Professional Documents
Culture Documents
A CASE DISCUSSION
1WK
INVESTIGATED 3 MONTHS EARLIER FOR THROMBOCYTOPENIA BONE MARROW EXAMINATION THEN REVEALED
NO ABNORMAL CELLS
INCREASED MEGAKARYOCYTES
PHYSICAL EXAMINATION
SICK CHILD PALLOR GENERALISED LYMPHADENOPATHY PURPURIC SPOTS HEPATOSPLENOMEGALY NORMAL CNS EXAMINATION OTHER SYSTEMS: WNL
INVESTIGATIONS
CHEST X RAY MEDIASTINAL MASS LN BIOPSYLYMPHOBLASTIC LYMPHOMA BONE MARROW STUDY INFILTRATION WITH ABNORMAL CELLS RESEMBLING LYMPHOBLASTS 65% CONSISTENT WITH LYMPHOBLASTIC LYMPHOMA WITH MARROW INFILTRATION
INTP - PPO, PHO, IAP. P7 5/22
TREATMENT
TREATED AS PER PROTOCOL FOR ACUTE LYMPHOBLASTIC LEUKEMIA REMISSION ACHIEVED CHILD STARTED ON MAINTENANCE CHEMOTHERAPY
2 WEEKS -- 1 WEEK
CLINICAL EXAMINATION
NORMAL SENSORIUM NO CRANIAL NERVE PALSIES UNSTEADY GAIT TAKES FEW STEPS WITH SUPPORT TENDERNESS TO PERCUSSION OVER 1ST AND 2nd LUMBAR VERTEBRAE EXAGGERATED DTRS PLANTAR REFLEX B/L UPGOING LOSS OF CREMASTERIC REFLEX
POSSIBLE DIAGNOSIS?
INTP - PPO, PHO, IAP. P7 8/22
CLINICAL POSSIBILITIES
RELAPSE OF LYMPHOBLASTIC LYMPHOMA WITH SPINAL CORD METASTASIS RESULTING IN SPINAL CORD COMPRESSION STEROID TOXICITY OSTEOPOROSIS AND VERTEBRAL COLLAPSE WITH SPINAL CORD COMPRESSION
PLAN OF MANAGEMENT
EMERGENCY ADMINISTRATION OF STEROIDS
FIRST AND MOST IMPORTANT STEP PRECEDES INVESTIGATIONS ORAL/IV DEXAMETHASONE IN PROPER DOSES
INVESTIGATE TO ESTABLISH DIAGNOSIS AND ASSESS SEVERITY AND EXTENT OF LESION TISSUE DIAGNOSIS OF RELAPSE INVOLVE NEUROSURGEON, RADIOTHERAPIST AND RADIOLOGIST IN MANAGEMENT CLOSELY MONITOR FOR PROGRESSION OF NEUROLOGICAL SIGNS AND SYMPTOMS
CHILD GIVEN IV DEXAMETHASONE, LOADING DOSE FOLLOWED BY 6TH HRLY MAINTENANCE DOSES AND FOLLOWED UP CLOSELY
AFTER STEROID ADMINISTRATION PLAIN XRAY AND MRI SCAN OF SPINE WAS DONE
PRE (L) AND POST (R) CONTRAST SCAN SHOWS VERTEBRAL BODY ENHANCES STRONGLY. NOTE CORD COMPRESSION.
AXIAL T-1 WEIGHTED MRI SCAN AT L-1 LEVEL SHOWS EPIDURAL NHL (LARGE ARROWS) WITH THECAL SAC COMPRESSION (SMALL ARROWS)
BY 48 HOURS
BACK PAIN REDUCED SHOOTING PAINS REDUCED MARKED IMPROVEMENT IN MUSCLE POWER. CHILD ABLE TO WALK WITH MINIMAL SUPPORT DTRS BRISK AND UPGOING PLANTAR
CT GUIDED BIOPSY FROM THE MASS REVEALED LYMPHOBLASTIC LYMPHOMA DIAGNOSIS OF SPINAL CORD COMPRESSION DUE TO LYMPHOBLASTIC LYMPHOMA (RELAPSE) CONFIRMED (MRI SCAN + BIOPSY)
NEXT STEP IN THERAPY?
INTP - PPO, PHO, IAP. P7 17/22
CHEMOTHERAPY FOR RELAPSED LYMPHOBLASTIC LYMPHOMA WITH 2ND LINE AGENTS STARTED SINCE:
CHILD IMPROVED MARKEDLY WITH STEROIDS AND NO NEUROLOGICAL PROGRESSION PRESENT LYMPHOBLASTIC LYMPHOMAS ARE CHEMOSENSITIVE TUMOURS
RADIO THERAPY USUALLY NOT FIRST LINE THERAPY MAY BE USED IF THERE IS NEUROLOGICAL PROGRESSION OR RADIO SENSITIVE TUMOUR RADIOTHERAPY CAN CAUSE IATROGENIC SPINAL DEFORMITIES AND SECOND CANCERS HENCE AVOID IF POSSIBLE
INTP - PPO, PHO, IAP. P7 19/22
CHILDS PROGRESS
RESPONDED WELL TO CHEMOTHERAPY
AT 4 WEEKS - NO SIGNIFICANT NEUROLOGICAL DEFICIT EXCEPT FOR MILD WEAKNESS OF LOWER LIMBS
INTP - PPO, PHO, IAP. P7 20/22
KEY POINTS
SPINAL CORD COMPRESSION A TRUE MEDICAL EMERGENCY SUSPECT IN ANY CHILD WITH KNOWN MALIGNANCY AND A PERSISTENT, SEVERE AND PROGRESSIVE BACK PAIN MAY BE A PRESENTING SIGN OF A MALIGNANCY EARLY ADMINISTRATION OF STEROIDS WILL OPTIMISE OUTCOME AND REDUCE MORBIDITY AND MORTALITY MRI PREFERRED FOR DIAGNOSIS MULTI DISCIPLINARY APPROACH
KEY POINTS
DEFINITIVE THERAPY MAY INVOLVE CHEMOTHERAPY AND/OR RADIOTHERAPY OR SURGERY
PROGNOSIS DIRECTLY RELATED TO EXTENT OF INVOLVEMENT AND TIME ELAPSED BETWEEN ONSET OF SYMPTOMS AND INTERVENTION