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An Official Journal of Epilepsy Society of Thailand

CONTENTS
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Epilepsy Highlight:
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- B'n European Congress on Epileptology U

September 21-25,2008 rnyiru rLdvra?Joirerx fil#er;raraulq 6oflr?l:r:fi'r:al'rFrdoerfl lufltua.r

- Epilepsy & Inflammatron 2 4iddd
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Continuum: ?r? dt? E1 n ur:-l t{o fl 0 { yn { fl ?t'r Ft }..r (www. th ai epi lepsysoeiety, com )
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- Difficult to treat epilepsy fl{1.{'tEytT}.t to Lx{tool.{til:918.J%1.t 71lf Ft6r[y1j::el]']fint:?'t?fi1:fl0fl0:JFtill
- Antiepileptic drugs & Drug interaction 1 otqI:I
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- Value of screening for bone demineralization in

an urban population of patienis with epilepsy I I
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Current Practices and Quizs. oir.:t:-lqrntes.r ttiu nrroonqrf;p.iru M-current potassium channel
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Current Practices and Quizs 9qJ

vd tection utnytilu antiepileptogenesis 6': taattsJfitnr:YnrqrT:enelfn

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FAQ rfi r': o ri r t ro^ r : uo n qr n filusj r r rl :; ril e( il { li ar"t6o':'r x 5vr r r fi r u p h ar-
1t macogenomrcs a.n'tfftunr:qqJ,cJ urn oulfftunr:rYon:ot ffrjrsfifiIonr a urvl
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HEAD OFFICE d I q a u T u ,l dt !4 vl v I q - ut JX
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 EPILEPSY HIGHLIGHT
Highlight from 8'h European on Epileptology September 2L-25,2OO8
Epilepsy 8c Inflammation
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lmmune system :-i:vnor6':a 2 nntn 6o innate immune tunr: ufi orl:o n a.r fr'n'tfi urri

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lfio hyperexcitation virl#rfioornr:#n"tuffsr5vrono{'td ra6o Inflammation in Human epilepsy & Seizure disorders

nuclear factortcB(NFl(B) d*',r-,.ronrvfr% proinflammatory Inflammatory markers

Epileptic syndrome

genes 6,: rilu gene fivitvrrirfi .n.ooing cytokines ttny Convulsive disorder Plasma or CSF Brain tissue Antiinflammatory treatments
Basmussen encephalit s GluR3 Ab, Munc-|8 Ab GluR3 Ah ACTH, steroids, lVlg

chemokine protein fi tfietr{atffinl:n:vfru comptement, CD-8+lymphocytes PEX,PAL,immunosuppressant

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West Syndrome IFN-a plta, TNF-alpha, lL2 n.d, ACTH, steroids, lVlg
cycrooxygenase-2, ttdv nitric oxide 6.lqvvit"t#finr:virnrel Lennox-Gastaul d,syndrome n n d, ACTH, steroids, lVlg
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fi ra n ngruatir auunrr rfi o ch ron ic i nf Iam matory response dt qao^ar

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rv tufrcJ9
r,llilfi neuronal loss i':eln-:-t gliosis fil3r:rx CA1 uuny dentate
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gyrus fi hippocampus tufr?flt1,\:Jilfinr:qt:rqilL lL-1 cx, IoEJi6
nr : lfi o n I : ffn ua:-l ( i nf am m at on ) o I aqy id fl 'J { o t n-:-t v',r s r6
immunohistochemistry lu cell fi erfirlmicroglia turdoaero,:fi
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Epnrpsy Drcrsr O ctob er-D e cemb er" 200 I 3

 CONTINUUM:
Difficult to treat epil.psy vda.a
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