanide Sulphurdecafluoxide Chorine trifluoride Trinitrobenzene Phosphorus trichloride Phosphorus pentochloride Acrylonitrile Acrylamine Acrolein Acetone cyanohydrin Demeton methyl Formaldehyde Formic acid n-Butyronitrile P-Nitroaniline P-chloronitrobenzene Isobutyronitrile Benzyl chloride Carbofuran o-Chloronitrobenzene Phenyl acetonitrile Aniline Number 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 Hydrazine Ethylene oxide Epichlorohydrin Tsumacide Ozone Fenthion Dipterex DDVP Fluorine Hydrogen fluoride Arsine Nicotine Hydrogen selenide Dimethyl sulfate Cyanoge Chorine Chlordane Chloropicrin Cyanogens chloride -Chloropropionitrile Chlorinated diphenyls Monochloromethane Chlorinated naphthalenes Chlorophenol Trichloromethyl chloroformate Bromomethane Iodomethane Carbonyl fluoride Phosphine Phosphamidon Name

Note: when the grade of toxicity harm is applied for ascertaining the technological requirements of compactness and airproof of pressured vessels, Carbontetrachloride, o-Toluidine and benzene should be listed in the table with high grade of toxicity harm.

Table 3.0.3-3 the common chemical with high grade of toxicity harm Number 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 Name Monoethanolamine Carbon monoxide Chloroacetic acid Ethylenediamine Diethyloxalate Ethylidene norbormene Ethylamine Ethyl mercaptan Acetonitrile Ethanoic acid Acetic anhydride 2,6Diethylaniline Dimethylamine Dimethylacetamide Dimethyldichlorsilane Dimethylformamide Dimethylaniline N,N-Dimethylaniline Sulfurdioxide Nitrogenoxide Carbon disulfide 1,2-Dichloroethylene 1,2-Dichloroethylene 1,2-Dichloroethane Dichloroethane Dichloroether 1,3Dichloroptopanol-2 Buthylamine Crotonaldehyde Sulfur triocide Tribromomethane 1,1,2-Trichloroethane 1,1,2-Dtrichloroethylene 1,2,4-Trichlorobenzene Trichloroacetic acid Trichlorosilane Adiponitrile Malathion Phosphorus pentofulfide 1,1,2,2-tetrabromoethane Tetrachloroethane Number 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 Name Glycidyl methacrylate Methyl mercaptan Methanol Butyl mercaptan n-Butyraldehyde n-methyl silicate Bogor Etrofolan Cylohexane Isobutyraldehyde Carbaryl Sumithion Pyridine o-Toluidine o-Nitrotoluene o-Nitrophenlo Benzene Phenol Benzaldehyde Styrene m-Cresol m-Methylaniline Resorcinol m-Nitrotoluene n-Chloroaniline Fluorobenzene Ammonia Vinylidene chloride Naphthalene -Naphthylamine -Naphtol Nitrobenzene Nitric acid Hydrogen sulfide Sulfuric acid Vinyl chloride Chloroethanol Chloroprene 3-Chloropropene Hydrogen chloride Chlorobenzene

42 43 44 45

Carbontetrachloride Allylalcohol Propyl mercapton Methylamine

87 88 89 90

Tri-n-butyl phosphate Trip-Cresyl phosphate Furfural Acetylene

Note: when the grade of toxicity harm is applied for ascertaining the technological requirements of compactness and airproof of pressured vessels, Carbontetrachloride, o-Toluidine and benzene should be listed in the table with high grade of toxicity harm, and vinyl chloride and -Naphthylamine should be listed in the table.

