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desmopressin Full Prescribing Information, Dosage & Side Effects | MIMS.

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2013/01/26
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Oral Cranial diabetes insipidus Adult: Initially, 100 mcg tid adjusted according to response. Maintenance: 100-200 mcg tid, up to 100-1200 mcg daily. Child: Initially, 100 mcg tid adjusted according to response. Maintenance: 100-200 mcg tid, up to 100-1200 mcg daily. Oral Primary nocturnal enuresis Adult: 200-400 mcg at bedtime. Child: 5 yr: 200-400 mcg at bedtime. Nasal Cranial diabetes insipidus Adult: 10-40 mcg daily as a single or divided doses. Child: 3 mth-12 yr: 5-30 mcg daily. Nasal Diagnosis of diabetes insipidus Adult: 20 mcg as a single dose. Child: 20 mcg as a single dose. Nasal Renal function testing Adult: 40 mcg as a single dose. Child: 1-15 yr: 20 mcg and infants: 10 mcg. To be given as a single dose. Nasal Primary nocturnal enuresis Adult: 20-40 mcg at bedtime. Child: 5 yr: 20-40 mcg at bedtime. Nasal Nocturia associated with multiple sclerosis Adult: 10-20 mcg at bedtime. Nasal Type I Von Willebrand's disease Adult: 300 mcg; <50 kg: 150 mcg. Should be given within 2 hr before the surgery. Parenteral Cranial diabetes insipidus Adult: 1-4 mcg daily IM, SC or IV. Child: 0.4 mcg IM, SC, or IV. Parenteral Diagnosis of diabetes insipidus Adult: 2 mcg as a single dose via SC/IM. Child: 2 mcg SC/IM. Parenteral Renal function testing Adult: 2 mcg given as SC or IM inj. Child: Infants: 0.4 mcg; children: 2 mcg. Dose to be given as SC or IM inj. Intravenous Type I Von Willebrand's disease Adult: 0.3-0.4 mcg/kg by slow infusion over 15-30 min before surgery. Intravenous Testing of fibrinolytic response Adult: 0.4 mcg/kg infused over 20 min. Child: 0.4 mcg/kg infused over 20 min. May be taken with or without food. Hypersensitivity. Impaired renal function (CrCl <50 ml/min). Decompensated cardiac failure with ongoing diuretic treatment. Not to be used in the treatment of Type IIb von Willebrand's disease and nephrogenic diabetes insipidus. Fluid intake restricted to a min and only to satisfy thirst for 8 hr after admin (particularly in the very young and the elderly). Nasal route avoided in patients with nasal mucosal diseases. Caution in CV diseases, oedema states, impairment, hypertension, elderly, cystic fibrosis, fluid and electrolyte imbalance, thrombotic disease; infants and young children. Inj not recommended for infants <3 mth for bleeding disorders. Pregnancy and lactation. Nausea, transient headache; nasal congestion, rhinitis; flushing; mild abdominal cramps; epistaxis; sore throat, cough, stuffiness; allergic reactions, inj site pain, erythema, swelling, BP changes and thrombotic events in predisposed individuals. Potentially Fatal: Water intoxication and dilutional hyponatraemia. Drugs that may potentiate antidiuretic effect of desmopressin: chlorpropamide, clofibrate, carbamazepine, fludrocortisone, urea, or TCAs. Drugs that may decrease antidiuretic effect of desmopressin: lithium, heparin, demeclocycline, noradrenaline, and alcohol. Caution when using with other vasopressors. Click to view more desmopressin Drug Interactions Cross-reacts with some antisera raised against arginine vasopressin and oxytocin, but as these assays are rarely performed in clinical practice, it has little significance.

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Lab Interference Pregnancy Category (US FDA)

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). Storage Mechanism of Action Intravenous: Refrigerate at 2-8C. Nasal: Refrigerate at 2-8C. Oral: Store at 20-25C. Parenteral: Refrigerate at 2-8C. Desmopressin increases the cellular permeability of the collecting ducts causing an increased water reabsorption, smooth muscle constriction. It also stimulates factor VIII and plasminogen activation activity in blood. Absorption: Absorbed from the nasal mucosa (intranasal), absorbed in sufficient amounts from the GI tract to produce therapeutic effects at high doses (oral). Metabolism: Largely destroyed in the GI tract. Excretion: Elimination T1/2 (biphasic): 8 min (initial phase), 75 min (terminal phase). Antidiuretics H01BA02 - desmopressin ; Belongs to the class of vasopressin and analogues. Used in posterior pituitary lobe hormone preparations.

MIMS Class ATC Classification

Related desmopressin information: Drugs interacting with desmopressin Find desmopressin in other countries Search desmopressin in Google Search desmopressin in PubMed Search related pubmed documents for desmopressin by indication/synonym: Cranial diabetes insipidus Renal function testing Primary nocturnal enuresis Diagnosis of diabetes insipidus Nocturia associated with multiple sclerosis Type I Von Willebrand's disease Testing of fibrinolytic response

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desmopressin Full Prescribing Information, Dosage & Side Effects | MIMS.com Indonesia

2013/01/26

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