VETOLEX ( BUPARVAQUONE)

Drug Form: Strile Soluble Injection Chemistry: Antiparasitic Composition: Each ml of drug contains 50 mg Buparvaquone Action: Buparvaquone is an analogous parvaquone (Hydroxy nephtoquinone) Buparvaquone is more resistant to metabolic reactions than Parvaquone. The mode of action of buparvaquone indicates an effect on energy generation, progressive vacuolation of the cytoplasm as the principal lesion. The surface membrane and the nuclear membrane remain apparently unaffected until the cytoplasmic disruption is very advanced. There is no apparent adverse effect on the structure of host lymphocytes, including mitochondria, which emphasizes the parasite-specificity of the mode of action of buparvaquone. Pharmacokinetics: Intra muscular Injection bioavaibility is approximately 3% mg/L after 3 hours and 17 minutes. Volume of distribution occur slowly and elimination half life approximately 26 hours and 44 minutes. Uses: Buparvaquone is indicated for the treatment of Theileria annulata and T.sergenti in cattle and is generally ineffective in cattle against arrested larval forms ( It is useful for pyroplasm and shyzont order of theileria). Buparvaquone is also used for treatment and prevention. Dosage Guide: For intramuscular injection 2.5 mg/kg single dose, but in sever form of disease repeat 48 72 hours later. This drug is only used for intramuscular injection and the best site is muscule of neck. Dont advice more than 10 mL for one site. Contra-indications: Intravenouse and subcoutaneus injection are forbidden. Vaccinate after clinical improvement Use antibiotic to control second infectious.

Withdrawal Time: Meat: 42 days Milk: 48 hours Storage: Vetolex products should be stored at room temperature (15-30 0C). Veterinary Labeled products: Vetolex Injection in 50 ml vials, One vial in a package.