Table 3.0.5 the chemical with explosive danger Number 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 Name Monomethylamine Carbon monoxide Chlorodlfluorocthane Ethylene glycol Acetylene Ethylamine Ethyl glycol Ethyl propylether Ethyl propylketone 5-ehyl-2-Methylpyridine Ethyl cyclobutane Ethyl cyclohexane Ethyl cyclopentane Ethyl benzene Ethylene Vinylacetylene Vinylethylether Vinyltoluene Ethane Ethyl mercaptan Acetonitrile Ethyl Dacetoacetate N,N-Dimethylacetamide Acetic acid Vinyl acetate Ethyl acetate Butyl acetate Isobutyl acetate Sec-butyl acetate Tert-butyl acetate Propyl acetate Isopropyl acetate Methyl acetate Amyl acetate Isopentyl acetate Cyclohexyl acetate Acetic anhydride Ethyl alcohol Ethoxyglycolacetate Ethylene imine acetaldehyde Number 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 Etyl ether 1,1-Diethoxyethane Diethylamine 3,3Dicthylpentane P-Diethylbenzene N,N-Diethylanilline Diethyl selenide m-Divinyl ether Divinyl ether n-dibutylamine Diisobutyl ketone Diacetone alcohol Diisopeopyl ether p-xylene o-xylene m-xylene Dinethylamine Dimethyldichlorosilane 2,2-Dimethylbutane 2,3-Dimethylbutane 2,2-Dimethylpeopane 2,3-Dimethylpeopane Dimethylformamide N,N-dimethylaniline (unsym)-Dimethylhydrazine Dimethyl sulfide Dimethyl ether Diphenyl ether 1,1-Cinyl difluoride 1,1- Difluoroethane 1,4-Dioxane Carbon disulfide 1,1-Dichloroethylene 1,2-dichloroethylenecis 1,2-dichloroethylenetrans Ethylenedichloride 1,3-Dichloropropene 1,2-Dichloropropane Dichloromethane o-Dichlorobenzene Diborane Name

Number 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 Dodecane

Name n-tetradecane Decahydronaphthalene 1,3-Butadiene 1,3-Butanediol n-butylbenzene Isobutylbenzene 2-Butyne Butylamine Tert-Butylamine Butyl glycol Sec-Butylamine Tert-Butylbenzene Butyllithium in hydrocarbon solvents 1-Butene Isobutylene Cis-butene-2 Trans-butene-2 Crotonaldehyde Butane Isobutene Butylnitrile 2-butanone Butyric acid Butyric alcohol Isobutyl alcohol Sec-butyl alcohol Tert-butyl alcohol n-butyraldehyde Isobutyl aldehyde Butyl ether Triethylamine Triethylene glycol Trimethylamine 2,2,5-trimethylhexane 2,2,3-trimethylpentane 2,2,4-trimethylpentane Isophorone 1,2,4-trimethylbenzene

Number 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164

Name Trichloroethylene Trichloroethane 1,2,3-trichloropropane Trichloroethylene Paraldehyde 1,4-hexadiene 1-hexene n-hexene Isohexane 2-hexanone Hydrazine anhydrous Natural gas 1-nonene n-nonene Dipentene Water gas 1,2-propanediol n-propylbenzene Isopropylbenzene Propylamine Isopropylamine p-isopropyltoluene Methyl acetylene Propylene Allylamine Isopropenylbenzene Arcylonitrile Ethyl acrylate n-butylacrylate Methyl acrylate Propylacarbonate Allyl alcohol Acrolein Propane Propionitrile Acetone Ethyl propionate Methyl propionate n-propyl alcohol Isopropyl alcohol Propyl aldehyde

Number 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206

Name Petroleum ether Isoprene 1-pentylamine 1-pentene 2-pentene n-pentane Isopentane Methyl propylkctone 3-pentanone n-amyl alcohol 3-pentanone Tert-amyl alcohol Isoamyl alcohol primary Isoamyl alcohol secondary Methyl ethyl ether Toluene 2,4-tolylene diisocyanate Methoxy butylacetate O-cresol m-cresol p-cresol Methyl glycol Methoxyl glycolacetate Methyl vinyl ketone Methyldichlorosilane Methylisobutyketone 3-methyl trichlorosilane Methyl trichlorosilane Ethyl methacrylate Methyl methacrylate 2-methyl acrolein 2-methyl-2,4-pentanedid 2-methyl pentane 3-methyl pyridine 2-methyl pyridine 3-methyl pyridine Methyl cyclohexane Methyl cyclopentadiene Methyl cyclopoentane Methyl hydrazine Methane Methyl mercaptan

