MODULE 16 THE GENITAL SYSTEM (PATHOLOGY)

PRACTICAL PATHOLOGY 1: CERVICAL CARCINOMA, OVARIAN CYSTS AND TUMORS.

A)Jars:1.Organ: Uterus (subtotal hysterectomy with unilateral salpingo-oophorectomy specimen) (Page 105 - Atlas of Gross Pathology) Description: An enlarged distorted uterus with nodular external surface. Cut section shows multiple variable sized well defined non encapsulated masses, grayish white in colour with a whorly cut surface The masses are subserosal, intersititial and submucosal in location Diagnosis: Multiple uterine leiomyomata

MODULE 16 THE GENITAL SYSTEM (PATHOLOGY)

MODULE 16 THE GENITAL SYSTEM (PATHOLOGY)

2. Organ: Uterus with adnexa (subtotal hysterectomy with bilateral salpingooophorectomy specimen) (Page 106) Description : An enlarged distorted uterus with nodular external surface. Cut section shows multiple well defined masses of variable sizes, grayish white in colour and whorly cut surfaces. Some of the masses are seen under the serosa (subserous), others are seen within the myometrium (interstitial) while others are seen protruding through the endometrial cavity and lined by endometrium (submucous). One of the masses shows focal chalky white areas of calcifications. Diagnosis: Multiple uterine leiomyomata with calcification.

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3. Organ : Uterus and cervix (total hysterectomy specimen) (Page 107) Description: A slightly enlarged uterus with markedly enlarged cervix On section, the myometrium shows a well defined grayish white mass with a whorly cut surface The cervix is enlarged and shows an invasive friable and focally necrotic non-capsulated grayish white tumour filling the cervical canal Diagnosis: Uterine leiomyoma and cancer cervix

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4. Organ : Uterus, cervix and adnexa (total hysterectomy with bilateral salpingooophorectomy specimen) (Page 108) Description: The uterus is enlarged On section, an irregular non-capsulated polypoidal grayish white tumour mass is seen filling the uterine cavity and invading the myometrium. Cut surface of the mass show foci of hemorrhage and necrosis. Diagnosis : Polypoidal endometrial carcinoma

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B) Slides :1. Simple endometrial hyperplasia (Page 94 - Atlas of Histopathology) Endometrial tissue showing: Increased number of glands relative to stroma The glands are of varying sizes and shapes, some are tubular, others are dilated and several ones show outpouchings. The lining epithelium is hyperplastic and shows no signs of nuclear atypia. The stroma is cellular.

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2. Leiomyoma of the uterus (Page 95) Part of the uterine wall showing in one area. Non-encapsulated and well delimited tumour tissue. The tumour is formed of spindle shaped smooth muscle cells showing benign spindle shaped nuclei within tapering cytoplasm. The tumour cells area arranged in interlacing bundles and fascicles. Intervening fibrovascular connective tissue is seen.

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