A service of the U.S.

National Library of Medicine

and the National Institues of Health

Select 7126425

1: Br J Cancer. 1982 Sep;46(3):354-67.

Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical Related Articles
repair and lymphocyte-related host resistance.
Study of blood vitamin C in lung and bladder cancer patients
[ActaA
before and after treatment with ascorbic acid. Vitaminol Enzymol.1982]
preliminary
Anthony HM, Schorah CJ.
[Vitamin C deficiency and leg ulcers. A case control study]
Plasma and buffy-coat vitamin C were estimated in 158 samples from 139 lung-cancer patients, [J Mal Vasc .2007]
at all stages of the disease. Most samples showed hypovitaminosis C in both estimations: 64% Seasonal and geographical variations in lung cancer prognosis
had plasma, and 25% buffy-coat values below the thresholds for incipient clinical scurvy (0.3 [LungCancer.2007]
in Norway. Does Vitamin D from the sun play a role?
mg% and 10 micrograms/10(8) cells respectively). Levels were diet-dependent and could be
Review [Deep lung--cellular reaction to HIV]
increased by oral supplements. Levels were low both in tumour-bearing patients and in those
[Rev Port Pneumol.2007]
clinically free of disease after resection. The latter had particularly low values during the first 6
months, indicating the utilization of vitamin C in surgical repair. The vitamin C content of 13 Review Tiotropium bromide. A review of its use as
primary lung tumours was assayed: tumours had a higher vitamin C content (mean 111.6 +/- maintenance therapy in patients with COPD. [TreatRespir Med.2004]
55.1 micrograms/g tissue) than normal lung (58.5 +/- 20.4 micrograms/g). Mononuclear cells
» See Reviews... | » See All...
from normal individuals show a higher vitamin C content than polymorphs, but in lung-cancer
patients the expected correlation of buffy-coat vitamin C with the proportion of lymphocytes in
peripheral blood was obscured by an inverse correlation in patients with relative lymphocytosis Cited by PubMed Central article
(greater than or equal to 25% lymphocytes), confirmed by an inverse correlation of the
proportion of lymphocytes in peripheral blood with mononuclear-cell vitamin C in 14 patients in Modulation of N-methyl-N-nitrosourea induced mammary tumors
whom this was measured. These correlations were unaffected by controlling for plasma values, [Breast
in Sprague-Dawley rats by combination of lysine, Cancer Res .2005]
proline,
and indicate the utilization of vitamin C in lymphocyte-related anti-tumour mechanisms. Vitamin
C is necessary for phagocytosis and for the expression of cell-mediated immunity. In view of the Patient Drug Information
increasing circumstantial evidence that immune mechanisms exert some measure of control on
tumour extension and metastasis in man, the effect of supplementation with vitamin C in Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...)
lung-cancer patients on survival should be tested in a clinical trial. Ascorbic acid is used to prevent and treat scurvy, a disease
caused by a lack of vitamin C in the body.
PMID: 7126425 [PubMed - indexed for MEDLINE]
Source: AHFS Consumer Medication Information

Recent Activity
 Turn Off Clear

Severe hypovitaminosis C in lung-cancer patients: the

utilization of vitamin C in surgical...

Chemoprevention of colorectal neoplasms. Ascorbic acid

and beta-carotene.

Dietary antioxidants and the risk of lung cancer.