Number 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248

Name Formic acid Ethyl formate Butyl formate Butyl formate Amyl formate Isoamyl formate Methyl formate Methyl alcohol Formaldehyde Lead tetraethyl Tetramethyllead Tetramethyl tin Tetrahydrofuran Tetrahydrofuryl alcohol Nickel tetracarbonyl Air gas Ethyl nitrite Fusel oil Dowtherm Furan Pyridine I-Octene n-Octane Gasoline Cyclobutane Cyclohexane Cyclohexanone Cyclopropane Cyclopentane Ethylene oxide 1,2-Bytylene oxide Propylene oxide Epichlorohydrin Benzene Phenylethylene Ethyl benzoate Benzaldehyde Aniline oil Ethyl lactate Methy lactate 1-Heptene n-Heptane

Number 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 Isoheptane Hydrogen 1-Decene Decane Nicotine

Name

Number 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292

Name 2-Chlorobutadiene-[1,3] Chlorobutene 1-chloro-2-butene 1-Chlorobutane Isobutyl chloride Benzyl chloride Allyl chloride 2-Chloropropene n-Propyl chloride Isopropyl chloride 1-Chloropentane Isoamyl chloride 3-Chloro-2-methylpropene Methyl chloride Chlorobenzene Coke oven gas Bromoethane 1-Bromobutane Allyl Bromide Bromobenzene Furfuryl alcohol Furfural

Liquefied petroleumgas Bicyclohexyl Nitroethane 1-Nitropropane 2- Nitropropane Nitromethane Nitrobenzene Ethyl nitrate Propyl nitrate Hydeogen sulfide Quinoline Cyanogen Hydrogen cyanide Vinyl chloride Chloroethane Monochloroaceticacid Ethylene chlorohydrine

Annex A The basis of ascertaining of grades of toxic harm (*) Grade Index Absorb by nose LC50.mg/m3 Absorb by skin LD50.mg/m3 Absorb by skin LD50.mg/m3 (extremely high grade of harm) <200 <100 <25 Subject to toxicosis in work with sever consequence (high grade of harm) 20010025Can result to toxicosis, can be cured well With a incidence of disease less than 5 percent, or with a incidence of symptom more than 20 percent Can be cured primarily without continuous contact Suspect carcinogen for human beings 0.1(middle grade of harm) 2000500500(low grade of harm) >20000 >2500 >5000 Not result to toxicosis up to now, but with acute toxicosis potential Not result to toxicosis, but with chronic toxicosis potential Can restore by oneself without bad consequence after cleaning No carcinogen >10

Acute toxicity

The state of disease with acute toxicosis

Result to toxicosis by accident

The state of disease with chronic toxicosis

With a incidence of disease more than 5 percent

Result to disease by accident, or with a incidence of symptom more than 10 percent

The consequence of chronic toxicosis Carcinogen The highest allowed concentration mg/m3 * Note: abstracted from GB 5044-85

Continue or cant be cured without continuous contact Carcinogen for human beings <0.1

Can restore without sever consequence after cleaning Carcinogen for animal in experiment 1.0-

