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Human Anatomy
Common Drugs and Vaccines
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Human Anatomy
Common Drugs and Vaccines
myoplasmal infections Amoxicillin Tetracycline Chloroquine Aspirin Antibiotic Antibiotic Antibiotic Analgesic antipyretic Paracetamol (Acetaminophen) Analgesic antipyretic Fever, pain Wide range of infections Cholera Malaria Fever, pain One of the most widely used medications in the world Broad spectrum
Vaccines A vaccine is a biological preparation that improves immunity to a particular disease. Vaccines were first used by Edward Jenner (England) in the 1770s to inoculate small pox using the cow microbe. Vaccines have resulted in the eradication of small pox, one of the most contagious and deadly diseases known to man. Other diseases like polio, measles, mumps, typhoid etc have been significantly reduced. Currently, polio is prevalent in only four countries: Afghanistan, Pakistan, Nigeria and India. Mechanism of action A vaccine is usually made from a weakened or dead from of the microbe that it is intended to fight. It stimulates the bodys immune system to recognize the microbe as foreign and destroy it and remember it. When the same microbe re appears later, the immune system easily recognizes and destroys it. When the body recognizes the virulent microbe attack, it neutralises the target microbe before it can enter body cells destroys infected cells before the microbe can spread to other cells and multiply
Types of vaccines Killed Vaccines: These are vaccines that contain micro organism that have killed using chemicals or heat. E.g. influenza, cholera, bubonic plague, polio, hepatitis A. Attenuated vaccines: These contain live attenuated (numerous) micro organisms. These are usually live viruses that have been cultivated under conditions which disable their virulent properties, or use closely related by less dangerous micro organisms. These vaccines provide more durable immune response and are preferred type for healthy adults. E.g. yellow fever, measles, rubella, mumps typhoid. Toxoid vaccines: inactivated toxic compounds that cause illness. E.g. tetanus, diphtheria. Subunit vaccines: These use protein subunits instead of the entire micro organism as a vaccine. E. g. Hepatitis B vaccine (which uses only surface proteins), Human Papillioma Virus (HPV) vaccine (which uses subunits of influenza virus).
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Human Anatomy
Common Drugs and Vaccines
o Host may have lowered immunity (such as due to diabetes, HIV, steroid use etc) o Host may not have a B cell capable of producing antibodies to that particular antigen The efficacy of a vaccine depends on a number of factors, namely o The disease itself o The strain of vaccine o The schedule of vaccination o Individual host factors o Genetic and ethnic predisposition Most vaccines use adjuvant to boost immune response. Adjuvants are compounds added to the vaccine that increase the immune response, without having any specific antigenic effect by themselves. Aluminium salts like aluminium phosphate and aluminium hydroxide are the most common adjuvants used. Vaccine Anthrax vaccine Bacillus Calmette Disease Anthrax Tuberculosis Type Protein subunit Live bacteria Notes
Guerin (BCG) DTP Diphtheria Pertussis (Whooping cough) Tetanus Gardasil (Human Papilloma Virus (HPV)) Polio vaccine Polio Killed/inactivated Polio is prevented only in humans. Currently polio has been eradicated from ail countries except Pakistan, Afghanistan, Cervical cancer Protein subunit
Nigeria and India MMR Measles Mumps Rubella Meningococcal vaccine Rabies vaccine Yellow fever vaccine Meningococcus Rabies Yellow fever Attenuated Attenuated
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