Scribd Logo
Upload

Welcome to Scribd!

  • Mycobacterium Tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes

    Uploaded by

    Shri Ram
    49 views2 pages
    Metabolism is a widely recognized facet of all host-pathogen interactions. Knowledge of its roles in pathogenesis, however, remains comparatively incomplete. Existing studies have emphasized metabolism as a cell autonomous property of pathogens used to fuel replication in a quantitative, rather than qualitatively specific, manner. For Mycobacterium tuberculosis, however, matters could not be more different. M. tuberculosis is a chronic facultative intracellular pathogen that resides in humans as its only known host. Within humans, M. tuberculosis resides chiefly within the macrophage phagosome, the cell type, and compartment most committed to its eradication. M. tuberculosis has thus evolved its metabolic network to both maintain and propagate its survival as a species within a single host. The specific ways in which its metabolic network serves these distinct, through interdependent, functions, however, remain incompletely defined. Here, we review existing knowledge of the M. tuberculosis-host interaction, highlighting the distinct phases of its natural life cycle and the diverse microenvironments encountered therein.

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Metabolism is a widely recognized facet of all host-pathogen interactions. Knowledge of its roles in pathogenesis, however, remains comparatively incomplete. Existing studies have emphasized metabolism as a cell autonomous property of pathogens used to fuel replication in a quantitative, rather than qualitatively specific, manner. For Mycobacterium tuberculosis, however, matters could not be more different. M. tuberculosis is a chronic facultative intracellular pathogen that resides in humans as its only known host. Within humans, M. tuberculosis resides chiefly within the macrophage phagosome, the cell type, and compartment most committed to its eradication. M. tuberculosis has thus evolved its metabolic network to both maintain and propagate its survival as a species within a single host. The specific ways in which its metabolic network serves these distinct, through interdependent, functions, however, remain incompletely defined. Here, we review existing knowledge of the M. tuberculosis-host interaction, highlighting the distinct phases of its natural life cycle and the diverse microenvironments encountered therein.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    49 views2 pages

    Mycobacterium Tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes

    Uploaded by

    Shri Ram
    Metabolism is a widely recognized facet of all host-pathogen interactions. Knowledge of its roles in pathogenesis, however, remains comparatively incomplete. Existing studies have emphasized metabolism as a cell autonomous property of pathogens used to fuel replication in a quantitative, rather than qualitatively specific, manner. For Mycobacterium tuberculosis, however, matters could not be more different. M. tuberculosis is a chronic facultative intracellular pathogen that resides in humans as its only known host. Within humans, M. tuberculosis resides chiefly within the macrophage phagosome, the cell type, and compartment most committed to its eradication. M. tuberculosis has thus evolved its metabolic network to both maintain and propagate its survival as a species within a single host. The specific ways in which its metabolic network serves these distinct, through interdependent, functions, however, remain incompletely defined. Here, we review existing knowledge of the M. tuberculosis-host interaction, highlighting the distinct phases of its natural life cycle and the diverse microenvironments encountered therein.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    Mycobacterium Tuberculosis Metabolism and Host Interaction: Mysteri...

    http://link.springer.com/chapter/10.1007/82_2012_299

    Find out how to Access preview-only content Look Inside Get access Current Topics in Microbiology and Immunology 2012,

    Mycobacterium Tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes


    Abstract
    Metabolism is a widely recognized facet of all hostpathogen interactions. Knowledge of its roles in pathogenesis, however, remains comparatively incomplete. Existing studies have emphasized metabolism as a cell autonomous property of pathogens used to fuel replication in a quantitative, rather than qualitatively specific, manner. For Mycobacterium tuberculosis, however, matters could not be more different. M. tuberculosis is a chronic facultative intracellular pathogen that resides in humans as its only known host. Within humans, M. tuberculosis resides chiefly within the macrophage phagosome, the cell type, and compartment most committed to its eradication. M. tuberculosis has thus evolved its metabolic network to both maintain and propagate its survival as a species within a single host. The specific ways in which its metabolic network serves these distinct, through interdependent, functions, however, remain incompletely defined. Here, we review existing knowledge of the M. tuberculosishost interaction, highlighting the distinct phases of its natural life cycle and the diverse microenvironments encountered therein.

    Within this Chapter


    1. Introduction 2. The Mycobacterium tuberculosis Host Niche: Down the Rabbit Hole 3. The Mycobacterium tuberculosis Looking Glass: Current Gaps in Knowledge 4. Concluding Remarks 5. References 6. References

    1 of 2

    02/02/2013 12:28 PM

    Mycobacterium Tuberculosis Metabolism and Host Interaction: Mysteri...

    http://link.springer.com/chapter/10.1007/82_2012_299

    Related Content References (148) About this Chapter


    Title Mycobacterium Tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes Book Title Copyright 2012 DOI 10.1007/82_2012_299 Series Title Current Topics in Microbiology and Immunology Series ISSN 0070-217X Publisher Springer Berlin Heidelberg Authors Sabine Ehrt (1) Kyu Rhee (2) Author Affiliations 1. Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, 10065, USA 2. Department of Medicine, Weill Cornell Medical College, New York, NY, 10065, USA

    Confirm download
    The cost of downloading this content will be charged to your organisation. If you have a cost code, please enter it:
    6,819,877 scientific documents at your fingertips Springer, Part of Springer Science+Business Media

    What is this?

    2 of 2

    02/02/2013 12:28 PM

    You might also like