Ascertaining of the Grades of Toxicity Harm and Explosion Danger of Chemical in Pressured Vessels HG 20660-2000
Introduction of edition 1 One of the two aims of edition is that designer, maker, maintainer, operator and manager of pressured vessels can have a specific table of grades of involved chemicals, and can ascertain the category of pressured vessels by the toxicity and flammability of chemicals. Another is that the standard can be applied to ascertain the technological requirements of compactness and airproof of pressured vessels in future, in addition to ascertain the category of pressured vessels. 2 We have ascertained the grades of toxicity harm and explosion danger according to GB 5044-85, as GB 5044 issued recently and the regulations of inspection of technological requirements for safety of pressured vessels do. 3 In the regulations of inspection of technological requirements for safety of pressured vessels, the chemical with toxicity and flammability is involved, to prevent it from injuring body, explosion and other succedent harm when it leak massively by accident. The acute toxicity and highest allowed concentration are taken as two primary indexes, and the other indexes should be taken into account synthetically, when the table of toxicity grades is applied to ascertain the category of pressured vessels. To ascertain the technological requirements of compactness and airproof of pressured vessels, not only is harm caused by massive leak by accident taken into account, but also do chronic harm caused by frequent light leak, especially carcinogen. So when this standard is quoted to ascertain the technological requirements of airproof of vessels, the index of carcinogen must be added to the principles of toxicity grading, and is taken as primary one. The grading principles in item of 3.0.4 are regulated accordingly. Table 3.0.3-1~table 3.0.3-3 is adjusted for taking carcinogen as primary index. Not taking carcinogen as primary index, vinyl chloride, -Naphthylamine, benzene, Carbontetrachloride and o-Toluidine are listed in volume of middle grade of harm. But those kinds of chemical are certainly carcinogens, so they are of extremely high harm or high harm in ascertaining the technological requirements of airproof of vessels. 4 This standard is applied for pressured vessels, to ascertain the grade of pressure or the technological requirements of pressured vessels, which is the same as the regulations of inspection of technological requirements for safety of pressured vessels do. This standard is applied in different scope and for different aims with the regulations of inspection of technological requirements for safety of pressured vessels, so do the grading principles and grades of some kinds of chemical. So user should choose accordingly. 5 Ammonia, a commonly used chemical, should be of low grade of harm as convention, but it is listed in volume of middle grade of harm according to the regulations of inspection of technological requirements for safety of pressured vessels and convention of industry of pressured vessels home and aboard. 6 The program of ascertaining the grade of toxicity harm of chemical: according to regulated principles, results of spots and experiments of past, and data of standard book and manual home an aboard, put into data table of harm grade of toxic chemical (refer to accessory table 1) the data of common kinds of chemical (gas or liquid) used in chemical engineering pressured vessels as following steps:

(1) Put the data of epidemiology from spots and experiment into the table. (2) As for unconcluded index or carcinogen without reference, take it as lowest grade, and adjust according to latter data or result. (3) The state of disease with acute toxicosis is estimated on the basis of data of documents. (4) The state of disease with chronic toxicosis is the worst one of some industry. (5) The highest allowed concentrations are from related standards of China, some are form standards of the Soviet Union and other country when no data available. (6) Ascertain the grade of toxicity harm of chemical on basis of the principles at last. 7 The grading principles of chemical with explosive danger are established according the definition of flammable chemical in the regulations of inspection of technological requirements for safety of pressured vessels. We had proposed to divide flammable chemical into flammable gas and flammable liquid in the course of edition. Because that would differ apparently with the definition and there is no uniform definition in standards of China, we take the definition of the regulations of inspection of technological requirements for safety of pressured vessels, not distinguish gas and liquid. On account of that the definition of flammable chemical means chemical with explosive danger, chemical with explosive danger is used in this standard. 8 To make the standard convenient of use, the Chinese and English name, formula of molecule, boiling point, flash point and explosion limit are listed in accessory table 2. The flash point is measured by Closed-Cup Test or by Cleveland Open Cup with a Note of (0.C). The boiling point is measured at a pressure of 760mmHg or at other pressure with a Note, such as 80(744) meaning at a pressure of 744mmHg and the boiling point is 80oC. The explosion limit is measured at 20oC and a pressure of 760mmHg, or at other condition with a Note.

Accessory table 1 Data table of grade of toxicity harm of chemical Acute harm index No. 1 2 3 4 5 6 7 Name Monoethanolaminc Carbon monoxide Chloroacetic acid Ethylenediamine Diethyloxalate Ethylidene norbormene =CHCH3 Disyston E E E H M L E Molecule formula H2NCH2CH2OH CO CICH2COOH N H2CH2CH2-NH2 (COOC2H5)2 Toxicity M M H M M M Toxicosis state M E M M L M L M Highest allowed concentration H L Chronic harm index State of disease M H L M M Toxcosis consequence M H L M L carcinog en L L L L M M M M M M grade remarks

