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Respiratory distress Increased work of breathing (respiratory effort) yang disertai peningkatan HR
Respiratory failure A clinical condition in which there is inadequate blood oxygenation and/or ventilation to meet the metabolic demands of body tissues
Etiology
Respiratory arrest (and impaired respiration that can progress to respiratory arrest) can be caused by Airway obstruction Decreased respiratory effort
Airway obstruction: Obstruction may involve the Upper airway Lower airway
Infants < 3 mo are usually nose breathers and thus may have upper airway obstruction secondary to nasal blockage. At all ages, loss of muscular tone with decreased consciousness may cause upper airway obstruction as the posterior portion of the tongue displaces into the oropharynx. Other causes of upper airway obstruction include blood, mucus, vomitus, or foreign body; spasm or edema of the vocal cords; and pharyngolaryngeal tracheal inflammation (eg, epiglottitis, croup), tumor, or trauma. Patients with congenital developmental disorders often have abnormal upper airways that are more easily obstructed. Lower airway obstruction may result from aspiration, bronchospasm, airspace filling disorders (eg, pneumonia, pulmonary edema, pulmonary hemorrhage), or drowning. Decreased respiratory effort: Decreased respiratory effort reflects CNS impairment due to one of the following: CNS disorder Adverse drug effect Metabolic disorder
CNS disorders that affect the brain stem (eg, stroke, infection, tumor) can cause hypoventilation. Disorders that increase intracranial pressure usually cause hyperventilation initially, but hypoventilation may develop if the brain stem is compressed. Drugs that decrease respiratory effort include opioids and sedative-hypnotics (eg, barbiturates, alcohol; less commonly, benzodiazepines). Usually, an overdose (iatrogenic, intentional, or unintentional) is involved, although a lower dose may decrease effort in patients who are more sensitive to the effects of these drugs (eg, the elderly, those with chronic respiratory insufficiency). CNS depression due to severe hypoglycemia or hypotension ultimately compromises respiratory effort. Respiratory muscle weakness: Weakness may be caused by Neuromuscular disorders Fatigue
Neuromuscular causes include spinal cord injury, neuromuscular diseases (eg, myasthenia gravis, botulism, poliomyelitis, Guillain-Barr syndrome), and neuromuscular blocking drugs.
Respiratory muscle fatigue can occur if patients breathe for extended periods at a minute ventilation exceeding about 70% of their maximum voluntary ventilation (eg, because of severe metabolic acidosis or hypoxemia).
Manifestasi Klinis
Cessation of breathing Cyanosis Progressive loss of consciousness Low blood oxygen levels
Mottling; peripheral and central cyanosis Unresponsive to voice or touch Absent chest wall motion Absent respirations Weak to absent pulses Bradycardia or asystole Limp muscle tone
Respiratory Arrest is caused by airway obstruction, decreased respiratory drive, or respiratory muscle weakness.
Signs and Symptoms of Respiratory Distress
Complaining of difficulty in breathing Tachypnoea Increased work while breathing Use of accessory muscles Abnormal Breath sounds (wheezing, rhonchi, rales, stridor) Cyanosis
Progressive colour change caused by lack of oxygen Unable to feel air coming from mouth and nose
Impending respiratory arrest: Before complete respiratory arrest, patients with intact neurologic function may be agitated, confused, and struggling to breathe. Tachycardia and diaphoresis are present; there may be intercostal or sternoclavicular retractions. Patients with CNS impairment or respiratory muscle weakness have feeble, gasping, or irregular respirations and paradoxical breathing movements. Patients with a foreign body in the airway may choke and point to their necks, exhibit inspiratory stridor, or neither. Monitoring end-tidal CO2 can alert practitioners to impending respiratory arrest in decompensating patients