M.Sc, III semester. Soft core paper-3.

ADVANCED GENETICS 48Hrs Unit I i) Genome organization: a) Genome in prokaryotes and eukaryotes b) DNA constancy and C- value paradox c) Split genes and alternative splicing d) Mobile genetic elements prokaryotes and eukaryotes ii) Mapping of genome: a) Linkage b) Cytogenetic map c) Physical map d) Molecular markers Unit II 8 i ) Genome projects: Structural, functional, evolutionary and comparative genomics ofa. C elegans b. Drosophila c. Mouse d. Homo sapiens ii)Behavioral genetics : a) Genetic control of behavior (Nest cleaning in honey bees, alcohol preference in mice) b) Sexual behavior in Drosophila Unit III 8 hrs Genome evolution a. The origin of genomes: DNA and RNA world b. Evolution of gene duplication c. Gene families hrs 8 hrs

Unit IV

8 hrs Microbial genetics: a) Microbes as experimental models for basic and applied genetic studies

b) Fine structure of bacterial and bacterial chromosome, plasmids, properties of some plasmids c) Bacterial transformation, transduction and conjugation d) Bacteriophages- types, life cycle, morphogenesis and recombination. Unit V 8 hrs a) Human genetics: a) History, pedigree analysis. b) Genetics of reproductive system. c) Psychosomatic disorders. d) Prenatal diagnosis. e) Genetic counseling. Unit VI 8 Heritable diseases in man: a) Monogenic b) Polygenic c) Multifactorial d) Imprinting e) Chromosomal Tutorials REFERENCES: 1. Gardner E.J. Simmons M.J. and D.P Snustad. 1991. Principles of Genetics. John Wiley and Sons. Inc. NY. 2. Griffiths A. J.F. Miller J.H. D. T. Suzuki., R. C. Lewontin and W. M. Gelbart. 1996. An, introduction to genetic analysis W. H. Freeman and Company. N.Y. 3. Lewin. B. 1997. Genes. VI. Oxford Universty Press, Oxford, NY, Tokyo. 4. Snustad D. P and M. J. Simmons. 1997. Principles of Genetics. John Wiley and Sons,Inc NY. 5. Strickberger M.W., 1996 Genetics, Mac Millan publishing Co. NY. 6. Watson J. D., N. H. Hopkins., J. W. Roberts., J. A. Steitz and A. M. Weiner. 1987. Molecular Biology of Genes. The Benjamin Cummings Publshing Company. Inc. Tokyo. 7. The Human Genome. 2001. Nature. Vol. 409 Series of articles on Human Genome. 8. Drosophila Genome. 2000. Sciene Vol. 267 9. C. e/egans Genome. 1998. Scienc VoL 282 10. Arabidopsis Genome. 2Q. Nature Vol. 408 11 Cummings, N. R. 1994. Human Heredity: Principles and Issues. West Publishing Company. 12. Epstein, R. 3. 2003. Human Molecular Biology. Cambridge Univ. Press, Cambridge 13. Jobling N. A., Hurles and Tyler-Smith. 2004. Human Evolutionary Genetics Origin, -16x2= 32 hours hrs

People & Disease. Garland & Science 14. Khoury, M. 3., 3. Little and W. Burke. 2004. Human Genonie Epidemiology. Oxford Univ. Press, Oxford. 15. Motulsky, V. 1977. Human Genetics. Springer & Verlag, Berlin.-6. Strachan, T. and A. P. Reads, 2004, Human Molecular Genetics. Garland Science.