Chloramphenicol Ophtalmic Ointments

Group II

Conventional dosage form

The conventional ocular dosage forms for the delivery of drug are : Eye drops Eye ointments Eye lotion

Convention Of Ointment Dosage Forms

causing blurring interfere with the healing of corneal lesions absorption drugs

The Recent Trends In Ophthalmic Drug Delivery

Phase transition system : in-situ gelling Ocular inserts or films: SODI, NODS, Lacriset, BODI, Dry drops and gelfoams, minidiscs Collagen shields Drug presoaked hydrogel type contact lens and pledgets Ocular lontophoresis (pulsatile drug delivery)

Good tolerability Formation of a protective film over the cornea Protection from conjunctival adhesion Active of the drug subtance is prolonged Leading to decreased frequency of administration non greasy and may be easily removed by washing Miscible with exudates from inflamed sites Generally compatible with the vast majority of therapeutic agents

FORMULA
Each 3,5 g contains : Chloramfenikol Benzalkonium klorida Sodium thiosulfate Disodium edetat Carbomer Aquadest

1% 0,02 % 0,05 % 0,1 % 2% ad 100 %

Carbomer

water

Homogenise, disperse, and mix (aseptic)

Add benzalkonium chloride, disodium edetat, sodium thiosulfat

Add micronized Chloramphenikol and mix

Fill gel product into ophthalmic tubes

Thank You