Pathophysiology of brain tumors: Due to causes like chemicals and radiation exposure

Irritation and damage to cell structure

As adaptive mechanism, changes in cell morphology occurs

as radiation exposure continue, the changes become irreversible causing gene mutations in DNA

inactivation of tumor supressor genes and activation of oncogenes

uncontrolled cell division and decreased apoptosis

hyperplasia of brain cells

brain tumors

disruption of brain tissue causes displacement and herniation of brain tissue

Compression of ventricles

Compression of blood flow to brain

Obstruction of CSF flow

Obstruction of blood flow to brain Cerebral hypoxia

Increases accumulation of CSF

Anaerobic metabolism

Increased intracranial pressure

Lactic acid accumulation

Loss of consciousness and coma