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Why gram-positive bacteria less threatening pathogens, and why gramnegative bacteria more pathogenic than gram positive.
Gram negative bacteria have less peptidoglycon in the cell wall. One of the several unique characteristics of Gram-negative bacteria is the structure of the outer membrane structure different to that of gram-positive bacteria. This membrane contains a complex lipopolysaccharide which acts as endotoxin. This is not present in Gram-positive bacteria. This outer membrane protects the bacteria from several antibiotics, which would normally damage the inner membrane or cell wall(peptidoglycon). The outer membrane provides these bacteria with resistance to lysozyme and penicillin. Other drugs can be used, for example chloramphenicol, streptomycin, and nalidixic acid. Gram positive bacteria are simply more dependent on peptidoglycon for their cell walls. Penicillin can across the peptidoglycon layer while it cant across the outer membrane of gram negative bacteria. Hence penicillin is more effective on gram positive bacteria than gram negative ones.
TYPHOID FEVER Also known as gasulic fever,abdominal typhus, infantile remittent fever, unuleated fever progress in four individual stages, each lasting approximately one week. A characteristic symptom of typhoid is a slowly progressive fever.
Refrences
Biology for Matriculation Semester 2, Second Edition, Oxford Fajar Sdn. Bhd, 2011 Campbell, N.A. & J.B Reece, Biology, Seventh Edition, University of California, The Benjamin Cummings Publishing Company, Inc, 2005 http:// www.wikipediabacteria.com. my Biology Laboratory Manual Semester 1 &2, Ninth Edition, Matriculation Division Ministry Of Education Malaysia www.studyofkingdommonera.com.my