8 9 10 11 12 13 14 15 16 17 18

Ethylamine Ethyl mercaptan Acetonitrile Ethanoic acid Acetic anhydride Ethyleneimine 2,6 Diethylaniline Dimethylamine Dimethylacetamide Dimethyldichlorsilane Dimethylformamide

C2 H5NH2 C H3CH2SH CH3CN CH3COOH (CH3CO)2O NHCH2CH2 C6 H5N(C2H5)2 (CH3)2NH CH3CON(CH3)2 (CH3)2SiCl2 (CH3)2NCOH

H M M M M E M M M H M M M H L M H M M M

L M M M L E M M M M M M H L M H L M M M M H H L L L M

M M M M M E M M M M M

Acute harm index No. Name Molecule formula Toxicity 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 Dimethylnitrosamine Dimethylhydrazine Dimethylaniline N,N-Dimethylaniline Toluene-2,4-diisoeyanat e Oxygen difluoxide Sulfurdioxide Nitrogenoxide Carbon disulfide Dinitrobenzene(m,o,p) Chloro-dinitrobenzene 1,2-Dibromoethane 1,2-Dibromo-3-Chloropropane Diborane 1,1-Dichloroethylene 1,2-Dichloroethylene 1,2-Dichloroethane Dichloroethane (CH3)2HNO (CH3)2NNH2 (CH3)2C6H3NH2 (CH3)2NC6H5 CH3C6H3 OF2 SO2 NO2 CS2 C6H4(NO2) 2 C6H3Cl(NO2) 2 CH2BrCH2Br CH2BrCHBrCH2Cl B2H6 CH2CCl2 ClCHCHCl (CH2Cl) 2 CH3CHCl2 E H M M E E H H M E H H H E M M M M M M M H H H H H H M H Toxico sis state E H

Highest allowed concentration E M M H H H M M M H H E E E L L L L

Chronic harm index State of disease Toxcosis consequence carcinog en H H M M H H E M E M H H H H H H H H H M M M L M H H L L L L H M L M M L L M

grade

remarks

E H M M H H M M M H H H H E M M M M

Acute harm index No. Name Molecule formula Toxicity 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 Dichloroethane 1,3 Dichloroptopano1-2 Dichlorotetrafluroproptone Selenium oxychloride Buthylamine Allylcyanide Crotonaldehyde Sulphurdecafluoxide Schradan Triethyl tin chioride Sulfur trioxide Chlorine trifluoride Tribromomethane 1,1,2-Trichloroethane 1,1,2-Trichloroethylene Phosphorus trichloride 1,2,4-Trichlorobenzene Trichloroacetic acid CICH2CH2OCH2CH2CI (CH2CI) 2CHOH CCIF2COCCIF2 SeOCl2 C4H9NH2 CH2=CHCH2CN CH3CHCHCHO S2F10 [(CH3) 2N]POOPO [N(CH3) 2] 2 (C2H5) 3 SnCl SO3 CIF3 CHBr3 CH2ClCHCl2 CHClCCl2 PCl3 C6H3Cl3 CCl3COOH H H H E M H M E E E H H M M M H M M M H M H M E H E M H Toxicosis state H M H H M

Highest allowed concentration State of disease L M M

Chronic harm index Toxcosis consequence H carcinog en L

grade

remarks

M M H

H M H M M M

H M H M H

L E M H M L L H M M M M M H M M L M H M M M L H L

E E M H M M M H M M

Acute harm index No. 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 Name Trichlorosilane Adiponitrile Malathion Phosphorus Pentoslfide Phosphorus pentochloride Pentaborane Systox Tetraethyl lead Tetrabromoethane Tetrachloroethane Carbontetrachloride Acrylonitrile Acrylamine Acrolein Acetone Cyanohydrin Allylalcohol Propyl mercapton Thimet Merhyl parathion CH2=CHCHO (CH3) 2C(OH)CN CH2=CHCH2OH C3H7SH (C2H5O) 2P(S)SCH2SC2H5 (CH3O) 2P(S)OC6H4NO2 Molecule formula Toxicity SiHCl3 NC(CH2)4CN (CH3O)2P(S)SCH(CH2COOC2H 5)-COOC2H5 P2S5 PCl5 B4H9 (C2H5O2)P(S)OCH2CH2SC2H5 Pb(C2H5)4 CHBr2CHBr2 Cl2CHCHCl2 CCl4 CH2=CH-CN M M M H H E E H H M M H H H H H M E E H H M M H H H H H H L H M H H M Toxicosis state M

Highest allowed concentration M L M M H E E E M M L M H H H M M S S

Chronic harm index State of disease M M M Toxcosis consequence carcinoge n grade M M M M H H E M H M H M H M H H H M L H H M L L M H H H H L M L L L E E E M M M H H H H M M E E H remarks

Acute harm index No. 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 Name Demeton methyl Formaldehyde Formic acid Methylamine Glycidyl methacrylate Methyl mercaptan Methanol n-Butyronitrile Butyl mer aptan n-Butyraldehyde n-methyl silicate Parathion P-Nitroaniline P-chloronitrobenzene Rogor Etrofolan Phosgene Methylisocynate Isobutyronitrile Isobutyraldehyde Carbaryl CH3SH CH3OH CH3CH2CH2CN C4H9SH CH3 (CH2) 2CHO Si(OCH3) 4 (C2H5O) 2P(S)OC6H4NO2 O2NC6H4NH2 ClC6H4NO2 (CH3O)2P(S)SCH2C(O)NHCH3 C11H15NO2 COCl2 CH3NCO (CH3) 2CHCN (CH3) 2CHCHO C10H7OCONHCH3 Molecule formula (CH3O)2P(S)OCH2CH2SC2H5 HCHO HCOOH CH3NH2 Toxicity H H H M M M M H M L M E M M M M E E H M H M E H H M M H E H M M M H M H M Toxicosis state H H H

Highest allowed concentration H M H M M M L M M M M E H H H E E M

Chronic harm index State of disease H H Toxcosis consequence M M Carcinogen H M Grade H H H M M M M M M M H L M H M M M H M M M L H M M M H H M L H H L L L M L L L M M E H H M M E E H M M M M

Remar ks

Acute harm index No. 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 Name Sumithion Benzyl chloride Carbofuran Pyridine Mercury o-Chloronitrobenzene o-Toluidine o-Nitrotoluene o-Nitrophenol Benzene Phenol Benzaldehyde Phenyl acetonitrile Aniline Styrene Hydrazine m-Cresol m-methylaniline Resorcinol m-Nitrotoluene m-Chloroaniline Hg ClC6H4NO2 C6H4 (CH3)NH2 NO2C6H4CH3 NO2CH6H4OH C6H6 C6H5OH C6H5CHO C6H5CH2CN C6H5NH2 C6H5CH=CH2 NH2NH2 CH3C6H4OH CH3C6H4NH2 C6H4(OH) 2 CH3C6H4NO2 ClC6H4NH2 Molecule formula (CH3O) 2P(S) OC6 H3 (CH3) NO2 C6H5CH2Cl C12H15NO3 Toxicity H H E M E H M M M L M M E H M H H M M H M Toxicosis state M H H M H H M M L M L L H H L H M H M M M

Highest allowed concentration M H H M E H M M M M M L H M L E M M M M E

Chronic harm index State of disease Toxcosis consequence carcinoge n M L M E H L H H M H M M H L M E H L E M L M H M H L M L L L L H L L E M L L L M M grade M H H M E H M M M M M M H H M H M M M M M (H) (H) remarks

Acute harm index No. Name Molecule formula Toxicity H H Toxicosis state H

Highest allowed concentration M H

Chronic harm index State of disease M H Toxcosis consequence carcinoge n H H grade remarks

116 117

Ethylene oxide Epichlorohydrin

H H

118 119 120 121 122 123 124 125 126 127

Tsumacide Ozone Fenthion Dipterex DDVP Fluorine Hydrogen fluoride Fluorobenzene Arsine Ammonia

C9H11NO2 O3 (CH2O) 2P(S)OCH6H3CH3SCH3 (CH3O) 2P(O)C(OH)HCCl3 (CH3O) 2 P(O) OCHCCl2 F2 HF C6H3F AsH3 NH3

H E H M E H H M S L

M H H H H H H L H H H H M H M H L M M H M H M H H

M M M H M H H M L

L L M L L L L L

H H H H H H H M H M Following the procedure

128 129

Vinylidene chloride Nicotine

CH2=CC l2

M E

M H

L H

M M

M L

M L

M H

130

Hydrogen selenide

H2Se

Acute harm index No. 131 132 133 134 135 Name Naphthalene a-Naphthylamine a-Naphthol Nitrobenzene Nitric acid Molecule formula C10H3 C10H7NH2 C10H7(OH) C6H5NO2 HNO3 Toxicity M M M M H H M Toxicosis state M L

Highest allowed concentration L

Chronic harm index State of disease M M M Toxcosis consequence H E H carcinoge n M E L grade M M M M M Integrati ng with domestic practice remarks (E)

M L

136 137 138 139 140 141 142 143 144 145 146 147 148

Hydrogen sulfide Sulfuric acid Dimethyl sulfate Sulfur mustard Cyanogen Hydrogeri cyanide Chorine Chloromethyl ether Chlordane Chloropicrin Cyanogen chloride

H2S H2SO4 (CH3)2SO4 S(CH2CH2Cl)2 HCN Cl2 ClCH2OCH3 C10H6Cl8 CCl2NO2 CNCl ClCH2CH2CN C12H10-nCln

H M E E H E H E H H H H M

H H E H E H H H H H H M

M M H L H H H H H H

M M

M H

L H E L

M M H E H E H E H H H H

H H E H H

M H E H

L L E L

-Chloropropionitrile
Chlorinated diphenyls

Acute harm index No. Name Molecule formula Toxicity M M H H L H M M M M H H H E E H Toxicosis state H M L H M H H L M M H H H E H H

Highest allowed concentration M H H

Chronic harm index State of disease M H L Toxcosis consequence H H L carcinoge n L L M grade remarks Refer to methane

149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164

Monochloromethanc Chlorinated naphthalenes chlorophenol Trichloromethyl chloroformate Vinyl chloride Chloroethanol Chloroprene 3-Chloropropene Hydrogen chloride Chlorobenzene Bromomethane Iodomethane Carboyl fluoride Nichel carbonyl Phosphine Phosphamidon

CH2Cl C10H8-nCln ClC6H4OH ClCOOCCl3 CH2=CHCl ClCH2CH2OH CH2=CClCH=CH2 CH2=CHCH2Cl HCl C6H5Cl CH3Br CH3I COF2 Ni(CO) 4 PH3

H H H H

L M M M L L H H M E H E

E M H H H M M M H H H

E M H H H M M H E H M

E M M M L L M L H L L

M M M M M M H H H E H H

(E)

165

Tri-n-butyl phosphate

(C4H9) 3PO4

Acute harm index No. 166 167 168 169 170 Name Trip-Cresyl phosphate Furfural Benzo(a)pyrene 2,4,6-Trinitrotoluene Cyclohexanone C20H12 C6H2CH3 (NO2) 3 Molecule formula [CH3(C6H4)O] 3PO Toxicity L H H H M M M Toxicosis state M M

Highest allowed concentration H L E H L

Chronic harm index State of disease M M E H E L Toxcosis consequence H carcinoge n L grade M M E H M remarks

Note: 1 The letters below the six indexes in table mean the grades got by one index separately according to the basis of GB 5044-85, that is ; E: extremely high grade of harm H: high grade of harm M: middle grade of harm L: low grade of harm 2 The letters below grade in table mean the grade of chemical according the grading principles in 3.0.2. The letters mean the same as those of Note 1. 3 The letters below remarks in table mean the grade of chemical according the grading principles in 3.0.3. The letters mean the same as those of Note 1.

Accessory table 2 Data table of chemical with explosion danger

All the un-annotated bibliography is [3].